Impact of ciprofloxacin and clindamycin administration on Gram-negative bacteria isolated from healthy volunteers and characterization of the resistance genes they harbor

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 8, 2015, Pages 4410-4416

  Card, Roderick M ^a   Mafura, Muriel ^a   Hunt, Theresa ^a   Kirchner, Miranda ^a   Weile, Jan ^b   Rashid, Mamun Ur ^c   Weintraub, Andrej ^c   Nord, Carl Erik ^c   Anjum, Muna F ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b ST JOSEF HOSPITAL   (Germany)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE CTX M; CHLORAMPHENICOL DERIVATIVE; CIPROFLOXACIN; CLINDAMYCIN; MACROLIDE; PLACEBO; QUINOLONE DERIVATIVE; SULFANILAMIDE; SULFONAMIDE; TETRACYCLINE DERIVATIVE; TRIMETHOPRIM; ANTIINFECTIVE AGENT; BETA LACTAMASE;

ADULT; AEROBIC BACTERIUM; ANAEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COUNT; BACTERIUM CULTURE; BACTERIUM ISOLATION; BACTEROIDES; CITROBACTER FREUNDII; COMAMONAS; COMAMONAS KERSTERSII; CONTROLLED STUDY; ENTEROBACTERIACEAE; ESCHERICHIA COLI; FECES ANALYSIS; FUSOBACTERIA; GENETIC ASSOCIATION; GRAM NEGATIVE BACTERIUM; HAFNIA ALVEI; HUMAN; KLEBSIELLA; KLEBSIELLA PNEUMONIAE; LEPTOTRICHIA; MICROBIAL DIVERSITY; MOLECULAR CLONING; NONHUMAN; NORMAL HUMAN; PREVOTELLA; PRIORITY JOURNAL; PROTEUS; RANDOMIZED CONTROLLED TRIAL; SALIVA ANALYSIS; VEILLONELLA; VEILLONELLA COCCI; DRUG EFFECTS; FECES; GENETICS; GRAM-NEGATIVE BACTERIAL INFECTIONS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MICROFLORA; SALIVA;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CIPROFLOXACIN; CLINDAMYCIN; DRUG RESISTANCE, BACTERIAL; FECES; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HEALTHY VOLUNTEERS; HUMANS; MICROBIOTA; SALIVA;

EID: 84939865017     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00068-15     Document Type: Article

References (36)

