메뉴 건너뛰기




Volumn 38, Issue 3, 2015, Pages 1012-1019

Investigation of the Anti-Inflammatory Effects of Safranal on High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

Author keywords

inflammation; oxidative stress; safranal; type 2 diabetes

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOHEXENE DERIVATIVE; GAMMA INTERFERON; GLUCOSE BLOOD LEVEL; IL1B PROTEIN, RAT; INTERLEUKIN 1BETA; INTERLEUKIN 6; SAFRANAL; STREPTOZOCIN; TERPENE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84939948222     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0065-1     Document Type: Article
Times cited : (52)

References (29)
  • 1
    • 84977777628 scopus 로고    scopus 로고
    • IDF Diabetes atlas, Sixth edition
    • IDF (International Diabetes Fedaration). 2014. IDF Diabetes atlas, Sixth edition, 12.
    • (2014) 12
  • 3
    • 58749109171 scopus 로고    scopus 로고
    • Treatmant of type 2 diabetes: a structured management plan
    • PID: 18330521
    • Baxter, M. 2008. Treatmant of type 2 diabetes: a structured management plan. Advances in Therapy 25(2): 106–114.
    • (2008) Advances in Therapy , vol.25 , Issue.2 , pp. 106-114
    • Baxter, M.1
  • 4
    • 0024886873 scopus 로고
    • Growth, flowering, vegetative reproduction and dormancy in the saffron crocus (Crocus sativus L.)
    • Negbi, M., B. Dagan, A. Dror, and D. Basker. 1989. Growth, flowering, vegetative reproduction and dormancy in the saffron crocus (Crocus sativus L.). Israel Journal of Botany 38: 95–113.
    • (1989) Israel Journal of Botany , vol.38 , pp. 95-113
    • Negbi, M.1    Dagan, B.2    Dror, A.3    Basker, D.4
  • 5
    • 0034609001 scopus 로고    scopus 로고
    • A non-destructive method to determine the safranal content of saffron (Crocus sativus L.) by supercritical carbon dioxide extraction combined with high-performance liquid chromatography and gas chromatography
    • COI: 1:CAS:528:DC%2BD3cXktlKku74%3D, PID: 10869688
    • Lozano, P., D. Delgado, D. Gómez, M. Rubio, and J.L. Iborra. 2000. A non-destructive method to determine the safranal content of saffron (Crocus sativus L.) by supercritical carbon dioxide extraction combined with high-performance liquid chromatography and gas chromatography. Journal of Biochemical and Biophysical Methods 43(1–3): 367–378.
    • (2000) Journal of Biochemical and Biophysical Methods , vol.43 , Issue.1-3 , pp. 367-378
    • Lozano, P.1    Delgado, D.2    Gómez, D.3    Rubio, M.4    Iborra, J.L.5
  • 6
    • 84884585943 scopus 로고    scopus 로고
    • Characterisation of secondary metabolites in saffron from central Italy (Cascia, Umbria)
    • Cossignani, L., E. Urbani, M.S. Simonetti, A. Maurizi, C. Chiesi, and F. Blasi. 2014. Characterisation of secondary metabolites in saffron from central Italy (Cascia, Umbria). Food Chemistry 15(143): 446–451.
    • (2014) Food Chemistry , vol.15 , Issue.143 , pp. 446-451
    • Cossignani, L.1    Urbani, E.2    Simonetti, M.S.3    Maurizi, A.4    Chiesi, C.5    Blasi, F.6
  • 7
    • 81255167465 scopus 로고    scopus 로고
    • Anti-hyperglycemic effects of saffron and its active constituents, crosin and safranal, in alloxan-induced diabetic rats
    • Kainbakht, S., and R. Hajiaghaee. 2011. Anti-hyperglycemic effects of saffron and its active constituents, crosin and safranal, in alloxan-induced diabetic rats. Journal of Medicinal Plant 10(39): 82–89.
