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Volumn 150, Issue 3, 2015, Pages 621-632

Combined hypoxia inducible factor-1α and homogeneous endothelial progenitor cell therapy attenuates shunt flow-induced pulmonary arterial hypertension in rabbits

Author keywords

Congenital heart disease; endothelial progenitor cells; HIF 1 ; pulmonary arterial hypertension; rabbits

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HIF1A PROTEIN, HUMAN;

EID: 84940448367     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2015.05.035     Document Type: Article
Times cited : (21)

References (41)
  • 1
    • 0024449294 scopus 로고
    • Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, primary pulmonary hypertension registry
    • G. Pietra, W. Edwards, J. Kay, S. Rich, J. Kernis, B. Schloo, and et al. Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, primary pulmonary hypertension registry Circulation 80 1989 1198 1206
    • (1989) Circulation , vol.80 , pp. 1198-1206
    • Pietra, G.1    Edwards, W.2    Kay, J.3    Rich, S.4    Kernis, J.5    Schloo, B.6
  • 2
    • 84920186290 scopus 로고    scopus 로고
    • Unidirectional valved patch closure of ventricular septal defects with severe pulmonary arterial hypertension: Hemodynamic outcomes
    • S. Talwar, V.K. Keshri, S.K. Choudhary, S.K. Gupta, S. Ramakrishnan, A. Saxena, and et al. Unidirectional valved patch closure of ventricular septal defects with severe pulmonary arterial hypertension: hemodynamic outcomes J Thorac Cardiovasc Surg 148 2014 2570 2575
    • (2014) J Thorac Cardiovasc Surg , vol.148 , pp. 2570-2575
    • Talwar, S.1    Keshri, V.K.2    Choudhary, S.K.3    Gupta, S.K.4    Ramakrishnan, S.5    Saxena, A.6
  • 3
    • 3042831454 scopus 로고    scopus 로고
    • Outcome of patients after surgical closure of ventricular septal defect at young age: Longitudinal follow-up of 22-34 years
    • J. Roos-Hesselink, F. Meijboom, S. Spitaels, R. Van Domburg, E. van Rijen, E. Utens, and et al. Outcome of patients after surgical closure of ventricular septal defect at young age: longitudinal follow-up of 22-34 years Eur Heart J 25 2004 1057 1062
    • (2004) Eur Heart J , vol.25 , pp. 1057-1062
    • Roos-Hesselink, J.1    Meijboom, F.2    Spitaels, S.3    Van Domburg, R.4    Van Rijen, E.5    Utens, E.6
  • 5
    • 33750560212 scopus 로고    scopus 로고
    • Right ventricular function and failure report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure
    • N.F. Voelkel, R.A. Quaife, L.A. Leinwand, R.J. Barst, M.D. McGoon, D.R. Meldrum, and et al. Right ventricular function and failure report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure Circulation 114 2006 1883 1891
    • (2006) Circulation , vol.114 , pp. 1883-1891
    • Voelkel, N.F.1    Quaife, R.A.2    Leinwand, L.A.3    Barst, R.J.4    McGoon, M.D.5    Meldrum, D.R.6
  • 6
    • 4644290657 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension
    • M. Humbert, O. Sitbon, and G. Simonneau Treatment of pulmonary arterial hypertension N Engl J Med 351 2004 1425 1436
    • (2004) N Engl J Med , vol.351 , pp. 1425-1436
    • Humbert, M.1    Sitbon, O.2    Simonneau, G.3
  • 7
    • 54049138069 scopus 로고    scopus 로고
    • Emerging concepts and translational priorities in pulmonary arterial hypertension
    • E.D. Michelakis, M.R. Wilkins, and M. Rabinovitch Emerging concepts and translational priorities in pulmonary arterial hypertension Circulation 118 2008 1486 1495
    • (2008) Circulation , vol.118 , pp. 1486-1495
    • Michelakis, E.D.1    Wilkins, M.R.2    Rabinovitch, M.3
  • 8
    • 43749107536 scopus 로고    scopus 로고
    • Management of pulmonary arterial hypertension associated with congenital systemic-to-pulmonary shunts and Eisenmenger's syndrome
