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Volumn 248, Issue 2, 2015, Pages 215-222

Effect of U18666a on Beta-Glucosidase, Sphingomyelinase, and Beta-Galactosidase Activities in Astrocytes of Young Rats

Author keywords

Astrocytes; Cholesterol; Lysosomal enzymes; Niemann Pick type C disease; U18666A

Indexed keywords

3-BETA-(2-(DIETHYLAMINO)ETHOXY)ANDROST-5-EN-17-ONE; ANDROSTANE DERIVATIVE; BETA GALACTOSIDASE; BETA GLUCOSIDASE; CHOLESTEROL; HYDROLASE; HYPOCHOLESTEROLEMIC AGENT; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84939955166     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-014-9761-x     Document Type: Article
Times cited : (3)

References (45)
  • 1
    • 0020533666 scopus 로고
    • Studies on sphingomyelinase and beta-glucosidase activities in Niemann-Pick disease variants. Phosphodiesterase activities measured with natural and artificial substrates
    • COI: 1:CAS:528:DyaL3sXksFWns7Y%3D, PID: 6303436
    • Besley GT, Moss SE (1983) Studies on sphingomyelinase and beta-glucosidase activities in Niemann-Pick disease variants. Phosphodiesterase activities measured with natural and artificial substrates. Biochim Biophys Acta 752:54–64
    • (1983) Biochim Biophys Acta , vol.752 , pp. 54-64
    • Besley, G.T.1    Moss, S.E.2
  • 2
    • 0018191970 scopus 로고
    • Induction of chronic epileptic form activity in the rat by an inhibitor of cholesterol synthesis, U18666A
    • COI: 1:CAS:528:DyaE1cXls1WjurY%3D, PID: 678974
    • Bierkamper GG, Cenedella RJ (1978) Induction of chronic epileptic form activity in the rat by an inhibitor of cholesterol synthesis, U18666A. Brain Res 150:343–351
    • (1978) Brain Res , vol.150 , pp. 343-351
    • Bierkamper, G.G.1    Cenedella, R.J.2
  • 3
    • 0033959713 scopus 로고    scopus 로고
    • ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking
    • COI: 1:CAS:528:DC%2BD3cXosFyjuw%3D%3D, PID: 10637304
    • Bishop N, Woodman P (2000) ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol Biol Cell 11:227–239
    • (2000) Mol Biol Cell , vol.11 , pp. 227-239
    • Bishop, N.1    Woodman, P.2
  • 4
    • 0018757006 scopus 로고
    • Mechanism of cataract production by 3-beta(2-diethyl-aminoethoxy)androst-5-en-17-one hydrochloride, U18666A: an inhibitor of cholesterol biosynthesis
    • COI: 1:CAS:528:DyaE1MXkvVektrY%3D, PID: 467524
    • Cenedella RJ, Bierkamper GG (1979) Mechanism of cataract production by 3-beta(2-diethyl-aminoethoxy)androst-5-en-17-one hydrochloride, U18666A: an inhibitor of cholesterol biosynthesis. Exp Eye Res 28:673–688
    • (1979) Exp Eye Res , vol.28 , pp. 673-688
    • Cenedella, R.J.1    Bierkamper, G.G.2
  • 6
    • 3543104951 scopus 로고    scopus 로고
    • Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
    • COI: 1:CAS:528:DC%2BD2cXmsFequ7o%3D, PID: 15254070
    • Dietschy JM, Turley SD (2004) Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 45:1375–1397
    • (2004) J Lipid Res , vol.45 , pp. 1375-1397
    • Dietschy, J.M.1    Turley, S.D.2
  • 7
    • 0030951557 scopus 로고    scopus 로고
    • Effects of a novel 2,3 oxi-dosqualenecyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo
    • COI: 1:CAS:528:DyaK2sXis12qsb8%3D, PID: 9101437
    • Eisele B, Budzinski R, Muller P, Maier R, Mark M (1997) Effects of a novel 2,3 oxi-dosqualenecyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J Lipid Res 38:564–575
