Gender Differences in Itch and Pain-related Sensations Provoked by Histamine, Cowhage and Capsaicin

Acta Dermato-Venereologica

Volumn 95, Issue 1, 2015, Pages 25-30

  Hartmann, Elisabeth M ^a   Handwerker, Hermann O ^a   Forster, Clemens ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Capsaicin; Cowhage; Gender difference; Histamine; Itch

Indexed keywords

CAPSAICIN; HISTAMINE; PLANT EXTRACT;

ADULT; BLOOD FLOW; CHEMICALLY INDUCED; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECTS; FEMALE; GERMANY; HUMAN; INNERVATION; LASER DOPPLER FLOWMETRY; MALE; MUCUNA; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PATHOPHYSIOLOGY; PRURITUS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SKIN; TIME; VASCULARIZATION; YOUNG ADULT;

ADULT; CAPSAICIN; FEMALE; GERMANY; HISTAMINE; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MUCUNA; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PLANT EXTRACTS; PRURITUS; QUESTIONNAIRES; REGIONAL BLOOD FLOW; SEX FACTORS; SKIN; TIME FACTORS; YOUNG ADULT;

EID: 84918771603     PISSN: 00015555     EISSN: 16512057     Source Type: Journal    
DOI: 10.2340/00015555-1894     Document Type: Article

References (41)

