Functional characterization of a WWP1/Tiul1 tumor-derived mutant reveals a paradigm of its constitutive activation in human cancer

Journal of Biological Chemistry

Volumn 290, Issue 34, 2015, Pages 21007-21018

  Courivaud, Thomas ^a,b   Ferrand, Nathalie ^a,b   Elkhattouti, Abdelouahid ^c   Kumar, Santosh ^c   Levy, Laurence ^a,b   Ferrigno, Olivier ^a,b   Atfi, Azeddine ^a,b,c   Prunier, Céline ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b CENTRE DE RECHERCHE SAINT ANTOINE   (France)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

CANCER PATHOGENESIS; E3 UBIQUITIN LIGASES; FUNCTIONAL CHARACTERIZATION; HUMAN PROSTATE CANCER; POLYUBIQUITINATION; POTENTIAL MECHANISM; REGULATORY MECHANISM; UBIQUITIN LIGASES;

DISEASES;

DOXYCYCLINE; PROTEIN WWP1 TIUL1; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; SMAD7 PROTEIN, HUMAN; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE; WWP1 PROTEIN, HUMAN;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; MALE; POINT MUTATION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MONOUBIQUITINATION; PROTEIN POLYUBIQUITINATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STEADY STATE; UBIQUITINATION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; PROTEIN DOMAIN;

CARCINOGENESIS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HELA CELLS; HUMANS; MCF-7 CELLS; POINT MUTATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84939824096     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.642314     Document Type: Article

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