Human surrogate models of histaminergic and non-histaminergic itch

Acta Dermato-Venereologica

Volumn 95, Issue 7, 2015, Pages 771-779

  Andersen, Hjalte H ^a   Elberling, Jesper ^b   Arendt Nielsen, Lars ^a  

^a AALBORG UNIVERSITY   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cowhage; Histamine; Histamine independent; Itch; Pruritus; Surrogate model

Indexed keywords

BRADYKININ; G PROTEIN COUPLED RECEPTOR; HISTAMINE; MAS RELATED G PROTEIN COUPLED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 4; SEROTONIN; SUBSTANCE P; UNCLASSIFIED DRUG; ANTIHISTAMINIC AGENT; ANTIPRURITIC AGENT;

ALLOKNESIS; CHRONIC DISEASE; DISEASE ASSESSMENT; DISEASE MODEL; DYSESTHESIA; EXPERIMENTAL PRURITUS; HUMAN; HUMAN MODEL; PRIORITY JOURNAL; REVIEW; URTICARIA; DRUG EFFECTS; HISTAMINE RELEASE; IMMUNOLOGY; INNERVATION; METABOLISM; PATHOPHYSIOLOGY; PRURITUS; SIGNAL TRANSDUCTION; SKIN;

ANTIPRURITICS; CHRONIC DISEASE; HISTAMINE ANTAGONISTS; HISTAMINE RELEASE; HUMANS; PRURITUS; SIGNAL TRANSDUCTION; SKIN;

EID: 84940022590     PISSN: 00015555     EISSN: 16512057     Source Type: Journal    
DOI: 10.2340/00015555-2146     Document Type: Review

References (81)

