Interferometric reflectance imaging sensor (IRIS)—a platform technology for multiplexed diagnostics and digital detection

Sensors (Switzerland)

Volumn 15, Issue 7, 2015, Pages 17649-17665

  Avci, Oguzhan ^a   Ünlü, Nese Lortlar ^a,b   Özkumur, Ayça Yalçın ^b   Ünlü, M Selim ^a  

^a Boston University   (United States)

^b BAHCESEHIR UNIVERSITY   (Turkey)

Author keywords

Digital detection; Interferometry; Label free; Nanoparticle; Optical biosensor; Single nucleotide polymorphism; Virus

Indexed keywords

BIOSENSORS; INTERFEROMETRY; MULTIPLEXING; NANOPARTICLES; NUCLEOTIDES; REFLECTION; VIRUSES;

CHARACTERIZATION OF NANOPARTICLES; DIGITAL DETECTIONS; EMERGING INFECTIOUS DISEASE; INDIVIDUAL NANOPARTICLES; LABEL FREE; MULTIFUNCTIONAL PLATFORMS; OPTICAL BIO-SENSORS; SINGLE NUCLEOTIDE POLYMORPHISMS;

DIAGNOSIS;

DEVICES; DIAGNOSTIC IMAGING; GENETIC PROCEDURES; HUMAN; INTERFEROMETRY; SIGNAL PROCESSING;

BIOSENSING TECHNIQUES; DIAGNOSTIC IMAGING; HUMANS; INTERFEROMETRY; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84940184248     PISSN: 14248220     EISSN: None     Source Type: Journal    
DOI: 10.3390/s150717649     Document Type: Review

References (38)

