Psoriasis in humans is associated with down-regulation of galectins in dendritic cells

Journal of Pathology

Volumn 228, Issue 2, 2012, Pages 193-203

  De La Fuente, H ^a,b   Perez Gala, Silvia ^a   Bonay, Pedro ^c   Cruz Adalia, Aranzazu ^a   Cibrian, Danay ^a   Sanchez Cuellar, Silvia ^a   Dauden, Esteban ^a   Fresno, Manuel ^c   García Diez, Amaro ^a   Sanchez Madrid, Francisco ^a,b  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

galectin; immunoregulation; myeloid dendritic cells; plasmacytoid cells; psoriasis; skin dendritic cells

Indexed keywords

ECALECTIN; GALECTIN 1; GALECTIN 3; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 17; MESSENGER RNA;

ADULT; AGED; ARTICLE; BLOOD; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CHRONIC INFLAMMATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE EXACERBATION; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; LANGERHANS CELL; MALE; MONOCYTE; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL; TH17 CELL;

ADULT; AGED; AGED, 80 AND OVER; COCULTURE TECHNIQUES; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; GALECTIN 1; GALECTIN 3; GALECTINS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; LANGERHANS CELLS; MALE; MIDDLE AGED; PSORIASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; T-LYMPHOCYTES;

EID: 84866255270     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.3996     Document Type: Article

References (40)

1. Leffler H, Carlsson S, Hedlund M, et al., Introduction to galectins. Glycoconj J 2004; 19: 433-440.
2. Rabinovich GA, Toscano MA,. Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 2009; 9: 338-352.
3. Toscano MA, Bianco GA, Ilarregui JM, et al., Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 2007; 8: 825-834.
4. van der Leij J, van den Berg A, Blokzijl T, et al., Dimeric galectin-1 induces IL-10 production in T lymphocytes: an important tool in the regulation of the immune response. J Pathol 2004; 204: 511-518.
5. Toscano MA, Commodaro AG, Ilarregui JM, et al., Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses. J Immunol 2006; 176: 6323-6332.
6. Santucci L, Fiorucci S, Rubinstein N, et al., Galectin-1 suppresses experimental colitis in mice. Gastroenterology 2003; 124: 1381-1394.
7. Rabinovich GA, Daly G, Dreja H, et al., Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. J Exp Med 1999; 190: 385-398.
8. Perone MJ, Bertera S, Tawadrous ZS, et al., Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 2006; 177: 5278-5289.
9. Seki M, Oomizu S, Sakata KM, et al., Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 2008; 127: 78-88.
10. Chou FC, Shieh SJ, Sytwu HK,. Attenuation of Th1 response through galectin-9 and T cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 2009; 39: 2403-2411.
11. Katoh S, Ishii N, Nobumoto A, et al., Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma. Am J Respir Crit Care Med 2007; 176: 27-35.
12. Arikawa T, Watanabe K, Seki M, et al., Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages. Clin Immunol 2009; 133: 382-392.
13. Henderson NC, Sethi T,. The regulation of inflammation by galectin-3. Immunol Rev 2009; 230: 160-171.
14. Lowes MA, Bowcock AM, Krueger JG,. Pathogenesis and therapy of psoriasis. Nature 2007; 445: 866-873.
15. Niwa H, Satoh T, Matsushima Y, et al., Stable form of galectin-9, a Tim-3 ligand, inhibits contact hypersensitivity and psoriatic reactions: a potent therapeutic tool for Th1- and/or Th17-mediated skin inflammation. Clin Immunol 2009; 132: 184-194.
16. Fujita H, Shemer A, Suarez-Farinas M, et al., Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets. J Allergy Clin Immunol 2011; 128: 574-582; e571-512.
17. de Koning HD, Rodijk-Olthuis D, van Vlijmen-Willems IM, et al., A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis. J Invest Dermatol 2010; 130: 2611-2620.
18. Di Cesare A, Di Meglio P, Nestle FO,. The IL-23-Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 2009; 129: 1339-1350.
19. Shibata S, Tada Y, Kanda N, et al., Possible roles of IL-27 in the pathogenesis of psoriasis. J Invest Dermatol 2009; 130: 1034-1039.
20. Bowcock AM, Krueger JG,. Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol 2005; 5: 699-711.
21. Magnaldo T, Fowlis D, Darmon M,. Galectin-7, a marker of all types of stratified epithelia. Differentiation 1998; 63: 159-168.
22. Chu CC, Di Meglio P, Nestle FO,. Harnessing dendritic cells in inflammatory skin diseases. Semin Immunol 2011; 23: 28-41.
23. Zaba LC, Fuentes-Duculan J, Eungdamrong NJ, et al., Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells. J Invest Dermatol 2009; 129: 79-88.
24. Banchereau J, Steinman RM,. Dendritic cells and the control of immunity. Nature 1998; 392: 245-252.
25. Villadangos JA, Young L,. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 2008; 29: 352-361.
26. Zhu C, Anderson AC, Schubart A, et al., The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 2005; 6: 1245-1252.
27. Ellis CN, Krueger GG,. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 2001; 345: 248-255.
28. Blaser C, Kaufmann M, Muller C, et al., β-Galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells. Eur J Immunol 1998; 28: 2311-2319.
29. Perillo NL, Pace KE, Seilhamer JJ, et al., Apoptosis of T cells mediated by galectin-1. Nature 1995; 378: 736-739.
30. Norling LV, Sampaio AL, Cooper D, et al., Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J 2008; 22: 682-690.
31. Fulcher JA, Chang MH, Wang S, et al., Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling. J Biol Chem 2009; 284: 26860-26870.
32. Cooper D, Norling LV, Perretti M,. Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol 2008; 83: 1459-1466.
33. Demetriou M, Granovsky M, Quaggin S, et al., Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 2001; 409: 733-739.
34. Ilarregui JM, Croci DO, Bianco GA, et al., Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009; 10: 981-991.
35. Cedeno-Laurent F, Barthel SR, Opperman MJ, et al., Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. J Immunol 2010; 185: 4659-4672.
36. Kuo PL, Hung JY, Huang SK, et al., Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway. J Immunol 2011; 186: 1521-1530.
37. Camby I, Le Mercier M, Lefranc F, et al., Galectin-1: a small protein with major functions. Glycobiology 2006; 16: 137-157R.
38. Santucci L, Fiorucci S, Cammilleri F, et al., Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice. Hepatology 2000; 31: 399-406.
39. Klima J, Lacina L, Dvorankova B, et al., Differential regulation of galectin expression/reactivity during wound healing in porcine skin and in cultures of epidermal cells with functional impact on migration. Physiol Res 2009; 58: 873-884.
40. Steinman RM, Nussenzweig MC,. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci USA 2002; 99: 351-358.