MicroRNA-195 induced apoptosis in hypoxic chondrocytes by targeting hypoxia-inducible factor 1 alpha

European Review for Medical and Pharmacological Sciences

Volumn 19, Issue 4, 2015, Pages 545-551

  Bai, R ^a   Zhao, A Q ^b   Zhao, Z Q ^a   Liu, W L ^a   Jiang, D M ^c  

^a The Second Affiliated Hospital of Inner Mongolia Medical University   (China)

^b Affiliated Hospital of Inner Mongolia Medical University   (China)

^c THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; ATDC 5; Chondrocytes; Hypoxia; Hypoxia inducible factor 1 alpha; MicroRNA; MicroRNA 195

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MICRORNA; MICRORNA 195; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN; MIRN195 MICRORNA, HUMAN;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL HYPOXIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPOXIC CELL; PROTEIN EXPRESSION; REPORTER GENE; TRANSIENT TRANSFECTION; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; UPREGULATION;

APOPTOSIS; CELL HYPOXIA; CELLS, CULTURED; CHONDROCYTES; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICRORNAS; UP-REGULATION;

EID: 84940026608     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. MIYAKI S, ASAHARA H. Macro view of microRNA function in osteoarthritis. Nat Rev Rheumatol 2012; 8: 543-552.
2. WANG M, SHEN J, JIN H, IM HJ, SANDY J, CHEN D. Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci 2011; 1240: 61-69.
3. MURPHY CL, THOMS BL, VAGHJIANI RJ, LAFONT JE. Hypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair. Arthritis Res Ther 2009; 11: 213.
4. COIMBRA IB,JIMENEZ SA,HAWKINS DF,PIERA-VELAZQUEZ S,STOKES DG. Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes Osteoarthritis Cartilage 2004 12, 336-345.
5. KUO HP, LEE DF, XIA W, WEI Y, HUNG MC. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochem Biophys Res Commun 2009; 389: 640-644.
6. PFANDER D, CRAMER T, SWOBODA B. Hypoxia and HIF-1alpha in osteoarthritis. Int Orthop 2005; 29: 6-9.
7. LEWIS BP, BURGE CB, BARTEL DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005; 120: 15-20.
8. BARTEL DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233.
9. FILIPOWICZ W, BHATTACHARYYA SN, SONENBERG N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 2008; 9: 102-114.
10. WIENHOLDS E, KLOOSTERMAN WP, MISKA E, ALVAREZSAAVEDRA E, BEREZIKOV E, DE BRUIJN E, HORVITZ HR, KAUPPINEN S, PLASTERK RH. MicroRNA expression in zebrafish embryonic development. Science 2005; 309: 310-311.
11. TUDDENHAM L, WHEELER G, NTOUNIA-FOUSARA S, WATERS J, HAJIHOSSEINI MK, CLARK I, DALMAY T. The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett 2006; 580: 4214-4217.
12. NAKAMURA Y, INLOES JB, KATAGIRI T, KOBAYASHI T. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Mol Cell Biol 2011; 31: 3019-3028.
13. SWINGLER TE, WHEELER G, CARMONT V, ELLIOTT HR, BARTER MJ, ABU-ELMAGD M, DONELL ST, BOOT-HANDFORD RP, HAJIHOSSEINI MK, MUNSTERBERG A, DAL MAY T, YOUNG DA, CLARK IM. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum 2012; 64: 1909-1919.
14. DUDEK KA, LAFONT JE, MARTINEZ-SANCHEZ A , MURPHY CL. Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J Biol Chem 2010; 285: 24381-24387.
15. MARTINEZ-SANCHEZ A, DUDEK KA, MURPHY CL. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J Biol Chem 2012; 287: 916-92 4.
16. SHANG W, CHEN X, NIE L, XU M, CHEN N, ZENG H, ZHOU Q. MiR199b Suppresses Expression of Hypoxia-Inducible Factor 1alpha (HIF-1alpha) in Prostate Cancer Cells. Int J Mol Sci 2013; 14: 8422-8436.