    • (1997) J Lipid Res , vol.38 , pp. 564-575
    • Eisele, B.1    Budzinski, R.2    Muller, P.3    Maier, R.4    Mark, M.5
  • 9
    • 0036734602 scopus 로고    scopus 로고
    • Modulation of cellular cholesterol transport and homeostasis by Rab11
    • COI: 1:CAS:528:DC%2BD38XntlGis7o%3D, PID: 12221119
    • Holtta-Vuori M, Tanhuanpaa K, Mobius W, Somerharju P, Ikonen E (2002) Modulation of cellular cholesterol transport and homeostasis by Rab11. Mol Biol Cell 13:3107–3122
    • (2002) Mol Biol Cell , vol.13 , pp. 3107-3122
    • Holtta-Vuori, M.1    Tanhuanpaa, K.2    Mobius, W.3    Somerharju, P.4    Ikonen, E.5
  • 10
    • 2942665893 scopus 로고    scopus 로고
    • Cellular pathology of Niemann-Pick type C disease
    • COI: 1:CAS:528:DC%2BD2cXltVCisLY%3D, PID: 15207834
    • Ikonen E, Holtta-Vuori M (2004) Cellular pathology of Niemann-Pick type C disease. Semin Cell Dev Biol 15:445–454
    • (2004) Semin Cell Dev Biol , vol.15 , pp. 445-454
    • Ikonen, E.1    Holtta-Vuori, M.2
  • 11
    • 0015692365 scopus 로고
    • Induction of a chronic somatosensory epilepsy in the opossum (Didelphisvirginiana Kerr) with an inhibitor of cholesterol biosynthesis
    • COI: 1:CAS:528:DyaE2cXhsVWms7w%3D, PID: 4798641
    • Jurgelski W Jr, Hudson PM, Vogel FS (1973) Induction of a chronic somatosensory epilepsy in the opossum (Didelphisvirginiana Kerr) with an inhibitor of cholesterol biosynthesis. Brain Res 64:466–471
    • (1973) Brain Res , vol.64 , pp. 466-471
    • Jurgelski, W.1    Hudson, P.M.2    Vogel, F.S.3
  • 12
    • 33744952845 scopus 로고    scopus 로고
    • The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux
    • COI: 1:CAS:528:DC%2BD28Xjslensbw%3D, PID: 16497666
    • Kiss RS, Ma Z, Nakada-Tsukui K, Brugnera E, Vassiliou G, McBride HM, Ravichandran KS, Marcel YL (2006) The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux. J Biol Chem 281:12081–12092
    • (2006) J Biol Chem , vol.281 , pp. 12081-12092
    • Kiss, R.S.1    Ma, Z.2    Nakada-Tsukui, K.3    Brugnera, E.4    Vassiliou, G.5    McBride, H.M.6    Ravichandran, K.S.7    Marcel, Y.L.8
  • 13
    • 0022869016 scopus 로고
    • Type C Niemann - Pick disease. Abnormal metabolism of low density lipoprotein in homozygous fibroblasts
    • COI: 1:CAS:528:DyaL28XmtVOit70%3D
    • Kruth HS, Comly ME, Butler JD (1986) Type C Niemann - Pick disease. Abnormal metabolism of low density lipoprotein in homozygous fibroblasts. J Biol Che 261:16769–16774
    • (1986) J Biol Che , vol.261 , pp. 16769-16774
    • Kruth, H.S.1    Comly, M.E.2    Butler, J.D.3
  • 14
    • 34250134345 scopus 로고
    • Mechanism of red blood cell acanthocytosis and echinocytosisin vivo
    • Lange Y, Steck TL (1994) Mechanism of red blood cell acanthocytosis and echinocytosisin vivo. J Membrane Biol 77:153–159
    • (1994) J Membrane Biol , vol.77 , pp. 153-159
    • Lange, Y.1    Steck, T.L.2
  • 15
    • 0032563304 scopus 로고    scopus 로고
    • Circulation of cholesterol between lysosomes and the plasma membrane
    • COI: 1:CAS:528:DyaK1cXltFGrtrw%3D, PID: 9668068
    • Lange Y, Ye J, Steck TL (1998) Circulation of cholesterol between lysosomes and the plasma membrane. J Biol Chem 273:18915–18922
    • (1998) J Biol Chem , vol.273 , pp. 18915-18922
    • Lange, Y.1    Ye, J.2    Steck, T.L.3