1. Gubala, V.; Harris, L.F.; Ricco, A.J.; Tan, M.X.; Williams, D.E. Point of care diagnostics: Status and future. Anal. Chem. 2012, 84, 487–515.
2. Li, R.; Wu, D.; Li, H.; Xu, C.; Wang, H.; Zhao, Y.; Cai, Y.; Wei, Q.; Du, B. Label-free amperometric immunosensor for the detection of human serum chorionic gonadotropin based on nanoporous gold and grapheme. Anal. Biochem. 2011, 414, 196–201.
3. Stoeva, S.I.; Lee, J.S.; Smith, J.E.; Rosen, S.T.; Mirkin, C.A. Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes. J. Am. Chem. Soc. 2006, 128, 8378–8379.
4. Özkumur, E.; Needham, J.W.; Bergstein, D.A.; Gonzalez, R.; Cabodi, M.; Gershoni, J.M.; Goldberg, B.B.; Ünlü, M.S. Label-free and dynamic detection of biomolecular interactions for high-throughput microarray applications. Proc. Natl. Acad. Sci. USA 2008, 105, 7988–7992.
5. Özkumur, E.; Yalçın, A.; Cretich, M.; Lopez, C.A.; Bergstein, D.A.; Goldberg, B.B.; Chiari, M.; Ünlü, M.S. Quantification of DNA and protein adsorption by optical phase shift. Biosens. Bioelectron. 2009, 25, 167–172.
6. Özkumur, E.; Ahn, S.; Yalçın, A.; Lopez, C.A.; Çevik, E.; Irani, R.J.; DeLisi, C.; Chiari, M.; Ünlü, M.S. Label-free microarray imaging for direct detection of DNA hybridization and single-nucleotide mismatches. Biosens. Bioelectron. 2010, 25, 1789–1795.
7. Lopez, C.A.; Daaboul, G.G.; Vedula, R.S.; Özkumur, E.; Bergstein, D.A.; Geisbert, T.W.; Fawcett, H.E.; Goldberg, B.B.; Connor, J.H.; Ünlü, M.S. Label-free, multiplexed virus detection using spectral reflectance imaging. Biosens. Bioelectron. 2011, 26, 3432–3437.
8. Daaboul, G.G.; Yurt, A.; Zhang, X.; Hwang, G.M.; Goldberg, B.B.; Ünlü, M.S. High-throughput detection and sizing of individual low-index nanoparticles and viruses for pathogen identification. Nano Lett. 2010, 10, 4727–4731.
9. Yurt, A.; Daaboul, G.G.; Connor, J.H.; Goldberg, B.B.; Ünlü, M.S. Single nanoparticle detectors for biological applications. Nanoscale 2012, 4, 715–726.
10. Daaboul, G.G.; Lopez, C.A.; Yurt, A.; Member, S.; Goldberg, B.B. Label-free optical biosensors for virus detection and characterization. Sel. Top. Quantum Electron. IEEE J. 2012, 18, 1422–1433.
11. Vedula, R.; Daaboul, G.; Reddington, A.; Özkumur, E.; Bergstein, D.A.; Ünlü, M.S. Self-referencing substrates for optical interferometric biosensors. J. Mod. Opt. 2010, 57, 1564–1569.
12. Ünlü, M.S. Digital detection of nanoparticles: Viral diagnostics and multiplexed protein and nucleic acid assays. MRS Proc. 2014, doi:10.1557/opl.2015.4.
13. Novotny, L.; Hecht, B. Principles of Nano-Optics, 2nd ed.; Cambridge University Press: Cambridge, UK, 2012.
14. Daaboul, G.G.; Vedula, R.S.; Ahn, S.; Lopez, C.A.; Reddington, A.; Ozkumur, E.; Ünlü, M.S. LED-based interferometric reflectance imaging sensor for quantitative dynamic monitoring of biomolecular interactions. Biosens. Bioelectron. 2011, 26, 2221–2227.
15. Reddington A.P. Instrument Design and Optimization of Interferometric Reflectance Imaging Sensors for in Vitro Diagnostics. Ph.D. Thesis, Boston University, Boston, MA, USA, January 2014.
16. Reddington, A.P.; Monroe, M.R.; Ünlü, M.S. Integrated imaging instrument for self-calibrated fluorescence protein microarrays. Rev. Sci. Instrum. 2013, 84, 103702.
17. Monroe, M.R.; Reddington, A.P.; Collins, A.D.; LaBoda, C.; Cretich, M.; Chiari, M.; Little, F.F.; Ünlü, M.S. Multiplexed method to calibrate and quantitate fluorescence signal for allergen-specific IgE. Anal. Chem. 2011, 83, 9485–9491.
18. Reddington, A.P.; Member, S.; Trueb, J.T.; Freedman, D.S.; Tuysuzoglu, A.; Member, S.; Daaboul, G.G.; Lopez, C.A.; Karl, W.C.; Member, S.; et al. An Interferometric Reflectance Imaging Sensor for Point of Care Viral Diagnostics. IEEE Trans. Biomed. Eng. 2013, 60, 3276–3283.
19. Ahn, S.; Huang, C.-L.; Ozkumur, E.; Zhang, X.; Chinnala, J.; Yalcin, A.; Bandyopadhyay, S.; Russek, S.; Ünlü, M.S.; De Lisi, C.; et al. TATA binding proteins can recognize nontraditional DNA sequences. Biophys. J. 2012, 103, 1510–1517.