17. GREER SN, METCALF JL, WANG Y, OHH M. The updated biology of hypoxia-inducible factor. EMBO J 2012; 31: 2448-2460.
18. HE J, JING Y, LI W, QIAN X, XU Q, LI FS, LIU LZ, JIANG BH, JIANG Y. Roles and mechanism of miR-199a and miR-125b in tumor angiogenesis. PLoS One 2013; 8: e56647.
19. BRUNING U, CERONE L, NEUFELD Z, FITZPATRICK SF, CHEONG A, SCHOLZ CC, SIMPSON DA, LEONARD MO, TAMBUWALA MM, CUMMINS EP, TAYLOR CT. MicroRNA 155 promotes resolution of hypoxia-inducible factor 1alpha a ctivity during prolonged hypoxia. Mol Cell Biol 2011; 31: 4087-4096.
20. KULSHRESHTHA R, DAVULURI RV, CALIN GA, IVAN M. A microRNA component of the hypoxic response. Cell Death Differ 2008; 15: 667-671.
21. BRAHIMI-HORN MC, POUYSSEGUR J. HIF at a glance. J Cell Sci 2009; 122: 1055-1057.
22. HUA Z, LV Q, YE W, WONG CK, CAI G, GU D, JI Y, ZHAO C, WANG J, YANG BB, ZHANG Y. MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One 2006; 1: e116.
23. CHA ST, CHEN PS, JOHANSSON G, CHU CY, WANG MY, JENG YM, YU SL, CHEN JS, CHANG KJ, JEE SH, TAN CT, LIN MT, KUO ML. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res 2010; 70: 2675-2685.
24. HUANG X, DING L, BENNEWITH KL, TONG RT, WELFORD SM, ANG KK, STORY M, LE QT, GIACCIA AJ. Hypoxiainducible mir-210 regulates normoxic gene expression involved in tumor initiation . Mol Cell 2009; 35: 856-867.
25. IVAN M, HARRIS AL, MARTELLI F, KULSHRESHTHA R. Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med 2008; 12: 1426-1431.
26. PUISSEGUR MP,MAZURE NM,BERTERO T,PRADELLI L,GROSSO S,ROBBE-SERMESANT K,MAURIN T,LEBRIGAND K,CARDINAUD B,HOFMAN V,FOURRE S,MAGNONE V,RICCI JE,POUYSSEGUR J,GOUNON P,HOFMAN P,BARBRY P,MARI B MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity Cell Death Differ 2011 18 465-478.
27. MCCORMICK RI, BLICK C, RAGOUSSIS J, SCHOEDEL J, MOLE DR, YOUNG AC, SELBY PJ, BANKS RE, HARRIS AL. miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis. Br J Cancer 2013; 108: 1133-1142.
28. FANG Y, YU X, LIU Y, KRIEGEL AJ, HENG Y, XU X, LIANG M, DING X. miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-Alpha activation. Am J Physiol Renal Physiol 2013; 304: F1274-1282.
29. TANAKA H, SASAYAMA T, TANAKA K, NAKAMIZO S, NISHIHARA M, MIZUKAWA K, KOHTA M, K OYAMA J, MIYAKE S, TANIGUCHI M, HOSODA K, KOHMURA E. MicroRNA-183 upregulates HIF-1alpha by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells. J Neurooncol 2013; 111: 273-283.
30. YUE J, GUAN J, WANG X, ZHANG L, YANG Z, AO Q, DENG Y, ZHU P, WANG G. MicroRNA-206 is involved in hypoxia-induced pulmonary hyper tension through targeting of the HIF-1alpha/Fhl-1 pathway. Lab Invest 2013; 93: 748-759.
31. ZHOU B, MA R, SI W, LI S, XU Y, TU X, WANG Q. MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth. Cancer Lett 2013; 333: 159-169.
32. HE JF, LUO YM, WAN XH, JIANG D. Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis. J Biochem Mol Toxicol 2011; 25: 404-408.
33. ZHOU Y, JIANG H, GU J, TANG Y, SHEN N AND JIN Y. MicroRNA-195 targets ADP-ribosylation factorlike protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells. Cell Death Dis 2013; 4: e695.
34. YANG G, WU D, ZHU J, JIANG O, SHI Q, TIAN J, WENG Y. Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1. O ncol Rep 2013; 30: 877-889.
35. CHEN YQ, WANG XX, YAO XM, ZHANG DL, YANG XF, TIAN SF, WANG NS. MicroRNA-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by B CL2 insufficiency. Am J Nephrol 2011; 34: 549-559.
36. LI HG, ZHAO LH, BAO XB, SUN PC, ZHAI BP. Metaanalysis of the differentially expressed colorectal cancer-related microRNA expression pro files. Eur Rev Med Pharmacol Sci 2014; 18: 2048-2057.