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Volumn 38, Issue 3, 2015, Pages 1250-1259

Treatment with the Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone Suppresses LPS-Induced Lung Inflammation

Author keywords

acute lung inflammation; extracellular matrix; hyaluronic acid; LPS

Indexed keywords

CYTOKINE; GLUCURONOSYLTRANSFERASE; HYALURONAN SYNTHASE; HYALURONIC ACID; HYMECROMONE; LIPOPOLYSACCHARIDE; MESSENGER RNA;

EID: 84940004666     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0092-y     Document Type: Article
Times cited : (39)

References (43)
  • 1
    • 1142299409 scopus 로고    scopus 로고
    • Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    • COI: 1:CAS:528:DC%2BD2cXhvVKjtr4%3D, PID: 14743496
    • Bhatia, M., and S. Moochhala. 2004. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. The Journal of Pathology 202: 145–156.
    • (2004) The Journal of Pathology , vol.202 , pp. 145-156
    • Bhatia, M.1    Moochhala, S.2
  • 3
    • 33847156932 scopus 로고    scopus 로고
    • Epidemiology and outcomes of acute lung injury
    • PID: 17296661
    • Rubenfeld, G.D., and M.S. Herridge. 2007. Epidemiology and outcomes of acute lung injury. Chest 131: 554–562.
    • (2007) Chest , vol.131 , pp. 554-562
    • Rubenfeld, G.D.1    Herridge, M.S.2
  • 4
    • 84867327006 scopus 로고    scopus 로고
    • Pharmacotherapy for acute respiratory distress syndrome
    • Shafeeq, H., and I. Lat 2012. Pharmacotherapy for acute respiratory distress syndrome. Pharmacotherapy. 32:943–57. doi:10.1002/j.1875-9114.2012.01115.
    • (2012) Pharmacotherapy , vol.32 , pp. 943-957
    • Shafeeq, H.1    Lat, I.2
  • 5
    • 84880416646 scopus 로고    scopus 로고
    • Consequences of acute ozone exposure imposed on the culminated allergic pulmonary inflammation in an established murine model of asthma
    • COI: 1:CAS:528:DC%2BC3sXhtVyru77E
    • Bao, A., L. Liang, F. Li, M. Zhang, and X. Zhou. 2013. Consequences of acute ozone exposure imposed on the culminated allergic pulmonary inflammation in an established murine model of asthma. Frontiers in Bioscience 18: 838–851.
    • (2013) Frontiers in Bioscience , vol.18 , pp. 838-851
    • Bao, A.1    Liang, L.2    Li, F.3    Zhang, M.4    Zhou, X.5
  • 7
    • 80054776633 scopus 로고    scopus 로고
    • Quercetin inhibits IL-1beta-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves’ orbitopathy
    • COI: 1:CAS:528:DC%2BC3MXhsVegtrfF, PID: 22039452
    • Yoon, J.S., H.J. Lee, S.H. Choi, E.J. Chang, S.Y. Lee, and E.J. Lee. 2011. Quercetin inhibits IL-1beta-induced inflammation, hyaluronan production and adipogenesis in orbital fibroblasts from Graves’ orbitopathy. PloS One 6: e26261.
    • (2011) PloS One , vol.6 , pp. 26261
    • Yoon, J.S.1    Lee, H.J.2    Choi, S.H.3    Chang, E.J.4    Lee, S.Y.5    Lee, E.J.6
  • 8
    • 77953914908 scopus 로고    scopus 로고
    • Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes
    • COI: 1:CAS:528:DC%2BC3cXnvVygu7k%3D, PID: 20435021
    • Campo, G.M., A. Avenoso, S. Campo, A. D’Ascola, G. Nastasi, and A. Calatroni. 2010. Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes. Biochemical Pharmacology 80: 480–490.
    • (2010) Biochemical Pharmacology , vol.80 , pp. 480-490
    • Campo, G.M.1    Avenoso, A.2    Campo, S.3    D’Ascola, A.4    Nastasi, G.5    Calatroni, A.6
  • 9
    • 84872191634 scopus 로고    scopus 로고
    • Corticosteroid administration reduces the concentration of hyaluronan in bronchoalveolar lavage in a murine model of eosinophilic airway inflammation
    • COI: 1:CAS:528:DC%2BC38Xhs1Ogt7vL, PID: 22842766
    • Ernst, G., S. Lompardia, R. Cordo Russo, V. Gentilini, S. Venturiello, F. Galindez, et al. 2012. Corticosteroid administration reduces the concentration of hyaluronan in bronchoalveolar lavage in a murine model of eosinophilic airway inflammation. Inflammation Research 61: 1309–1317.
