Pseudomonas quinolone signalling system: A component of quorum sensing cascade is a crucial player in the acute urinary tract infection caused by Pseudomonas aeruginosa

International Journal of Medical Microbiology

Volumn 304, Issue 8, 2014, Pages 1199-1208

  Bala, Anju ^a   Chhibber, Sanjay ^a   Harjai, Kusum ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Acute urinary tract infection; Pathogenicity; Pseudomonas aeruginosa; Pseudomonas quinolone signal; Quorum sensing

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; NITRIC OXIDE SYNTHASE; QUINOLONE;

ACUTE PYELONEPHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL LOAD; BACTERIAL VIRULENCE; CELL AGGREGATION; CELL VACUOLE; CONTROLLED STUDY; CYSTITIS; DISEASE COURSE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HISTOPATHOLOGY; HYPERPLASIA; KIDNEY HOMOGENATE; KIDNEY PARENCHYMA; LIPID PEROXIDATION; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; PSEUDOMONAS QUINOLONE SIGNALLING SYSTEM; PYELONEPHRITIS; QUORUM SENSING; TISSUE HOMOGENATE; TISSUE INJURY; TRANSPOSON; UPREGULATION; URINARY TRACT INFECTION;

EID: 84940166135     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2014.08.013     Document Type: Article

References (36)

