메뉴 건너뛰기




Volumn 36, Issue 8, 2015, Pages 5881-5890

T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines

Author keywords

Brachyury; Chemokine; Lung cancer; Macrophage infiltration

Indexed keywords

MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR BRACHYURY; UNCLASSIFIED DRUG; BRACHYURY PROTEIN; CCL2 PROTEIN, HUMAN; CCL4 PROTEIN, HUMAN; CXCL10 PROTEIN, HUMAN; FETOPROTEIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MONOCYTE CHEMOTACTIC PROTEIN 1;

EID: 84940438239     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3260-2     Document Type: Article
Times cited : (8)

References (46)
  • 3
    • 84857820489 scopus 로고    scopus 로고
    • Tumor heterogeneity and personalized medicine
    • COI: 1:CAS:528:DC%2BC38XktFOgurY%3D, PID: 22397658
    • Longo DL. Tumor heterogeneity and personalized medicine. N Engl J Med. 2012;366:956–7.
    • (2012) N Engl J Med , vol.366 , pp. 956-957
    • Longo, D.L.1
  • 4
    • 84896737116 scopus 로고    scopus 로고
    • The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets
    • COI: 1:CAS:528:DC%2BC3sXhslejtLzJ, PID: 24176790
    • Wood SL, Pernemalm M, Crosbie PA, Whetton AD. The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev. 2014;40:558–66.
    • (2014) Cancer Treat Rev , vol.40 , pp. 558-566
    • Wood, S.L.1    Pernemalm, M.2    Crosbie, P.A.3    Whetton, A.D.4
  • 5
    • 33847020833 scopus 로고    scopus 로고
    • Inflammation in wound repair: molecular and cellular mechanisms
    • COI: 1:CAS:528:DC%2BD2sXhs1CrtL0%3D, PID: 17299434
    • Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127:514–25.
    • (2007) J Invest Dermatol , vol.127 , pp. 514-525
    • Eming, S.A.1    Krieg, T.2    Davidson, J.M.3
  • 6
    • 58049097873 scopus 로고    scopus 로고
    • Macrophages in the embryo and beyond: much more than just giant phagocytes
    • PID: 18781633
    • Ovchinnikov DA. Macrophages in the embryo and beyond: much more than just giant phagocytes. Genesis. 2008;46:447–62.
    • (2008) Genesis , vol.46 , pp. 447-462
    • Ovchinnikov, D.A.1
  • 7
    • 84873743410 scopus 로고    scopus 로고
    • M1 and m2 macrophages: oracles of health and disease
    • COI: 1:CAS:528:DC%2BC3sXjvFWns7s%3D, PID: 23428224
    • Mills CD. M1 and m2 macrophages: oracles of health and disease. Crit Rev Immunol. 2012;32:463–88.
    • (2012) Crit Rev Immunol , vol.32 , pp. 463-488
    • Mills, C.D.1
  • 8
    • 0031107175 scopus 로고    scopus 로고
    • Surgical physiology of wound healing: a review
    • COI: 1:STN:280:DC%2BD3c3gsVyqtw%3D%3D, PID: 10740722
    • Deodhar AK, Rana RE. Surgical physiology of wound healing: a review. J Postgrad Med. 1997;43:52–6.
    • (1997) J Postgrad Med , vol.43 , pp. 52-56
    • Deodhar, A.K.1    Rana, R.E.2
  • 9
    • 0031791075 scopus 로고    scopus 로고
    • The role of apoptosis in wound healing
    • COI: 1:CAS:528:DyaK1cXmsVGmsbs%3D, PID: 9785465
    • Greenhalgh DG. The role of apoptosis in wound healing. Int J Biochem Cell Biol. 1998;30:1019–30.
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 1019-1030
    • Greenhalgh, D.G.1
  • 11
    • 0035021253 scopus 로고    scopus 로고
    • T-box genes in development: from hydra to humans
    • COI: 1:CAS:528:DC%2BD3MXktlCmsr8%3D, PID: 11352264
    • Papaioannou VE. T-box genes in development: from hydra to humans. Int Rev Cytol. 2001;207:1–70.
    • (2001) Int Rev Cytol , vol.207 , pp. 1-70
    • Papaioannou, V.E.1
  • 12
    • 0035115845 scopus 로고    scopus 로고
    • T-targets: clues to understanding the functions of t-box proteins
    • COI: 1:CAS:528:DC%2BD3MXhsl2gsb4%3D, PID: 11148447
    • Tada M, Smith JC. T-targets: clues to understanding the functions of t-box proteins. Dev Growth Differ. 2001;43:1–11.