    • N. Galie, A. Manes, M. Palazzini, L. Negro, A. Marinelli, S. Gambetti, and et al. Management of pulmonary arterial hypertension associated with congenital systemic-to-pulmonary shunts and Eisenmenger's syndrome Drugs 68 2008 1049 1066
    • (2008) Drugs , vol.68 , pp. 1049-1066
    • Galie, N.1    Manes, A.2    Palazzini, M.3    Negro, L.4    Marinelli, A.5    Gambetti, S.6
  • 9
    • 77952885832 scopus 로고    scopus 로고
    • Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia
    • B. Cristofaro, O.A. Stone, A. Caporali, D. Dawbarn, N. Ieronimakis, M. Reyes, and et al. Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia Arterioscler Thromb Vasc Biol 30 2010 1143 1150
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1143-1150
    • Cristofaro, B.1    Stone, O.A.2    Caporali, A.3    Dawbarn, D.4    Ieronimakis, N.5    Reyes, M.6
  • 10
    • 77149180381 scopus 로고    scopus 로고
    • Molecular magnetic resonance imaging of myocardial angiogenesis after acute myocardial infarction
    • M. Oostendorp, K. Douma, A. Wagenaar, J.M. Slenter, T.M. Hackeng, M.A. van Zandvoort, and et al. Molecular magnetic resonance imaging of myocardial angiogenesis after acute myocardial infarction Circulation 121 2010 775 783
    • (2010) Circulation , vol.121 , pp. 775-783
    • Oostendorp, M.1    Douma, K.2    Wagenaar, A.3    Slenter, J.M.4    Hackeng, T.M.5    Van Zandvoort, M.A.6
  • 11
    • 84868594163 scopus 로고    scopus 로고
    • Platelet-mediated mesenchymal stem cells homing to the lung reduces monocrotaline-induced rat pulmonary hypertension
    • L. Jiang, X.H. Song, P. Liu, C.L. Zeng, Z.S. Huang, L.J. Zhu, and et al. Platelet-mediated mesenchymal stem cells homing to the lung reduces monocrotaline-induced rat pulmonary hypertension Cell Transplant 21 2012 1463 1475
    • (2012) Cell Transplant , vol.21 , pp. 1463-1475
    • Jiang, L.1    Song, X.H.2    Liu, P.3    Zeng, C.L.4    Huang, Z.S.5    Zhu, L.J.6
  • 12
    • 79957859304 scopus 로고    scopus 로고
    • Adipose-derived stromal cell autologous transplantation ameliorates pulmonary arterial hypertension induced by shunt flow in rat models
    • K. Liu, R. Liu, G. Cao, H. Sun, X. Wang, and S. Wu Adipose-derived stromal cell autologous transplantation ameliorates pulmonary arterial hypertension induced by shunt flow in rat models Stem Cells Develop 20 2010 1001 1010
    • (2010) Stem Cells Develop , vol.20 , pp. 1001-1010
    • Liu, K.1    Liu, R.2    Cao, G.3    Sun, H.4    Wang, X.5    Wu, S.6
  • 13
    • 79951987330 scopus 로고    scopus 로고
    • Endothelial progenitor cells in pulmonary hypertension - Dawn of cell-based therapy?
    • M. Toshner, and N.W. Morrell Endothelial progenitor cells in pulmonary hypertension - dawn of cell-based therapy? Int J Clin Pract Suppl 165 2010 7 12
    • (2010) Int J Clin Pract Suppl , vol.165 , pp. 7-12
    • Toshner, M.1    Morrell, N.W.2
  • 14
    • 44449126784 scopus 로고    scopus 로고
    • Autologous transplantation of bone marrow-derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats
    • H.K. Yip, L.T. Chang, C.K. Sun, J.J. Sheu, C.H. Chiang, A.A. Youssef, and et al. Autologous transplantation of bone marrow-derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats Crit Care Med 36 2008 873 880
    • (2008) Crit Care Med , vol.36 , pp. 873-880
    • Yip, H.K.1    Chang, L.T.2    Sun, C.K.3    Sheu, J.J.4    Chiang, C.H.5    Youssef, A.A.6
  • 15
    • 50249173894 scopus 로고    scopus 로고
    • Effects of the antioxidative β-blocker celiprolol on endothelial progenitor cells in hypertensive rats
    • E.H. Yao, N. Fukuda, T. Matsumoto, M. Katakawa, C. Yamamoto, Y. Han, and et al. Effects of the antioxidative β-blocker celiprolol on endothelial progenitor cells in hypertensive rats Am J Hyperten 21 2008 1062 1068
