DHA Inhibited AGEs-Induced Retinal Microglia Activation Via Suppression of the PPARγ/NFκB Pathway and Reduction of Signal Transducers in the AGEs/RAGE Axis Recruitment into Lipid Rafts

Neurochemical Research

Volumn 40, Issue 4, 2015, Pages 713-722

  Wang, Li ^a   Chen, Ka ^a   Liu, Kai ^a   Zhou, Yong ^a   Zhang, Ting ^a   Wang, Bin ^a   Mi, Mantian ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

AGEs; DHA; Diabetic retinopathy; Lipid raft; RAGE; Retinal microglia

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; AGER PROTEIN, RAT; DOCOSAHEXAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ANIMAL; CELL MEMBRANE; CYTOLOGY; DRUG EFFECTS; METABOLISM; MICROGLIA; PHYSIOLOGY; RAT; RETINA; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; DOCOSAHEXAENOIC ACIDS; GLYCOSYLATION END PRODUCTS, ADVANCED; MEMBRANE MICRODOMAINS; MICROGLIA; NF-KAPPA B; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; RETINA; SIGNAL TRANSDUCTION;

EID: 84939986934     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1517-1     Document Type: Article

References (24)

1. Abcouwer SF (2012) Neural inflammation and the microglial response in diabetic retinopathy. J Ocul Biol Dis Inform 4:25–33
2. Tikhonenko M, Lydic TA, Opreanu M et al (2013) N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. PLoS One 8:e55177
3. Tikhonenko M, Lydic TA et al (2010) Remodeling of retinal fatty acids in an animal model of diabetes: a decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4. Diabetes 59:219–227
4. Decsi T, Minda H, Hermann R et al (2002) Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. Prostaglandins Leukot Essent Fatty Acids 67:203–210
5. Wang AL, Yu AC, He QH et al (2007) AGEs mediated expression and secretion of TNF alpha in rat retinal microglia. Exp Eye Res 84:905–913
6. Shaikh SB, Uy B, Perera A et al (2012) AGEs–RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells. Neurochem Int 60:640–651
7. Shi L, Yu X, Yang H et al (2013) Advanced glycation end products induce human corneal epithelial cells apoptosis through generation of reactiveoxygen species and activation of JNK and p38 MAPK pathways. PLoS One 8:e66781
8. Yu L, Zhao Y, Xu S et al (2013) Advanced glycation end product (AGE)-AGE receptor (RAGE) system upregulated connexin43 expression in rat cardiomyocytes via PKC and Erk MAPK pathways. Int J Mol Sci 14:2242–2257
9. Yamagishi S (2011) Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes. Exp Gerontol 46:217–224
10. Wang Y, Lin QW, Zheng PP et al (2013) DHA inhibits protein degradation more efficiently than EPA by regulating the PPARγ/NFκB pathway in C2C12 myotubes. Biomed Res Int 2013:318981
11. Turk HF, Chapkin RS (2013) Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids 88:43–47
12. Kim K, Jung N, Lee K et al (2013) Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulatingtoll-like receptor recruitment into lipid rafts. Clin Nutr 32:855–862
13. Chen W, Jump DB, Esselman WJ et al (2007) Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts bydocosahexaenoic acid. Invest Ophthalmol Vis Sci 48:18–26
14. Connor KM, SanGiovanni JP, Lofqvist C et al (2007) Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med 13:868–873
15. SanGiovanni JP, Chew EY (2005) The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res 24:87–138
16. Harris WS, Dayspring TD, Moran TJ (2013) Omega-3 fatty acids and cardiovascular disease: new developments and applications. Postgrad Med 125:100–113
17. Xie J, Méndez JD, Méndez-Valenzuela V et al (2013) Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal 25:2185–2197
18. Li H, Ruan XZ, Powis SH et al (2005) EPA and DHA reduce LPS induced inflammation responses in HK-2 cells: evidence for a PPAR-γ-dependent mechanism. Kidney Int 67:867–874
19. Remels HV, Langen RCJ, Gosker HR et al (2009) PPARγ inhibits NF-κB-dependent transcriptional activation in skeletal muscle. Am J Physiol 297:174–183
20. Matrone C, Djelloul M, Taglialatela G et al (2014) Inflammatory risk factors and pathologies promoting Alzheimer’s disease progression: is RAGE the key? Histol Histopathol [Epub ahead of print]
21. Leurs P, Lindholm B (2013) The AGE–RAGE pathway and its relation to cardiovascular disease in patients with chronic kidney disease. Arch Med Res 44:601–610
22. Chuah YK, Basir R, Talib H et al (2013) Receptor for advanced glycation end products and its involvement in inflammatory diseases. Int J Inflam 2013:403–460
23. Daffu G, del Pozo CH, O’Shea KM et al (2013) Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond. Int J Mol Sci 14:19891–19910
24. Gaens KH, Stehouwer CD, Schalkwijk CG (2013) Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity. Curr Opin Lipidol 24:4–11