1. Anjaneyulu M., Chopra K. Effect of irbesartan on the antioxidant defence system and nitric oxide release in diabetic rat kidney. Am. J. Nephrol. 2004, 24:488-496.
2. Bala A., Kumar R., Harjai K. Inhibition of quorum sensing in P. aeruginosa by azithromycin and its effectiveness in urinary tract infections. J. Med. Microbiol. 2011, 60:300-306.
3. Bala A., Gupta R.K., Chhibber S., Harjai K. Detection and quantification of quinolone signalling molecule: a third quorum sensing molecule of Pseudomonas aeruginosa by high performance-thin layer chromatography. J. Chromatogr. B 2013, 930:30-35.
4. Bradley J.R. TNF-mediated inflammatory disease. J. Pathol. 2008, 214:149-160.
5. Cao H., Krishnan G., Goumnerov B., Tsongalis J., Tompkins R., Rahme L.G. A quorum sensing-associated virulence gene of P. aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proc. Natl. Acad. Sci. 2001, 98:14613-14618.
6. Chowdhury P., Sacks S.H., Sheerin N.S. Minireview: functions of the renal tract epithelium in coordinating the innate immune response to infection. Kidney Int. 2004, 66:1334-1344.
7. Deziel E., Lepine F., Milot S., He J., Mindrinos M.N., Tompkins R.G., Rahme L.G. Analysis of P. aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc. Natl. Acad. Sci. 2004, 101:1339-1344.
8. Deziel E., Gopalan S., Tampakaki A.P., Lepine F., Padfield K.E., Saucier M., Xiao G., Rahme L.G. The contribution of MvfR to P. aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-l-homoserine lactones. Mol. Microbiol. 2005, 55:998-1014.
9. Diggle S.P., Winzer K., Chhabra S.R., Worrall K.E., Camara M., Williams P. The P. aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol. Microbiol. 2003, 50:29-43.
10. Diggle S.P., Cornelis P., Williams P., Camara M. 4-Quinolone signalling in P. aeruginosa: old molecules, new perspectives. Int. J. Med. Microbiol. 2006, 296:83-91.
11. Duell B.L., Tan C.K., Carey A.J., Wu F., Cripps A.W., Ulett G.C. Recent insights into microbial triggers of interleukin-10 production in the host and the impact on infectious disease pathogenesis. FEMS Immunol. Med. Microbiol. 2012, 64:295-313.
12. Erickson D.L., Endersby R., Kirkham A., Stuber K., Vollman D.D., Rabin H.R., Mitchell I., Storey D.G. P. aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect. Immunol. 2002, 70:1783-1790.
13. Gallagher L.A., McKnight S.L., Kuznetsova M.S., Pesci E.C., Manoil C. Functions required for extracellular quinolone signaling by P. aeruginosa. J. Bacteriol. 2002, 184:6472-6480.
14. Garg U.C., Ganguly N.K., Sharma S., Chakravati R.N., Bhatnagar R.K. Quantitative histopathological method for evaluation of experimental ascending pyelonephritis. Med. Sci. Res. 1987, 15:367-368.
15. Gupta R.K., Chhibber S., Harjai K. Quorum sensing signal molecules cause renal tissue inflammation through local cytokine responses in experimental UTI caused by P. aeruginosa. Immunobiology 2013, 218(2):181-185.
16. Harjai K., Mittal R., Chhibber S., Sharma S. Contribution of Tamm-Horsfall protein to the virulence of P. aeruginosa in relation to urinary tract infections. Microbes Infect. 2005, 7:132-137.
17. Hooi D.S., Bycroft B.W., Chhabra S.R., Williams P., Pritchard D.I. Differential immune modulatory activity of P. aeruginosa quorum-sensing signal molecules. Infect. Immunol. 2004, 72:6463-6470.
18. Hopkins W.J., Gendron-Fitzpatrick A., Balish E., Uehling D.T. Time course and host responses to Escherichia coli urinary tract Infection in genetically distinct mouse strains. Infect. Immunol. 1998, 66(6):2798-2802.
19. Ilangovan A., Fletcher M., Rampioni G., Pustelny C., Rumbaugh K., Heeb Stephan, Camara M., Truman A., Chhabra S.R., Emsley J., Williams P. Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (mvfR). PLoS Pathog. 2013, 9(7):e1003508.
20. Kim K., Kim Y.U., Koh B.H., Hwang S.S., Kim S., Lepine F., Cho Y., Lee G.R. HHQ and PQS, two P. aeruginosa quorum-sensing molecules, downregulate the innate immune responses through the nuclear factor-κB pathway. Immunology 2010, 129:578-588.
21. Kumar R., Chhibber S., Harjai K. Quorum sensing is necessary for the virulence of P. aeruginosa during urinary tract infection. Kidney Int. 2009, 76:286-292.
22. McGrath S., Wade D.S., Pesci E.C. Dueling quorum sensing systems in P. aeruginosa control the production of the Pseudomonas quinolone signal (PQS). FEMS Microbiol. Lett. 2004, 230:27-34.
23. McKnight S.L., Iglewski B.H., Pesci E.C. The Pseudomonas quinolone signal regulates rhl quorum sensing in P. aeruginosa. J. Bacteriol. 2000, 182:2702-2708.
24. Pearson J.P., Feldman M., Iglewski B.H., Prince A. P. aeruginosa cell to- cell signaling is required for virulence in a model of acute pulmonary infection. Infect. Immunol. 2000, 68:4331-4334.
25. Pesci E.C., Milbank J.B.J., Pearson J.P., McKnight S., Kende A.S., Greenberg E.P., Iglewski B.H. Quinolone signaling in the cell-to-cell communication system of P. aeruginosa. Proc. Natl. Acad. Sci. 1999, 96:11229-11234.
26. Rampioni G., Pustelny C., Fletcher M.P., Wright V.J., Bruce M., Rumbaugh K.P., Heeb S., Camara M., Williams P. Transcriptomic analysis reveals a global alkyl-quinolone independent regulatory role for PqsE in facilitating the environmental adaptation of P. aeruginosa to plant and animal hosts. Environ. Microbiol. 2010, 12:1659-1673.
27. Reen F.J., Mooij M.J., Holcombe L.J., McSweeney C.M., McGlacken G.P., Morrissey J.P., O'Gara F. The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behavior. FEMS Microbiol. Ecol. 2011, 77:413-428.
28. Rockett K.A., Awburn M.M., Rockett E.J., Cowden W.B., Clark I.A. Possible role of nitric oxide in malarial immunosuppression. Parasite Immunol. 1994, 16:243-249.
29. Ronald A. The etiology of urinary tract infection: traditional and emerging pathogens. Dis. Mon. 2003, 49:71-82.
30. Rumbaugh K.P., Griswold J.A., Iglewski B.H., Hamood A.N. Contribution of quorum sensing to the virulence of P. aeruginosa in burn wound infections. Infect. Immunol. 1999, 67:5854-5862.
31. Shah D., Mahajan N., Sah S., Nath S.K., Paudyal B. Oxidative stress and its biomarkers in systemic lupus erythematosus. J. Biomed. Sci. 2014, 21(1):1-23.
32. Smith E.A. Pyelonephritis, renal scarring and reflux nephropathy: a pediatric urologist's perspective. Pediatr. Radiol. 2008, 38(Suppl 1):S76-S82.
33. Wade D.S., Calfee M.W., Rocha E.R., Ling E.A., Engstrom E., Coleman J.P., Pesci E.C. Regulation of Pseudomonas quinolone signal synthesis in P. aeruginosa. J. Bacteriol. 2005, 187:4372-4380.
34. Williams P., Winzer K., Chan W.C., Camara M. Look who's talking: communication and quorum sensing in the bacterial world. Philos. Trans. R. Soc. London, Ser. B 2007, 362(1483):1119-1134.
35. Wink D.A., Mitchell J.B. The chemical biology of nitric oxide: insights into regulatory, cytotoxic and cytoprotective mechanisms of nitric oxide. Free Radic. Biol. Med. 1998, 25:434-456. 1998.
36. Zhu H., Bandara R., Conibear T.C., Thuruthyil S.J., Rice S.A., Kjelleberg S., Givskov M., Willcox M.D. P. aeruginosa with lasI quorum-sensing deficiency during corneal infection. Invest. Ophthalmol. Vis. Sci. 2004, 45:1897-1903.