    • (2012) Inflammation Research , vol.61 , pp. 1309-1317
    • Ernst, G.1    Lompardia, S.2    Cordo Russo, R.3    Gentilini, V.4    Venturiello, S.5    Galindez, F.6
  • 10
    • 84864361826 scopus 로고    scopus 로고
    • Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation
    • COI: 1:CAS:528:DC%2BC38XhtFamsr%2FI, PID: 22848468
    • Esser, P.R., U. Wolfle, C. Durr, F.D. von Loewenich, C.M. Schempp, M.A. Freudenberg, et al. 2012. Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation. PloS One 7: e41340.
    • (2012) PloS One , vol.7 , pp. 41340
    • Esser, P.R.1    Wolfle, U.2    Durr, C.3    von Loewenich, F.D.4    Schempp, C.M.5    Freudenberg, M.A.6
  • 11
    • 33746040501 scopus 로고    scopus 로고
    • Hyaluronan fragments: An information-rich system
    • COI: 1:CAS:528:DC%2BD28XptlSnt7c%3D, PID: 16822580
    • Stern, R., A.A. Asari, and K.N. Sugahara. 2006. Hyaluronan fragments: An information-rich system. European Journal of Cell Biology 85: 699–715.
    • (2006) European Journal of Cell Biology , vol.85 , pp. 699-715
    • Stern, R.1    Asari, A.A.2    Sugahara, K.N.3
  • 13
    • 84894208979 scopus 로고    scopus 로고
    • Low molecular weight hyaluronan activates cytosolic phospholipase A2alpha and eicosanoid production in monocytes and macrophages
    • COI: 1:CAS:528:DC%2BC2cXisFSlurs%3D, PID: 24366870
    • Sokolowska, M., L.Y. Chen, M. Eberlein, A. Martinez-Anton, Y. Liu, S. Alsaaty, et al. 2014. Low molecular weight hyaluronan activates cytosolic phospholipase A2alpha and eicosanoid production in monocytes and macrophages. The Journal of Biological Chemistry 289: 4470–4488.
    • (2014) The Journal of Biological Chemistry , vol.289 , pp. 4470-4488
    • Sokolowska, M.1    Chen, L.Y.2    Eberlein, M.3    Martinez-Anton, A.4    Liu, Y.5    Alsaaty, S.6
  • 14
    • 34548727522 scopus 로고    scopus 로고
    • Cutting edge: High molecular weight hyaluronan promotes the suppressive effects of CD4+ CD25+ regulatory T cells
    • COI: 1:CAS:528:DC%2BD2sXnt1Wms74%3D
    • Bollyky, P.L., J.D. Lord, S.A. Masewicz, S.P. Evanko, J.H. Buckner, T.N. Wight, et al. 2007. Cutting edge: High molecular weight hyaluronan promotes the suppressive effects of CD4+ CD25+ regulatory T cells. Journal of Immunology 179: 744–747.
    • (2007) Journal of Immunology , vol.179 , pp. 744-747
    • Bollyky, P.L.1    Lord, J.D.2    Masewicz, S.A.3    Evanko, S.P.4    Buckner, J.H.5    Wight, T.N.6
  • 15
    • 0031985770 scopus 로고    scopus 로고
    • Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion
    • COI: 1:CAS:528:DyaK1cXjtV2rsw%3D%3D, PID: 9421471
    • Mohamadzadeh, M., H. DeGrendele, H. Arizpe, P. Estess, and M. Siegelman. 1998. Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion. The Journal of Clinical Investigation 101: 97–108.
    • (1998) The Journal of Clinical Investigation , vol.101 , pp. 97-108
    • Mohamadzadeh, M.1    DeGrendele, H.2    Arizpe, H.3    Estess, P.4    Siegelman, M.5
  • 17
    • 77955300229 scopus 로고    scopus 로고
    • Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium
    • COI: 1:CAS:528:DC%2BC3cXpsFemtrs%3D, PID: 20504769
    • Asari, A., T. Kanemitsu, and H. Kurihara. 2010. Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium. The Journal of Biological Chemistry 285: 24751–24758.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 24751-24758
    • Asari, A.1    Kanemitsu, T.2    Kurihara, H.3
  • 18
    • 84870896939 scopus 로고    scopus 로고
    • The role of hyaluronic acid in SEB-induced acute lung inflammation
    • COI: 1:CAS:528:DC%2BC38XhvVKqu77I, PID: 23246605
    • Uchakina, O.N., C.M. Castillejo, C.C. Bridges, and R.J. McKallip. 2013. The role of hyaluronic acid in SEB-induced acute lung inflammation. Clinical Immunology 146: 56–69.
