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Volumn 16, Issue 3-4, 2014, Pages 65-72

Immunotherapy and complexity: Overcoming barriers to control of advanced cancer

Author keywords

Cancer control; Cuba; Immunotherapy; Molecular immunology; Monoclonal antibodies

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; BIOLOGICAL PRODUCT; CANCER VACCINE; CETUXIMAB; CYTOTOXIC AGENT; IPILIMUMAB; MOLECULAR MARKER; MONOCLONAL ANTIBODY; NIMOTUZUMAB; ONCOPROTEIN; PANITUMUMAB; PROGRAMMED DEATH 1 RECEPTOR; RECOMBINANT INTERLEUKIN 2; RITUXIMAB; TRASTUZUMAB;

EID: 84940352893     PISSN: 15557960     EISSN: 15273172     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (10)

References (65)
  • 2
    • 84940299994 scopus 로고    scopus 로고
    • Programa integral para el control del cáncer en Cuba. Havana: Editorial Ciencias Médicas; Spanish
    • Programa integral para el control del cáncer en Cuba. Estrategia Nacional para el Control del Cáncer. Havana: Editorial Ciencias Médicas; 2012. Spanish.
    • (2012) Estrategia Nacional para El Control del Cáncer
  • 3
    • 84871812256 scopus 로고    scopus 로고
    • Clinical cancer advances 2012: Annual report on progress against cancer from the American Society of Clinical Oncology
    • Jan 1
    • Roth BJ, Krilov L, Adams S, Aghajanian CA, Bach P, Braiteh F, et al. Clinical cancer advances 2012: annual report on progress against cancer from the American Society of Clinical Oncology. J Clin Oncol. 2013 Jan 1;31(1):131-61.
    • (2013) J Clin Oncol , vol.31 , Issue.1 , pp. 131-161
    • Roth, B.J.1    Krilov, L.2    Adams, S.3    Aghajanian, C.A.4    Bach, P.5    Braiteh, F.6
  • 4
    • 84859480058 scopus 로고    scopus 로고
    • European cancer mortality predictions for the year 2012
    • Apr
    • Malvezzi M, Bertuccio P, Levi F, La Vecchia C, Negri E. European cancer mortality predictions for the year 2012. Ann Oncol. 2012 Apr;23(4):1044-52.
    • (2012) Ann Oncol , vol.23 , Issue.4 , pp. 1044-1052
    • Malvezzi, M.1    Bertuccio, P.2    Levi, F.3    La Vecchia, C.4    Negri, E.5
  • 5
    • 84879379247 scopus 로고    scopus 로고
    • Targeted therapy for non-small-cell lung cancer: Past, present and future
    • Jun
    • Forde PM, Ettinger DS. Targeted therapy for non-small-cell lung cancer: past, present and future. Expert Rev Anticancer Ther. 2013 Jun;13(6):745-58.
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.6 , pp. 745-758
    • Forde, P.M.1    Ettinger, D.S.2
  • 7
    • 79953273918 scopus 로고    scopus 로고
    • Control of advanced cancer: The road to chronicity
    • Mar
    • Lage A, Crombet T. Control of advanced cancer: the road to chronicity. Int J Environ Res Public Health. 2011 Mar;8(3):683-97.
    • (2011) Int J Environ Res Public Health , vol.8 , Issue.3 , pp. 683-697
    • Lage, A.1    Crombet, T.2
  • 8
    • 79953237895 scopus 로고    scopus 로고
    • Cancer chronicity: New research and policy challenges
    • Apr
    • Berlinger N, Gusmano M. Cancer chronicity: new research and policy challenges. J Health Serv Res Policy. 2011 Apr;16(2):121-3.
    • (2011) J Health Serv Res Policy , vol.16 , Issue.2 , pp. 121-123
    • Berlinger, N.1    Gusmano, M.2
  • 9
    • 77957112422 scopus 로고    scopus 로고
    • Research on cancer prevention, detection and management in low- and medium-income countries
    • Oct
    • Sankaranarayanan R, Boffetta P. Research on cancer prevention, detection and management in low- and medium-income countries. Ann Oncol. 2010 Oct;21(10):1935-43.
