Neuropsin Expression Correlates with Dendritic Marker MAP2c Level in Different Brain Regions of Aging Mice

Molecular Neurobiology

Volumn 51, Issue 3, 2015, Pages 1130-1138

  Konar, Arpita ^a   Thakur, M K ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Aging; Gene expression; L1CAM; MAP2c; Neuropsin

Indexed keywords

KALLIKREIN; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, MOUSE; PRSS19 PROTEIN, MOUSE;

AGING; ANIMAL; BIOSYNTHESIS; BRAIN; DENDRITE; GENE EXPRESSION REGULATION; MALE; METABOLISM; MOUSE; PATHOLOGY;

AGING; ANIMALS; BRAIN; DENDRITES; GENE EXPRESSION REGULATION; KALLIKREINS; MALE; MICE; MICROTUBULE-ASSOCIATED PROTEINS;

EID: 84939880145     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8780-z     Document Type: Article

References (33)

1. Chen ZL, Yoshida S, Kate K, Momota Y, Suzuki J, Tanaka T, lto J, Nishino H, Aimoto S, Hiroshi K, Shiosaka S (1995) Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus. J Neurosci 75:5088–5097
2. Tamura H, Ishikawa Y, Hino N, Maeda M, Yoshida S, Kaku S, Shiosaka S (2006) Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo. J Physiol 570:541–551
3. Matsumoto-Miyai K, Ninomiya A, Yamasaki H, Tamura H, Nakamura Y, Shiosaka S (2003) NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. J Neurosci 23:7727–7736
4. Nakamura Y, Tamura H, Horinouchi K, Shiosaka S (2005) Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons. J Cell Sci 119:1341–1349
5. Uthaman SB, Godenschwege TA (2009) L1-type cell adhesion molecules: distinct roles in synaptic targeting, organization and function. In: Umemori H, Hortsch M (eds) The sticky synapse cell adhesion molecules and their role in synapse formation and maintenance. Springer, New York, pp 247–263
6. Poplawski GHD, Tranziska AK, Leshchyns’ka I, Meier ID, Streichert T, Sytnyk V, Schachner M (2012) L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth. Mol Cell Neurosci 50:169–178
7. Haley GE, Kohama SG, Urbanski HF, Raber J (2010) Age-related decreases in SYN levels associated with increases in MAP-2, apoE, and GFAP levels in the rhesus macaque prefrontal cortex and hippocampus. Age (Dordr) 32:283–296
8. Bano D, Agostini M, Melino G, Nicotera P (2011) Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect. Mol Neurobiol 43:124–130
9. Gleichmann M, Zhang Y, Wood WH III, Becker KG, Mughal MR, Pazin MJ, Praaga H, Kobiloa T, Zonderman AB, Troncoso JC, Markesbery WR, Mattson MP (2012) Molecular changes in brain aging and Alzheimer’s disease are mirrored in experimentally silenced cortical neuron networks. Neurobiol Aging 33:205.e1–205.e18
10. Sibille E (2013) Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders. Dialogues Clin Neurosci 15:53–56
11. Rutten BP, Korr H, Steinbusch HW, Schmitz C (2003) The aging brain: less neurons could be better. Mech Ageing Dev 124:349–355
12. Schliebs R, Arendt T (2011) The cholinergic system in aging and neuronal degeneration. Behav Brain Res 221:555–563
13. Thakur MK, Konar A, Gautam A (2012) Brain aging: a critical reappraisal. In: Thakur MK, Rattan SIS (eds) Brain aging and therapeutic interventions. Springer, New York, pp 1–18
14. Burger C (2010) Region-specific genetic alterations in the aging hippocampus: implications for cognitive aging. Front Aging Neurosci 2:1–8
15. Kumar A, Thakur MK (2012) Presenilin 1 and 2 are expressed differentially in the cerebral cortex of mice during development. Neurochem Int 61:778–782
16. Harada A, Shiosaka S, Ishikawa Y, Komai S (2008) Acute stress increases neuropsin mRNA expression in the mouse hippocampus through the glucocorticoid pathway. Neurosci Lett 436:273–277
17. Xu Q, Walker D, Bernardo A, Brodbeck J, Balestra EM, Huang Y (2008) Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS. J Neurosci 28:1452–1459
18. Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A, Shiosaka S (1995) Ontogeny of neuropsin mRNA expression in the mouse brain. Neurosci Res 23:345–351
19. Burke SN, Barnes CA (2006) Neural plasticity in the ageing brain. Nat Rev Neurosci 7:30–40
20. Crivello NA, Rosenberg IH, Shukitt-Hale B, Bielinski D, Dallal GE, Joseph JA (2007) Aging modifies brain region-specific vulnerability to experimental oxidative stress induced by low dose hydrogen peroxide. Age (Dordr) 4:191–203
21. Zhao C, Deng W, Gage FH (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132:645–660
22. Konar A (2013) Molecular analysis of neuropsin in ashwagandha-mediated recovery of scopolamine-induced amnesia and in aging mouse brain. Phd Thesis. Banaras Hindu University, India
23. Loers G, Chen S, Grumet M, Schachner M (2005) Signal transduction pathways implicated in neural recognition molecule L1 triggered neuroprotection and neuritogenesis. J Neurochem 92:1463–1476
24. Riedle S, Kiefel H, Gast D, Bondong S, Wolterink S, Gutwein P, Altevogt P (2009) Nuclear translocation and signalling of L1-CAM in human carcinoma cells requiresADAM10 and presenilin/gamma-secretase activity. Biochem J 420:391–402
25. Wallace AS, Schmidt C, Schachner M, Wegner M, Anderson RB (2010) L1cam acts as a modifier gene during enteric nervous system development. Neurobiol Dis 40:622–633
26. Kiefel H, Pfeifer M, Bondong S, Hazin J, Altevogt P (2010) Linking L1CAM-mediated signaling to NF-κB activation. Trends Mol Med 17:178–187
27. Viereck C, Tucker RP, Matus A (1989) The adult rat olfactory system expresses microtubule-associated proteins found in the developing brain. J Neurosci 9:3547–3557
28. Palmer TD, Takahashi J, Gage FH (1997) The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8:389–404
29. Di Stefano G, Casoli T, Fattoretti P, Gracciotti N, Solazzi M, Bertoni-Freddari C (2001) Distribution of map2 in hippocampus and cerebellum of young and old rats by quantitative immunohistochemistry. J Histochem Cytochem 49:1065–1066
30. Pavlov I, Lauri S, Taira T, Rauvala H (2004) The role of ECM molecules in activity-dependent synaptic development and plasticity. Birth Defects Res 72:12–24
31. Lee TW, Tsang VW, Birch NP (2008) Synaptic plasticity associated proteases and protease inhibitors in the brain linked to the processing of extracellular matrix and cell adhesion molecules. Neuron Glia Biol 4:223–234
32. Dityatev A, Schachner M, Sonderegger P (2010) The dual role of the extracellular matrix in synaptic plasticity and homeostasis. Nat Rev Neurosci 11:735–746
33. Wlodarczyk J, Mukhina I, Kaczmarek L, Dityatev A (2011) Extracellular matrix molecules, their receptors, and secreted proteases in synaptic plasticity. 71: 1040-1053