1. Patel T, Yosipovitch G. Therapy of pruritus. Expert Opin Pharmacother 2010; 11: 1673–1682
2. Frese T, Herrmann K, Sandholzer H. Pruritus as reason for encounter in general practice. J Clin Med Res 2011; 3: 223–229
3. Shim W-S, Oh U. Histamine-induced itch and its relationship with pain. Mol Pain 2008; 4: 29–29
4. Anand P. Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key. Gut 2003; 52: 1233–1235
5. Ständer S, Weisshaar E, Mettang T, Szepietowski JC, Carstens E, Ikoma A, et al. Clinical classification of itch: a position paper of the International Forum for the Study of Itch. Acta Derm Venereol 2007; 87: 291–294
6. Weisshaar E, Gieler U, Kupfer J, Furue M, Saeki H, Yosipovitch G. Questionnaires to assess chronic itch: a consensus paper of the special interest group of the International Forum on the Study of Itch. Acta Derm Venereol 2012; 92: 493–496
7. Bautista DM, Wilson SR, Hoon Ma. Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci 2014; 17: 175–182
8. Shelley WB, Arthur RP. Mucunain, the active pruritogenic proteinase of cowhage. Science (New York, NY) 1955; 122: 469–470
9. Hägermark O. Influence of antihistamines, sedatives, and aspirin on experimental itch. Acta Derm Venereol 1973; 53: 363–368
10. Ikoma A, Handwerker H, Miyachi Y, Schmelz M. Electrically evoked itch in humans. Pain 2005; 113: 148–154
11. Johanek LM, Meyer Ra, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, et al. Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci 2007; 27: 7490–7497
12. Namer B, Carr R, Johanek LM, Schmelz M, Handwerker HO, Ringkamp M. Separate peripheral pathways for pruritus in man. J Neurophysiol 2008; 100: 2062–2069
13. Twycross R. Itch: scratching more than the surface. QJM 2003; 96: 7–26
14. Papoiu ADP, Tey HL, Coghill RC, Wang H, Yosipovitch G. Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch. PLoS One 2011; 6: e17786–e17786
15. Sikand P, Dong X, LaMotte RH. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci 2011; 31: 7563–7567
16. Woolf CJ, Bennett GJ, Doherty M, Dubner R, Kidd B, Koltzenburg M, et al. Towards a mechanism-based classification of pain? Pain 1998; 77: 227–229
17. Arendt-Nielsen L, Yarnitsky D. Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera. J Pain 2009; 10: 556–572
18. Nakagawa H, Hiura A. Four possible itching pathways related to the TRPV1 channel, histamine, PAR-2 and serotonin. Malays J Med Sci 2013; 20: 5–12
19. Dhand A, Aminoff MJ. The neurology of itch. Brain 2013; 137: 313–322
20. Papoiu ADP, Kraft Ra, Coghill RC, Yosipovitch G. Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei. A pharmacological fMRI study. J Invest Dermatol 2014: 1–29
21. Papoiu ADP, Coghill RC, Kraft Ra, Wang H, Yosipovitch G. A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch. Neuroimage 2012; 59: 3611–3623
22. Handwerker HO. Microneurography of pruritus. Neurosci Lett 2010; 470: 193–196
23. Sikand P, Shimada SG, Green BG, LaMotte RH. Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage. Pain 2009; 144: 66–75
24. Hartmann EM, Handwerker HO, Forster C. Gender differences in itch and pain-related sensations provoked by histamine, cowhage and capsaicin. Acta Derm Venereol 2015; 95: 25–30
25. Sandkühler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev 2009: 707–758
26. Bickford RGL. Experiments relating to the itch sensation, its peripheral mechanism, and central pathways. Clin Sci 1938; 3: 377–386
27. Simone Da, Alreja M, LaMotte RH. Psychophysical studies of the itch sensation and itchy skin (“alloknesis”) produced by intracutaneous injection of histamine. Somatosens Mot Res 1991; 8: 271–279
28. LaMotte R. Allodynia and Alloknesis. In: Gebhart G, Schmidt R, editors. Encyclopedia of pain. Berlin: Springer, 2013: p. 87–90
29. Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, Lamotte RH. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosens Mot Res 1999; 16: 291–298
30. Brull SJ, Atanassoff PG, Silverman DG, Zhang J, Lamotte RH. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosens Mot Res 1999; 16: 299–303
31. LaMotte RH, Shimada SG, Green BG, Zelterman D. Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage. J Neurophysiol 2009; 101: 1430–1443
32. Lamotte RH. Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis. Am Pain Soc J 1992; 1: 115–126
33. Davidson S, Zhang X, Khasabov SG, Moser HR, Honda CN, Simone Da, et al. Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate. J Neurophysiol 2012; 108: 1711–1723
34. Rukwied RR, Main M, Weinkauf B, Schmelz M. NGF sensitizes nociceptors for cowhage- but not histamine-induced itch in human skin. J Invest Dermatol 2013; 133: 268–270
35. Schmelz M, Michael K, Weidner C, Torebjörk HE, Handwerker HO. Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport 2000; 11: 645–648
36. Lischetzki G, Rukwied R, Handwerker HO, Schmelz M. Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin. Eur J Pain 2001; 5: 49–57
37. Sikand P, Shimada SG, Green BG, LaMotte RH. Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain 2011; 152: 2485–2494
38. Bjerring P, Arendt-Nielsen L. A quantitative comparison of the effect of local analgesics on argon laser induced cutaneous pain and on histamine induced wheal, flare and itch. Acta Derm Venereol 1990; 70: 126–131
39. Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, et al. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci USA 2009; 106: 11330–11335
40. Shim W-S, Tak M-H, Lee M-H, Kim M, Kim M, Koo J-Y, et al. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci 2007; 27: 2331–2337
41. Heyer G, Hornstein OP, Handwerker HO. Skin reactions and itch sensation induced by epicutaneous histamine application in atopic dermatitis and controls. J Invest Dermatol 1989; 93: 492–496
42. Bromma B, Scharein E, Darsow U, Ring J. Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett 1995; 187: 157–160