    • (2010) Ann Oncol , vol.21 , Issue.10 , pp. 1935-1943
    • Sankaranarayanan, R.1    Boffetta, P.2
  • 10
    • 84900452836 scopus 로고    scopus 로고
    • Prostate Cancer Screening and Risk of Litigation: Caught Between Scylla and Charybdis
    • Mar 18. doi: 10.1016/j.juro.2014.03.085. [Epub ahead of print]
    • Hsieh MH, Meng MV. Prostate Cancer Screening and Risk of Litigation: Caught Between Scylla and Charybdis. J Urol. 2014 Mar 18. doi: 10.1016/j.juro.2014.03.085. [Epub ahead of print].
    • (2014) J Urol
    • Hsieh, M.H.1    Meng, M.V.2
  • 11
    • 84891625661 scopus 로고    scopus 로고
    • Molecularly targeted cancer therapy: Some lessons from the past decade
    • Jan
    • Huang M, Shen A, Ding J, Geng M. Molecularly targeted cancer therapy: some lessons from the past decade. Trends Pharmacol Sci. 2014 Jan;35(1):41-50.
    • (2014) Trends Pharmacol Sci , vol.35 , Issue.1 , pp. 41-50
    • Huang, M.1    Shen, A.2    Ding, J.3    Geng, M.4
  • 12
  • 13
    • 84940337935 scopus 로고    scopus 로고
    • Washington, DC: Pharmaceutical Research and Manufacturers of America (PhRMA); [cited 2014 Mar 21]. Available from
    • Biologics. Medicines in Development. 2013 Report [Internet]. Washington, DC: Pharmaceutical Research and Manufacturers of America (PhRMA); c2013 [cited 2014 Mar 21]. 87 p. Available from: http://www.phrma.org/sites/default/files/ pdf/biologics2013.pdf
    • (2013) Biologics. Medicines in Development. 2013 Report [Internet] , pp. 87
  • 15
    • 84890814629 scopus 로고    scopus 로고
    • Breakthrough of the year 2013. Cancer immunotherapy
    • Dec 20
    • Couzin-Frankel J. Breakthrough of the year 2013. Cancer immunotherapy. Science. 2013 Dec 20;342(6165):1432-3.
    • (2013) Science , vol.342 , Issue.6165 , pp. 1432-1433
    • Couzin-Frankel, J.1
  • 16
    • 84880849129 scopus 로고    scopus 로고
    • Nimotuzumab as a radiosensitizing agent in the treatment of high grade glioma: Challenges and opportunities
    • Jul 24
    • Díaz A, Martínez GS. Nimotuzumab as a radiosensitizing agent in the treatment of high grade glioma: challenges and opportunities. Onco Targets Ther. 2013 Jul 24;6:931-42.
    • (2013) Onco Targets Ther , vol.6 , pp. 931-942
    • Díaz, A.1    Martínez, G.S.2
  • 17
    • 0036302172 scopus 로고    scopus 로고
    • Programmed contraction of CD8+ T cells after infection
    • DOI 10.1038/ni804
    • Badovinac VP, Porter BB, Harty JT. Programmed contraction of CD8(+) T cells after infection. Nat Immunol. 2002 Jul;3(7):619-26. (Pubitemid 34752470)
    • (2002) Nature Immunology , vol.3 , Issue.7 , pp. 619-626
    • Badovinac, V.P.1    Porter, B.B.2    Harty, J.T.3
  • 18
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Jun
    • Wherry EJ. T cell exhaustion. Nat Immunol. 2011 Jun;12(6):492-9.
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 492-499
    • Wherry, E.J.1
  • 19
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Mar 22
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012 Mar 22;12(4):252-64.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 20
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Apr
    • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol. 2012 Apr;24(2):207-12.
