메뉴 건너뛰기




Volumn 14, Issue 7, 2015, Pages 2807-2818

A Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery

Author keywords

biomarker; breast cancer; estrogen receptor; HER2; LC MS MS; MRM; N glycosylation; shotgun proteomics; SRM; targeted proteomics

Indexed keywords

BIOLOGICAL MARKER; ESTROGEN RECEPTOR; GLYCOPEPTIDE; PROTEOME; TUMOR MARKER;

EID: 84939840284     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.5b00315     Document Type: Article
Times cited : (29)

References (72)
  • 1
    • 84860663487 scopus 로고    scopus 로고
    • The descriptive epidemiology of female breast cancer: An international comparison of screening, incidence, survival and mortality
    • Youlden, D. R.; Cramb, S. M.; Dunn, N. A.; Muller, J. M.; Pyke, C. M.; Baade, P. D. The descriptive epidemiology of female breast cancer: an international comparison of screening, incidence, survival and mortality Cancer Epidemiol. 2012, 36 (3) 237-248
    • (2012) Cancer Epidemiol. , vol.36 , Issue.3 , pp. 237-248
    • Youlden, D.R.1    Cramb, S.M.2    Dunn, N.A.3    Muller, J.M.4    Pyke, C.M.5    Baade, P.D.6
  • 5
    • 33750541932 scopus 로고    scopus 로고
    • Molecular classification of breast cancer: Implications for selection of adjuvant chemotherapy
    • Andre, F.; Pusztai, L. Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy Nat. Clin. Pract. Oncol. 2006, 3 (11) 621-632
    • (2006) Nat. Clin. Pract. Oncol. , vol.3 , Issue.11 , pp. 621-632
    • Andre, F.1    Pusztai, L.2
  • 6
    • 84925831666 scopus 로고    scopus 로고
    • Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications
    • Iqbal, N.; Iqbal, N. Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications Mol. Biol. Int. 2014, 2014, 852748
    • (2014) Mol. Biol. Int. , vol.2014 , pp. 852748
    • Iqbal, N.1    Iqbal, N.2
  • 7
    • 23144442644 scopus 로고    scopus 로고
    • Breast cancer metastasis: Markers and models
    • Weigelt, B.; Peterse, J. L.; van t Veer, L. J. Breast cancer metastasis: markers and models Nat. Rev. Cancer 2005, 5 (8) 591-602
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.8 , pp. 591-602
    • Weigelt, B.1    Peterse, J.L.2    Van t Veer, L.J.3
  • 8
    • 39149113165 scopus 로고    scopus 로고
    • Development of the 21-gene assay and its application in clinical practice and clinical trials
    • Sparano, J. A.; Paik, S. Development of the 21-gene assay and its application in clinical practice and clinical trials J. Clin. Oncol. 2008, 26 (5) 721-728
    • (2008) J. Clin. Oncol. , vol.26 , Issue.5 , pp. 721-728
    • Sparano, J.A.1    Paik, S.2
  • 10
    • 0033016717 scopus 로고    scopus 로고
    • Correlation between protein and mRNA abundance in yeast
    • Gygi, S. P.; Rochon, Y.; Franza, B. R.; Aebersold, R. Correlation between protein and mRNA abundance in yeast Mol. Cell. Biol. 1999, 19 (3) 1720-1730
    • (1999) Mol. Cell. Biol. , vol.19 , Issue.3 , pp. 1720-1730
    • Gygi, S.P.1    Rochon, Y.2    Franza, B.R.3    Aebersold, R.4
  • 12
    • 0030895921 scopus 로고    scopus 로고
    • A comparison of selected mRNA and protein abundances in human liver
    • Anderson, L.; Seilhamer, J. A comparison of selected mRNA and protein abundances in human liver Electrophoresis 1997, 18 (3-4) 533-537
