4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors

British Journal of Dermatology

Volumn 162, Issue 6, 2010, Pages 1224-1232

  Edward, M ^a   Quinn, J A ^a   Pasonen Seppanen S M ^b   McCann, B A ^a   Tammi, R H ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Fibroblast; Hyaluronan; Invasion; Melanoma; Methylumbelliferone; Tumour stroma

Indexed keywords

COLLAGEN; GLUCOSAMINE DERIVATIVE; HYALURONIC ACID; HYMECROMONE; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER INVASION; CARBOHYDRATE SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; FIBROBLAST; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; MONOLAYER CULTURE; PRIORITY JOURNAL;

ADULT; APOPTOSIS; CELL MOVEMENT; CELL PROLIFERATION; CULTURE MEDIA, CONDITIONED; FIBROBLASTS; GLUCURONOSYLTRANSFERASE; GLYCOSAMINOGLYCANS; HUMANS; HYALURONIC ACID; HYMECROMONE; MELANOMA; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; SKIN NEOPLASMS; STROMAL CELLS; TUMOR CELLS, CULTURED;

EID: 77952698239     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2010.09699.x     Document Type: Article

References (38)

1. Stern R. Hyaluronan catabolism: A new metabolic pathway. Eur J Cell Biol 2004 83 : 317 325.
2. Ponta H, Sherman L, Herlich PA. CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003 4 : 33 45.
3. Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 2004 4 : 528 539.
4. Tammi RH, Kultti A, Kosma V-M et al. Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan. Semin Cancer Biol 2008 18 : 288 295.
5. Itano N, Zhuo L, Kimata K. Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression. Cancer Sci 2008 99 : 1720 1725.
6. Lipponen P, Aaltomaa S, Tammi RH et al. High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer. Eur J Cancer 2001 37 : 849 856.
7. Anttila MA, Tammi RH, Tammi MI et al. High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer. Cancer Res 2000 60 : 150 155.
8. Auvinen P, Tammi RH, Parkkinen JJ et al. Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am J Pathol 2000 156 : 529 536.
9. Lokeshwar VB, Rubinowitz D, Schroeder GL et al. Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer. J Biol Chem 2001 276 : 11922 11932.
10. Ropponen K, Tammi MI, Parkkinen J et al. Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer. Cancer Res 1998 58 : 342 347.
11. Edward M, Gillan C, Micha D, Tammi RH. Tumour regulation of fibroblast hyaluronan expression: A mechanism to facilitate tumour growth and invasion. Carcinogenesis 2005 26 : 1215 1223.
12. Tzircotis G, Thorne RF, Isacke CM. Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding. J Cell Sci 2005 118 : 5119 5128.
13. Liu DC, Pearlman E, Diaconu E et al. Expression of hyaluronidase by tumor cells induces angiogenesis in vivo. Proc Natl Acad Sci USA 1996 93 : 7832 7837.
14. Sugahara KN, Hirata T, Hayasaka H et al. Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. J Biol Chem 2006 281 : 5861 5868.
15. Bullard KM, Kim HR, Wheeler MA et al. Hyaluronan synthase 3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth. Int J Cancer 2003 107 : 739 746.
16. Nakamura T, Takagaki K, Shibata S et al. Hyaluronic acid-deficient extracellular matrix induced by addition of 4-methylumbelliferone to the medium of cultured human skin fibroblasts. Biochem Biophys Res Commun 1995 208 : 470 475.
17. Nakamura T, Funabashi M, Takagaki K et al. Effect of 4- methylumbelliferone on cell-free synthesis of hyaluronic acid. Biochem Mol Biol Int 1997 43 : 263 268.
18. Kudo D, Kon A, Yoshihara S et al. Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion. Biochem Biophys Res Commun 2004 321 : 783 787.
19. Morohashi H, Kon A, Yoshihara S et al. Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL). Biochem Biophys Res Commun 2006 345 : 1454 1459.
20. Kultti A, Pasonen-Seppanen SM, Jauhiainen M et al. 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. Exp Cell Res 2009 315 : 1914 1923.
21. Welch DR, Bisi JE, Miller BE et al. Characterisation of a highly invasive and spontaneously metastatic human malignant melanoma cell line. Int J Cancer 1991 47 : 227 237.
22. Van Muijen GN, Jansen KF, Cornelissen IM et al. Establishment and characterisation of a human melanoma cell line (MV3) which is highly metastatic in nude mice. Int J Cancer 1991 48 : 85 91.
23. Edward M. Effects of retinoids on glycosaminoglycan synthesis by human skin fibroblasts grown as monolayers and within contracted collagen lattices. Br J Dermatol 1995 133 : 223 230.
24. Tammi RH, Ågren UM, Tuhkanen A-L, Tammi MI. Hyaluronan metabolism in skin. Prog Histochem Cytochem 1994 29 : 1 77.
25. Tammi RH, Ripellino JA, Margolis RU et al. Hyaluronate accumulation in human epidermis treated with retinoic acid in skin organ culture. J Invest Dermatol 1989 92 : 326 332.
26. Kakizaki I, Kojima K, Takagaki K et al. A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone. J Biol Chem 2004 279 : 33281 33289.
27. Vigetti D, Ori M, Viola M et al. Molecular cloning and characterisation of UDP-glucose dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan synthesis. J Biol Chem 2006 281 : 8254 8263.
28. Rilla K, Pasonen-Seppänen SM, Rieppo J et al. The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor. J Invest Dermatol 2004 123 : 708 714.
29. Bakkers J, Kramer C, Pothof J et al. Has2 is required upstream of rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 2004 131 : 525 537.
30. Simpson MA, Wilson CM, McCarthy JB. Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularisation in immunocompromised mice. Am J Pathol 2002 161 : 849 857.
31. Udabage L, Brownlee GR, Waltham M et al. Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Cancer Res 2005 65 : 6139 6150.
32. Nishida Y, Knudson W, Knudson CB, Ishiguro N. Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity. Exp Cell Res 2005 307 : 194 203.
33. Liu N, Gao F, Xu X et al. Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. Cancer Res 2001 61 : 5207 5214.
34. Itano N, Atsumi F, Sawai T et al. Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Proc Natl Acad Sci USA 2002 99 : 3609 3614.
35. Jacobson A, Rahmanian M, Rubin K, Heldin P. Expression of hyaluronan synthase or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors. Int J Cancer 2002 102 : 212 219.
36. Kennedy CI, Diegelmann RF, Haynes JH, Yager DR. Proinflammatory cytokines differentially regulate hyaluronan synthase isoforms in fetal and adult fibroblasts. J Pediatr Surg 2000 35 : 874 879.
37. Camenisch TD, Spicer AP, Brehm-Gibson T et al. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J Clin Invest 2000 106 : 349 360.
38. Ichikawa T, Itano N, Sawai T et al. Increased synthesis of hyaluronate enhances motility of human melanoma cells. J Invest Dermatol 1999 113 : 935 939.