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Volumn 89, Issue 2, 2015, Pages 201-210

8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine concentrations in various human body fluids: implications for their measurement and interpretation

Author keywords

Deproteinization; Online SPE LC MS MS; Oxidatively damaged DNA; Plasma; Saliva; Transport mechanism

Indexed keywords

2'-DEOXY-7,8-DIHYDRO-8-OXOADENOSINE; 8-HYDROXYGUANINE; DEOXYADENOSINE DERIVATIVE; GUANINE;

EID: 84939896010     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1255-1     Document Type: Article
Times cited : (36)

References (47)
  • 1
    • 84868341190 scopus 로고    scopus 로고
    • Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3sXovVCnsA%3D%3D, PID: 22582895
    • Agha-Hosseini F, Mirzaii-Dizgah I, Farmanbar N, Abdollahi M (2012) Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma. J Oral Pathol Med 41:736–740
    • (2012) J Oral Pathol Med , vol.41 , pp. 736-740
    • Agha-Hosseini, F.1    Mirzaii-Dizgah, I.2    Farmanbar, N.3    Abdollahi, M.4
  • 2
    • 77951624862 scopus 로고    scopus 로고
    • Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine as a noninvasive biomarker of oxidative stress
    • COI: 1:CAS:528:DC%2BC3cXktlOqtrs%3D, PID: 19966135
    • Evans MD, Olinski R, Loft S, Cooke MS (2010) Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine as a noninvasive biomarker of oxidative stress. FASEB J 24:1249–1260
    • (2010) FASEB J , vol.24 , pp. 1249-1260
    • Evans, M.D.1    Olinski, R.2    Loft, S.3    Cooke, M.S.4
  • 4
    • 49749144430 scopus 로고    scopus 로고
    • Blood oxidative stress biomarkers: influence of sex, exercise training status, and dietary intake
    • PID: 18727988
    • Bloomer RJ, Fisher-Wellman KH (2008) Blood oxidative stress biomarkers: influence of sex, exercise training status, and dietary intake. Gend Med 5:218–228
    • (2008) Gend Med , vol.5 , pp. 218-228
    • Bloomer, R.J.1    Fisher-Wellman, K.H.2
  • 5
    • 0032820533 scopus 로고    scopus 로고
    • A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: a 1-year evaluation of methods
    • COI: 1:CAS:528:DyaK1MXls12nsL4%3D, PID: 10490286
    • Bogdanov MB, Beal MF, McCabe DR, Griffin RM, Matson WR (1999) A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: a 1-year evaluation of methods. Free Radic Biol Med 27:647–666
    • (1999) Free Radic Biol Med , vol.27 , pp. 647-666
    • Bogdanov, M.B.1    Beal, M.F.2    McCabe, D.R.3    Griffin, R.M.4    Matson, W.R.5
  • 6
    • 0037214731 scopus 로고    scopus 로고
    • Measurement of 8-hydroxy-2 ‘-deoxyguanosine by a commercially available ELISA test: comparison with HPLC/electrochemical detection in calf thymus DNA and determination in human serum
    • COI: 1:CAS:528:DC%2BD3sXitlSktrg%3D
    • Breton J, Sichel F, Bianchini F, Prevost V (2003) Measurement of 8-hydroxy-2 ‘-deoxyguanosine by a commercially available ELISA test: comparison with HPLC/electrochemical detection in calf thymus DNA and determination in human serum. Anal Lett 36:123–134
    • (2003) Anal Lett , vol.36 , pp. 123-134
    • Breton, J.1    Sichel, F.2    Bianchini, F.3    Prevost, V.4
  • 7
    • 84858115501 scopus 로고    scopus 로고
    • Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids
    • COI: 1:CAS:528:DC%2BC38Xjs1SksL0%3D, PID: 22263561
