Identification of a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population by next-generation sequencing

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Yang, Xiaochen ^a,b   Wu, Jiong ^a,b   Lu, Jingsong ^a,b   Liu, Guangyu ^a,b   Di, Genhong ^a,b   Chen, Canming ^a,b   Hou, Yifeng ^a,b   Sun, Menghong ^a,b   Yang, Wentao ^a,b   Xu, Xiaojing ^c   Zhao, Ying ^c   Hu, Xin ^a,b   Li, Daqiang ^a,b   Cao, Zhigang ^a,b   Zhou, Xiaoyan ^a,b   Huang, Xiaoyan ^a,b   Liu, Zhebin ^a,b   Chen, Huan ^a,b   Gu, Yanzi ^a,b   Chi, Yayun ^a,b   Yan, Xia ^a,b   Han, Qixia ^a,b   Shen, Zhenzhou ^a,b   Shao, Zhimin ^a,b   Hu, Zhen ^a,b   more..

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c National Engineering Center for Biochip at Shanghai   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; PROTEIN MLH1; PROTEIN MSH3; PROTEIN P53; UVOMORULIN; DNA BINDING PROTEIN; MSH3 PROTEIN, HUMAN;

ADENOMATOUS POLYP; ARTICLE; BREAST CANCER; CANCER GENETICS; CANCER PATIENT; CDKN2A GENE; CHINA; CHINESE; CODON; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CYP17A1 GENE; CYSTOSARCOMA PHYLLOIDES; DINUCLEOTIDE REPEAT; EXON; FAMILIAL CANCER; FANCD2 GENE; FANCI GENE; FGFR3 GENE; GENE; GENE FREQUENCY; GENE INTERACTION; GENE MUTATION; GENETIC CONSERVATION; GENETIC COUNSELING; GENETIC VARIABILITY; GERMLINE MUTATION; HEREDITARY BREAST AND OVARIAN CANCER SYNDROME; HEREDITARY BREAST CANCER; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HEREDITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALIGNANT NEOPLASTIC DISEASE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MISSENSE MUTATION; MUTYH GENE; NEXT GENERATION SEQUENCING; NONSENSE MUTATION; PALB2 GENE; PATHOGENICITY; PHENOTYPE; PLEIOTROPY; RAD50 GENE; RAD51C GENE; RGSL1 GENE; SEGREGATION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SLX4 GENE; SPINK1 GENE; TNFRSF13B GENE; WERNER SYNDROME; WRN GENE; ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGY; BREAST NEOPLASMS; EPISTASIS; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HEALTH SURVEY; HIGH THROUGHPUT SEQUENCING; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; ONSET AGE; PEDIGREE; TUMOR SUPPRESSOR GENE;

ADULT; AGE OF ONSET; ASIAN CONTINENTAL ANCESTRY GROUP; BREAST NEOPLASMS; CHINA; COMPUTATIONAL BIOLOGY; DNA-BINDING PROTEINS; EPISTASIS, GENETIC; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GERM-LINE MUTATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PEDIGREE; POPULATION SURVEILLANCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84940087115     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125571     Document Type: Article

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