    • (2012) Curr Opin Immunol , vol.24 , Issue.2 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 21
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Aug
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002 Aug;8(8):793-800.
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 22
    • 84903208336 scopus 로고    scopus 로고
    • PD-1 Pathway Inhibitors: Changing the Landscape of Cancer Immunotherapy
    • Jul
    • Dolan DE, Gupta S. PD-1 Pathway Inhibitors: Changing the Landscape of Cancer Immunotherapy. Cancer Control. 2014 Jul;21(3):231-7.
    • (2014) Cancer Control , vol.21 , Issue.3 , pp. 231-237
    • Dolan, D.E.1    Gupta, S.2
  • 23
    • 41949097030 scopus 로고    scopus 로고
    • The biology of interleukin-2
    • DOI 10.1146/annurev.immunol.26.021607.090357
    • Malek TR. The biology of interleukin-2. Annu Rev Immunol. 2008;26:453-79. (Pubitemid 351600382)
    • (2008) Annual Review of Immunology , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 24
    • 84892140453 scopus 로고    scopus 로고
    • Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics
    • Dec 11
    • León K, García K, Carmenate T. Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics. Front Immunol. 2013 Dec 11;4:439.
    • (2013) Front Immunol , vol.4 , pp. 439
    • León, K.1    García, K.2    Carmenate, T.3
  • 25
    • 77649337932 scopus 로고    scopus 로고
    • Modeling the role of IL-2 in the interplay between CD4+ helper and regulatory T cells: Assessing general dynamical properties
    • Feb 21
    • García K, León K. Modeling the role of IL-2 in the interplay between CD4+ helper and regulatory T cells: assessing general dynamical properties. J Theor Biol. 2010 Feb 21;262(4):720-32.
    • (2010) J Theor Biol , vol.262 , Issue.4 , pp. 720-732
    • García, K.1    León, K.2
  • 26
    • 84879091213 scopus 로고    scopus 로고
    • Human IL-2 mutein with higher antitumor efficacy than wild type IL-2
    • Jun 15
    • Carmenate T, Pacios A, Enamorado M, Moreno E, García K, Fuente D, et al. Human IL-2 mutein with higher antitumor efficacy than wild type IL-2. J Immunol. 2013 Jun 15;190(12):6230-8.
    • (2013) J Immunol , vol.190 , Issue.12 , pp. 6230-6238
    • Carmenate, T.1    Pacios, A.2    Enamorado, M.3    Moreno, E.4    García, K.5    Fuente, D.6
  • 28
    • 84876535364 scopus 로고    scopus 로고
    • Understanding immunosenescence to improve responses to vaccines
    • May
    • Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol. 2013 May;14(5):428-36.
    • (2013) Nat Immunol , vol.14 , Issue.5 , pp. 428-436
    • Goronzy, J.J.1    Weyand, C.M.2
  • 30
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol. 1994;12:991-1045. (Pubitemid 24140436)
    • (1994) Annual Review of Immunology , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 31
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
    • Jul
    • Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis. 2009 Jul;30(7):1073-81.
    • (2009) Carcinogenesis , vol.30 , Issue.7 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3    Garlanda, C.4    Mantovani, A.5
  • 32
    • 84857138799 scopus 로고    scopus 로고
    • Inflammation and immune surveillance in cancer
    • Feb
    • Chow MT, Möller A, Smyth MJ. Inflammation and immune surveillance in cancer. Semin Cancer Biol. 2012 Feb;22(1):23-32.
    • (2012) Semin Cancer Biol , vol.22 , Issue.1 , pp. 23-32
    • Chow, M.T.1    Möller, A.2    Smyth, M.J.3
  • 34
    • 84991030573 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells - A new therapeutic target in the treatment of cancer
    • Jul 15
    • Wesolowski R, Markowitz J, Carson WE 3rd. Myeloid derived suppressor cells - a new therapeutic target in the treatment of cancer. J Immunother Cancer. 2013 Jul 15;1:10.
