Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcumin

European Journal of Medicinal Chemistry

Volumn 103, Issue , 2015, Pages 44-55

  Weng, Qiaoyou ^a   Fu, Lili ^a   Chen, Gaozhi ^a   Hui, Junguo ^a   Song, Jingjing ^a   Feng, Jianpeng ^a   Shi, Dengjian ^a   Cai, Yuepiao ^a   Ji, Jiansong ^a   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Anticancer drug; Apoptosis; Drug design; Gastric cancer; MACs

Indexed keywords

1 (2,3 DIMETHOXYPHENYL) 5 [3 METHOXY 4 (3 MORPHILINOPROPOXY)PHENYL]PENTA 1,4 DIEN 3 ONE; 1 [3 METHOXY 4 (3 MORPHOLINOPROPOXY)PHENYL] 5 (2 METHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 2,6 BIS[4 [3 (DIETHYLAMINO)PROPOXY] 3 METHOXYBENZYLIDENE]CYCLOHEXANONE; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; CURCUMIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER MODEL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MOUSE; MTS ASSAY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; STOMACH CARCINOMA; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MICE; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84940393236     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.08.036     Document Type: Article

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