FBXW7 negatively regulates ENO1 expression and function in colorectal cancer

Laboratory Investigation

Volumn 95, Issue 9, 2015, Pages 995-1004

  Zhan, Panpan ^a   Wang, Yuli ^a   Zhao, Shihu ^a   Liu, Chunyan ^a   Wang, Yunshan ^a   Wen, Mingxin ^a   Mao, Jian Hua ^b   Wei, Guangwei ^a   Zhang, Pengju ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENOLASE; F BOX AND WD40 DOMAIN PROTEIN 7; LACTIC ACID; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; ENO1 PROTEIN, HUMAN; F BOX PROTEIN; FBXW7 PROTEIN, HUMAN; PRIMER DNA; TUMOR MARKER; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CANCER TISSUE; CELL MIGRATION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; WESTERN BLOTTING; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REGRESSION ANALYSIS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

BIOMARKERS, TUMOR; BLOTTING, WESTERN; CELL CYCLE PROTEINS; COLORECTAL NEOPLASMS; DNA PRIMERS; DNA-BINDING PROTEINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; F-BOX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; PHOSPHOPYRUVATE HYDRATASE; REAL-TIME POLYMERASE CHAIN REACTION; REGRESSION ANALYSIS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84940382996     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2015.71     Document Type: Article

References (39)

1. Kang HJ, Jung SK, Kim SJ., et al. Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. Acta Crystallogr D Biol Crystallogr. 2008; 64: 651-657.
2. Yu L, Shi J, Cheng S., et al. Estrogen promotes prostate cancer cell migration via paracrine release of ENO1 from stromal cells. Mol Endocrinol. 2012; 26: 1521-1530.
3. Migneco G, Whitaker-Menezes D, Chiavarina B., et al. Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling. Cell Cycle. 2010; 9: 2412-2422.
4. Gao J, Zhao R, Xue Y., et al. Role of enolase-1 in response to hypoxia in breast cancer: exploring the mechanisms of action. Oncol Rep. 2013; 29: 1322-1332.
5. Bae S, Kim H, Lee N., et al. Alpha-enolase expressed on the surfaces of monocytes and macrophages induces robust synovial inflammation in rheumatoid arthritis. J Immunol. 2012; 189: 365-372.
6. Tsai ST, Chien IH, Shen WH., et al. ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction. Eur J Cancer. 2010; 46: 1712-1723.
7. Kashat L, So AK, Masui O., et al. Secretome-based identification and characterization of potential biomarkers in thyroid cancer. J Proteome Res. 2010; 9: 5757-5769.
8. Tu SH, Chang CC, Chen CS., et al. Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells. Breast Cancer Res Treat. 2010; 121: 539-553.
9. Yu L, Shen J, Mannoor K., et al. Identification of ENO1 as a potential sputum biomarker for early-stage lung cancer by shotgun proteomics. Clin Lung Cancer. 2014; 15: 372-378.
10. Pernemalm M, De Petris L, Branca RM., et al. Quantitative proteomics profiling of primary lung adenocarcinoma tumors reveals functional perturbations in tumor metabolism. J Proteome Res. 2013; 12: 3934-3943.
11. Duijvesz D, Burnum-Johnson KE, Gritsenko MA., et al. Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. PLoS One. 2013; 8: e82589.
12. Jiang W, Li X, Rao S., et al. Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements. BMC Syst Biol. 2008; 2: 72.
13. Bai Z, Ye Y, Liang B., et al. Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer. Int J Oncol. 2011; 38: 375-383.
14. Song Y, Luo Q, Long H., et al. Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma. Mol Cancer. 2014; 13: 65.
15. Yonglitthipagon P, Pairojkul C, Bhudhisawasdi V., et al. Proteomicsbased identification of alpha-enolase as a potential prognostic marker in cholangiocarcinoma. Clin Biochem. 2012; 45: 827-834.
16. Hamaguchi T, Iizuka N, Tsunedomi R., et al. Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma. Int J Oncol. 2008; 33: 725-731.
17. Cui Y, Xie S, Luan J., et al. Quantitative proteomics and protein network analysis of A549 lung cancer cells affected by miR-206. Biosci Trends. 2013; 7: 259-263.
18. Chen S, Duan G, Zhang R., et al. Helicobacter pylori cytotoxin-Associated gene A protein upregulates alpha-enolase expression via Src/MEK/ERK pathway: implication for progression of gastric cancer. Int J Oncol. 2014; 45: 764-770.
19. Trojanowicz B, Winkler A, Hammje K., et al. Retinoic acid-mediated down-regulation of ENO1/MBP-1 gene products caused decreased invasiveness of the follicular thyroid carcinoma cell lines. J Mol Endocrinol. 2009; 42: 249-260.
20. Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer. 2008; 8: 83-93.
21. Van Vlierberghe P, Homminga I, Zuurbier L., et al. Cooperative genetic defects in TLX3 rearranged pediatric T-ALL. Leukemia. 2008; 22: 762-770.
22. Klotz K, Cepeda D, Tan Y., et al. SCF Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis. Exp Cell Res. 2009; 315: 1832-1839.
23. Snyder JL, Kearns CA, Appel B. Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate. Neural Dev. 2012; 7: 15.
24. Mao JH, Kim IJ, Wu D., et al. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science. 2008; 321: 1499-1502.
25. Wang Y, Liu Y, Lu J., et al. Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. Biochem Biophys Res Commun. 2013; 434: 352-356.
26. Mao JH, Perez-Losada J, Wu D., et al. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature. 2004; 432: 775-779.
27. Kwon YW, Kim IJ, Wu D., et al. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012; 10: 834-844.
28. Park MJ, Taki T, Oda M., et al. FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma. Br J Haematol. 2009; 145: 198-206.
29. Grim JE. Fbxw7 hotspot mutations and human colon cancer: mechanistic insights from new mouse models. Gut. 2013; 63: 707-709.
30. Davis H, Lewis A, Spencer-Dene B., et al. FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol. 2011; 224: 180-189.
31. Akhoondi S, Sun D, von der Lehr N., et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res. 2007; 67: 9006-9012.
32. Sancho R, Jandke A, Davis H., et al. F-box and WD repeat domaincontaining 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology. 2010; 139: 929-941.
33. Finkin S, Aylon Y, Anzi S., et al. Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent druginduced polyploidy. Oncogene. 2008; 27: 4411-4421.
34. Otto T, Horn S, Brockmann M., et al. Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell. 2009; 15: 67-78.
35. Kanei-Ishii C, Nomura T, Takagi T., et al. Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J Biol Chem. 2008; 283: 30540-30548.
36. Yang J, Zhou M, Zhao R., et al. Identification of candidate biomarkers for the early detection of nasopharyngeal carcinoma by quantitative proteomic analysis. J Proteomics. 2014; 109C: 162-175.
37. Takashima M, Kuramitsu Y, Yokoyama Y., et al. Overexpression of alpha enolase in hepatitis C virus-related hepatocellular carcinoma: association with tumor progression as determined by proteomic analysis. Proteomics. 2005; 5: 1686-1692.
38. Cappello P, Rolla S, Chiarle R., et al. Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer. Gastroenterology. 2013; 144: 1098-1106.
39. Trojanowicz B, Sekulla C, Lorenz K., et al. Proteomic approach reveals novel targets for retinoic acid-mediated therapy of thyroid carcinoma. Mol Cell Endocrinol. 2010; 325: 110-117.