    • Cadet J, Loft S, Olinski R, Evans MD, Bialkowski K, Richard Wagner J, Dedon PC, Moller P, Greenberg MM, Cooke MS (2012) Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radic Res 46:367–381
    • (2012) Free Radic Res , vol.46 , pp. 367-381
    • Cadet, J.1    Loft, S.2    Olinski, R.3    Evans, M.D.4    Bialkowski, K.5    Richard Wagner, J.6    Dedon, P.C.7    Moller, P.8    Greenberg, M.M.9    Cooke, M.S.10
  • 8
    • 0026592966 scopus 로고
    • 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G—T and A—C substitutions
    • COI: 1:CAS:528:DyaK38XjvFWlug%3D%3D, PID: 1730583
    • Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G—T and A—C substitutions. J Biol Chem 267:166–172
    • (1992) J Biol Chem , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 9
    • 19444382663 scopus 로고    scopus 로고
    • DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
    • COI: 1:CAS:528:DC%2BD2MXks1eitLg%3D, PID: 15914207
    • Cooke MS, Evans MD, Dove R, Rozalski R, Gackowski D, Siomek A, Lunec J, Olinski R (2005) DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine. Mutat Res 574:58–66
    • (2005) Mutat Res , vol.574 , pp. 58-66
    • Cooke, M.S.1    Evans, M.D.2    Dove, R.3    Rozalski, R.4    Gackowski, D.5    Siomek, A.6    Lunec, J.7    Olinski, R.8
  • 10
    • 32044466239 scopus 로고    scopus 로고
    • Does measurement of oxidative damage to DNA have clinical significance?
    • COI: 1:CAS:528:DC%2BD28XhtFaqtrY%3D, PID: 16214123
    • Cooke MS, Olinski R, Evans MD (2006) Does measurement of oxidative damage to DNA have clinical significance? Clin Chim Acta 365:30–49
    • (2006) Clin Chim Acta , vol.365 , pp. 30-49
    • Cooke, M.S.1    Olinski, R.2    Evans, M.D.3
  • 11
    • 0024841281 scopus 로고
    • Structural and conformational analyses of 8-hydroxy-2′-deoxyguanosine
    • COI: 1:CAS:528:DyaL1MXmt1Kqu74%3D, PID: 2519731
    • Culp SJ, Cho BP, Kadlubar FF, Evans FE (1989) Structural and conformational analyses of 8-hydroxy-2′-deoxyguanosine. Chem Res Toxicol 2:416–422
    • (1989) Chem Res Toxicol , vol.2 , pp. 416-422
    • Culp, S.J.1    Cho, B.P.2    Kadlubar, F.F.3    Evans, F.E.4
  • 12
    • 70249148054 scopus 로고    scopus 로고
    • Elevated level of 8-oxo-7,8-dihydro-2′-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls
    • COI: 1:CAS:528:DC%2BD1MXhtVOms7nP, PID: 19623658
    • Dziaman T, Huzarski T, Gackowski D, Rozalski R, Siomek A, Szpila A, Guz J, Lubinski J, Olinski R (2009) Elevated level of 8-oxo-7,8-dihydro-2′-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls. Int J Cancer 125:2209–2213
    • (2009) Int J Cancer , vol.125 , pp. 2209-2213
    • Dziaman, T.1    Huzarski, T.2    Gackowski, D.3    Rozalski, R.4    Siomek, A.5    Szpila, A.6    Guz, J.7    Lubinski, J.8    Olinski, R.9
  • 13
    • 55849089954 scopus 로고    scopus 로고
    • Analysis of urinary 8-oxo-7,8-dihydro-purine-2′-deoxyribonucleosides by LC–MS/MS and improved ELISA
    • COI: 1:CAS:528:DC%2BD1cXhtlensL%2FM, PID: 18985483
    • Evans MD, Singh R, Mistry V, Sandhu K, Farmer PB, Cooke MS (2008) Analysis of urinary 8-oxo-7,8-dihydro-purine-2′-deoxyribonucleosides by LC–MS/MS and improved ELISA. Free Radic Res 42:831–840
    • (2008) Free Radic Res , vol.42 , pp. 831-840
    • Evans, M.D.1    Singh, R.2    Mistry, V.3    Sandhu, K.4    Farmer, P.B.5    Cooke, M.S.6
  • 14
    • 77956245228 scopus 로고    scopus 로고
