Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12

Tumor Biology

Volumn 36, Issue 8, 2015, Pages 6497-6505

  Xie, Zongtao ^a   Cai, Liming ^a   Li, Runsheng ^a   Zheng, Jinyu ^b   Wu, Hongyan ^b   Yang, Xiaoqi ^a   Li, Hu ^a   Wang, Zhiqiang ^a  

^a JIANGNAN UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

EMT; Invasion; miR 489; NSCLC; SUZ12

Indexed keywords

MEMBRANE PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 489; NERVE CELL ADHESION MOLECULE; PROTEIN SUZ12; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; MIRN489 MICRORNA, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2; SUZ12 PROTEIN, HUMAN; TUMOR MARKER;

3' UNTRANSLATED REGION; ADULT; APOPTOSIS; ARTICLE; BIOINFORMATICS; CANCER GROWTH; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; LUNG CANCER CELL LINE; LUNG CARCINOGENESIS; LUNG METASTASIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NON SMALL CELL LUNG CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR INVASION; TUMOR VOLUME; UPREGULATION; WESTERN BLOTTING; AGED; BIOSYNTHESIS; GENETICS; PATHOLOGY; TUMOR CELL LINE;

AGED; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS; POLYCOMB REPRESSIVE COMPLEX 2; TUMOR MARKERS, BIOLOGICAL;

EID: 84940438904     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3340-3     Document Type: Article

References (27)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: Cancer J Clin. 2011;61:69–90.
2. Verdecchia A, Francisci S, Brenner H, Gatta G, Micheli A, Mangone L, et al. Recent cancer survival in Europe: a 2000-02 period analysis of eurocare-4 data. Lancet Oncol. 2007;8:784–96.
3. Osada H, Takahashi T. Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Oncogene. 2002;21:7421–34.
4. Cheng L, Yang T, Kuang Y, Kong B, Yu S, Shu H, et al. Microrna-23a promotes neuroblastoma cell metastasis by targeting cdh1. Oncol Lett. 2014;7:839–45.
5. Miao L, Xiong X, Lin Y, Cheng Y, Lu J, Zhang J, et al. Mir-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells. Oncol Lett. 2014;7:658–62.
6. Esquela-Kerscher A, Slack FJ. Oncomirs - micrornas with a role in cancer. Nat Rev Cancer. 2006;6:259–69.
7. Yongchun Z, Linwei T, Xicai W, Lianhua Y, Guangqiang Z, Ming Y, et al. Microrna-195 inhibits non-small cell lung cancer cell proliferation, migration and invasion by targeting myb. Cancer Lett. 2014;347:65–74.
8. 8 Yang Y, Meng H, Peng Q, Yang X, Gan R, Zhao L, Chen Z, Lu J, Meng QH: Downregulation of microrna-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4. Cancer gene therapy 2014.
9. Gallardo E, Navarro A, Vinolas N, Marrades RM, Diaz T, Gel B, et al. Mir-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. Carcinogenesis. 2009;30:1903–9.
10. Lei L, Huang Y, Gong W. Mir-205 promotes the growth, metastasis and chemoresistance of nsclc cells by targeting pten. Oncol Rep. 2013;30:2897–902.
11. Xu TP, Zhu CH, Zhang J, Xia R, Wu FL, Han L, et al. Microrna-155 expression has prognostic value in patients with non-small cell lung cancer and digestive system carcinomas. Asian Pacific J Cancer Prevent: APJCP. 2013;14:7085–90.
12. Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K. Suz12 is essential for mouse development and for ezh2 histone methyltransferase activity. EMBO J. 2004;23:4061–71.
13. Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K. Loss of mir-200 inhibition of suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell. 2010;39:761–72.
14. Li H, Cai Q, Wu H, Vathipadiekal V, Dobbin ZC, Li T, et al. Suz12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing hrk. Molec Cancer Res: MCR. 2012;10:1462–72.
15. Martin-Perez D, Sanchez E, Maestre L, Suela J, Vargiu P, Di Lisio L, et al. Deregulated expression of the polycomb-group protein suz12 target genes characterizes mantle cell lymphoma. Am J Pathol. 2010;177:930–42.
16. Liu C, Shi X, Wang L, Wu Y, Jin F, Bai C, et al. Suz12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis. Tumour Biol: J Int Soc Oncodev Biol Med. 2014;35:6073–82.
17. Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, Labarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G: Cul4a induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating zeb1 expression. Cancer Res 2013.
18. Liu J, Ruan B, You N, Huang Q, Liu W, Dang Z, et al. Downregulation of mir-200a induces emt phenotypes and csc-like signatures through targeting the beta-catenin pathway in hepatic oval cells. PLoS One. 2013;8:e79409.
19. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2:442–54.
20. da Silva SD, Alaoui-Jamali MA, Soares FA, Carraro DM, Brentani HP, Hier M, et al. Twist1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target. Cancer. 2014;120:352–62.
21. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA: Cancer J Clin. 2013;63:11–30.
22. Fidler IJ. Critical factors in the biology of human cancer metastasis: twenty-eighth g.H.A. Clowes memorial award lecture. Cancer Res. 1990;50:6130–8.
23. Markou A, Sourvinou I, Vorkas PA, Yousef GM, Lianidou E. Clinical evaluation of microrna expression profiling in non small cell lung cancer. Lung Cancer. 2013;81:388–96.
24. Paterson EL, Kazenwadel J, Bert AG, Khew-Goodall Y, Ruszkiewicz A, Goodall GJ. Down-regulation of the mirna-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates emt is involved in cancer progression. Neoplasia. 2013;15:180–91.
25. Ouyang H, Gore J, Deitz S, Korc M: Microrna-10b enhances pancreatic cancer cell invasion by suppressing tip30 expression and promoting egf and tgf-beta actions. Oncogene 2013.
26. Kitamura K, Seike M, Okano T, Matsuda K, Miyanaga A, Mizutani H, Noro R, Minegishi Y, Kubota K, Gemma A: Mir-134/487b/655 cluster regulates tgf-beta-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting magi2 in lung adenocarcinoma cells. Mol Cancer Ther 2013.
27. Benoit YD, Witherspoon MS, Laursen KB, Guezguez A, Beausejour M, Beaulieu JF, et al. Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells. Exp Cell Res. 2013;319:1463–70.