    • (1997) Electrophoresis , vol.18 , Issue.34 , pp. 533-537
    • Anderson, L.1    Seilhamer, J.2
  • 13
    • 0037338365 scopus 로고    scopus 로고
    • Proteomic analysis of post-translational modifications
    • Mann, M.; Jensen, O. N. Proteomic analysis of post-translational modifications Nat. Biotechnol. 2003, 21 (3) 255-261
    • (2003) Nat. Biotechnol. , vol.21 , Issue.3 , pp. 255-261
    • Mann, M.1    Jensen, O.N.2
  • 16
    • 77953240454 scopus 로고    scopus 로고
    • Precision mapping of an in vivo N-glycoproteome reveals rigid topological and sequence constraints
    • Zielinska, D. F.; Gnad, F.; Wisniewski, J. R.; Mann, M. Precision mapping of an in vivo N-glycoproteome reveals rigid topological and sequence constraints Cell 2010, 141 (5) 897-907
    • (2010) Cell , vol.141 , Issue.5 , pp. 897-907
    • Zielinska, D.F.1    Gnad, F.2    Wisniewski, J.R.3    Mann, M.4
  • 17
    • 84873948403 scopus 로고    scopus 로고
    • Characterization of disease-associated N-linked glycoproteins
    • Tian, Y.; Zhang, H. Characterization of disease-associated N-linked glycoproteins Proteomics 2013, 13 (3-4) 504-511
    • (2013) Proteomics , vol.13 , Issue.34 , pp. 504-511
    • Tian, Y.1    Zhang, H.2
  • 18
    • 78650486082 scopus 로고    scopus 로고
    • Clinical application of proteomics in breast cancer: State of the art and perspectives
    • Goncalves, A.; Bertucci, F. Clinical application of proteomics in breast cancer: State of the art and perspectives Med. Princ. Pract. 2011, 20 (1) 4-18
    • (2011) Med. Princ. Pract. , vol.20 , Issue.1 , pp. 4-18
    • Goncalves, A.1    Bertucci, F.2
  • 21
    • 53049107225 scopus 로고    scopus 로고
    • Proteome profile of human breast cancer tissue generated by LC-ESI-MS/MS combined with sequential protein precipitation and solubilization
    • Gong, Y.; Wang, N.; Wu, F.; Cass, C. E.; Damaraju, S.; Mackey, J. R.; Li, L. Proteome profile of human breast cancer tissue generated by LC-ESI-MS/MS combined with sequential protein precipitation and solubilization J. Proteome Res. 2008, 7 (8) 3583-3590
    • (2008) J. Proteome Res. , vol.7 , Issue.8 , pp. 3583-3590
    • Gong, Y.1    Wang, N.2    Wu, F.3    Cass, C.E.4    Damaraju, S.5    Mackey, J.R.6    Li, L.7
  • 23
    • 60849093488 scopus 로고    scopus 로고
    • Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis
    • Bouchal, P.; Roumeliotis, T.; Hrstka, R.; Nenutil, R.; Vojtesek, B.; Garbis, S. D. Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis J. Proteome Res. 2009, 8 (1) 362-373
    • (2009) J. Proteome Res. , vol.8 , Issue.1 , pp. 362-373
    • Bouchal, P.1    Roumeliotis, T.2    Hrstka, R.3    Nenutil, R.4    Vojtesek, B.5    Garbis, S.D.6
  • 24
    • 67049095042 scopus 로고    scopus 로고
    • Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry
    • Leth-Larsen, R.; Lund, R.; Hansen, H. V.; Laenkholm, A. V.; Tarin, D.; Jensen, O. N.; Ditzel, H. J. Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry Mol. Cell Proteomics 2009, 8 (6) 1436-1449
    • (2009) Mol. Cell Proteomics , vol.8 , Issue.6 , pp. 1436-1449
    • Leth-Larsen, R.1    Lund, R.2    Hansen, H.V.3    Laenkholm, A.V.4    Tarin, D.5    Jensen, O.N.6    Ditzel, H.J.7
  • 25