    • (2001) Dev Growth Differ , vol.43 , pp. 1-11
    • Tada, M.1    Smith, J.C.2
  • 13
    • 0001045827 scopus 로고
    • Regarding the spontaneous mortification of the tail of a new-born mouse and the existence of a hereditary characteristic (factor)
    • Dobrovolskaia-Zavadskaia N. Regarding the spontaneous mortification of the tail of a new-born mouse and the existence of a hereditary characteristic (factor). C R Seances Soc Biol Fil. 1927;97:114–6.
    • (1927) C R Seances Soc Biol Fil , vol.97 , pp. 114-116
    • Dobrovolskaia-Zavadskaia, N.1
  • 14
    • 0025054992 scopus 로고
    • Expression pattern of the mouse t gene and its role in mesoderm formation
    • COI: 1:CAS:528:DyaK3cXhtlKnurY%3D, PID: 1689462
    • Wilkinson DG, Bhatt S, Herrmann BG. Expression pattern of the mouse t gene and its role in mesoderm formation. Nature. 1990;343:657–9.
    • (1990) Nature , vol.343 , pp. 657-659
    • Wilkinson, D.G.1    Bhatt, S.2    Herrmann, B.G.3
  • 15
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • COI: 1:CAS:528:DC%2BD1cXltVGlu7c%3D, PID: 18432252
    • Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8:387–98.
    • (2008) Nat Rev Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 16
  • 17
    • 84880321452 scopus 로고    scopus 로고
    • Role of oestrogen receptors in bladder cancer development
    • COI: 1:CAS:528:DC%2BC3sXpsVyrtLc%3D, PID: 23588401
    • Hsu I, Vitkus S, Da J, Yeh S. Role of oestrogen receptors in bladder cancer development. Nat Rev Urol. 2013;10:317–26.
    • (2013) Nat Rev Urol , vol.10 , pp. 317-326
    • Hsu, I.1    Vitkus, S.2    Da, J.3    Yeh, S.4
  • 18
    • 84891840587 scopus 로고    scopus 로고
    • Targeting notch signaling pathway in cancer: clinical development advances and challenges
    • COI: 1:CAS:528:DC%2BC3sXhs12lsLbM, PID: 24076266
    • Takebe N, Nguyen D, Yang SX. Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther. 2014;141:140–9.
    • (2014) Pharmacol Ther , vol.141 , pp. 140-149
    • Takebe, N.1    Nguyen, D.2    Yang, S.X.3
  • 19
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: from development to cancer
    • COI: 1:CAS:528:DC%2BC3cXps1Gktg%3D%3D, PID: 20094046
    • Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer. 2010;10:116–29.
    • (2010) Nat Rev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 20
    • 77955739897 scopus 로고    scopus 로고
    • Genome-wide identification of pax3-fkhr binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer
    • COI: 1:CAS:528:DC%2BC3cXhtVWqu7nN, PID: 20663909
    • Cao L, Yu Y, Bilke S, Walker RL, Mayeenuddin LH, Azorsa DO, et al. Genome-wide identification of pax3-fkhr binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer. Cancer Res. 2010;70:6497–508.
    • (2010) Cancer Res , vol.70 , pp. 6497-6508
    • Cao, L.1    Yu, Y.2    Bilke, S.3    Walker, R.L.4    Mayeenuddin, L.H.5    Azorsa, D.O.6
  • 21
    • 84926136268 scopus 로고    scopus 로고
    • Prostate cancer: Brachyury—a biomarker for progression and prognosis?
    • Thoma C. Prostate cancer: Brachyury—a biomarker for progression and prognosis? Nat Rev Urol. 2014.
    • (2014) Nat Rev Urol
    • Thoma, C.1
  • 22
    • 84905172130 scopus 로고    scopus 로고
    • Brachyury: a new player in promoting breast cancer aggressiveness
    • Pires MM, Aaronson SA. Brachyury: a new player in promoting breast cancer aggressiveness. J Natl Cancer Inst. 2014;106.
    • (2014) J Natl Cancer Inst , pp. 106
    • Pires, M.M.1    Aaronson, S.A.2
  • 23
    • 84907916641 scopus 로고    scopus 로고
    • T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness, Clin Cancer Res
    • Pinto F, Pertega-Gomes N, Pereira MS, Vizcaino JR, Monteiro P, Henrique RM, et al. T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res. 2014.