  • 16
    • 0034625354 scopus 로고    scopus 로고
    • Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles
    • COI: 1:CAS:528:DC%2BD3cXktFaksLc%3D, PID: 10751394
    • Lange Y, Ye J, Rigney M, Steck T (2000) Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles. J Biol Chem 275:17468–17475
    • (2000) J Biol Chem , vol.275 , pp. 17468-17475
    • Lange, Y.1    Ye, J.2    Rigney, M.3    Steck, T.4
  • 17
    • 0036186426 scopus 로고    scopus 로고
    • Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts
    • COI: 1:CAS:528:DC%2BD38XitVegs74%3D, PID: 11861661
    • Lange Y, Ye J, Rigney M, Steck TL (2002) Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts. J Lipid Res 43:198–204
    • (2002) J Lipid Res , vol.43 , pp. 198-204
    • Lange, Y.1    Ye, J.2    Rigney, M.3    Steck, T.L.4
  • 18
    • 48749131177 scopus 로고    scopus 로고
    • CREB has a context dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis
    • Lemberg T, Parktina JR, Chai M, Schütz G, Engblom D (2008) CREB has a context dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis. FASEB J 22:2872–2879
    • (2008) FASEB J , vol.22 , pp. 2872-2879
    • Lemberg, T.1    Parktina, J.R.2    Chai, M.3    Schütz, G.4    Engblom, D.5
  • 19
    • 33846089323 scopus 로고    scopus 로고
    • Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells
    • COI: 1:CAS:528:DC%2BD2sXmsFygtQ%3D%3D, PID: 17050734
    • Linder MD, Uronen RL, Holtta-Vuori M, van der Sluijs P, Peränen J, Ikonen E (2007) Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. Mol Biol Cell 18:47–56
    • (2007) Mol Biol Cell , vol.18 , pp. 47-56
    • Linder, M.D.1    Uronen, R.L.2    Holtta-Vuori, M.3    van der Sluijs, P.4    Peränen, J.5    Ikonen, E.6
  • 20
    • 0024312609 scopus 로고
    • The intracellular transport of low density lipoprotein- derived cholesterol is inhibited in CHO cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one
    • COI: 1:CAS:528:DyaL1MXkvFSltrY%3D, PID: 2745416
    • Liscum L, Faust JR (1989) The intracellular transport of low density lipoprotein- derived cholesterol is inhibited in CHO cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J Biol Chem 264:11796–11806
    • (1989) J Biol Chem , vol.264 , pp. 11796-11806
    • Liscum, L.1    Faust, J.R.2
  • 21
    • 4944230810 scopus 로고    scopus 로고
    • Intracellular trafficking of Niemann-Pick C proteins 1 and 2: obligate components of subcellular lipid transport
    • COI: 1:CAS:528:DC%2BD2cXotFCksbg%3D, PID: 15465423
    • Liscum L, Sturley SL (2004) Intracellular trafficking of Niemann-Pick C proteins 1 and 2: obligate components of subcellular lipid transport. Biochim Biophys Acta 1685:22–27
    • (2004) Biochim Biophys Acta , vol.1685 , pp. 22-27
    • Liscum, L.1    Sturley, S.L.2
  • 23
    • 71849104860 scopus 로고
    • Protein measurement with the folin phenol reagent
    • COI: 1:CAS:528:DyaG38XhsVyrsw%3D%3D, PID: 14907713
    • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3    Randall, R.J.4
  • 26
    • 61849180931 scopus 로고    scopus 로고
    • Marked Differences in cholesterol syn- thesis between neurons and glial cells from postnatal rats
    • COI: 1:CAS:528:DC%2BD1MXktVWhtrw%3D, PID: 19166509
    • Nieweg K, Schaller H, Pfrieger FW (2009) Marked Differences in cholesterol syn- thesis between neurons and glial cells from postnatal rats. J Neurochem 109:125–134
