Pinellia ternata lectin exerts a pro-inflammatory effect on macrophages by inducing the release of pro-inflammatory cytokines, the activation of the nuclear factor-?B signaling pathway and the overproduction of reactive oxygen species

International Journal of Molecular Medicine

Volumn 36, Issue 4, 2015, Pages 1127-1135

  Yu, Hong Li ^a,b   Zhao, Teng Fei ^a   Wu, Hao ^a,b   Pan, Yao Zong ^a   Zhang, Qian ^a   Wang, Kui Long ^a   Zhang, Chen Chao ^a   Jin, Yang Ping ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Cytokine; Macrophage; Neutrophil migration; Nuclear factor ?B; Pinellia ternata lectin; Reactive oxygen species production

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PINELLIA TERNATA LECTIN; PLANT LECTIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; RELA PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL SWELLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATION; LIQUID CHROMATOGRAPHY; MACROPHAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PINELLIA; PINELLIA TERNATA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SIZE EXCLUSION CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; PERITONEUM MACROPHAGE;

ANIMALS; CYTOKINES; INFLAMMATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED ICR; PINELLIA; PLANT LECTINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84940385336     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2315     Document Type: Article

References (32)

1. Peumans WJ and Van Damme EJ: Lectins as plant defense proteins. Plant Physiol 109: 347-352, 1995.
2. Moreira RA, Ainouz IL, De Oliveira JT and Cavada BS: Plant lectins, chemical and biological aspects. Mem Inst Oswaldo Cruz 86 (Suppl 2): 211-218, 1991.
3. Cavada BS, Santos CF, Grangeiro TB, Nunes EP, Sales PV, Ramos RL, De Sousa FA, Crisostomo CV and Calvete JJ: Purification and characterization of a lectin from seeds of Vatairea macrocarpa Duke. Phytochemistry 49: 675-680, 1998.
4. Gabius HJ and Gabius S: Glycosciences: Status and perspectives. Wiley-VCH, New York, p659, 2002.
5. Alencar VB, Brito GA, Alencar NM, Assreuy AM, Pinto VP, Teixeira EH, Souza EP, Debray H, Ribeiro RA and Cavada BS: Helianthus tuberosus agglutinin directly induces neutrophil migration, which can be modulated/inhibited by resident mast cells. Biochem Cell Biol 83: 659-666, 2005.
6. Mota MR, Criddle DN, Alencar NM, Gomes RC, Meireles AV, Santi-Gadelha T, Gadelha CA, Oliveira CC, Benevides RG, Cavada BS, et al: Modulation of acute inflammation by a chitin-binding lectin from Araucaria angustifolia seeds via mast cells. Naunyn Schmiedebergs Arch Pharmacol 374: 1-10, 2006.
7. Santos-de-Oliveira R, Dias-Baruffi M, Thomaz SM, Beltramini LM and Roque-Barreira MC: A neutrophil migration-inducing lectin from Artocarpus integrifolia. J Immunol 153: 1798-1807, 1994.
8. Assreuy AM, Shibuya MD, Martins GJ, De Souza ML, Cavada BS, Moreira RA, Oliveira JT, Ribeiro RA and Flores CA: Anti-inflammatory effect of glucose-mannose binding lectins isolated from Brazilian beans. Mediators Inflamm 6: 201-210, 1997.
9. Alencar NM, Teixeira EH, Assreuy AM, Cavada BS, Flores CA and Ribeiro RA: Leguminous lectins as tools for studying the role of sugar residues in leukocyte recruitment. Mediators Inflamm 8: 107-113, 1999.
10. Cavada BS, Barbosa T, Arruda S, Grangeiro TB and Barral-Netto M: Revisiting proteus: Do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins. Curr Protein Pept Sci 2: 123-135, 2001.
11. Alencar NM, Assreuy AM, Alencar VB, Melo SC, Ramos MV, Cavada BS, Cunha FQ and Ribeiro RA: The galactose-binding lectin from Vatairea macrocarpa seeds induces in vivo neutrophil migration by indirect mechanism. Int J Biochem Cell Biol 35: 1674-1681, 2003.