    • (2014) et al
    • Pinto, F.1    Pertega-Gomes, N.2    Pereira, M.S.3    Vizcaino, J.R.4    Monteiro, P.5    Henrique, R.M.6
  • 25
    • 84894428819 scopus 로고    scopus 로고
    • Knockdown of the t-box transcription factor brachyury increases sensitivity of adenoid cystic carcinoma cells to chemotherapy and radiation in vitro: Implications for a new therapeutic principle
    • COI: 1:CAS:528:DC%2BC2cXpsFehsbs%3D, PID: 24504414
    • Kobayashi Y, Sugiura T, Imajyo I, Shimoda M, Ishii K, Akimoto N, et al. Knockdown of the t-box transcription factor brachyury increases sensitivity of adenoid cystic carcinoma cells to chemotherapy and radiation in vitro: Implications for a new therapeutic principle. Int J Oncol. 2014;44:1107–17.
    • (2014) Int J Oncol , vol.44 , pp. 1107-1117
    • Kobayashi, Y.1    Sugiura, T.2    Imajyo, I.3    Shimoda, M.4    Ishii, K.5    Akimoto, N.6
  • 26
    • 84863955851 scopus 로고    scopus 로고
    • Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer
    • COI: 1:CAS:528:DC%2BC38XhtVelurzN, PID: 22611028
    • Roselli M, Fernando RI, Guadagni F, Spila A, Alessandroni J, Palmirotta R, et al. Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer. Clin Cancer Res. 2012;18:3868–79.
    • (2012) Clin Cancer Res , vol.18 , pp. 3868-3879
    • Roselli, M.1    Fernando, R.I.2    Guadagni, F.3    Spila, A.4    Alessandroni, J.5    Palmirotta, R.6
  • 27
    • 36248939277 scopus 로고    scopus 로고
    • Epigenetic silencing of human t (brachyury homologue) gene in non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BD2sXhtlCrsL3E, PID: 17980147
    • Park JC, Chae YK, Son CH, Kim MS, Lee J, Ostrow K, et al. Epigenetic silencing of human t (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun. 2008;365:221–6.
    • (2008) Biochem Biophys Res Commun , vol.365 , pp. 221-226
    • Park, J.C.1    Chae, Y.K.2    Son, C.H.3    Kim, M.S.4    Lee, J.5    Ostrow, K.6
  • 28
    • 0030481706 scopus 로고    scopus 로고
    • Drosophila brachyenteron regulates gene activity and morphogenesis in the gut
    • COI: 1:CAS:528:DyaK2sXhtVOmtL8%3D, PID: 9012492
    • Singer JB, Harbecke R, Kusch T, Reuter R, Lengyel JA. Drosophila brachyenteron regulates gene activity and morphogenesis in the gut. Development. 1996;122:3707–18.
    • (1996) Development , vol.122 , pp. 3707-3718
    • Singer, J.B.1    Harbecke, R.2    Kusch, T.3    Reuter, R.4    Lengyel, J.A.5
  • 29
    • 84887642718 scopus 로고    scopus 로고
    • Chemokine receptor cx3cr1 contributes to macrophage survival in tumor metastasis
    • PID: 24245985
    • Zheng J, Yang M, Shao J, Miao Y, Han J, Du J. Chemokine receptor cx3cr1 contributes to macrophage survival in tumor metastasis. Mol Cancer. 2013;12:141.
    • (2013) Mol Cancer , vol.12 , pp. 141
    • Zheng, J.1    Yang, M.2    Shao, J.3    Miao, Y.4    Han, J.5    Du, J.6
  • 30
    • 77955741107 scopus 로고    scopus 로고
    • Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of cc chemokine ligand 3/macrophage inflammatory protein-1alpha
    • COI: 1:CAS:528:DC%2BC3cXhtVWqu7nL, PID: 20663902
    • Iida N, Nakamoto Y, Baba T, Nakagawa H, Mizukoshi E, Naito M, et al. Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of cc chemokine ligand 3/macrophage inflammatory protein-1alpha. Cancer Res. 2010;70:6556–65.