    • (2013) Clinical Immunology , vol.146 , pp. 56-69
    • Uchakina, O.N.1    Castillejo, C.M.2    Bridges, C.C.3    McKallip, R.J.4
  • 19
    • 84883552824 scopus 로고    scopus 로고
    • Targeting hyaluronic acid production for the treatment of leukemia: Treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia
    • Uchakina, O.N., H. Ban, and R.J. McKallip 2013. Targeting hyaluronic acid production for the treatment of leukemia: Treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia. Leukemia Research. 1294–301. doi:10.1016/j.leukres.2013.07.009.
    • (2013) Leukemia Research , pp. 1294-1301
    • Uchakina, O.N.1    Ban, H.2    McKallip, R.J.3
  • 20
    • 84861567719 scopus 로고    scopus 로고
    • CD44 as a novel target for treatment of staphylococcal enterotoxin B-induced acute inflammatory lung injury
    • COI: 1:CAS:528:DC%2BC38XosVarsL4%3D, PID: 22659034
    • Sun, J., G.P. Law, C.C. Bridges, and R.J. McKallip. 2012. CD44 as a novel target for treatment of staphylococcal enterotoxin B-induced acute inflammatory lung injury. Clinical Immunology 144: 41–52.
    • (2012) Clinical Immunology , vol.144 , pp. 41-52
    • Sun, J.1    Law, G.P.2    Bridges, C.C.3    McKallip, R.J.4
  • 22
    • 77950845327 scopus 로고    scopus 로고
    • Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells
    • COI: 1:CAS:528:DC%2BC3cXktFynsLc%3D, PID: 20332231
    • Lokeshwar, V.B., L.E. Lopez, D. Munoz, A. Chi, S.P. Shirodkar, S.D. Lokeshwar, et al. 2010. Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells. Cancer Research 70: 2613–2623.
    • (2010) Cancer Research , vol.70 , pp. 2613-2623
    • Lokeshwar, V.B.1    Lopez, L.E.2    Munoz, D.3    Chi, A.4    Shirodkar, S.P.5    Lokeshwar, S.D.6
  • 23
    • 84886543816 scopus 로고    scopus 로고
    • Treatment with the hyaluronic acid synthesis inhibitor 4-methylumbelliferone suppresses SEB-induced lung inflammation
    • McKallip, R.J., H.F. Hagele, and O.N. Uchakina. 2013. Treatment with the hyaluronic acid synthesis inhibitor 4-methylumbelliferone suppresses SEB-induced lung inflammation. Toxins (Basel) 5: 1814–1826.
    • (2013) Toxins (Basel) , vol.5 , pp. 1814-1826
    • McKallip, R.J.1    Hagele, H.F.2    Uchakina, O.N.3
  • 24
    • 83655167411 scopus 로고    scopus 로고
    • Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo
    • COI: 1:CAS:528:DC%2BC3MXhs1Snsr7F
    • Urakawa, H., Y. Nishida, J. Wasa, E. Arai, L. Zhuo, K. Kimata, et al. 2012. Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo. International Journal of Cancer 130: 454–466.
    • (2012) International Journal of Cancer , vol.130 , pp. 454-466
    • Urakawa, H.1    Nishida, Y.2    Wasa, J.3    Arai, E.4    Zhuo, L.5    Kimata, K.6
  • 25
    • 84856016321 scopus 로고    scopus 로고
    • Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
    • COI: 1:CAS:528:DC%2BC3MXhs1Sisb7I, PID: 22045192
    • Arai, E., Y. Nishida, J. Wasa, H. Urakawa, L. Zhuo, K. Kimata, et al. 2011. Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo. British Journal of Cancer 105: 1839–1849.
    • (2011) British Journal of Cancer , vol.105 , pp. 1839-1849
    • Arai, E.1    Nishida, Y.2    Wasa, J.3    Urakawa, H.4    Zhuo, L.5    Kimata, K.6
  • 26
    • 77952698239 scopus 로고    scopus 로고
    • 4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors
    • COI: 1:CAS:528:DC%2BC3cXos1Gnsr8%3D, PID: 20163414
    • Edward, M., J.A. Quinn, S.M. Pasonen-Seppanen, B.A. McCann, and R.H. Tammi. 2010. 4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors. The British Journal of Dermatology 162: 1224–1232.
