Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR

Molecular Psychiatry

Volumn 20, Issue 9, 2015, Pages 1069-1078

  Oguro Ando, A ^a,b   Rosensweig, C ^a,b   Herman, E ^d,e   Nishimura, Y ^a,f   Werling, D ^a   Bill, B R ^a   Berg, J M ^a   Gao, F ^a   Coppola, G ^a   Abrahams, B S ^a,g   Geschwind, D H ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASMIC FMR1 INTERACTING PROTEIN 1; FRAGILE X MENTAL RETARDATION PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 2; RAPAMYCIN; TRANSCRIPTOME; UNCLASSIFIED DRUG; CYFIP1 PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ADULT; ARTICLE; ASTROCYTE; AUTISM; BRAIN CORTEX; BRAIN WEIGHT; CELL DENSITY; CELL DIFFERENTIATION; CELL SIZE; CELL STRUCTURE; CEREBELLUM; CONTROLLED STUDY; DENDRITIC SPINE; FEMALE; FRONTAL CORTEX; GENE DOSAGE; GENE LOCUS; GENE ONTOLOGY; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GOLGI STAIN; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOBLASTOID CELL LINE; MICROARRAY ANALYSIS; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PYRAMIDAL NERVE CELL; SIGNAL TRANSDUCTION; SUPERIOR TEMPORAL GYRUS; TEMPORAL CORTEX; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHROMOSOME 15; COPY NUMBER VARIATION; DENDRITIC CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTISM SPECTRUM DISORDER; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 15; DENDRITIC CELLS; DENDRITIC SPINES; DNA COPY NUMBER VARIATIONS; FEMALE; FRAGILE X MENTAL RETARDATION PROTEIN; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84940440506     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2014.124     Document Type: Article

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