    • (2008) Am J Hyperten , vol.21 , pp. 1062-1068
    • Yao, E.H.1    Fukuda, N.2    Matsumoto, T.3    Katakawa, M.4    Yamamoto, C.5    Han, Y.6
  • 16
    • 84879187782 scopus 로고    scopus 로고
    • Recombinant human hepatocyte growth factor transfection alleviates hyperkinetic pulmonary artery hypertension in rabbit models
    • W. Wang, K. Liu, F. Zhang, G. Cao, Y. Zhang, R. Liu, and et al. Recombinant human hepatocyte growth factor transfection alleviates hyperkinetic pulmonary artery hypertension in rabbit models J Thorac Cardiovasc Surg 146 2013 198 205
    • (2013) J Thorac Cardiovasc Surg , vol.146 , pp. 198-205
    • Wang, W.1    Liu, K.2    Zhang, F.3    Cao, G.4    Zhang, Y.5    Liu, R.6
  • 17
    • 38349096471 scopus 로고    scopus 로고
    • Gene transfer of endothelial nitric oxide synthase attenuates flow-induced pulmonary hypertension in rabbits
    • F. Zhang, S. Wu, X. Lu, M. Wang, and M. Liu Gene transfer of endothelial nitric oxide synthase attenuates flow-induced pulmonary hypertension in rabbits Ann Thorac Surg 85 2008 581 585
    • (2008) Ann Thorac Surg , vol.85 , pp. 581-585
    • Zhang, F.1    Wu, S.2    Lu, X.3    Wang, M.4    Liu, M.5
  • 18
    • 66449098872 scopus 로고    scopus 로고
    • Vegf ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats
    • L. Farkas, D. Farkas, K. Ask, A. Moller, J. Gauldie, P. Margetts, and et al. Vegf ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats J Clin Invest 119 2009 1298 1311
    • (2009) J Clin Invest , vol.119 , pp. 1298-1311
    • Farkas, L.1    Farkas, D.2    Ask, K.3    Moller, A.4    Gauldie, J.5    Margetts, P.6
  • 19
    • 84902977193 scopus 로고    scopus 로고
    • Attenuation of monocrotaline-induced pulmonary hypertension by luminal aav serotype 9 gene transfer of prostacyclin synthase
    • I.B. Gubrij, S.R. Martin, A.K. Pangle, R.C. Kurten, and L.G. Johnson Attenuation of monocrotaline-induced pulmonary hypertension by luminal aav serotype 9 gene transfer of prostacyclin synthase Hum Gene Ther 25 2014 498 505
    • (2014) Hum Gene Ther , vol.25 , pp. 498-505
    • Gubrij, I.B.1    Martin, S.R.2    Pangle, A.K.3    Kurten, R.C.4    Johnson, L.G.5
  • 20
    • 77952771680 scopus 로고    scopus 로고
    • Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats
    • K. Takemiya, H. Kai, H. Yasukawa, N. Tahara, S. Kato, and T. Imaizumi Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats Basic Res Cardiol 105 2010 409 417
    • (2010) Basic Res Cardiol , vol.105 , pp. 409-417
    • Takemiya, K.1    Kai, H.2    Yasukawa, H.3    Tahara, N.4    Kato, S.5    Imaizumi, T.6
  • 21
    • 68549122789 scopus 로고    scopus 로고
    • Prevention of pulmonary hypertension by angiotensin-converting enzyme 2 gene transfer
    • Y. Yamazato, A.J. Ferreira, K.H. Hong, S. Sriramula, J. Francis, M. Yamazato, and et al. Prevention of pulmonary hypertension by angiotensin-converting enzyme 2 gene transfer Hypertension 54 2009 365 371
    • (2009) Hypertension , vol.54 , pp. 365-371
    • Yamazato, Y.1    Ferreira, A.J.2    Hong, K.H.3    Sriramula, S.4    Francis, J.5    Yamazato, M.6
  • 22
    • 0037047038 scopus 로고    scopus 로고
    • Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model
    • H. Su, J. Arakawa-Hoyt, and Y.W. Kan Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model Proc Natl Acad Sci 99 2002 9480 9485
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 9480-9485
    • Su, H.1    Arakawa-Hoyt, J.2    Kan, Y.W.3
  • 23
    • 0141640863 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
    • M. Yamakawa, L.X. Liu, T. Date, A.J. Belanger, K.A. Vincent, G.Y. Akita, and et al. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors Circ Res 93 2003 664 673
