An interferometric reflectance imaging sensor for point of care viral diagnostics

IEEE Transactions on Biomedical Engineering

Volumn 60, Issue 12, 2013, Pages 3276-3283

  Reddington, Alexander P ^a   Trueb, Jacob T ^a   Freedman, David S ^a   Tuysuzoglu, Ahmet ^a   Daaboul, George G ^a   Lopez, Carlos A ^a   Karl, W Clem ^a   Connor, John H ^b   Fawcett, Helen ^a   Unlu, M Selim ^a  

^a Boston University   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

Automation; biosensors; label free; nanoparticle detection; point of care; virus detection

Indexed keywords

AUTOMATED DATA ACQUISITION; EARLY DISEASE DETECTION; IN-VITRO DIAGNOSTIC; LABEL FREE; POINT OF CARE; REFLECTANCE IMAGING; SOFTWARE INTERFACES; VIRUS DETECTION;

AUTOMATION; BIOSENSORS; INTERFEROMETRY; REFLECTION; VIRUSES;

DIAGNOSIS;

ARTICLE; ASSAY; BIOSENSOR; BLOOD ANALYSIS; COMPUTER; COMPUTER PROGRAM; CONTROLLED STUDY; IMAGING SYSTEM; INFORMATION PROCESSING; POINT OF CARE TESTING; SENSOR; SINGLE PARTICLE INTERFEROMETRIC REFLECTANCE IMAGING SENSOR; VIRUS EXAMINATION;

BIOSENSING TECHNIQUES; EQUIPMENT DESIGN; HUMANS; INTERFEROMETRY; NANOPARTICLES; POINT-OF-CARE SYSTEMS; SOFTWARE; VIRUS DISEASES; VIRUSES;

EID: 84887349603     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2013.2272666     Document Type: Article

References (26)