    • (2013) J Immunother Cancer , vol.1 , pp. 10
    • Wesolowski, R.1    Markowitz, J.2    Carson III, W.E.3
  • 35
    • 84856899903 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in cancer patients: A clinical perspective
    • Feb-Mar
    • Montero AJ, Díaz CM, Kyriakopoulos CE, Bronte V, Mandruzzato S. Myeloid-derived suppressor cells in cancer patients: a clinical perspective. J Immunother. 2012 Feb-Mar;35(2):107-15.
    • (2012) J Immunother , vol.35 , Issue.2 , pp. 107-115
    • Montero, A.J.1    Díaz, C.M.2    Kyriakopoulos, C.E.3    Bronte, V.4    Mandruzzato, S.5
  • 36
    • 79251551682 scopus 로고    scopus 로고
    • Inhibition of tumor-induced myeloid-derived suppressor cell function by a nanoparticulated adjuvant
    • Jan 1
    • Fernández A, Mesa C, Marigo I, Dolcetti L, Clavell M, Oliver L, et al. Inhibition of tumor-induced myeloid-derived suppressor cell function by a nanoparticulated adjuvant. J Immunol. 2011 Jan 1;186(1):264-74.
    • (2011) J Immunol , vol.186 , Issue.1 , pp. 264-274
    • Fernández, A.1    Mesa, C.2    Marigo, I.3    Dolcetti, L.4    Clavell, M.5    Oliver, L.6
  • 37
    • 84859424756 scopus 로고    scopus 로고
    • Very small size proteoliposomes derived from Neisseria meningitidis: An effective adjuvant for antigen-specific cytotoxic T lymphocyte response stimulation under leukopenic conditions
    • Apr 19
    • Oliver L, Fernández A, Raymond J, López A, Fernández LE, Mesa C. Very small size proteoliposomes derived from Neisseria meningitidis: an effective adjuvant for antigen-specific cytotoxic T lymphocyte response stimulation under leukopenic conditions. Vaccine. 2012 Apr 19;30(19):2963-72.
    • (2012) Vaccine , vol.30 , Issue.19 , pp. 2963-2972
    • Oliver, L.1    Fernández, A.2    Raymond, J.3    López, A.4    Fernández, L.E.5    Mesa, C.6
  • 38
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Mar
    • Clevers H. The cancer stem cell: premises, promises and challenges. Nat Med. 2011 Mar;17(3):313-9.
    • (2011) Nat Med , vol.17 , Issue.3 , pp. 313-319
    • Clevers, H.1
  • 39
    • 62549129875 scopus 로고    scopus 로고
    • Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies
    • Mar 24
    • Díaz A, Rolff J, Lemm M, Fichtner I, Pérez R, Montero E. Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies. Br J Cancer. 2009 Mar 24;100(6):950-8.
    • (2009) Br J Cancer , vol.100 , Issue.6 , pp. 950-958
    • Díaz, A.1    Rolff, J.2    Lemm, M.3    Fichtner, I.4    Pérez, R.5    Montero, E.6
  • 42
    • 81255203382 scopus 로고    scopus 로고
    • Induction of immunogenic apoptosis by blockade of epidermal growth factor receptor activation with a specific antibody
    • Nov 15
    • Garrido G, Rabasa A, Sánchez B, López MV, Blanco R, López A, et al. Induction of immunogenic apoptosis by blockade of epidermal growth factor receptor activation with a specific antibody. J Immunol. 2011 Nov 15;187(10):4954-66.