    • (2003) Circ Res , vol.93 , pp. 664-673
    • Yamakawa, M.1    Liu, L.X.2    Date, T.3    Belanger, A.J.4    Vincent, K.A.5    Akita, G.Y.6
  • 24
    • 0037297359 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Therapeutic angiogenesis for limb and myocardial ischemia
    • T. Khan, F. Sellke, and R. Laham Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemia Gene Ther 10 2003 285 291
    • (2003) Gene Ther , vol.10 , pp. 285-291
    • Khan, T.1    Sellke, F.2    Laham, R.3
  • 25
    • 59249107409 scopus 로고    scopus 로고
    • Decreased vascular repair and neovascularization with ageing: Mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1
    • M.R. Hoenig, C. Bianchi, A. Rosenzweig, and F.W. Sellke Decreased vascular repair and neovascularization with ageing: mechanisms and clinical relevance with an emphasis on hypoxia-inducible factor-1 Curr Mol Med 8 2008 754 767
    • (2008) Curr Mol Med , vol.8 , pp. 754-767
    • Hoenig, M.R.1    Bianchi, C.2    Rosenzweig, A.3    Sellke, F.W.4
  • 26
    • 0042433541 scopus 로고    scopus 로고
    • Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells
    • N. Nagaya, K. Kangawa, M. Kanda, M. Uematsu, T. Horio, N. Fukuyama, and et al. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells Circulation 108 2003 889 895
    • (2003) Circulation , vol.108 , pp. 889-895
    • Nagaya, N.1    Kangawa, K.2    Kanda, M.3    Uematsu, M.4    Horio, T.5    Fukuyama, N.6
  • 27
    • 0037065852 scopus 로고    scopus 로고
    • Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration
    • H. Iwaguro, J.I. Yamaguchi, C. Kalka, S. Murasawa, H. Masuda, S.-I. Hayashi, and et al. Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration Circulation 105 2002 732 738
    • (2002) Circulation , vol.105 , pp. 732-738
    • Iwaguro, H.1    Yamaguchi, J.I.2    Kalka, C.3    Murasawa, S.4    Masuda, H.5    Hayashi, S.-I.6
  • 28
    • 14844360656 scopus 로고    scopus 로고
    • Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease
    • Y.D. Zhao, D.W. Courtman, Y. Deng, L. Kugathasan, Q. Zhang, and D.J. Stewart Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease Circ Res 96 2005 442 450
    • (2005) Circ Res , vol.96 , pp. 442-450
    • Zhao, Y.D.1    Courtman, D.W.2    Deng, Y.3    Kugathasan, L.4    Zhang, Q.5    Stewart, D.J.6
  • 29
    • 34447570619 scopus 로고    scopus 로고
    • Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension
    • Q. Zhao, Z. Liu, Z. Wang, C. Yang, J. Liu, and J. Lu Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension Ann Thorac Surg 84 2007 544 552
    • (2007) Ann Thorac Surg , vol.84 , pp. 544-552
    • Zhao, Q.1    Liu, Z.2    Wang, Z.3    Yang, C.4    Liu, J.5    Lu, J.6
  • 30
    • 84911001877 scopus 로고    scopus 로고
    • Establishment and comparison of two reliable hyperkinetic pulmonary hypertension models in rabbits
    • C. Liu, Z. Yan, C. Fang, G. Cao, B. Wang, S. Li, and et al. Establishment and comparison of two reliable hyperkinetic pulmonary hypertension models in rabbits J Thorac Cardiovasc Surg 148 2014 2353 2359
    • (2014) J Thorac Cardiovasc Surg , vol.148 , pp. 2353-2359
    • Liu, C.1    Yan, Z.2    Fang, C.3    Cao, G.4    Wang, B.5    Li, S.6
  • 31
    • 0038368989 scopus 로고    scopus 로고
    • Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells
    • D.P. Griese, S. Achatz, C.A. Batzlsperger, U.G. Strauch, B. Grumbeck, J. Weil, and et al. Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells Cardiovasc Res 58 2003 469 477
    • (2003) Cardiovasc Res , vol.58 , pp. 469-477
    • Griese, D.P.1    Achatz, S.2    Batzlsperger, C.A.3    Strauch, U.G.4    Grumbeck, B.5    Weil, J.6