1. Freire-Moran L, Aronsson B, Manz C, Gyssens IC, So AD, Monnet DL, Cars O, ECDC-EMA Working Group. 2011. Critical shortage of new antibiotics in development against multidrug-resistant bacteria-Time to react is now. Drug Resist Updat 14:118-124. http://dx.doi.org/10.1016/j.drup.2011.02.003.
2. Jakobsson HE, Jernberg C, Andersson AF, Sjolund-Karlsson M, Jansson JK, Engstrand L. 2010. Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. PLoS One 5:e9836. http://dx.doi.org/10.1371/journal.pone.0009836.
3. Löfmark S, Jernberg C, Jansson JK, Edlund C. 2006. Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes. J Antimicrob Chemother 58:1160-1167. http://dx.doi.org/10.1093/jac/dkl420.
4. Nord CE, Sillerstrom E, Wahlund E. 2006. Effect of tigecycline on normal oropharyngeal and intestinal microflora. Antimicrob Agents Chemother 50:3375-3380. http://dx.doi.org/10.1128/AAC.00373-06.
5. Nyberg SD, Osterblad M, Hakanen AJ, Lofmark S, Edlund C, Huovinen P, Jalava J. 2007. Long-term antimicrobial resistance in Escherichia coli from human intestinal microbiota after administration of clindamycin. Scand J Infect Dis 39:514-520. http://dx.doi.org/10.1080/00365540701199790.
6. Kirchner M, Mafura M, Hunt T, Abu-Oun M, Nunez-Garcia J, Hu Y, Weile J, Coates A, Card R, Anjum MF. 2014. Antimicrobial resistance characteristics and fitness of Gram negative faecal bacteria from volunteers treated with minocycline or amoxicillin. Front Microbiol 5:722. http://dx.doi.org/10.3389/fmicb.2014.00722.
7. Machado E, Coque TM, Canton R, Sousa JC, Peixe L. 2013. Commensal Enterobacteriaceae as reservoirs of extended-spectrum beta-lactamases, integrons, and sul genes in Portugal. Front Microbiol 4:80. http://dx.doi.org/10.3389/fmicb.2013.00080.
8. TEM-containing transposons in commensal Escherichia coli. J Antimicrob Chemother 66:745-751. http://dx.doi.org/10.1093/jac/dkq529.
9. Salyers AA, Gupta A, Wang Y. 2004. Human intestinal bacteria as reservoirs for antibiotic resistance genes. Trends Microbiol 12:412-416. http://dx.doi.org/10.1016/j.tim.2004.07.004.
10. Sommer MO, Dantas G, Church GM. 2009. Functional characterization of the antibiotic resistance reservoir in the human microflora. Science 325:1128-1131. http://dx.doi.org/10.1126/science.1176950.
11. Zhang L, Kinkelaar D, Huang Y, Li Y, Li X, Wang HH. 2011. Acquired antibiotic resistance: are we born with it? Appl Environ Microbiol 77:7134-7141. http://dx.doi.org/10.1128/AEM.05087-11.
12. Card RM, Warburton PJ, MacLaren N, Mullany P, Allan E, Anjum MF. 2014. Application of microarray and functional-based screening methods for the detection of antimicrobial resistance genes in the microbiomes of healthy humans. PLoS One 9:e86428. http://dx.doi.org/10.1371/journal.pone.0086428.
13. Pallett A, Hand K. 2010. Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria. J Antimicrob Chemother 65(Suppl 3):iii25-iii33. http://dx.doi.org/10.1093/jac/dkq298.
14. Woodford N, Turton JF, Livermore DM. 2011. Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. FEMS Microbiol Rev 35:736-755. http://dx.doi.org/10.1111/j.1574-6976.2011.00268.x.
15. Jacoby GA. 2005. Mechanisms of resistance to quinolones. Clin Infect Dis 41(Suppl 2):S120-S126. http://dx.doi.org/10.1086/428052.
16. Gold HS, Moellering RC, Jr. 1999. Macrolides and clindamycin, p 291-297. In Root RK, Waldvogel F, Corey L, Stamm WE (ed), Clinical infectious diseases: a practical approach. Oxford University Press, New York, NY.
17. Fitzgerald C, Collins M, van Duyne S, Mikoleit M, Brown T, Fields P. 2007. Multiplex, bead-based suspension array for molecular determination of common Salmonella serogroups. J Clin Microbiol 45:3323-3334. http://dx.doi.org/10.1128/JCM.00025-07.
18. Seng P, Drancourt M, Gouriet F, La Scola B, Fournier PE, Rolain JM, Raoult D. 2009. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis 49:543-551. http://dx.doi.org/10.1086/600885.