1. Ross SE. Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease. Curr Opin Neurobiol 2011; 21: 880-887.
2. Sikand P, Shimada SG, Green BG, LaMotte RH. Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage. Pain 2009; 144: 66-75.
3. Sikand P, Shimada SG, Green BG, LaMotte RH. Sensory responses to injection and punctate application of capsaicin and histamine to the skin. Pain 2011; 152: 2485-2494.
4. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjörk HE. Specific C-receptors for itch in human skin. J Neurosci 1997; 17: 8003-8008.
5. Namer B, Carr R, Johanek LM, Schmelz M, Handwerker HO, Ringkamp M. Separate peripheral pathways for pruritus in man. J Neurophysiol 2008; 100: 2062-2069.
6. Ringkamp M, Schepers RJ, Shimada SG, Johanek LM, Hartke TV, Borzan J, et al. A role for nociceptive, myelinated nerve fibers in itch sensation. J Neurosci 2011; 31: 14841-14849.
7. Schmelz M, Schmidt R, Weidner C, Hilliges M, Torebjork HE, Handwerker HO. Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol 2003; 89: 2441-2448.
8. Herde L, Forster C, Strupf M, Handwerker HO. Itch induced by a novel method leads to limbic deactivations a functional MRI study. J Neurophysiol 2007; 98: 2347-2356.
9. Leknes SG, Bantick S, Willis CM, Wilkinson JD, Wise RG, Tracey I. Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamineinduced itch in humans. J Neurophysiol 2007; 97: 415-422.
10. Davidson S, Giesler GJ. The multiple pathways for itch and their interactions with pain. Trends Neurosci 2010; 33: 550-558.
11. Papoiu ADP, Coghill RC, Kraft RA, Wang H, Yosipovitch G. A tale of two itches - Common features and notable differences in brain activation evoked by cowhage and histamine induced itch. Neuroimage 2011; 59: 3611-3623.
12. Dhand A, Aminoff MJ. The neurology of itch. Brain 2014; 137: 313-322.
13. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL. Sex, gender, and pain: a review of recent clinical and experimental findings. Pain 2009; 10: 447-485.
14. Kosteletzky F, Namer B, Forster C, Handwerker HO. Impact of scratching on itch and sympathetic reflexes induced by cowhage (Mucuna pruriens) and histamine. Acta Derm Venereol 2009; 89: 271-277.
15. Magerl W, Westerman RA, Möhner B, Handwerker HO. Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region. J Invest Dermatol 1990; 94: 347-352.
16. Lewis T. Pain. New York: Macmillian Company, 1942.
17. Shelley WB, Arthur RP. Studies on cowhage (Mucuna pruriens) and its pruritogenic proteinase, mucunain. Arch Dermatol 1955; 72: 399-406.
18. Schmelz M, Michael K, Weidner C, Schmidt R, Torebjörk HE, Handwerker HO. Which nerve fibers mediate the axon reflex flare in human skin? Neuroreport 2000; 11: 645-648.
19. Shim W, Tak M, Lee M, Kim M, Kim M, Koo J, et al. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci 2007; 27: 2331-2337.
20. Handwerker HO. From pattern to specificity and to population coding. In: Akiyama T, Carstens E, editors. Itch: mechanisms and treatment. Boca Raton, FL: CRC Press, 2013: p. 1-8.
21. McMahon SB, Koltzenburg M. Itching for an explanation. Trends Neurosci 1992; 15: 497-501.
22. Xiao B, Patapoutian A. Scratching the surface: a role of painsensing TRPA1 in itch. Nat Neurosci 2011; 14: 540-542.
23. Reddy VB, Iuga AO, Shimada SG, LaMotte RH, Lerner EA. Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci 2008; 28: 4331-4335.
24. Wilson SR, Gerhold KA, Bifolck-Fisher A, Liu Q, Patel KN, Dong X, et al. TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci 2011; 14: 595-602.
25. Johanek LM, Meyer RA, Friedman RM, Greenquist KW, Shim B, Borzan J, et al. A role for polymodal C-fiber afferents in nonhistaminergic itch. J Neurosci 2008; 28: 7659-7669.
26. Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, Giesler GJ. The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 2007; 27: 10007-10014.
27. Gazerani P, Andersen OK, Arendt-Nielsen L. Site-specific, dose-dependent, and sex-related responses to the experimental pain model induced by intradermal injection of capsaicin to the foreheads and forearms of healthy humans. J Orofac Pain 2007; 21: 289-302.
28. Weisshaar E, Heyer G, Forster C, Handwerker HO. Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. Arch Dermatol Res 1998; 290: 306-311.
29. Malisza KL, Docherty JC. Capsaicin as a source for painful stimulation in functional MRI. J Magn Reson Imaging 2001; 14: 341-347.
30. Greenspan JD, Craft RM, LeResche L, Arendt-Nielsen L, Berkley KJ, Fillingim RB, et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain 2007; 132: 26-45.
31. Racine M, Tousignant-Laflamme Y, Kloda LA, Dion D, Dupuis G, Choinière M. A systematic literature review of 10 years of research on sex/gender and experimental pain perception - part 1: are there really differences between women and men? Pain 2012; 153: 602-618.
32. Frot M, Feine JS, Bushnell MC. Sex differences in pain perception and anxiety. A psychophysical study with topical capsaicin. Pain 2004; 108: 230-236.
33. Ständer S, Stumpf A, Osada N, Wilp S, Chatzigeorgakidis E, Pfleiderer B. Gender differences in chronic pruritus: women present different morbidity, more scratch lesions and higher burden. Br J Dermatol 2013; 168: 1273-1280.
34. Craft RM, Mogil JS, Aloisi AM. Sex differences in pain and analgesia: the role of gonadal hormones. Pain 2004; 8: 397-411.
35. Craft RM. Modulation of pain by estrogens. Pain 2007; 132: S3-12.
36. Smith YR, Stohler CS, Nichols TE, Bueller JA, Koeppe RA, Zubieta J. Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women. J Neurosci 2006; 26: 5777-5785.
37. Nag S, Mokha SS. Activation of alpha2-adrenoceptors in the trigeminal region produces sex-specific modulation of nociception in the rat. Neuroscience 2006; 142: 1255-1262.
38. Lambert JJ, Belelli D, Peden DR, Vardy AW, Peters JA. Neurosteroid modulation of GABAA receptors. Prog Neurobiol 2003; 71: 67-80.
39. Craft RM, Ulibarri C. Sexual differentiation of rat reproductive versus opioid antinociceptive systems. Gend Med 2009; 6: 208-224.
40. Thompson AD, Angelotti T, Nag S, Mokha SS. Sex-specific modulation of spinal nociception by alpha2-adrenoceptors: differential regulation by estrogen and testosterone. Neuroscience 2008; 153: 1268-1277.
41. Stumpf A, Burgmer M, Schneider G, Heuft G, Schmelz M, Phan NQ, et al. Sex differences in itch perception and modulation by distraction - an FMRI pilot study in healthy volunteers. PLoS ONE 2013; 8: e79123.