  • 32
    • 66249125011 scopus 로고    scopus 로고
    • Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension
    • J.M. Aliotta, P.J. Keaney, R.R. Warburton, M. DelTatto, M.S. Dooner, M.A. Passero, and et al. Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension Stem Cells Develop 18 2008 773 781
    • (2008) Stem Cells Develop , vol.18 , pp. 773-781
    • Aliotta, J.M.1    Keaney, P.J.2    Warburton, R.R.3    DelTatto, M.4    Dooner, M.S.5    Passero, M.A.6
  • 33
    • 84879028705 scopus 로고    scopus 로고
    • Beneficial effects of a novel agonist of the adenosine a2a receptor on monocrotaline-induced pulmonary hypertension in rats
    • A.K. Alencar, S.L. Pereira, T.L. Montagnoli, R.C. Maia, A.E. Kümmerle, S.S. Landgraf, and et al. Beneficial effects of a novel agonist of the adenosine a2a receptor on monocrotaline-induced pulmonary hypertension in rats Br J Pharmacol 169 2013 953 962
    • (2013) Br J Pharmacol , vol.169 , pp. 953-962
    • Alencar, A.K.1    Pereira, S.L.2    Montagnoli, T.L.3    Maia, R.C.4    Kümmerle, A.E.5    Landgraf, S.S.6
  • 35
    • 82955201759 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein and β-glycerophosphate synergistically induce endothelial progenitor cell ossification
    • L. Liu, Z.Z. Liu, H. Chen, G.J. Zhang, Y.H. Kong, and X.X. Kang Oxidized low-density lipoprotein and β-glycerophosphate synergistically induce endothelial progenitor cell ossification Acta Pharmacol Sinica 32 2011 1491 1497
    • (2011) Acta Pharmacol Sinica , vol.32 , pp. 1491-1497
    • Liu, L.1    Liu, Z.Z.2    Chen, H.3    Zhang, G.J.4    Kong, Y.H.5    Kang, X.X.6
  • 36
    • 84877088786 scopus 로고    scopus 로고
    • Oestradiol ameliorates monocrotaline pulmonary hypertension via no, prostacyclin and endothelin-1 pathways
    • P. Yuan, W.H. Wu, L. Gao, Z.Q. Zheng, D. Liu, H.Y. Mei, and et al. Oestradiol ameliorates monocrotaline pulmonary hypertension via no, prostacyclin and endothelin-1 pathways Eur Respir J 41 2013 1116 1125
    • (2013) Eur Respir J , vol.41 , pp. 1116-1125
    • Yuan, P.1    Wu, W.H.2    Gao, L.3    Zheng, Z.Q.4    Liu, D.5    Mei, H.Y.6
  • 37
    • 38149035012 scopus 로고    scopus 로고
    • Angiogenesis by transplantation of hif-1 alpha modified epcs into ischemic limbs
    • M. Jiang, B. Wang, C. Wang, B. He, H. Fan, T.B. Guo, and et al. Angiogenesis by transplantation of hif-1 alpha modified epcs into ischemic limbs J Cell Biochem 103 2008 321 334
    • (2008) J Cell Biochem , vol.103 , pp. 321-334
    • Jiang, M.1    Wang, B.2    Wang, C.3    He, B.4    Fan, H.5    Guo, T.B.6
  • 38
    • 34249007471 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling
    • J. Hanze, N. Weissmann, F. Grimminger, W. Seeger, and F. Rose Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling Thromb Haemost 97 2007 774
    • (2007) Thromb Haemost , vol.97 , pp. 774
    • Hanze, J.1    Weissmann, N.2    Grimminger, F.3    Seeger, W.4    Rose, F.5
  • 39
    • 0034006016 scopus 로고    scopus 로고
    • Hif-1: Mediator of physiological and pathophysiological responses to hypoxia
    • G.L. Semenza Hif-1: mediator of physiological and pathophysiological responses to hypoxia J Appl Physiol 88 2000 1474 1480
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 40
    • 0032576971 scopus 로고    scopus 로고
    • Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
    • J. Hu, D.J. Discher, N.H. Bishopric, and K.A. Webster Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand Biochem Biophys Res Commun 245 1998 894 899
    • (1998) Biochem Biophys Res Commun , vol.245 , pp. 894-899
    • Hu, J.1    Discher, D.J.2    Bishopric, N.H.3    Webster, K.A.4


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