1. A. Rajan and H. Glorikian, "Point-of-care diagnostics: Market trends and growth drivers," Expert Opin. Med. Diagnos., vol. 3, no. 1, pp. 1-4, 2009.
2. M. Debnath, G. B. K. S. Prasad, and P. S. Bisen, "Segments of molecular diagnostics-Market place," in Molecular Diagnostics: Promises and Possibilities. Dordrecht, The Netherlands: Springer, 2010, pp. 503-513.
3. Y. J. Choi, H. S. Nam, J. S. Park, H. J. Kim, K.B. Park, M.H. Jeon, C. J. Kim, Y. Hwangbo, K. S. Park, and K. A. Baek, "Comparative analysis of the multiple test methods for the detection of pandemic influenza A/H1N1 2009 Virus," J. Microbiol. Biotechnol., vol. 20, no. 10, pp. 1450-1456, Oct. 2010.
4. C. Chartrand, M. M. G. Leeflang, J. Minion, T. Brewer, and M. Pai, "Accuracy of rapid influenza diagnostic tests: A meta-analysis," Ann. Internal Med., vol. 156, pp. 500-511, 2012.
5. S. A. Harper, J. S. Bradley, J. A. Englund, T. M. File, S. Gravenstein, F. G. Hayden, A. J. McGeer, K. M. Neuzil, A. T. Pavia, M. L. Tapper, T. M. Uyeki, and R. K. Zimmerman, "Seasonal influenza in adults and children-diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: Clinical practice guidelines of the Infectious Diseases Society of America," Clin. Infect. Dis., vol. 48, no. 8, pp. 1003-1032, Apr. 2009.
6. B. T. Cunningham and R. C. Zangar, "Photonic crystal enhanced fluorescence for early breast cancer biomarker detection," J. Biophoton., vol. 8-9, pp. 617-628, Jun. 2012.
7. M. A. Santiago-Cordoba, M. Cetinkaya, S. V Boriskina, F. Vollmer, and M. C. Demirel, "Ultrasensitive detection of a protein by optical trapping in a photonic-plasmonic microcavity," J. Biophoton., vol. 638, no. 8, pp. 629-638, Jun. 2012.
8. V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, and S. Arnold, "Taking whispering gallery-mode single virus detection and sizing to the limit," Appl. Phys. Lett., vol. 101, no. 4, pp. 043704-043708, 2012.
9. H. Zhu, S. O. Isikman, O. Mudanyali, A. Greenbaum, and A. Ozcan, "Optical imaging techniques for point-of-care diagnostics," Lab Chip, vol. 13, pp. 51-67, Oct. 2012.
10. B. Veigas, J. M. Jacob, M. N. Costa, D. S. Santos, M. Viveiros, J. Ińacio, R. Martins, P. Barquinha, E. Fortunato, and P. V. Baptista, "Gold on paperpaper platform for Au-nanoprobe TB detection," Lab Chip, vol. 12, no. 22, pp. 4802-4808, Oct. 2012.
11. O. Mudanyali, S. Dimitrov, U. Sikora, S. Padmanabhan, I. Navruz, and A. Ozcan, "Integrated rapid-diagnostic-test reader platform on a cellphone," Lab Chip, vol. 12, no. 15, pp. 2678-2686, Aug. 2012.
12. F. Ahmad and S. A. Hashsham, "Miniaturized nucleic acid amplification systems for rapid and point-of-care diagnostics: A review," Analytica Chimica Acta, vol. 733, pp. 1-15, Jul. 2012.
13. M. D. Estes, J. Yang, B. Duane, S. Smith, C. Brooks, A. Nordquist, and F. Zenhausern, "Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis," Analyst, vol. 137, no. 23, pp. 5510-5519, Dec. 2012.
14. A. Puren, J. L. Gerlach, B. H. Weigl, D. M. Kelso, and G. J. Domingo, "Laboratory operations, specimen processing, and handling for viral load testing and surveillance," J. Infect. Dis., vol. 201, no. Suppl. 1, pp. S27-S36, 2010.
15. G. G. Daaboul, R. S. Vedula, S. Ahn, C. A. Lopez, A. Reddington, E. Ozkumur, and M. S. Ü nlü, "LED-based interferometric reflectance imaging sensor for quantitative dynamic monitoring of biomolecular interactions," Biosens. Bioelectron., vol. 26, no. 5, pp. 2221-2227, Jan. 2011.
16. C. A. Lopez, G. G. Daaboul, R. S. Vedula, E. Ozkumur, D. A. Bergstein, T. W. Geisbert, H. E. Fawcett, B. B. Goldberg, J. H. Connor, and M. S. U nlu, "Label-Free multiplexed virus detection using spectral reflectance imaging," Biosens. Bioelectron., vol. 26, no. 8, pp. 3432-3437, Apr. 2011.
17. G. G. Daaboul, A. Yurt, X. Zhang, G. M. Hwang, B. B. Goldberg, and M. S. U nlu, "High-throughput detection and sizing of individual lowindex nanoparticles and viruses for pathogen identification," Nano Lett., vol. 10, no. 11, pp. 4727-4731, Nov. 2010.
18. A. Yurt, G. G. Daaboul, J. H. Connor, B. B. Goldberg, and M. S. U nlu, "Single nanoparticle detectors for biological applications," Nanoscale, vol. 4, no. 3, pp. 715-726, Feb. 2012.
19. G. G. Daaboul, C. A. Lopez, A. Yurt, B. B. Goldberg, J. H. Connor, and M. S. U nlu, "Label-Free optical biosensors for virus detection and characterization," IEEE J. Sel. Topics Quantum Electron., vol. 18, no. 4, pp. 1422-1433, Jul./Aug. 2012.
20. M. R. Monroe, G. G. Daaboul, A. Tuysuzoglu, C. A. Lopez, F. F. Little, and M. S. U nlu, "Single nanoparticle detection for multiplexed protein diagnostics with attomolar sensitivity in serum and unprocessed whole blood," Analytical Chem., vol. 85, no. 7, pp. 3698-3706, 2013.
21. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small particles. New York, NY, USA: Wiley, 1998.
22. L. Novotny and B. Hecht, Principles of Nano-optics. Cambridge, U.K.: Cambridge Univ. Press, 2006.
23. D. G. Lowe, "Distinctive image features from scale-invariant keypoints," Int. J. Comput. Vis., vol. 60, no. 2, pp. 91-110, Nov. 2004.
24. T. Lindeberg, "Scale-Space Theory : A basic tool for analysing structures at different scales," J. Appl. Statist., vol. 21, no. 2, pp. 224-270, 1994.
25. C. Harris and M. Stephens, "A combined corner and edge detector," in Proc. 4th Alvey Vis. Conf., 1988, pp. 147-152.
26. J. M. Mateos-Ṕerez, R. Redondo, R. Nava, J. C. Valdiviezo, G. Crist́obal, B. Escalante-Raḿ?rez, M. J. Ruiz-Serrano, J. Pascau, and M. Desco, "Comparative evaluation of autofocus algorithms for a real-time system for automatic detection of mycobacterium tuberculosis," Cytometry Part A : J. Int. Soc. Advancement Cytometry, vol. 81, no. 3, pp. 213-221, Mar. 2012.