    • (2011) Journal of Medicinal Plant , vol.10 , Issue.39 , pp. 82-89
    • Kainbakht, S.1    Hajiaghaee, R.2
  • 8
    • 29244478599 scopus 로고    scopus 로고
    • Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents
    • COI: 1:CAS:528:DC%2BD28Xnt12iuw%3D%3D, PID: 16317646
    • Assimopoulou, A.N., Z. Sinakos, and V.P. Papageorgiou. 2005. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytotherapy Research 19: 997–1000.
    • (2005) Phytotherapy Research , vol.19 , pp. 997-1000
    • Assimopoulou, A.N.1    Sinakos, Z.2    Papageorgiou, V.P.3
  • 9
    • 84896336480 scopus 로고    scopus 로고
    • Evaluation of lung and bronchoalveolar lavage fluid oxidative stress indices for assessing the preventing effects of safranal on respiratory distress in diabetic rats. The Scientific World Journal, Article ID 251378
    • Samarghandian, S., R. Afshari, A. Sadati. 2014. Evaluation of lung and bronchoalveolar lavage fluid oxidative stress indices for assessing the preventing effects of safranal on respiratory distress in diabetic rats. The Scientific World Journal, Article ID 251378, 6 pages http://dx.doi.org/10.1155/251378.
    • (2014) 6 pages
    • Samarghandian, S.1    Afshari, R.2    Sadati, A.3
  • 10
    • 84872867286 scopus 로고    scopus 로고
    • Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in Wistar rats
    • PID: 23638293
    • Mehdizadeh, R., M.R. Parizadeh, A.R. Khooei, S. Mehri, and H. Hosseinzadeh. 2013. Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in Wistar rats. Iranıan Journal of Basıc Medical Sciences 16(1): 56–63.
    • (2013) Iranıan Journal of Basıc Medical Sciences , vol.16 , Issue.1 , pp. 56-63
    • Mehdizadeh, R.1    Parizadeh, M.R.2    Khooei, A.R.3    Mehri, S.4    Hosseinzadeh, H.5
  • 11
    • 0030047682 scopus 로고    scopus 로고
    • Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro
    • COI: 1:CAS:528:DyaK28XhtVCisLw%3D, PID: 8620447
    • Escribano, J., G.L. Alonso, M. Coca-Prados, and J.A. Fernandez. 1996. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Letters 100: 23–30.
    • (1996) Cancer Letters , vol.100 , pp. 23-30
    • Escribano, J.1    Alonso, G.L.2    Coca-Prados, M.3    Fernandez, J.A.4
  • 12
    • 77954497958 scopus 로고    scopus 로고
    • Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats
    • COI: 1:CAS:528:DC%2BC3cXhtValt7zF, PID: 20013822
    • Imenshahidi, M., H. Hosseinzadeh, and Y. Javadpour. 2010. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytotherapy Research 24(7): 990–994.
    • (2010) Phytotherapy Research , vol.24 , Issue.7 , pp. 990-994
    • Imenshahidi, M.1    Hosseinzadeh, H.2    Javadpour, Y.3
  • 14
    • 65549131015 scopus 로고    scopus 로고
    • The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Experimental Diabetes Research
    • Zhang, M., M.Y. Lv, J. Lı, Z.G. Xu, L. Chen. 2008. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Experimental Diabetes Research, Article ID 704045, 1–9.
    • (2008) Article ID , pp. 1-9
    • Zhang, M.1    Lv, M.Y.2    Lı, J.3    Xu, Z.G.4    Chen, L.5
  • 15
    • 0346023040 scopus 로고    scopus 로고
    • A novel automated method to measure total antioxidant response against potent free radical reactions
    • COI: 1:CAS:528:DC%2BD2cXjtFChtg%3D%3D, PID: 14725941
    • Erel, Ö. 2004. A novel automated method to measure total antioxidant response against potent free radical reactions. Clinical Biochemistry 37(2): 112–119.