    • DNA repair and the origins of urinary oxidized 2′-deoxyribonucleosides
    • COI: 1:CAS:528:DC%2BC3cXhtV2hsr7M, PID: 20522520
    • Evans MD, Saparbaev M, Cooke MS (2010) DNA repair and the origins of urinary oxidized 2′-deoxyribonucleosides. Mutagenesis 25:433–442
    • (2010) Mutagenesis , vol.25 , pp. 433-442
    • Evans, M.D.1    Saparbaev, M.2    Cooke, M.S.3
  • 16
    • 0025373259 scopus 로고
    • Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine
    • COI: 1:CAS:528:DyaK3cXkslGqsrk%3D, PID: 2352934
    • Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN (1990) Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 87:4533–4537
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4533-4537
    • Fraga, C.G.1    Shigenaga, M.K.2    Park, J.W.3    Degan, P.4    Ames, B.N.5
  • 17
    • 0035695310 scopus 로고    scopus 로고
    • 8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine levels in human urine do not depend on diet
    • COI: 1:CAS:528:DC%2BD38XmvVejug%3D%3D, PID: 11811533
    • Gackowski D, Rozalski R, Roszkowski K, Jawien A, Foksinski M, Olinski R (2001) 8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine levels in human urine do not depend on diet. Free Radic Res 35:825–832
    • (2001) Free Radic Res , vol.35 , pp. 825-832
    • Gackowski, D.1    Rozalski, R.2    Roszkowski, K.3    Jawien, A.4    Foksinski, M.5    Olinski, R.6
  • 18
    • 11244327638 scopus 로고    scopus 로고
    • Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study
    • COI: 1:CAS:528:DC%2BD2MXitVCquw%3D%3D, PID: 15533950
    • Gedik CM, Collins A, Escodd (2005) Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J 19:82–84
    • (2005) FASEB J , vol.19 , pp. 82-84
    • Gedik, C.M.1    Collins, A.2
  • 19
    • 79953107369 scopus 로고    scopus 로고
    • Multi-class determination of around 50 pharmaceuticals, including 26 antibiotics, in environmental and wastewater samples by ultra-high performance liquid chromatography–tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BC3MXkt12nsL4%3D, PID: 21388627
    • Gracia-Lor E, Sancho JV, Hernandez F (2011) Multi-class determination of around 50 pharmaceuticals, including 26 antibiotics, in environmental and wastewater samples by ultra-high performance liquid chromatography–tandem mass spectrometry. J Chromatogr A 1218:2264–2275
    • (2011) J Chromatogr A , vol.1218 , pp. 2264-2275
    • Gracia-Lor, E.1    Sancho, J.V.2    Hernandez, F.3
  • 20
    • 0027375887 scopus 로고
    • Factors influencing the saliva/plasma ratio of drugs
    • COI: 1:CAS:528:DyaK3sXms1Wrt7w%3D, PID: 8215049
    • Haeckel R (1993) Factors influencing the saliva/plasma ratio of drugs. Ann N Y Acad Sci 694:128–142
    • (1993) Ann N Y Acad Sci , vol.694 , pp. 128-142
    • Haeckel, R.1
  • 21
    • 0029932091 scopus 로고    scopus 로고
    • Application of saliva for drug monitoring. An in vivo model for transmembrane transport
    • COI: 1:CAS:528:DyaK28Xis1ejs74%3D, PID: 8721405
    • Haeckel R, Hanecke P (1996) Application of saliva for drug monitoring. An in vivo model for transmembrane transport. Eur J Clin Chem Clin Biochem 34:171–191
    • (1996) Eur J Clin Chem Clin Biochem , vol.34 , pp. 171-191
    • Haeckel, R.1    Hanecke, P.2
  • 22
    • 0031889780 scopus 로고    scopus 로고
    • DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine
    • COI: 1:CAS:528:DyaK1cXjtl2itw%3D%3D, PID: 9419368
