Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3

Journal of Proteome Research

Volumn 13, Issue 11, 2014, Pages 4910-4918

  Bauer, Kerry M ^a   Watts, Tanya N ^a   Buechler, Steven ^a   Hummon, Amanda B ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

colon cancer; ITGA3; iTRAQ; NOX4; Q Exactive

Indexed keywords

ALPHA3 INTEGRIN; INTEGRIN ALPHA 3 BETA 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; UNCLASSIFIED DRUG; NOX4 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; VERY LATE ACTIVATION ANTIGEN 3;

ARTICLE; BIOINFORMATICS; CANCER LOCALIZATION; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CARCINOGENESIS; CELL LABELING; CELL MIGRATION; COLON CANCER; COLON METASTASIS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME MECHANISM; FUNCTIONAL PROTEOMICS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE SILENCING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR BIOLOGY; PHENOTYPIC VARIATION; PREDICTIVE VALUE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RISK ASSESSMENT; RNA INTERFERENCE; TUMOR GROWTH; BIOLOGY; COLON TUMOR; GENE EXPRESSION REGULATION; GENETICS; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; PROGNOSIS; RECURRENT DISEASE;

COLONIC NEOPLASMS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHA3BETA1; MASS SPECTROMETRY; NADPH OXIDASE; PHENOTYPE; PROGNOSIS; RECURRENCE; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84908884351     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500557n     Document Type: Article

References (39)