19. Kirchner M, Mafura M, Hunt T, Card R, Anjum MF. 2013. Antibiotic resistance gene profiling of faecal and oral anaerobes collected during an antibiotic challenge trial. Anaerobe 23:20-22. http://dx.doi.org/10.1016/j.anaerobe.2013.07.011.
20. Card R, Zhang J, Das P, Cook C, Woodford N, Anjum MF. 2013. Evaluation of an expanded microarray for detecting antibiotic resistance genes in a broad range of gram-negative bacterial pathogens. Antimicrob Agents Chemother 57:458-465. http://dx.doi.org/10.1128/AAC.01223-12.
21. Whiting JL, Cheng N, Chow AW. 1987. Interactions of ciprofloxacin with clindamycin, metronidazole, cefoxitin, cefotaxime, and mezlocillin against gram-positive and gram-negative anaerobic bacteria. Antimicrob Agents Chemother 31:1379-1382. http://dx.doi.org/10.1128/AAC.31.9.1379.
22. Couturier MR, Slechta ES, Goulston C, Fisher MA, Hanson KE. 2012. Leptotrichia bacteremia in patients receiving high-dose chemotherapy. J Clin Microbiol 50:1228-1232. http://dx.doi.org/10.1128/JCM.05926-11.
23. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. 2005. Diversity of the human intestinal microbial flora. Science 308:1635-1638. http://dx.doi.org/10.1126/science.1110591.
24. Keijser BJ, Zaura E, Huse SM, van der Vossen JM, Schuren FH, Montijn RC, ten Cate JM, Crielaard W. 2008. Pyrosequencing analysis of the oral microflora of healthy adults. J Dent Res 87:1016-1020. http://dx.doi.org/10.1177/154405910808701104.
25. Blahna MT, Zalewski CA, Reuer J, Kahlmeter G, Foxman B, Marrs CF. 2006. The role of horizontal gene transfer in the spread of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada. J Antimicrob Chemother 57:666-672. http://dx.doi.org/10.1093/jac/dkl020.
26. Philippon A, Arlet G, Jacoby GA. 2002. Plasmid-determined AmpC-type beta-lactamases. Antimicrob Agents Chemother 46:1-11. http://dx.doi.org/10.1128/AAC.46.1.1-11.2002.
27. Jacoby GA, Griffin CM, Hooper DC. 2011. Citrobacter spp. as a source of qnrB alleles. Antimicrob Agents Chemother 55:4979-4984. http://dx.doi.org/10.1128/AAC.05187-11.
28. Strahilevitz J, Jacoby GA, Hooper DC, Robicsek A. 2009. Plasmid-mediated quinolone resistance: a multifaceted threat. Clin Microbiol Rev 22:664-689. http://dx.doi.org/10.1128/CMR.00016-09.
29. Coque TM, Baquero F, Canton R. 2008. Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe. Euro Surveill 13(47):pii:19044. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19044.
30. Kirchner M, Abuoun M, Mafura M, Bagnall M, Hunt T, Thomas C, Weile J, Anjum MF. 2013. Cefotaxime resistant Escherichia coli collected from a healthy volunteer; characterisation and the effect of plasmid loss. PLoS One 8:e84142. http://dx.doi.org/10.1371/journal.pone.0084142.
31. Tenaillon O, Skurnik D, Picard B, Denamur E. 2010. The population genetics of commensal Escherichia coli. Nat Rev Microbiol 8:207-217. http://dx.doi.org/10.1038/nrmicro2298.
32. Wexler HM. 2007. Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev 20:593-621. http://dx.doi.org/10.1128/CMR.00008-07.
33. Tribble GD, Garza JJ, Yeung VL, Rigney TW, Dao DH, Rodrigues PH, Walker CB, Smith CJ. 2010. Genetic analysis of mobile tetQ elements in oral Prevotella species. Anaerobe 16:604-609. http://dx.doi.org/10.1016/j.anaerobe.2010.08.008.
34. Park BH, Levy SB. 1988. The cryptic tetracycline resistance determinant on Tn4400 mediates tetracycline degradation as well as tetracycline efflux. Antimicrob Agents Chemother 32:1797-1800. http://dx.doi.org/10.1128/AAC.32.12.1797.
35. Iwahara K, Kuriyama T, Shimura S, Williams DW, Yanagisawa M, Nakagawa K, Karasawa T. 2006. Detection of cfxA and cfxA2, the beta-lactamase genes of Prevotella spp., in clinical samples from dentoalveolar infection by real-time PCR. J Clin Microbiol 44:172-176. http://dx.doi.org/10.1128/JCM.44.1.172-176.2006.
36. van Hoek AH, Mevius D, Guerra B, Mullany P, Roberts AP, Aarts HJ. 2011. Acquired antibiotic resistance genes: an overview. Front Microbiol 2:203. http://dx.doi.org/10.3389/fmicb.2011.00203.