43. Heyer G, Ulmer FJ, Schmitz J, Handwerker HO. Histamineinduced itch and alloknesis (itchy skin) in atopic eczema patients and controls. Acta Derm Venereol 1995; 75: 348–352
44. Wahlgren CF, Ekblom A. Perception of histamine-induced itch elicited in three different skin regions. Acta Derm Venereol 1991; 71: 205–208
45. McMahon SB, Koltzenburg M. Itching for an explanation. Trends Neurosci 1992; 15: 497–501
46. Ross SE. Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease. Curr Opin Neurobiol 2011; 21: 880–887
47. Handwerker HO, Schmelz M. Pain: itch without pain–a labeled line for itch sensation? Nat Rev Neurol 2009; 5: 640–641
48. Wilson SR, Nelson AM, Batia L, Morita T, Estandian D, Owens DM, et al. The ion channel TRPA1 is required for chronic itch. J Neurosci 2013; 33: 9283–9294
49. Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, et al. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci 2011; 14: 595–602
50. Terada Y, Fujimura M, Nishimura S, Tsubota M, Sekiguchi F, Nishikawa H, et al. Contribution of TRPA1 as a downstream signal of proteinase-activated receptor-2 to pancreatic pain. J Pharmacol Sci 2013; 123: 284–287
51. Olsen RV, Andersen HH, Møller HG, Eskelund PW, Arendt- Nielsen L. Somatosensory and vasomotor manifestations of individual and combined stimulation of TRPM8 and TRPA1 using topical L-menthol and trans-cinnamaldehyde in healthy volunteers. Eur J Pain 2014; 18: 1333–1342
52. Højland CR, Andersen HH, Poulsen JN, Arendt-Nielsen L, Gazerani P. A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde. Acta Derm Venereol 2015; 95: 798–803
53. Tuckett RP. Itch evoked by electrical stimulation of the skin. J Invest Dermatol 1982; 79: 368–373
54. van Laarhoven AIM, Kraaimaat FW, Wilder-Smith OH, van de Kerkhof PCM, Evers AWM. Heterotopic pruritic conditioning and itch–analogous to DNIC in pain? Pain 2010; 149: 332–337
55. Pud D, Granovsky Y, Yarnitsky D. The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans. Pain 2009; 144: 16–19
56. Fukuoka M, Miyachi Y, Ikoma A. Mechanically evoked itch in humans. Pain 2013; 154: 897–904
57. Broadbent JL. Observations on itching produced by cowhage, and on the part played by histamine as a mediator of the itch sensation. Br J Pharmacol Chemother 1953; 8: 263–270
58. Reddy VB, Lerner EA. Plant cysteine proteases that evoke itch activate protease-activated receptors. Br J Dermatol 2010; 163: 532–535
59. Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA. Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci 2008; 28: 4331–4335
60. Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 2003; 23: 6176–6180
61. Shelley WB, Arthur RP. Studies on cowhage (Mucuna pruriens) and its pruritogenic proteinase, mucunain. AMA Arch Derm 1955; 72: 399–406
62. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988; 119: 535–540
63. Arthur RP, Shelley WB. The role of proteolytic enzymes in the production of pruritus in man. J Invest Dermatol 1955; 25: 341–346
64. Zylka MJ, Rice FL, Anderson DJ. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 2005; 45: 17–25
65. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 2001; 106: 619–632
66. Lembo PMC, Grazzini E, Groblewski T, O’Donnell D, Roy M-O, Zhang J, et al. Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs. Nat Neurosci 2002; 5: 201–209
67. Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 2009; 139: 1353–1365
68. Liu Q, Sikand P, Ma C, Tang Z, Han L, Li Z, et al. Mechanisms of itch evoked by β-alanine. J Neurosci 2012; 32: 14532–14537
69. Schwörer H, Hartmann H, Ramadori G. Relief of cholestatic pruritus by a novel class of drugs: 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists: effectiveness of ondansetron. Pain 1995; 61: 33–37
70. Fitzsimons EJ, Dagg JH, McAllister EJ. Pruritus of polycythaemia vera: a place for pizotifen? Br Med J (Clin Res Ed) 1981; 283: 277–277
71. Weisshaar E, Ziethen B, Gollnick H. Lack of efficacy of topical capsaicin in serotonin-induced itch. Skin Pharmacol Appl Skin Physiol 2000; 13: 1–8
72. Rausl A, Nordlind K, Wahlgren C-F. Pruritic and vascular responses induced by serotonin in patients with atopic dermatitis and in healthy controls. Acta Derm Venereol 2013; 93: 277–280
73. Hosogi M, Schmelz M, Miyachi Y, Ikoma A. Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch. Pain 2006; 126: 16–23
74. Thomsen JS, Sonne M, Benfeldt E, Jensen SB, Serup J, Menné T. Experimental itch in sodium lauryl sulphateinflamed and normal skin in humans: a randomized, double-blind, placebo-controlled study of histamine and other inducers of itch. Br J Dermatol 2002; 146: 792–800
75. Heyer G, Hornstein OP, Handwerker HO. Reactions to intradermally injected substance P and topically applied mustard oil in atopic dermatitis patients. Acta Derm Venereol 1991; 71: 291–295
76. Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, et al. Acute effects of substance P and calcitonin gene-related peptide in human skin–a microdialysis study. J Invest Dermatol 2000; 115: 1015–1020
77. Hägermark O. Studies on experimental itch induced by kallikrein and bradykinin. Acta Derm Venereol 1974; 54: 397–400
78. Davidson S, Giesler GJ. The multiple pathways for itch and their interactions with pain. Trends Neurosci 2010; 33: 550–558
79. Magerl W, Westerman RA, Möhner B, Handwerker HO. Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region. J Invest Dermatol 1990; 94: 347–352
80. Simone Da, Ngeow JY, Whitehouse J, Becerra-Cabal L, Putterman GJ, LaMotte RH. The magnitude and duration of itch produced by intracutaneous injections of histamine. Somatosens Res 1987; 5: 81–92
81. Weisshaar E, Ziethen B, Gollnick H. Can a serotonin type 3 (5-HT3) receptor antagonist reduce experimentally-induced itch? Inflamm Res 1997; 46: 412–416.