    • (2009) J Neurochem , vol.109 , pp. 125-134
    • Nieweg, K.1    Schaller, H.2    Pfrieger, F.W.3
  • 31
    • 0017174536 scopus 로고
    • Differentation of beta-glucocerebrosidase from beta-glucosidase in human tissues using sodium taurocholate
    • Petters SP, Coyle P, Glew RH (1976) Differentation of beta-glucocerebrosidase from beta-glucosidase in human tissues using sodium taurocholate. Arch Biochem Biophys 175:569–571
    • (1976) Arch Biochem Biophys , vol.175 , pp. 569-571
    • Petters, S.P.1    Coyle, P.2    Glew, R.H.3
  • 33
    • 0037092050 scopus 로고    scopus 로고
    • Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysossomes: implications for Pelizaeus-Merzbacher disease
    • COI: 1:CAS:528:DC%2BD38XivFKktLc%3D, PID: 11956232
    • Simons M, Kramer EM, Macchi P, Rathke-Harlieb S, Trotter J, Nave KA, Schulz JB (2002) Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysossomes: implications for Pelizaeus-Merzbacher disease. J Cell Biol 157:327–336
    • (2002) J Cell Biol , vol.157 , pp. 327-336
    • Simons, M.1    Kramer, E.M.2    Macchi, P.3    Rathke-Harlieb, S.4    Trotter, J.5    Nave, K.A.6    Schulz, J.B.7
  • 34
    • 0014806327 scopus 로고
    • Globoid cell leucodystrophy (Krabbe’s disease): deficiency of galactocerebroside beta-galactosidase
    • COI: 1:CAS:528:DyaE3cXks1Chtr4%3D, PID: 5271165
    • Suzuki K, Suzuki Y (1970) Globoid cell leucodystrophy (Krabbe’s disease): deficiency of galactocerebroside beta-galactosidase. Proc Nat Acad Sci USA 66:302–309
    • (1970) Proc Nat Acad Sci USA , vol.66 , pp. 302-309
    • Suzuki, K.1    Suzuki, Y.2
  • 35
    • 79953312249 scopus 로고    scopus 로고
    • Niemann- Pick Type C disease: characterizing lipid levels in patients with variant lysosomal choles terol storage
    • Tängerno C, Weber D, Theiss S, Mengel E, Runz H (2011) Niemann- Pick Type C disease: characterizing lipid levels in patients with variant lysosomal choles terol storage. J Lipid Res 52:813–825
    • (2011) J Lipid Res , vol.52 , pp. 813-825
    • Tängerno, C.1    Weber, D.2    Theiss, S.3    Mengel, E.4    Runz, H.5
  • 36
    • 0029996993 scopus 로고    scopus 로고
    • Quantitative analyses of hydrophobic amine inhibition of intracellular cholesterol transport
    • COI: 1:CAS:528:DyaK28XksFOiu74%3D, PID: 8827526
    • Underwood KW, Andemariam B, McWilliams GL, Liscum L (1996) Quantitative analyses of hydrophobic amine inhibition of intracellular cholesterol transport. J Lipid Res 37:1556–1568
    • (1996) J Lipid Res , vol.37 , pp. 1556-1568
    • Underwood, K.W.1    Andemariam, B.2    McWilliams, G.L.3    Liscum, L.4
  • 37
    • 77953019480 scopus 로고    scopus 로고
    • Niemann-Pick disease type C
    • PID: 20525256
    • Vanier MT (2010) Niemann-Pick disease type C. Orphanet J Rare Dis 5:16
    • (2010) Orphanet J Rare Dis , vol.5 , pp. 16
    • Vanier, M.T.1
  • 38
    • 0018879888 scopus 로고
    • Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease: development and evaluation of a microprocedure
    • COI: 1:STN:280:DyaL3M%2FitlSitg%3D%3D, PID: 6251986
    • Vanier MT, Revol A, Fichet M (1980) Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease: development and evaluation of a microprocedure. Clin Chim Acta 106:257–267
    • (1980) Clin Chim Acta , vol.106 , pp. 257-267