    • (2010) The British Journal of Dermatology , vol.162 , pp. 1224-1232
    • Edward, M.1    Quinn, J.A.2    Pasonen-Seppanen, S.M.3    McCann, B.A.4    Tammi, R.H.5
  • 27
    • 84856244394 scopus 로고    scopus 로고
    • Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice
    • COI: 1:CAS:528:DC%2BC38XhsFCltr4%3D, PID: 22038477
    • Piccioni, F., M. Malvicini, M.G. Garcia, A. Rodriguez, C. Atorrasagasti, N. Kippes, et al. 2012. Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice. Glycobiology 22: 400–410.
    • (2012) Glycobiology , vol.22 , pp. 400-410
    • Piccioni, F.1    Malvicini, M.2    Garcia, M.G.3    Rodriguez, A.4    Atorrasagasti, C.5    Kippes, N.6
  • 28
    • 0036733398 scopus 로고    scopus 로고
    • Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens
    • COI: 1:CAS:528:DC%2BD38Xms1Gmsrk%3D, PID: 12202399
    • McKallip, R.J., Y. Do, M.T. Fisher, J.L. Robertson, P.S. Nagarkatti, and M. Nagarkatti. 2002. Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens. International Immunology 14: 1015–1026.
    • (2002) International Immunology , vol.14 , pp. 1015-1026
    • McKallip, R.J.1    Do, Y.2    Fisher, M.T.3    Robertson, J.L.4    Nagarkatti, P.S.5    Nagarkatti, M.6
  • 29
    • 0033609860 scopus 로고    scopus 로고
    • Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
    • COI: 1:CAS:528:DyaK1MXls1ymur8%3D, PID: 10455188
    • Itano, N., T. Sawai, M. Yoshida, P. Lenas, Y. Yamada, M. Imagawa, et al. 1999. Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. The Journal of Biological Chemistry 274: 25085–25092.
    • (1999) The Journal of Biological Chemistry , vol.274 , pp. 25085-25092
    • Itano, N.1    Sawai, T.2    Yoshida, M.3    Lenas, P.4    Yamada, Y.5    Imagawa, M.6
  • 32
    • 33644797914 scopus 로고    scopus 로고
    • 4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD28XhtFehsro%3D, PID: 16341905
    • Nakazawa, H., S. Yoshihara, D. Kudo, H. Morohashi, I. Kakizaki, A. Kon, et al. 2006. 4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells. Cancer Chemotherapy and Pharmacology 57: 165–170.
    • (2006) Cancer Chemotherapy and Pharmacology , vol.57 , pp. 165-170
    • Nakazawa, H.1    Yoshihara, S.2    Kudo, D.3    Morohashi, H.4    Kakizaki, I.5    Kon, A.6
  • 33
    • 75449117700 scopus 로고    scopus 로고
    • Differential effect of molecular mass hyaluronan on lipopolysaccharide-induced damage in chondrocytes
    • COI: 1:CAS:528:DC%2BC3cXns1Sgtbc%3D, PID: 19710088
    • Campo, G.M., A. Avenoso, S. Campo, A. D’Ascola, P. Traina, C.A. Rugolo, et al. 2010. Differential effect of molecular mass hyaluronan on lipopolysaccharide-induced damage in chondrocytes. Innate Immunity 16: 48–63.
    • (2010) Innate Immunity , vol.16 , pp. 48-63
    • Campo, G.M.1    Avenoso, A.2    Campo, S.3    D’Ascola, A.4    Traina, P.5    Rugolo, C.A.6
  • 34
    • 65249162177 scopus 로고    scopus 로고
    • High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells
    • COI: 1:CAS:528:DC%2BD1MXktlajtL8%3D, PID: 19325714
    • Pauloin, T., M. Dutot, F. Joly, J.M. Warnet, and P. Rat. 2009. High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells. Molecular Vision 15: 577–583.
    • (2009) Molecular Vision , vol.15 , pp. 577-583
    • Pauloin, T.1    Dutot, M.2    Joly, F.3    Warnet, J.M.4    Rat, P.5
  • 35
    • 58149181980 scopus 로고    scopus 로고
    • Hyaluronan induces cell death in activated T cells through CD44
    • COI: 1:CAS:528:DC%2BD1cXhtlaisrrJ
    • Ruffell, B., and P. Johnson. 2008. Hyaluronan induces cell death in activated T cells through CD44. Journal of Immunology 181: 7044–7054.