    • Helbock HJ, Beckman KB, Shigenaga MK, Walter PB, Woodall AA, Yeo HC, Ames BN (1998) DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci USA 95:288–293
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 288-293
    • Helbock, H.J.1    Beckman, K.B.2    Shigenaga, M.K.3    Walter, P.B.4    Woodall, A.A.5    Yeo, H.C.6    Ames, B.N.7
  • 23
    • 74149083811 scopus 로고    scopus 로고
    • Urinary analysis of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine by isotope-dilution LC–MS/MS with automated solid-phase extraction: study of 8-oxo-7,8-dihydroguanine stability
    • COI: 1:CAS:528:DC%2BD1MXhsFyku7jN, PID: 19836447
    • Hu CW, Chao MR, Sie CH (2010a) Urinary analysis of 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine by isotope-dilution LC–MS/MS with automated solid-phase extraction: study of 8-oxo-7,8-dihydroguanine stability. Free Radic Biol Med 48:89–97
    • (2010) Free Radic Biol Med , vol.48 , pp. 89-97
    • Hu, C.W.1    Chao, M.R.2    Sie, C.H.3
  • 24
    • 77954145429 scopus 로고    scopus 로고
    • Correlation between concentrations of 8-oxo-7,8-dihydro-2′-deoxyguanosine in urine, plasma and saliva measured by on-line solid-phase extraction LC–MS/MS
    • COI: 1:CAS:528:DC%2BC3cXotVCmsr0%3D, PID: 20438722
    • Hu CW, Huang YJ, Li YJ, Chao MR (2010b) Correlation between concentrations of 8-oxo-7,8-dihydro-2′-deoxyguanosine in urine, plasma and saliva measured by on-line solid-phase extraction LC–MS/MS. Clin Chim Acta 411:1218–1222
    • (2010) Clin Chim Acta , vol.411 , pp. 1218-1222
    • Hu, C.W.1    Huang, Y.J.2    Li, Y.J.3    Chao, M.R.4
  • 26
    • 84861017463 scopus 로고    scopus 로고
    • Rapid measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography–tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BC38XotVeiurw%3D, PID: 22542794
    • Lam PM, Mistry V, Marczylo TH, Konje JC, Evans MD, Cooke MS (2012) Rapid measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography–tandem mass spectrometry. Free Radic Biol Med 52:2057–2063
    • (2012) Free Radic Biol Med , vol.52 , pp. 2057-2063
    • Lam, P.M.1    Mistry, V.2    Marczylo, T.H.3    Konje, J.C.4    Evans, M.D.5    Cooke, M.S.6
  • 28
    • 0037663202 scopus 로고    scopus 로고
    • Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS
    • COI: 1:CAS:528:DC%2BD3sXltV2jsL8%3D, PID: 12964746
    • Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 75:3019–3030
    • (2003) Anal Chem , vol.75 , pp. 3019-3030
    • Matuszewski, B.K.1    Constanzer, M.L.2    Chavez-Eng, C.M.3
  • 29
    • 84895602967 scopus 로고    scopus 로고
    • Saliva as a matrix for human biomonitoring in occupational and environmental medicine. Int Arch Occup Environ Health
    • Michalke B, Rossbach B, Göen T, Schäferhenrich A, Scherer G (2014) Saliva as a matrix for human biomonitoring in occupational and environmental medicine. Int Arch Occup Environ Health. doi:10.1007/s00420-014-0938-5
    • (2014)
    • Michalke, B.1    Rossbach, B.2    Göen, T.3    Schäferhenrich, A.4    Scherer, G.5
  • 31
    • 41849133569 scopus 로고    scopus 로고
    • The change of oxidative stress products in diabetes mellitus and diabetic retinopathy
    • PID: 18369071
    • Pan HZ, Zhang H, Chang D, Li H, Sui H (2008) The change of oxidative stress products in diabetes mellitus and diabetic retinopathy. Br J Ophthalmol 92:548–551