    • Vanier, M.T.1    Revol, A.2    Fichet, M.3
  • 39
    • 0023879638 scopus 로고
    • Niemann- Pick disease group C: clinical variability and diagnosis based on defective cholesterol esterification. A collaborative study on 70 patients
    • COI: 1:STN:280:DyaL1c3ktF2ksw%3D%3D, PID: 3378364
    • Vanier MT, Wenger DA, Comly ME, Rousson R, Brady RO, Pentchev PG (1988) Niemann- Pick disease group C: clinical variability and diagnosis based on defective cholesterol esterification. A collaborative study on 70 patients. Clin Genet 33:331–348
    • (1988) Clin Genet , vol.33 , pp. 331-348
    • Vanier, M.T.1    Wenger, D.A.2    Comly, M.E.3    Rousson, R.4    Brady, R.O.5    Pentchev, P.G.6
  • 40
    • 0025777970 scopus 로고
    • Type C Niemann- Pick disease: spectrum of phenotypic variation in disruption of intracellular LDL- derived cholesterol processing
    • COI: 1:CAS:528:DyaK3MXksVOhtbk%3D, PID: 2065104
    • Vanier MT, Rodriguez-Lafrasse C, Rousson R, Gazzah N, Juge MC, Pentchev PG, Revol A, Louisot P (1991) Type C Niemann- Pick disease: spectrum of phenotypic variation in disruption of intracellular LDL- derived cholesterol processing. Biochim Biophys Acta 1096:328–337
    • (1991) Biochim Biophys Acta , vol.1096 , pp. 328-337
    • Vanier, M.T.1    Rodriguez-Lafrasse, C.2    Rousson, R.3    Gazzah, N.4    Juge, M.C.5    Pentchev, P.G.6    Revol, A.7    Louisot, P.8
  • 41
    • 78649916808 scopus 로고    scopus 로고
    • Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes
    • PID: 20674861
    • Wang ML, Motamed M, Infante RE, Abi- Mosleh L, Kwon HJ, Brown MS, Golds-tein JL (2010) Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes. Cell Metab 12:166–173
    • (2010) Cell Metab , vol.12 , pp. 166-173
    • Wang, M.L.1    Motamed, M.2    Infante, R.E.3    Abi- Mosleh, L.4    Kwon, H.J.5    Brown, M.S.6    Golds-tein, J.L.7
  • 42
    • 0016204278 scopus 로고
    • An improved method for the identification of patients and carriers of Krabbe’s disease
    • COI: 1:STN:280:DyaE2M%2Fls12ltA%3D%3D, PID: 4434632
    • Wenger DA, Sattler M, Clark C, McKelvey H (1974) An improved method for the identification of patients and carriers of Krabbe’s disease. Clin Chim Acta 56:199–206
    • (1974) Clin Chim Acta , vol.56 , pp. 199-206
    • Wenger, D.A.1    Sattler, M.2    Clark, C.3    McKelvey, H.4
  • 43
    • 7744231974 scopus 로고    scopus 로고
    • Mechanistic similarities between cultured cell models of cystic fibrosis and Niemann-Pick type C
    • COI: 1:CAS:528:DC%2BD2cXpvVCgt78%3D, PID: 15256387
    • White NM, Corey DA, Kelley TJ (2004) Mechanistic similarities between cultured cell models of cystic fibrosis and Niemann-Pick type C. Am J Respir Cell Mol Biol 31:538–543
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 538-543
    • White, N.M.1    Corey, D.A.2    Kelley, T.J.3
  • 44
    • 0035928841 scopus 로고    scopus 로고
    • Critical role for glycosphingolipids in Niemann-Pick disease type C
    • COI: 1:CAS:528:DC%2BD3MXmsFers7o%3D, PID: 11525744
    • Zervas M, Somers KL, Thrall MA, Walkley SU (2001) Critical role for glycosphingolipids in Niemann-Pick disease type C. Curr Biol 11:1283–1287
    • (2001) Curr Biol , vol.11 , pp. 1283-1287
    • Zervas, M.1    Somers, K.L.2    Thrall, M.A.3    Walkley, S.U.4


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