    • (2010) Cancer Res , vol.70 , pp. 6556-6565
    • Iida, N.1    Nakamoto, Y.2    Baba, T.3    Nakagawa, H.4    Mizukoshi, E.5    Naito, M.6
  • 31
    • 70350705942 scopus 로고    scopus 로고
    • The chemokine ccl2 increases prostate tumor growth and bone metastasis through macrophage and osteoclast recruitment
    • COI: 1:CAS:528:DC%2BD1MXhtlarsr%2FM, PID: 19881959
    • Mizutani K, Sud S, McGregor NA, Martinovski G, Rice BT, Craig MJ, et al. The chemokine ccl2 increases prostate tumor growth and bone metastasis through macrophage and osteoclast recruitment. Neoplasia. 2009;11:1235–42.
    • (2009) Neoplasia , vol.11 , pp. 1235-1242
    • Mizutani, K.1    Sud, S.2    McGregor, N.A.3    Martinovski, G.4    Rice, B.T.5    Craig, M.J.6
  • 32
    • 0025062325 scopus 로고
    • Cloning of the t gene required in mesoderm formation in the mouse
    • COI: 1:CAS:528:DyaK3cXlt1Ogurw%3D, PID: 2154694
    • Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H. Cloning of the t gene required in mesoderm formation in the mouse. Nature. 1990;343:617–22.
    • (1990) Nature , vol.343 , pp. 617-622
    • Herrmann, B.G.1    Labeit, S.2    Poustka, A.3    King, T.R.4    Lehrach, H.5
  • 33
    • 84940444212 scopus 로고
    • Brachyura, accompanying the bendings and the genetic structure of the tail of the mouse
    • Dobrovolskaia-Zavadskaia N. Brachyura, accompanying the bendings and the genetic structure of the tail of the mouse. C R Seances Soc Biol Fil. 1927;97:1583–5.
    • (1927) C R Seances Soc Biol Fil , vol.97 , pp. 1583-1585
    • Dobrovolskaia-Zavadskaia, N.1
  • 34
    • 81455158378 scopus 로고    scopus 로고
    • In silico and in vivo identification of the intermediate filament vimentin that is downregulated downstream of brachyury during xenopus embryogenesis
    • COI: 1:CAS:528:DC%2BC3MXhsVymt7fF, PID: 21963995
    • Yamada A, Koyanagi KO, Watanabe H. In silico and in vivo identification of the intermediate filament vimentin that is downregulated downstream of brachyury during xenopus embryogenesis. Gene. 2012;491:232–6.
    • (2012) Gene , vol.491 , pp. 232-236
    • Yamada, A.1    Koyanagi, K.O.2    Watanabe, H.3
  • 35
    • 84886619437 scopus 로고    scopus 로고
    • Functional brachyury binding sites establish a temporal read-out of gene expression in the ciona notochord
    • COI: 1:CAS:528:DC%2BC3sXhslags7nJ, PID: 24204212
    • Katikala L, Aihara H, Passamaneck YJ, Gazdoiu S, Jose-Edwards DS, Kugler JE, et al. Functional brachyury binding sites establish a temporal read-out of gene expression in the ciona notochord. PLoS Biol. 2013;11:e1001697.
    • (2013) PLoS Biol , vol.11
    • Katikala, L.1    Aihara, H.2    Passamaneck, Y.J.3    Gazdoiu, S.4    Jose-Edwards, D.S.5    Kugler, J.E.6
  • 36
    • 79953690193 scopus 로고    scopus 로고
    • Brachyury expression predicts poor prognosis at early stages of colorectal cancer
    • PID: 21220197
    • Kilic N, Feldhaus S, Kilic E, Tennstedt P, Wicklein D, Wasielewski R, et al. Brachyury expression predicts poor prognosis at early stages of colorectal cancer. Eur J Cancer. 2011;47:1080–5.
    • (2011) Eur J Cancer , vol.47 , pp. 1080-1085
    • Kilic, N.1    Feldhaus, S.2    Kilic, E.3    Tennstedt, P.4    Wicklein, D.5    Wasielewski, R.6
  • 37
    • 83655201491 scopus 로고    scopus 로고
    • Brachyury confers cancer stem cell characteristics on colorectal cancer cells
    • COI: 1:CAS:528:DC%2BC3MXhs1SgurnN, PID: 21365650
    • Sarkar D, Shields B, Davies ML, Muller J, Wakeman JA. Brachyury confers cancer stem cell characteristics on colorectal cancer cells. Int J Cancer. 2012;130:328–37.