    • (2008) Br J Ophthalmol , vol.92 , pp. 548-551
    • Pan, H.Z.1    Zhang, H.2    Chang, D.3    Li, H.4    Sui, H.5
  • 32
    • 0037420211 scopus 로고    scopus 로고
    • Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography–tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BD3sXmtVaksbc%3D, PID: 12554139
    • Polson C, Sarkar P, Incledon B, Raguvaran V, Grant R (2003) Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography–tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 785:263–275
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.785 , pp. 263-275
    • Polson, C.1    Sarkar, P.2    Incledon, B.3    Raguvaran, V.4    Grant, R.5
  • 33
    • 84942857793 scopus 로고    scopus 로고
    • Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid
    • COI: 1:CAS:528:DC%2BC3sXhtVOrtLnP, PID: 23791936
    • Poulsen HE, Nadal LL, Broedbaek K, Nielsen PE, Weimann A (2014) Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluid. Biochim Biophys Acta 1840:801–808
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 801-808
    • Poulsen, H.E.1    Nadal, L.L.2    Broedbaek, K.3    Nielsen, P.E.4    Weimann, A.5
  • 34
    • 84859418108 scopus 로고    scopus 로고
    • Urinary 8-oxoguanine as a predictor of survival in patients undergoing radiotherapy
    • COI: 1:CAS:528:DC%2BC38XkvVCjtbc%3D, PID: 22301827
    • Roszkowski K, Olinski R (2012) Urinary 8-oxoguanine as a predictor of survival in patients undergoing radiotherapy. Cancer Epidemiol Biomarkers Prev 21:629–634
    • (2012) Cancer Epidemiol Biomarkers Prev , vol.21 , pp. 629-634
    • Roszkowski, K.1    Olinski, R.2
  • 36
    • 84858256306 scopus 로고    scopus 로고
    • Increased salivary levels of 8-hydroxydeoxyguanosine may be a marker for disease activity for periodontitis
    • COI: 1:CAS:528:DC%2BC38XivV2htLk%3D, PID: 22377732
    • Sezer U, Cicek Y, Canakci CF (2012) Increased salivary levels of 8-hydroxydeoxyguanosine may be a marker for disease activity for periodontitis. Dis Markers 32:165–172
    • (2012) Dis Markers , vol.32 , pp. 165-172
    • Sezer, U.1    Cicek, Y.2    Canakci, C.F.3
  • 37
  • 38
    • 77949542434 scopus 로고    scopus 로고
    • 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer
    • COI: 1:CAS:528:DC%2BC3cXjt1ymsr8%3D, PID: 20179711
    • Sova H, Jukkola-Vuorinen A, Puistola U, Kauppila S, Karihtala P (2010) 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer. Br J Cancer 102:1018–1023
    • (2010) Br J Cancer , vol.102 , pp. 1018-1023
    • Sova, H.1    Jukkola-Vuorinen, A.2    Puistola, U.3    Kauppila, S.4    Karihtala, P.5
  • 39
    • 61449175649 scopus 로고    scopus 로고
    • Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease
    • COI: 1:CAS:528:DC%2BD1MXivVKgtbg%3D, PID: 19280702
    • Su H, Gornitsky M, Velly AM, Yu H, Benarroch M, Schipper HM (2009) Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease. Free Radic Biol Med 46:914–921
    • (2009) Free Radic Biol Med , vol.46 , pp. 914-921
    • Su, H.1    Gornitsky, M.2    Velly, A.M.3    Yu, H.4    Benarroch, M.5    Schipper, H.M.6
  • 41
    • 0028948592 scopus 로고
    • Changes in the urinary excretion level of 8-hydroxyguanine by exposure to reactive oxygen-generating substances
    • COI: 1:CAS:528:DyaK2MXjsFyhurc%3D, PID: 9101233
    • Suzuki J, Inoue Y, Suzuki S (1995) Changes in the urinary excretion level of 8-hydroxyguanine by exposure to reactive oxygen-generating substances. Free Radic Biol Med 18:431–436