    • 75749095246 scopus 로고    scopus 로고
    • The bottleneck in the cancer biomarker pipeline and protein quantification through mass spectrometry-based approaches: Current strategies for candidate verification
    • Makawita, S.; Diamandis, E. P. The bottleneck in the cancer biomarker pipeline and protein quantification through mass spectrometry-based approaches: current strategies for candidate verification Clin. Chem. 2010, 56 (2) 212-222
    • (2010) Clin. Chem. , vol.56 , Issue.2 , pp. 212-222
    • Makawita, S.1    Diamandis, E.P.2
  • 27
    • 55349134214 scopus 로고    scopus 로고
    • The interface between biomarker discovery and clinical validation: The tar pit of the protein biomarker pipeline
    • Paulovich, A. G.; Whiteaker, J. R.; Hoofnagle, A. N.; Wang, P. The interface between biomarker discovery and clinical validation: The tar pit of the protein biomarker pipeline Proteomics Clin. Appl. 2008, 2 (10-11) 1386-1402
    • (2008) Proteomics Clin. Appl. , vol.2 , Issue.1011 , pp. 1386-1402
    • Paulovich, A.G.1    Whiteaker, J.R.2    Hoofnagle, A.N.3    Wang, P.4
  • 28
    • 54049090766 scopus 로고    scopus 로고
    • Selected reaction monitoring for quantitative proteomics: A tutorial
    • Lange, V.; Picotti, P.; Domon, B.; Aebersold, R. Selected reaction monitoring for quantitative proteomics: a tutorial Mol. Syst. Biol. 2008, 4, 222
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 222
    • Lange, V.1    Picotti, P.2    Domon, B.3    Aebersold, R.4
  • 34
    • 84860508745 scopus 로고    scopus 로고
    • Proteomic portrait of human breast cancer progression identifies novel prognostic markers
    • Geiger, T.; Madden, S. F.; Gallagher, W. M.; Cox, J.; Mann, M. Proteomic portrait of human breast cancer progression identifies novel prognostic markers Cancer Res. 2012, 72 (9) 2428-2439
    • (2012) Cancer Res. , vol.72 , Issue.9 , pp. 2428-2439
    • Geiger, T.1    Madden, S.F.2    Gallagher, W.M.3    Cox, J.4    Mann, M.5
  • 36
    • 84908306037 scopus 로고    scopus 로고
    • Combination of a discovery LC-MS/MS analysis and a label-free quantification for the characterization of an epithelial-mesenchymal transition signature
    • Biarc, J.; Gonzalo, P.; Mikaelian, I.; Fattet, L.; Deygas, M.; Gillet, G.; Lemoine, J.; Rimokh, R. Combination of a discovery LC-MS/MS analysis and a label-free quantification for the characterization of an epithelial-mesenchymal transition signature J. Proteomics 2014, 110, 183-194
    • (2014) J. Proteomics , vol.110 , pp. 183-194
    • Biarc, J.1    Gonzalo, P.2    Mikaelian, I.3    Fattet, L.4    Deygas, M.5    Gillet, G.6    Lemoine, J.7    Rimokh, R.8
  • 38
    • 0029903614 scopus 로고    scopus 로고
    • Randomized trial of two versus five years of adjuvant tamoxifen for postmenopausal early stage breast cancer
    • Swedish Breast Cancer Cooperative Group, ()
    • Swedish Breast Cancer Cooperative Group Randomized trial of two versus five years of adjuvant tamoxifen for postmenopausal early stage breast cancer J. Natl. Cancer Inst. 1996, 88 (21) 1543-1549
    • (1996) J. Natl. Cancer Inst. , vol.88 , Issue.21 , pp. 1543-1549
  • 39
  • 41
    • 84892511644 scopus 로고    scopus 로고