    • (2004) Clinical Biochemistry , vol.37 , Issue.2 , pp. 112-119
    • Erel, Ö.1
  • 16
    • 29144527533 scopus 로고    scopus 로고
    • A new automated colorimetric method for measuring total oxidant status
    • COI: 1:CAS:528:DC%2BD2MXhtlaisbjL, PID: 16214125
    • Erel, Ö. 2005. A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry 38(12): 1103–1111.
    • (2005) Clinical Biochemistry , vol.38 , Issue.12 , pp. 1103-1111
    • Erel, Ö.1
  • 17
    • 59749094309 scopus 로고    scopus 로고
    • Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia
    • COI: 1:CAS:528:DC%2BD1MXltVSktr4%3D, PID: 19192421
    • Gutierrez, D.A., M.J. Puglisi, and A.H. Hasty. 2009. Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Current Diabetes Reports 9(1): 26–32.
    • (2009) Current Diabetes Reports , vol.9 , Issue.1 , pp. 26-32
    • Gutierrez, D.A.1    Puglisi, M.J.2    Hasty, A.H.3
  • 19
    • 84896324646 scopus 로고    scopus 로고
    • Increased concentration of C-reactive protein in obese patients with type 2 diabetes is associated with obesity and presence of diabetes but not with macrovascular and microvascular complications or glycemic control
    • COI: 1:CAS:528:DC%2BC2cXktFentL8%3D, PID: 24197824
    • Fronczyk, A., P. Molęda, K. Safranow, W. Piechota, and L. Majkowska. 2014. Increased concentration of C-reactive protein in obese patients with type 2 diabetes is associated with obesity and presence of diabetes but not with macrovascular and microvascular complications or glycemic control. Inflammation 37(2): 349–357.
    • (2014) Inflammation , vol.37 , Issue.2 , pp. 349-357
    • Fronczyk, A.1    Molęda, P.2    Safranow, K.3    Piechota, W.4    Majkowska, L.5
  • 20
    • 44149086375 scopus 로고    scopus 로고
    • Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet
    • COI: 1:CAS:528:DC%2BD1cXms1Wktro%3D, PID: 19083440
    • Kim, Y.J., and T. Park. 2008. Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet. Nutrition Research 28: 414–422.
    • (2008) Nutrition Research , vol.28 , pp. 414-422
    • Kim, Y.J.1    Park, T.2
  • 21
    • 0037383261 scopus 로고    scopus 로고
    • A controlled high-Fat diet induces an obese syndrome in rats
    • COI: 1:CAS:528:DC%2BD3sXivVeku78%3D, PID: 12672923
    • Woods, S.C., R.J. Seeley, P.A. Rushing, D. D’Alessio, and P. Tso. 2003. A controlled high-Fat diet induces an obese syndrome in rats. The Journal of Nutrition 133: 1081–1087.
    • (2003) The Journal of Nutrition , vol.133 , pp. 1081-1087
    • Woods, S.C.1    Seeley, R.J.2    Rushing, P.A.3    D’Alessio, D.4    Tso, P.5
  • 22
    • 0028072540 scopus 로고
    • Development and characterization of a purified diet to identify obesity-susceptible and resistant rat populations
    • COI: 1:CAS:528:DyaK2cXmvF2rtbw%3D, PID: 7965201
    • Lauterio, T.J., J.P. Bond, and E.A. Ulman. 1994. Development and characterization of a purified diet to identify obesity-susceptible and resistant rat populations. The Journal of Nutrition 124: 2172–2178.
    • (1994) The Journal of Nutrition , vol.124 , pp. 2172-2178
    • Lauterio, T.J.1    Bond, J.P.2    Ulman, E.A.3
  • 23
    • 0033761823 scopus 로고    scopus 로고
    • A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat
    • COI: 1:CAS:528:DC%2BD3cXot1GmsL0%3D, PID: 11092499
    • Reed, M.J., K. Meszaros, L.J. Entes, M.D. Claypool, J.G. Pinkett, T.M. Gadbois, and G.M. Reaven. 2000. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 49(11): 1390–1394.