    • (2011) J Immunol , vol.187 , Issue.10 , pp. 4954-4966
    • Garrido, G.1    Rabasa, A.2    Sánchez, B.3    López, M.V.4    Blanco, R.5    López, A.6
  • 43
    • 45349091152 scopus 로고    scopus 로고
    • Heterophilic NeuGc-GM3 ganglioside cancer vaccine in advanced melanoma patients: Results of a Phase Ib/IIa study
    • Apr
    • Osorio M, García E, Rodríguez E, Saurez G, Arango C, Noris E, et al. Heterophilic NeuGc-GM3 ganglioside cancer vaccine in advanced melanoma patients: results of a Phase Ib/IIa study. Cancer Biol Ther. 2008 Apr;7(4):488-95.
    • (2008) Cancer Biol Ther , vol.7 , Issue.4 , pp. 488-495
    • Osorio, M.1    García, E.2    Rodríguez, E.3    Saurez, G.4    Arango, C.5    Noris, E.6
  • 44
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • May 1; discussion 3080. doi: 10.1158/0008-5472.CAN-07-3293. Review
    • Weinstein IB, Joe A. Oncogene addiction. Cancer Res. 2008 May 1;68(9):3077-80; discussion 3080. doi: 10.1158/0008-5472.CAN-07-3293. Review.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 45
    • 84881517936 scopus 로고    scopus 로고
    • A view on EGFR-targeted therapies from the oncogene-addiction perspective
    • Apr 26
    • Pérez R, Crombet T, de León J, Moreno E. A view on EGFR-targeted therapies from the oncogene-addiction perspective. Front Pharmacol. 2013 Apr 26;4:53.
    • (2013) Front Pharmacol , vol.4 , pp. 53
    • Pérez, R.1    Crombet, T.2    De León, J.3    Moreno, E.4
  • 46
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • DOI 10.1038/nature05236, PII NATURE05236
    • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006 Dec 7;444(7120):756-60. (Pubitemid 44949604)
    • (2006) Nature , vol.444 , Issue.7120 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6    Dewhirst, M.W.7    Bigner, D.D.8    Rich, J.N.9
  • 47
    • 33750412872 scopus 로고    scopus 로고
    • Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: Implications for cancer therapy
    • DOI 10.1016/j.cellsig.2006.05.015, PII S0898656806001057
    • Henson ES, Gibson SB. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell Signal. 2006 Dec;18(12):2089-97. (Pubitemid 44642342)
    • (2006) Cellular Signalling , vol.18 , Issue.12 , pp. 2089-2097
    • Henson, E.S.1    Gibson, S.B.2
  • 48
    • 34548467199 scopus 로고    scopus 로고
    • Complicated is not complex
    • [Editorial]. Jun; doi: 10.1038/9772
    • Complicated is not complex [Editorial]. Nat Biotechnol. 1999 Jun;17(6):511. doi: 10.1038/9772.
    • (1999) Nat Biotechnol , vol.17 , Issue.6 , pp. 511
  • 49
    • 0036665103 scopus 로고    scopus 로고
    • Immunotherapy and immunoregulation: The barrier of complexity
    • Lage A. Immunotherapy and Immunoregulation: The Barrier of Complexity. Biotecnol Aplicada. 2002 Jul-Dec;19(3-4):175-7. (Pubitemid 36342988)
    • (2002) Biotecnologia Aplicada , vol.19 , Issue.3-4 , pp. 175-177
    • Lage, A.1
  • 50
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Sep 19
    • Burrell RA, McGranahan N, Bartek J, Swanton C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature. 2013 Sep 19;501(7467):338-45.
    • (2013) Nature , vol.501 , Issue.7467 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3    Swanton, C.4
  • 51
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network. Sep 27
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep 27;489(7417):519-25.
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
  • 53
    • 24744454199 scopus 로고    scopus 로고
    • Time of our lives. What controls the length of life?
    • Jul
    • Kirkwood TB. Time of our lives. What controls the length of life? EMBO Rep. 2005 Jul;6 Spec No:S4-8.
    • (2005) EMBO Rep , vol.6 , Issue.SPEC NO
    • Kirkwood, T.B.1
  • 54
    • 77952302657 scopus 로고    scopus 로고
    • Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
    • Dec
    • Goto M. Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? Biosci Trends. 2008 Dec;2(6):218-30.