    • Large-scale gene function analysis with the PANTHER classification system
    • Mi, H.; Muruganujan, A.; Casagrande, J. T.; Thomas, P. D. Large-scale gene function analysis with the PANTHER classification system Nat. Protoc. 2013, 8 (8) 1551-1566
    • (2013) Nat. Protoc. , vol.8 , Issue.8 , pp. 1551-1566
    • Mi, H.1    Muruganujan, A.2    Casagrande, J.T.3    Thomas, P.D.4
  • 42
    • 84874969184 scopus 로고    scopus 로고
    • PANTHER in 2013: Modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees
    • DATABASE ISSUE
    • Mi, H.; Muruganujan, A.; Thomas, P. D. PANTHER in 2013: Modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees Nucleic Acids Res. 2013, 41 (Database issue) D377-D386
    • (2013) Nucleic Acids Res. , vol.41 , pp. D377-D386
    • Mi, H.1    Muruganujan, A.2    Thomas, P.D.3
  • 44
    • 0036523840 scopus 로고    scopus 로고
    • Proteomic 2DE database for spot selection, automated annotation, and data analysis
    • Malmstrom, L.; Malmstrom, J.; Marko-Varga, G.; Westergren-Thorsson, G. Proteomic 2DE database for spot selection, automated annotation, and data analysis J. Proteome Res. 2002, 1 (2) 135-138
    • (2002) J. Proteome Res. , vol.1 , Issue.2 , pp. 135-138
    • Malmstrom, L.1    Malmstrom, J.2    Marko-Varga, G.3    Westergren-Thorsson, G.4
  • 47
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    • Gyorffy, B.; Lanczky, A.; Eklund, A. C.; Denkert, C.; Budczies, J.; Li, Q.; Szallasi, Z. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients Breast Cancer Res. Treat. 2010, 123 (3) 725-731
    • (2010) Breast Cancer Res. Treat. , vol.123 , Issue.3 , pp. 725-731
    • Gyorffy, B.1    Lanczky, A.2    Eklund, A.C.3    Denkert, C.4    Budczies, J.5    Li, Q.6    Szallasi, Z.7
  • 51
    • 84884368148 scopus 로고    scopus 로고
    • Western Blots vs. SRM Assays: Time to turn the tables?
    • Aebersold, R.; Burlingame, A. L.; Bradshaw, R. A. Western Blots vs. SRM Assays: Time to turn the tables? Mol. Cell Proteomics 2013, 12 (9) 2381-2382
    • (2013) Mol. Cell Proteomics , vol.12 , Issue.9 , pp. 2381-2382
    • Aebersold, R.1    Burlingame, A.L.2    Bradshaw, R.A.3
  • 53
    • 84895072645 scopus 로고    scopus 로고
    • Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins
    • Kennedy, J. J.; Abbatiello, S. E.; Kim, K. Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins Nat. Methods 2014, 11 (2) 149-155
    • (2014) Nat. Methods , vol.11 , Issue.2 , pp. 149-155
    • Kennedy, J.J.1    Abbatiello, S.E.2    Kim, K.3
  • 54
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen, P.; Hunter, T. Oncogenic kinase signalling Nature 2001, 411 (6835) 355-65
    • (2001) Nature , vol.411 , Issue.6835 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 55
    • 84879320040 scopus 로고    scopus 로고
    • Application of selected reaction monitoring for multiplex quantification of clinically validated biomarkers in formalin-fixed, paraffin-embedded tumor tissue
    • Hembrough, T.; Thyparambil, S.; Liao, W. L.; Darfler, M. M.; Abdo, J.; Bengali, K. M.; Hewitt, S. M.; Bender, R. A.; Krizman, D. B.; Burrows, J. Application of selected reaction monitoring for multiplex quantification of clinically validated biomarkers in formalin-fixed, paraffin-embedded tumor tissue J. Mol. Diagn 2013, 15 (4) 454-465