20. Yu, C.; Lopez, C.A.; Hu, H.; Xia, Y.; Freedman, D.S.; Reddington, A.P.; Daaboul, G.G.; Ünlü, M.S.; Genco, C.A. A high-throughput method to examine protein-nucleotide interactions identifies targets of the bacterial transcriptional regulatory protein Fur. PLoS ONE 2014, 9, e96832.
21. Hessner, M.; Singh, V.; Wang, X.; Khan, S.; Tschannen, M.; Zahrt, T. Utilization of a labeled tracking oligonucleotide for visualization and quality control of spotted 70-mer arrays. BMC Genomics 2004, 5, 12.
22. Francesca, B.; Francesco, D.; Vincenza, C.; Silvia, G.; Gabriele, D.C.; Manuela, S.; Luigi, P.; Maurizio, F.; Marcella, C.; Laura, C. High-sensitive microarray substrates specifically designed to improve sensitivity for the identification of fetal paternally inherited sequences in maternal plasma. Clin. Chem. Lab. Med. 2009, 47, 818–823.
23. Cretich, M.; Monroe, M.R.; Reddington, A.; Zhang, X.; Daaboul, G.G.; Damin, F.; Sola, L.; Unlu, M.S.; Chiari, M. Interferometric silicon biochips for label and label-free DNA and protein microarrays. Proteomics 2012, 12, 2963–2977.
24. Sevenler, D.; Ünlü, N.L.; Ünlü, M.S. Nanoparticle biosensing with interferometric reflectance imaging. In Nanobiosensors and Nanobioanalyses; Vestergaard, M.C., Kerman, K., Hsing, I.M., Tamiya, E., Eds.; Springer: Tokyo, Japan, 2015.
25. Daaboul, G.G.; Lopez, C.A.; Chinnala, J.; Goldberg, B.B.; Connor, J.H.; Ünlü, M.S. Digital sensing and sizing of vesicular stomatitis virus pseudotypes in complex media: A model for ebola and marburg detection. ACS Nano 2014, 8, 6047–6055.
26. Luchansky, M.S.; Washburn, A.L.; McClellan, M.S.; Bailey, R.C. Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads. Lab Chip 2011, 11, 2042–2044.
27. Sheehan, P.E.; Whitman, L.J. Detection limits for nanoscale biosensors. Nano Lett. 2005, 5, 803–807.
28. Monroe, M.R.; Daaboul, G.G.; Tuysuzoglu, A.; Lopez, C.A.; Little, F.F.; Ünlü, M.S. Single nanoparticle detection for multiplexed protein diagnostics with attomolar sensitivity in serum and unprocessed whole blood. Anal. Chem. 2013, 85, 3698–3706.
29. Steiner, G. Surface plasmon resonance imaging. Anal. Bioanal. Chem. 2004, 379, 328–331.
30. Zhuo, Y.; Hu, H.; Chen, W.; Lu, M.; Tian, L.; Yu, H.; Long, K.D.; Chow, E.; King, W.P.; Singamaneni, S.; et al. Single nanoparticle detection using photonic crystal enhanced microscopy. Analyst 2014, 139, 1007–1015.
31. Vollmer, F.; Arnold, S. Whispering-gallery-mode biosensing: Label-free detection down to single molecules. Nat. Meth. 2008, 5, 591–596.
32. Lindfors, K.; Kalkbrenner, T.; Stoller, P.; Sandoghdar, V. Detection and spectroscopy of gold nanoparticles using supercontinuum white light confocal microscopy. Phys. Rev. Lett. 2004, 93, 037401.
33. Ortega-Arroyo, J.; Kukura, P. Interferometric scattering microscopy (iSCAT): New frontiers in ultrafast and ultrasensitive optical microscopy. Phys. Chem. Chem. Phys. 2012, 14, 15625.
34. Ignatovich, F.V.; Novotny, L. Real-time and background-free detection of nanoscale particles. Phys. Rev. Lett. 2006, 96, 013901.
35. Piliarik, M.; Sandoghdar, V. Direct optical sensing of single unlabelled proteins and super-resolution imaging of their binding sites. Nat. Commun. 2014, 5, doi:10.1038/ncomms5495
36. Vollmer, F.; Arnold, S.; Keng, D. Single virus detection from the reactive shift of a whispering-gallery mode. Proc. Natl. Acad. Sci. USA 2008, 105, 20701–20704.
37. Lee, H.J.; Nedelkov, D.; Corn, R.M. Surface plasmon resonance imaging measurements of antibody arrays for the multiplexed detection of low molecular weight protein biomarkers. Anal. Chem. 2006, 78, 6504–6510.
38. Nelson, B.P.; Grimsrud, T.E.; Liles, M.R.; Goodman, R.M.; Corn, R.M. Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays. Anal. Chem. 2001, 73, 1–7.