    • (2012) Int J Cancer , vol.130 , pp. 328-337
    • Sarkar, D.1    Shields, B.2    Davies, M.L.3    Muller, J.4    Wakeman, J.A.5
  • 38
    • 84868213270 scopus 로고    scopus 로고
    • A common single-nucleotide variant in t is strongly associated with chordoma
    • COI: 1:CAS:528:DC%2BC38XhsV2rsLbI, PID: 23064415
    • Pillay N, Plagnol V, Tarpey PS, Lobo SB, Presneau N, Szuhai K, et al. A common single-nucleotide variant in t is strongly associated with chordoma. Nat Genet. 2012;44:1185–7.
    • (2012) Nat Genet , vol.44 , pp. 1185-1187
    • Pillay, N.1    Plagnol, V.2    Tarpey, P.S.3    Lobo, S.B.4    Presneau, N.5    Szuhai, K.6
  • 39
    • 84883599418 scopus 로고    scopus 로고
    • Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis
    • COI: 1:CAS:528:DC%2BC3sXhtlentLvI, PID: 23965741
    • Kitamura Y, Sasaki H, Kimura T, Miwa T, Takahashi S, Kawase T, et al. Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis. J Neuropathol Exp Neurol. 2013;72:816–23.
    • (2013) J Neuropathol Exp Neurol , vol.72 , pp. 816-823
    • Kitamura, Y.1    Sasaki, H.2    Kimura, T.3    Miwa, T.4    Takahashi, S.5    Kawase, T.6
  • 40
    • 84877275234 scopus 로고    scopus 로고
    • From notochord formation to hereditary chordoma: the many roles of brachyury
    • PID: 23662285
    • Nibu Y, Jose-Edwards DS, Di Gregorio A. From notochord formation to hereditary chordoma: the many roles of brachyury. Biomed Res Int. 2013;2013:826435.
    • (2013) Biomed Res Int , vol.2013 , pp. 826435
    • Nibu, Y.1    Jose-Edwards, D.S.2    Di Gregorio, A.3
  • 41
    • 84893776140 scopus 로고    scopus 로고
    • Brachyury: a diagnostic marker for the differential diagnosis of chordoma and hemangioblastoma versus neoplastic histological mimickers
    • PID: 24591762
    • Barresi V, Ieni A, Branca G, Tuccari G. Brachyury: a diagnostic marker for the differential diagnosis of chordoma and hemangioblastoma versus neoplastic histological mimickers. Dis Markers. 2014;2014:514753.
    • (2014) Dis Markers , vol.2014 , pp. 514753
    • Barresi, V.1    Ieni, A.2    Branca, G.3    Tuccari, G.4
  • 43
    • 84892818249 scopus 로고    scopus 로고
    • Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma
    • PID: 23456319
    • Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T, et al. Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma. Ann Surg Oncol. 2013;20 Suppl 3:S509–516.
    • (2013) Ann Surg Oncol , vol.20 , pp. S509-S516
    • Haro, A.1    Yano, T.2    Kohno, M.3    Yoshida, T.4    Koga, T.5    Okamoto, T.6
  • 44
    • 84868030361 scopus 로고    scopus 로고
    • Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer
    • PID: 23145206
    • Quatromoni JG, Eruslanov E. Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. Am J Transl Res. 2012;4:376–89.
    • (2012) Am J Transl Res , vol.4 , pp. 376-389
    • Quatromoni, J.G.1    Eruslanov, E.2
  • 45
    • 84890906410 scopus 로고    scopus 로고
    • The prognostic impact of tumor-associated macrophages and intra-tumoral apoptosis in non-small cell lung cancer
    • PID: 23939555
    • Becker M, Muller CB, De Bastiani MA, Klamt F. The prognostic impact of tumor-associated macrophages and intra-tumoral apoptosis in non-small cell lung cancer. Histol Histopathol. 2014;29:21–31.
    • (2014) Histol Histopathol , vol.29 , pp. 21-31
    • Becker, M.1    Muller, C.B.2    De Bastiani, M.A.3    Klamt, F.4
  • 46
    • 84863643882 scopus 로고    scopus 로고
    • Tumor-stromal interactions in lung cancer: novel candidate targets for therapeutic intervention
    • COI: 1:CAS:528:DC%2BC38XhtVWjsrfL, PID: 22667993
    • El-Nikhely N, Larzabal L, Seeger W, Calvo A, Savai R. Tumor-stromal interactions in lung cancer: novel candidate targets for therapeutic intervention. Expert Opin Investig Drugs. 2012;21:1107–22.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 1107-1122
    • El-Nikhely, N.1    Larzabal, L.2    Seeger, W.3    Calvo, A.4    Savai, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.