    • (2013) J. Mol. Diagn , vol.15 , Issue.4 , pp. 454-465
    • Hembrough, T.1    Thyparambil, S.2    Liao, W.L.3    Darfler, M.M.4    Abdo, J.5    Bengali, K.M.6    Hewitt, S.M.7    Bender, R.A.8    Krizman, D.B.9    Burrows, J.10
  • 56
    • 84860849265 scopus 로고    scopus 로고
    • Multiplexed quantification of estrogen receptor and HER2/Neu in tissue and cell lysates by peptide immunoaffinity enrichment mass spectrometry
    • Schoenherr, R. M.; Whiteaker, J. R.; Zhao, L.; Ivey, R. G.; Trute, M.; Kennedy, J.; Voytovich, U. J.; Yan, P.; Lin, C.; Paulovich, A. G. Multiplexed quantification of estrogen receptor and HER2/Neu in tissue and cell lysates by peptide immunoaffinity enrichment mass spectrometry Proteomics 2012, 12 (8) 1253-1260
    • (2012) Proteomics , vol.12 , Issue.8 , pp. 1253-1260
    • Schoenherr, R.M.1    Whiteaker, J.R.2    Zhao, L.3    Ivey, R.G.4    Trute, M.5    Kennedy, J.6    Voytovich, U.J.7    Yan, P.8    Lin, C.9    Paulovich, A.G.10
  • 57
    • 33645728120 scopus 로고    scopus 로고
    • Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells
    • Zimmerman, A. W.; Joosten, B.; Torensma, R.; Parnes, J. R.; van Leeuwen, F. N.; Figdor, C. G. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells Blood 2006, 107 (8) 3212-3220
    • (2006) Blood , vol.107 , Issue.8 , pp. 3212-3220
    • Zimmerman, A.W.1    Joosten, B.2    Torensma, R.3    Parnes, J.R.4    Van Leeuwen, F.N.5    Figdor, C.G.6
  • 59
    • 84883190665 scopus 로고    scopus 로고
    • Integrin alpha 7 Binds Tissue Inhibitor of Metalloproteinase 3 to Suppress Growth of Prostate Cancer Cells
    • Tan, L. Z.; Song, Y.; Nelson, J.; Yu, Y. P.; Luo, J. H. Integrin alpha 7 Binds Tissue Inhibitor of Metalloproteinase 3 to Suppress Growth of Prostate Cancer Cells Am. J. Pathol. 2013, 183 (3) 831-840
    • (2013) Am. J. Pathol. , vol.183 , Issue.3 , pp. 831-840
    • Tan, L.Z.1    Song, Y.2    Nelson, J.3    Yu, Y.P.4    Luo, J.H.5
  • 60
    • 84902339148 scopus 로고    scopus 로고
    • Role of secreted type i collagen derived from stromal cells in two breast cancer cell lines
    • Kim, S. H.; Lee, H. Y.; Jung, S. P.; Kim, S.; Lee, J. E.; Nam, S. J.; Bae, J. W. Role of secreted type I collagen derived from stromal cells in two breast cancer cell lines Oncol. Lett. 2014, 8 (2) 507-512
    • (2014) Oncol. Lett. , vol.8 , Issue.2 , pp. 507-512
    • Kim, S.H.1    Lee, H.Y.2    Jung, S.P.3    Kim, S.4    Lee, J.E.5    Nam, S.J.6    Bae, J.W.7
  • 62
    • 84898948755 scopus 로고    scopus 로고
    • Biglycan enhances gastric cancer invasion by activating FAK signaling pathway
    • Hu, L.; Duan, Y. T.; Li, J. F.; Su, L. P.; Yan, M.; Zhu, Z. G.; Liu, B. Y.; Yang, Q. M. Biglycan enhances gastric cancer invasion by activating FAK signaling pathway Oncotarget 2014, 5 (7) 1885-1896
    • (2014) Oncotarget , vol.5 , Issue.7 , pp. 1885-1896
    • Hu, L.1    Duan, Y.T.2    Li, J.F.3    Su, L.P.4    Yan, M.5    Zhu, Z.G.6    Liu, B.Y.7    Yang, Q.M.8
  • 63
    • 84896737072 scopus 로고    scopus 로고
    • Expression and significance of biglycan in endometrial cancer
    • Liu, Y.; Li, W.; Li, X.; Tai, Y.; Lu, Q.; Yang, N.; Jiang, J. Expression and significance of biglycan in endometrial cancer Arch Gynecol. Obstet. 2014, 289 (3) 649-655