    • (2008) Biosci Trends , vol.2 , Issue.6 , pp. 218-230
    • Goto, M.1
  • 56
    • 84887015191 scopus 로고    scopus 로고
    • Genetic alterations defining NSCLC subtypes and their therapeutic implications
    • Nov
    • Pikor LA, Ramnarine VR, Lam S, Lam WL. Genetic alterations defining NSCLC subtypes and their therapeutic implications. Lung Cancer. 2013 Nov;82(2):179-89.
    • (2013) Lung Cancer , vol.82 , Issue.2 , pp. 179-189
    • Pikor, L.A.1    Ramnarine, V.R.2    Lam, S.3    Lam, W.L.4
  • 57
    • 0021808158 scopus 로고
    • Factors associated with prognosis in human breast cancer. V. The simultaneous use of estrogen and progesterone receptor measurements for prediction of short-term relapse
    • Pascual MR, Macías A, Moreno L, Lage A. Factors associated with prognosis in human breast cancer. V. The simultaneous use of estrogen and progesterone receptor measurements for prediction of short-term relapse. Neoplasma. 1985;32(2):247-56. (Pubitemid 15078955)
    • (1985) Neoplasma , vol.32 , Issue.2 , pp. 247-256
    • Pascual, M.R.1    Macias, A.2    Moreno, L.3    Lage, A.4
  • 58
    • 84894363816 scopus 로고    scopus 로고
    • Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab
    • Dec 10
    • Gómez C, Plaza JC, Pazo R, Salud A, Pons F, Fonseca P, et al. Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab. J Clin Oncol. 2013 Dec 10;31(35):4445-52.
    • (2013) J Clin Oncol , vol.31 , Issue.35 , pp. 4445-4452
    • Gómez, C.1    Plaza, J.C.2    Pazo, R.3    Salud, A.4    Pons, F.5    Fonseca, P.6
  • 59
    • 84875909425 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC
    • May
    • Pallis AG, Syrigos KN. Epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of NSCLC. Lung Cancer. 2013 May;80(2):120-30.
    • (2013) Lung Cancer , vol.80 , Issue.2 , pp. 120-130
    • Pallis, A.G.1    Syrigos, K.N.2
  • 60
    • 84866292562 scopus 로고    scopus 로고
    • Molecular predictors of response to tyrosine kinase inhibitors in patients with Non-Small-Cell Lung Cancer
    • Sep 19
    • Murray S, Karavasilis V, Bobos M, Razis E, Papadopoulos S, Christodoulou C, et al. Molecular predictors of response to tyrosine kinase inhibitors in patients with Non-Small-Cell Lung Cancer. J Exp Clin Cancer Res. 2012 Sep 19;31:77.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 77
    • Murray, S.1    Karavasilis, V.2    Bobos, M.3    Razis, E.4    Papadopoulos, S.5    Christodoulou, C.6
  • 63
    • 0347572864 scopus 로고    scopus 로고
    • Tolerance and immunity in a mathematical model of T-cell mediated suppression
    • Nov 7
    • León K, Lage A, Carneiro J. Tolerance and immunity in a mathematical model of T-cell mediated suppression. J Theor Biol. 2003 Nov 7;225(1):107-26.
    • (2003) J Theor Biol , vol.225 , Issue.1 , pp. 107-126
    • León, K.1    Lage, A.2    Carneiro, J.3
  • 65
    • 84940338634 scopus 로고    scopus 로고
    • [place unknown]: Xplore, Inc; c2001-2014 [cited 2014 Jun 7]; [about 1 screen]. Available from
    • Brainy Quotes [Internet]. [place unknown]: Xplore, Inc; c2001-2014 [cited 2014 Jun 7]; [about 1 screen]. Available from: http://www.brainyquote.com/ quotes/quotes/a/alberteins112012.html
    • Brainy Quotes [Internet]


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.