    • (2008) Journal of Immunology , vol.181 , pp. 7044-7054
    • Ruffell, B.1    Johnson, P.2
  • 36
    • 67349260101 scopus 로고    scopus 로고
    • 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
    • COI: 1:CAS:528:DC%2BD1MXms1Oqu78%3D, PID: 19285976
    • Kultti, A., S. Pasonen-Seppanen, M. Jauhiainen, K.J. Rilla, R. Karna, E. Pyoria, et al. 2009. 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. Experimental Cell Research 315: 1914–1923.
    • (2009) Experimental Cell Research , vol.315 , pp. 1914-1923
    • Kultti, A.1    Pasonen-Seppanen, S.2    Jauhiainen, M.3    Rilla, K.J.4    Karna, R.5    Pyoria, E.6
  • 37
    • 84880941723 scopus 로고    scopus 로고
    • Development of a novel treatment for leukemia directed at tumor-associated mRNA splicing
    • Daines, D.A., J. Sun, O.N. Uchakina, and R.J. McKallip 2013. Development of a novel treatment for leukemia directed at tumor-associated mRNA splicing. Leukemia Research. 1125–31. doi:10.1016/j.leukres.2013.06.017.
    • (2013) Leukemia Research , pp. 1125-1131
    • Daines, D.A.1    Sun, J.2    Uchakina, O.N.3    McKallip, R.J.4
  • 38
    • 0034614641 scopus 로고    scopus 로고
    • In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity
    • COI: 1:CAS:528:DC%2BD3cXjvVKhsA%3D%3D, PID: 10617644
    • Yoshida, M., N. Itano, Y. Yamada, and K. Kimata. 2000. In vitro synthesis of hyaluronan by a single protein derived from mouse HAS1 gene and characterization of amino acid residues essential for the activity. The Journal of Biological Chemistry 275: 497–506.
    • (2000) The Journal of Biological Chemistry , vol.275 , pp. 497-506
    • Yoshida, M.1    Itano, N.2    Yamada, Y.3    Kimata, K.4
  • 40
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • COI: 1:CAS:528:DC%2BD2MXhtFOhsLvI, PID: 16244651
    • Jiang, D., J. Liang, J. Fan, S. Yu, S. Chen, Y. Luo, et al. 2005. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nature Medicine 11: 1173–1179.
    • (2005) Nature Medicine , vol.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3    Yu, S.4    Chen, S.5    Luo, Y.6
  • 41
    • 78751670809 scopus 로고    scopus 로고
    • Hyaluronan as an immune regulator in human diseases
    • COI: 1:CAS:528:DC%2BC3MXisVCht70%3D, PID: 21248167
    • Jiang, D., J. Liang, and P.W. Noble. 2011. Hyaluronan as an immune regulator in human diseases. Physiological Reviews 91: 221–264.
    • (2011) Physiological Reviews , vol.91 , pp. 221-264
    • Jiang, D.1    Liang, J.2    Noble, P.W.3
  • 42
    • 0037023364 scopus 로고    scopus 로고
    • Resolution of lung inflammation by CD44
    • COI: 1:CAS:528:DC%2BD38XivVWjsLs%3D, PID: 11935029
    • Teder, P., R.W. Vandivier, D. Jiang, J. Liang, L. Cohn, E. Pure, et al. 2002. Resolution of lung inflammation by CD44. Science 296: 155–158.
    • (2002) Science , vol.296 , pp. 155-158
    • Teder, P.1    Vandivier, R.W.2    Jiang, D.3    Liang, J.4    Cohn, L.5    Pure, E.6
  • 43
    • 70149120971 scopus 로고    scopus 로고
    • Intact extracellular matrix and the maintenance of immune tolerance: High molecular weight hyaluronan promotes persistence of induced CD4+ CD25+ regulatory T cells
    • COI: 1:CAS:528:DC%2BD1MXhtFahtb7N, PID: 19401397
    • Bollyky, P.L., B.A. Falk, R.P. Wu, J.H. Buckner, T.N. Wight, and G.T. Nepom. 2009. Intact extracellular matrix and the maintenance of immune tolerance: High molecular weight hyaluronan promotes persistence of induced CD4+ CD25+ regulatory T cells. Journal of Leukocyte Biology 86: 567–572.
    • (2009) Journal of Leukocyte Biology , vol.86 , pp. 567-572
    • Bollyky, P.L.1    Falk, B.A.2    Wu, R.P.3    Buckner, J.H.4    Wight, T.N.5    Nepom, G.T.6


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