MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 33, 2015, Pages 10461-10466

  Lahiri, Amit ^a   Hedl, Matija ^a   Abraham, Clara ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Crohn's disease; Genetics; NOD2; Toll like receptors; Ulcerative colitis

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; JANUS KINASE; MYOTUBULARIN RELATED PROTEIN 3; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; CYTOKINE; LIGAND; MTMR3 PROTEIN, HUMAN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR;

ALLELE; ARTICLE; AUTOPHAGY; BONE MARROW CELL; CELL CYCLE PROGRESSION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOMEOSTASIS; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; METABOLISM; MONONUCLEAR CELL; PROTEIN TERTIARY STRUCTURE; RISK FACTOR;

ALLELES; AUTOPHAGY; CASPASE 1; CYTOKINES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMEOSTASIS; HUMANS; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; LEUKOCYTES, MONONUCLEAR; LIGANDS; MACROPHAGES; MONOCYTES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR; RISK FACTORS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84939825171     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501752112     Document Type: Article

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