12. Assreuy AM, Alencar NM, Cavada BS, Rocha-Filho DR, Feitosa RF, Cunha FQ, Calvete JJ and Ribeiro RA: Porcine spermadhesin PSP-I/PSP-II stimulates macrophages to release a neutrophil chemotactic substance: Modulation by mast cells. Biol Reprod 68: 1836-1841, 2003.
13. Alencar NM, Assreuy AM, Criddle DN, Souza EP, Soares PM, Havt A, Aragão KS, Bezerra DP, Ribeiro RA and Cavada BS: Vatairea macrocarpa lectin induces paw edema with leukocyte infiltration. Protein Pept Lett 11: 195-200, 2004.
14. Alencar VB, Assreuy AM, Alencar NM, Meireles AV, Mota MR, Aragão KS, Cajazeiras JB, Nagano CS, Brito GA, Silva LI, et al: Lectin of Pisum arvense seeds induces in vivo and in vitro neutrophil migration. J Pharm Pharmacol 57: 375-381, 2005.
15. McEver RP: Leukocyte-endothelial cell interactions. Curr Opin Cell Biol 4: 840-849, 1992.
16. Cronstein BN and Weissmann G: The adhesion molecules of inflammation. Arthritis Rheum 36: 147-157, 1993.
17. Malik AB and Lo SK: Vascular endothelial adhesion molecules and tissue inflammation. Pharmacol Rev 48: 213-229, 1996.
18. Alencar NM, Assreuy AM, Havt A, Benevides RG, de Moura TR, de Sousa RB, Ribeiro RA, Cunha FQ and Cavada BS: Vatairea macrocarpa (Leguminosae) lectin activates cultured macrophages to release chemotactic mediators. Naunyn Schmiedebergs Arch Pharmacol 374: 275-282, 2007.
19. Liu XQ, Wu H, Yu HL, Zhao TF, Pan YZ and Shi RJ: Purification of a lectin from Arisaema erubescens (Wall.) Schott and its pro-inflammatory effects. Molecules 16: 9480-9494, 2011.
20. Yu HL, Zhu FG and Wu G: Toxic proteins on Raphides from Pinellia ternata and Pinellia pedatisecta. Chin J Tradit Chin Med Pharm 26: 1037-1042, 2011.
21. Sawant KV, Cho H, Lyons M, Ly LH and McMurray DN: Guinea pig neutrophil-macrophage interactions during infection with Mycobacterium tuberculosis. Microbes Infect 12: 828-837, 2010.
22. Sánchez-Fidalgo S, da Silva MS, Cárdeno A, Aparicio-Soto M, Salvador MJ, Frankland Sawaya AC, Souza-Brito AR and de la Lastra CA: Abarema cochliacarpos reduces LPS-induced inflammatory response in murine peritoneal macrophages regulating ROS-MAPK signal pathway. J Ethnopharmacol 149: 140-147, 2013.
23. Kim MK, Chung SW, Kim DH, Kim JM, Lee EK, Kim JY, Ha YM, Kim YH, No JK, Chung HS, et al: Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. Exp Gerontol 45: 419-426, 2010.
24. Shangary S, Singh J, Kamboj SS, Kamboj KK and Sandhu RS: Purification and properties of four monocot lectins from the family Araceae. Phytochemistry 40: 449-455, 1995.
25. Anstead GM, Chandrasekar B, Zhang Q and Melby PC: Multinutrient undernutrition dysregulates the resident macrophage proinflammatory cytokine network, nuclear factor-kappaB activation, and nitric oxide production. J Leukoc Biol 74: 982-991, 2003.
26. Silva MT: When two is better than one: Macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system. J Leukoc Biol 87: 93-106, 2010.
27. Alencar VB, Alencar NM, Assreuy AM, Mota ML, Brito GA, Aragão KS, Bittencourt FS, Pinto VP, Debray H, Ribeiro RA, et al: Pro-inflammatory effect of Arum maculatum lectin and role of resident cells. Int J Biochem Cell Biol 37: 1805-1814, 2005.
28. Gloire G, Legrand-Poels S and Piette J: NF-kappaB activation by reactive oxygen species: Fifteen years later. Biochem Pharmacol 72: 1493-1505, 2006.
29. Kim YS, Morgan MJ, Choksi S and Liu ZG: TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 26: 675-687, 2007.
30. Han J, Zhong CQ and Zhang DW: Programmed necrosis: Backup to and competitor with apoptosis in the immune system. Nat Immunol 12: 1143-1149, 2011.
31. Kung G, Konstantinidis K and Kitsis RN: Programmed necrosis, not apoptosis, in the heart. Circ Res 108: 1017-1036, 2011.
32. McCall K: Genetic control of necrosis-another type of programmed cell death. Curr Opin Cell Biol 22: 882-888, 2010.