    • (2014) Arch Gynecol. Obstet. , vol.289 , Issue.3 , pp. 649-655
    • Liu, Y.1    Li, W.2    Li, X.3    Tai, Y.4    Lu, Q.5    Yang, N.6    Jiang, J.7
  • 64
    • 84893450991 scopus 로고    scopus 로고
    • Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan
    • Bischof, A. G.; Yuksel, D.; Mammoto, T.; Mammoto, A.; Krause, S.; Ingber, D. E. Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan Integr. Biol. 2013, 5 (8) 1045-1056
    • (2013) Integr. Biol. , vol.5 , Issue.8 , pp. 1045-1056
    • Bischof, A.G.1    Yuksel, D.2    Mammoto, T.3    Mammoto, A.4    Krause, S.5    Ingber, D.E.6
  • 66
    • 84897009392 scopus 로고    scopus 로고
    • Functional role of endothelial adhesion molecules in the early stages of brain metastasis
    • Soto, M. S.; Serres, S.; Anthony, D. C.; Sibson, N. R. Functional role of endothelial adhesion molecules in the early stages of brain metastasis Neuro-Oncology 2014, 16 (4) 540-551
    • (2014) Neuro-Oncology , vol.16 , Issue.4 , pp. 540-551
    • Soto, M.S.1    Serres, S.2    Anthony, D.C.3    Sibson, N.R.4
  • 68
    • 84908884351 scopus 로고    scopus 로고
    • Proteomic and Functional Investigation of the Colon Cancer Relapse-Associated Genes NOX4 and ITGA3
    • Bauer, K. M.; Watts, T. N.; Buechler, S.; Hummon, A. B. Proteomic and Functional Investigation of the Colon Cancer Relapse-Associated Genes NOX4 and ITGA3 J. Proteome Res. 2014, 13 (11) 4910-4918
    • (2014) J. Proteome Res. , vol.13 , Issue.11 , pp. 4910-4918
    • Bauer, K.M.1    Watts, T.N.2    Buechler, S.3    Hummon, A.B.4
  • 69
    • 84910610355 scopus 로고    scopus 로고
    • Hypoxia-induced Changes to Integrin alpha 3 Glycosylation Facilitate Invasion in Epidermoid Carcinoma Cell Line A431
    • Ren, Y.; Hao, P.; Law, S. K.; Sze, S. K. Hypoxia-induced Changes to Integrin alpha 3 Glycosylation Facilitate Invasion in Epidermoid Carcinoma Cell Line A431 Mol. Cell Proteomics 2014, 13 (11) 3126-3137
    • (2014) Mol. Cell Proteomics , vol.13 , Issue.11 , pp. 3126-3137
    • Ren, Y.1    Hao, P.2    Law, S.K.3    Sze, S.K.4
  • 70
    • 55949105532 scopus 로고    scopus 로고
    • Membrane glycoproteins associated with breast tumor cell progression identified by a lectin affinity approach
    • Wang, Y.; Ao, X.; Vuong, H.; Konanur, M.; Miller, F. R.; Goodison, S.; Lubman, D. M. Membrane glycoproteins associated with breast tumor cell progression identified by a lectin affinity approach J. Proteome Res. 2008, 7 (10) 4313-4325
    • (2008) J. Proteome Res. , vol.7 , Issue.10 , pp. 4313-4325
    • Wang, Y.1    Ao, X.2    Vuong, H.3    Konanur, M.4    Miller, F.R.5    Goodison, S.6    Lubman, D.M.7
  • 72
    • 0028179150 scopus 로고
    • Estrogen receptor expression of benign breast epithelium and its association with breast cancer
    • Khan, S. A.; Rogers, M. A.; Obando, J. A.; Tamsen, A. Estrogen receptor expression of benign breast epithelium and its association with breast cancer Cancer Res. 1994, 54 (4) 993-997
    • (1994) Cancer Res. , vol.54 , Issue.4 , pp. 993-997
    • Khan, S.A.1    Rogers, M.A.2    Obando, J.A.3    Tamsen, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.