Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects

Journal of Thoracic and Cardiovascular Surgery

Volumn 150, Issue 3, 2015, Pages 645-654.e3

  Kishimoto, Yasuaki ^a   Kato, Taichi ^a   Ito, Mikako ^a   Azuma, Yoshiteru ^a   Fukasawa, Yoshie ^a   Ohno, Kinji ^a   Kojima, Seiji ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

molecular hydrogen; NFAT; pulmonary arterial hypertension; reactive oxygen species; STAT3

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALPHA SMOOTH MUSCLE ACTIN; CD68 ANTIGEN; CYCLINE; HYDROGEN; MONOCYTE CHEMOTACTIC PROTEIN 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; MONOCROTALINE; STAT3 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HEART; HEART RIGHT VENTRICLE HYPERTROPHY; HEMODYNAMICS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LUNG; LUNG BLOOD VESSEL; MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY HYPERTENSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; HYPERTENSION, PULMONARY; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PULMONARY ARTERY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; HYDROGEN; HYPERTENSION, PULMONARY; MALE; MONOCROTALINE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NFATC TRANSCRIPTION FACTORS; PHOSPHORYLATION; PULMONARY ARTERY; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; VASCULAR REMODELING;

EID: 84940447681     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2015.05.052     Document Type: Article

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