    • (1995) Free Radic Biol Med , vol.18 , pp. 431-436
    • Suzuki, J.1    Inoue, Y.2    Suzuki, S.3
  • 42
    • 33745805544 scopus 로고    scopus 로고
    • Urinary 8-hydroxyguanine may be a better marker of oxidative stress than 8-hydroxydeoxyguanosine in relation to the life spans of various species
    • COI: 1:CAS:528:DC%2BD28XlsFOntbg%3D, PID: 16771688
    • Svoboda P, Maekawa M, Kawai K, Tominaga T, Savela K, Kasai H (2006) Urinary 8-hydroxyguanine may be a better marker of oxidative stress than 8-hydroxydeoxyguanosine in relation to the life spans of various species. Antioxid Redox Signal 8:985–992
    • (2006) Antioxid Redox Signal , vol.8 , pp. 985-992
    • Svoboda, P.1    Maekawa, M.2    Kawai, K.3    Tominaga, T.4    Savela, K.5    Kasai, H.6
  • 43
    • 77954675024 scopus 로고    scopus 로고
    • Involvement of oxidatively damaged DNA and repair in cancer development and aging
    • COI: 1:CAS:528:DC%2BC3cXms1Wls7s%3D, PID: 20589166
    • Tudek B, Winczura A, Janik J, Siomek A, Foksinski M, Olinski R (2010) Involvement of oxidatively damaged DNA and repair in cancer development and aging. Am J Transl Res 2:254–284
    • (2010) Am J Transl Res , vol.2 , pp. 254-284
    • Tudek, B.1    Winczura, A.2    Janik, J.3    Siomek, A.4    Foksinski, M.5    Olinski, R.6
  • 44
    • 0037082154 scopus 로고    scopus 로고
    • Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography–electrospray tandem mass spectrometry
    • PID: 11788733
    • Weimann A, Belling D, Poulsen HE (2002) Quantification of 8-oxo-guanine and guanine as the nucleobase, nucleoside and deoxynucleoside forms in human urine by high-performance liquid chromatography–electrospray tandem mass spectrometry. Nucleic Acids Res 30:E7
    • (2002) Nucleic Acids Res , vol.30 , pp. E7
    • Weimann, A.1    Belling, D.2    Poulsen, H.E.3
  • 45
    • 0034633110 scopus 로고    scopus 로고
    • Oral mucosal embryology and histology
    • COI: 1:STN:280:DC%2BD3M7gtlWksw%3D%3D, PID: 11134845
    • Winning TA, Townsend GC (2000) Oral mucosal embryology and histology. Clin Dermatol 18:499–511
    • (2000) Clin Dermatol , vol.18 , pp. 499-511
    • Winning, T.A.1    Townsend, G.C.2
  • 46
    • 0031912917 scopus 로고    scopus 로고
    • Simultaneous determination of creatine, uric acid, creatinine and hippuric acid in urine by high performance liquid chromatography
    • COI: 1:CAS:528:DyaK1cXit1Gjsb8%3D, PID: 9568268
    • Yang YD (1998) Simultaneous determination of creatine, uric acid, creatinine and hippuric acid in urine by high performance liquid chromatography. Biomed Chromatogr 12:47–49
    • (1998) Biomed Chromatogr , vol.12 , pp. 47-49
    • Yang, Y.D.1
  • 47
    • 48249157303 scopus 로고    scopus 로고
    • Urinary excretion of an oxidative stress marker, 8-hydroxyguanine (8-OH-Gua), among nickel–cadmium battery workers
    • COI: 1:CAS:528:DC%2BD1cXotFeitb0%3D, PID: 18408348
    • Yoshioka N, Nakashima H, Hosoda K, Eitaki Y, Shimada N, Omae K (2008) Urinary excretion of an oxidative stress marker, 8-hydroxyguanine (8-OH-Gua), among nickel–cadmium battery workers. J Occup Health 50:229–235
    • (2008) J Occup Health , vol.50 , pp. 229-235
    • Yoshioka, N.1    Nakashima, H.2    Hosoda, K.3    Eitaki, Y.4    Shimada, N.5    Omae, K.6


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