1. Li, F. Y.; Lai, M. D. Colorectal cancer, one entity or three J. Zhejiang Univ., Sci., B 2009, 10, 219-29
2. Iacopetta, B. Are there two sides to colorectal cancer? Int. J. Cancer 2002, 101, 403-8
3. Bufill, J. A. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location Ann. Int. Med. 1990, 113, 779-88
4. Bauer, K. M.; Hummon, A. B.; Buechler, S. Right-side and left-side colon cancer follow different pathways to relapse Mol. Carcinog. 2012, 51, 411-21
5. Gonzales, M.; Haan, K.; Baker, S. E.; Fitchmun, M.; Todorov, I.; Weitzman, S.; Jones, J. C. A cell signal pathway involving laminin-5, α3β1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation Mol. Biol. Cell 1999, 10, 259-70
6. Manohar, A.; Shome, S. G.; Lamar, J.; Stirling, L.; Iyer, V.; Pumiglia, K.; DiPersio, C. M. α3β1 integrin promotes keratinocyte cell survival through activation of a MEK/ERK signaling pathway J. Cell Sci. 2004, 117, 4043-54
7. Wen, T.; Zhang, Z.; Yu, Y.; Qu, H.; Koch, M.; Aumailley, M. Integrin α3 subunit regulates events linked to epithelial repair, including keratinocyte migration and protein expression Wound Repair Regener. 2010, 18, 325-34
8. Ura, H.; Denno, R.; Hirata, K.; Yamaguchi, K.; Yasoshima, T. Separate functions of alpha2beta1 and alpha3beta1 integrins in the metastatic process of human gastric carcinoma Surg. Today 1998, 28, 1001-6
9. Kurokawa, A.; Nagata, M.; Kitamura, N.; Noman, A. A.; Ohnishi, M.; Ohyama, T.; Kobayashi, T.; Shingaki, S.; Takagi, R. Diagnostic value of integrin α3, β4, and β5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma Cancer 2008, 112, 1272-81
10. Yang, G. Y.; Xu, K. S.; Pan, Z. Q.; Zhang, Z. Y.; Mi, Y. T.; Wang, J. S.; Chen, R.; Niu, J. Integrin αvβ6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver Cancer Sci. 2008, 99, 879-87
11. Vonlaufen, A.; Wiedle, G.; Borisch, B.; Birrer, S.; Luder, P.; Imhof, B. A. Integrin α(v)β(3) expression in colon carcinoma correlates with survival Mod. Pathol. 2001, 14, 1126-32
12. Lei, Y. H.; Kai; Gao, C.; Lau, Q. C.; Pan, H.; Xie, K.; Li, L.; Liu, R.; Zhang, T.; Xie, N.; Nai, H. S.; Wu, H.; Gong, Q.; Zhao, X.; Nice, E.; Huang, C.; Wei, Y. Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells Mol. Cell. Proteomics 2011, 10, M110.005397
13. Altenhöfer, S.; Kleikers, P. W.; Radermacher, K. A.; Scheurer, P.; Rob Hermans, J. J.; Schiffers, P.; Ho, H.; Wingler, K.; Schmidt, H. H. The NOX toolbox: validating the role of NADPH oxidases in physiology and disease Cell. Mol. Life Sci. 2012, 69, 2327-43
14. Bonner, M. Y.; Arbiser, J. L. Targeting NADPH oxidases for the treatment of cancer and inflammation Cell. Mol. Life Sci. 2012, 69, 2435-42
15. Weyemi, U.; Dupuy, C. The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responses Mutat. Res. 2012, 751, 77-81
16. Tobar, N.; Guerrero, J.; Smith, P. C.; Martinez, J. NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration Br. J. Cancer 2010, 103, 1040-7
17. Boudreau, H. E.; Casterline, B. W.; Rada, B.; Korzeniowska, A.; Leto, T. L. Nox4 involvement in TGF-β and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells Free Radical Biol. Med. 2012, 53, 1489-99
18. Zhang, B.; Liu, Z.; Hu, X. Inhibiting cancer metastasis via targeting NAPDH oxidase 4 Biochem. Pharmacol. 2013, 86, 253-66
19. Shimada, K.; Fujii, T.; Anai, S.; Fujimoto, K.; Konishi, N. ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder BMC Urol. 2011, 11, 22
20. Yamaura, M.; Mitsushita, J.; Furuta, S.; Kiniwa, Y.; Ashida, A.; Goto, Y.; Shang, W. H.; Kubodera, M.; Kato, M.; Takata, M.; Saida, T.; Kamata, T. NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression Cancer Res. 2009, 69, 2647-54
21. Masters, J. R.; Thomson, J. A.; Daly-Burns, B.; Reid, Y. A.; Dirks, W. G.; Packer, P.; Toji, L. H.; Ohno, T.; Tanabe, H.; Arlett, C. F.; Kelland, L. R.; Harrison, M.; Virmani, A.; Ward, T. H.; Ayres, K. L.; Debenham, P. G. Short tandem repeat profiling provides an international reference standard for human cell lines Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 8012-7
22. Geback, T.; Schulz, M. M.; Koumoutsakos, P.; Detmar, M. TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays BioTechniques 2009, 46, 265-74
23. Flatmark, K.; Maelandsmo, G. M.; Martinsen, M.; Rasmussen, H.; Fodstad, O. Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice Eur. J. Cancer 2004, 40, 1593-8
24. Eshleman, J. R.; L, E.; Bowerfind, G. K.; Parsons, R.; Vogelstein, B.; Willson, J. K.; Veigl, M. L.; Sedwick, W. D.; Markowitz, S. D. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer Oncogene 1995, 10, 33-37
25. Sugai, T.; Habano, W.; Jiao, Y. F.; Tsukahara, M.; Takeda, Y.; Otsuka, K.; Nakamura, S. Analysis of molecular alterations in left-and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas J. Mol. Diagn. 2006, 8, 193-201
26. Ahmed, D.; Eide, P. W.; Eilertsen, I. A.; Danielsen, S. A.; Eknaes, M.; Hektoen, M.; Lind, G. E.; Lothe, R. A. Epigenetic and genetic features of 24 colon cancer cell lines Oncogenesis 2013, 2, e71
27. Richman, S.; Adlard, J. Left and right sided large bowel cancer BMJ. 2002, 324, 931-2
28. Wingler, K.; Altenhoefer, S. A.; Kleikers, P. W.; Radermacher, K. A.; Kleinschnitz, C.; Schmidt, H. H. VAS2870 is a pan-NADPH oxidase inhibitor Cell. Mol. Life Sci. 2012, 69, 3159-60
29. Solaini, G.; Sgarbi, G.; Baracca, A. Oxidative phosphorylation in cancer cells Biochim. Biophys. Acta 2011, 1807, 534-42
30. 2-, HNE-, or tBH-treated ARPE-19 cells Free Radical Biol. Med. 2002, 33, 1419-32
31. Huttenlocher, A.; Horwitz, A. R. Integrins in cell migration Cold Spring Harbor Perspect. Biol. 2011, 3, a005074
32. Graham, K. A.; Kulawiec, M.; Owens, K. M.; Li, X.; Desouki, M. M.; Chandra, D.; Singh, K. K. NADPH oxidase 4 is an oncoprotein localized to mitochondria Cancer Biol. Ther. 2010, 10, 223-31
33. Juhasz, A.; Ge, Y.; Markel, S.; Chiu, A.; Matsumoto, L.; van Balgooy, J.; Roy, K.; Doroshow, J. H. Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues Free Radical Res. 2009, 43, 523-32
34. Zhang, B.; Liu, Z.; Hu, X. Inhibiting cancer metastasis via targeting NAPDH oxidase 4 Biochem. Pharmacol. 2013, 86, 253-66
35. Ellen, T. P.; Ke, Q.; Zhang, P.; Costa, M. NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states Carcinogenesis 2008, 29, 2-8
36. Hsu, C. C.; Leu, Y. W.; Tseng, M. J.; Lee, K. D.; Kuo, T. Y.; Yen, J. Y.; Lai, Y. L.; Hung, Y. C.; Sun, W. S.; Chen, C. M.; Chu, P. Y.; Yeh, K. T.; Yan, P. S.; Chang, Y. S.; Huang, T. H.; Hsiao, S. H. Functional characterization of Trip10 in cancer cell growth and survival J. Biomed. Sci. 2011, 18, 12
37. Chen, H. J.; Lin, C. M.; Lin, C. S.; Perez-Olle, R.; Leung, C. L.; Liem, R. K. The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway Genes Dev. 2006, 20, 1933-45
38. Luo, M. L.; Wang, M. R. CTTN (EMS1): an oncogene contributing to the metastasis of esophageal squamous cell carcinoma Cell Res. 2007, 17, 298-300
39. Arpin, M.; Chirivino, D.; Naba, A.; Zwaenepoel, I. Emerging role for ERM proteins in cell adhesion and migration Cell Adhes. Migr. 2011, 5, 199-206