    • (2000) Metabolism , vol.49 , Issue.11 , pp. 1390-1394
    • Reed, M.J.1    Meszaros, K.2    Entes, L.J.3    Claypool, M.D.4    Pinkett, J.G.5    Gadbois, T.M.6    Reaven, G.M.7
  • 24
    • 84903448009 scopus 로고    scopus 로고
    • Effects of oral anti-diabetic agent sitagliptin on total antioxidant and oxidant status in rats with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXitVWqsb%2FM
    • Hazman, Ö., and S. Çelik. 2014. Effects of oral anti-diabetic agent sitagliptin on total antioxidant and oxidant status in rats with type 2 diabetes mellitus. Journal of Applied Biological Sciences 8(1): 31–37.
    • (2014) Journal of Applied Biological Sciences , vol.8 , Issue.1 , pp. 31-37
    • Hazman, Ö.1    Çelik, S.2
  • 25
    • 45249090859 scopus 로고    scopus 로고
    • Role of NFkB in β-cell death
    • COI: 1:CAS:528:DC%2BD1cXmtVKlsLw%3D, PID: 18481952
    • Melloul, D. 2008. Role of NFkB in β-cell death. Biochemical Society Transactions 36: 334–339.
    • (2008) Biochemical Society Transactions , vol.36 , pp. 334-339
    • Melloul, D.1
  • 26
    • 84877757564 scopus 로고    scopus 로고
    • Molecular basis of NF-κB signaling
    • COI: 1:CAS:528:DC%2BC3sXhtFGrs7fK, PID: 23495970
    • Napetschnig, J., and H. Wu. 2013. Molecular basis of NF-κB signaling. Annual Review of Biophysics 42: 443–468.
    • (2013) Annual Review of Biophysics , vol.42 , pp. 443-468
    • Napetschnig, J.1    Wu, H.2
  • 27
    • 0034668171 scopus 로고    scopus 로고
    • Oxidative stress interference with the nuclear factor-kB activation pathways
    • COI: 1:CAS:528:DC%2BD3cXmslOjsb4%3D, PID: 11007944
    • Schoonbroodt, S., and J. Piette. 2000. Oxidative stress interference with the nuclear factor-kB activation pathways. Biochemical Pharmacology 60: 1075–1083.
    • (2000) Biochemical Pharmacology , vol.60 , pp. 1075-1083
    • Schoonbroodt, S.1    Piette, J.2
  • 28
    • 0033990345 scopus 로고    scopus 로고
    • Oxidative stress and nuclear factor-kappa B activation: a reassessment of the evidence in the light of recent discoveries
    • COI: 1:CAS:528:DC%2BD3cXhtV2hsw%3D%3D, PID: 10605930
    • Bowie, A., and L.A. O’Neill. 2000. Oxidative stress and nuclear factor-kappa B activation: a reassessment of the evidence in the light of recent discoveries. Biochemical Pharmacology 59(1): 13–23.
    • (2000) Biochemical Pharmacology , vol.59 , Issue.1 , pp. 13-23
    • Bowie, A.1    O’Neill, L.A.2
  • 29
    • 84901928344 scopus 로고    scopus 로고
    • Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice
    • COI: 1:CAS:528:DC%2BC2cXitlSgu7g%3D, PID: 24668740
    • Maeda, A., K. Kai, M. Ishii, T. Ishii, and M. Akagawa. 2014. Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice. Molecular Nutrition Food Research 58: 1177–1189.
    • (2014) Molecular Nutrition Food Research , vol.58 , pp. 1177-1189
    • Maeda, A.1    Kai, K.2    Ishii, M.3    Ishii, T.4    Akagawa, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.