WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Negatively Regulates TLR4-Mediated TNF-α and IL-6 Production by Proteasomal Degradation of TNF Receptor Associated Factor 6 (TRAF6)

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Lin, Xiao Wen ^a,b   Xu, Wei Cheng ^b   Luo, Jian Gang ^b   Guo, Xue Jiao ^b   Sun, Tao ^b   Zhao, Xu Li ^b   Fu, Zhi Jian ^b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; UBIQUITINATION;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-PROTEIN LIGASES;

NEGIBACTERIA;

EID: 84879177581     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067633     Document Type: Article

References (33)

1. Beutler B, Jiang Z, Georgel P, Crozat K, Croker B, et al. (2006) Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol 24: 353-389.
2. Kawai T, Akira S, (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
3. Iwasaki A, Medzhitov R, (2010) Regulation of adaptive immunity by the innate immune system. Science 327: 291-295.
4. Liew FY, Xu D, Brint EK, O'Neill LA, (2005) Negative regulation of toll-like receptor mediated immune responses. Nat Rev Immunol 5: 446-458.
5. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, et al. (1998) Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
6. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752.
7. O′Neill LA, Bowie AG, (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7: 353-364.
8. Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, et al. (1998) MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2: 253-258.
9. Akira S, Takeda K, (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
10. Roach JM, Racioppi L, Jones CD, Masci AM, (2013) Phylogeny of toll-like receptor signaling: adapting the innate response. PLoS One 8: e54156.
11. Jiang Z, Mak TW, Sen G, Li X, (2004) Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A 101: 3533-3538.
12. Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, et al. (2003) Maniatis. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4: 491-496.
13. Chen C, Zhou Z, Ross JS, Zhou W, Dong JT, (2007) The amplified WWP1 gene is a potential molecular target in breast cancer. Int J Cancer 121: 2834-2841.
14. Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, et al. (2007) NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell 128: 129-139.
15. Suzuki A, Shibata T, Shimada Y, Murakami Y, Horii A, et al. (2008) Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization. Cancer Sci 99: 986-994.
16. Fukuchi M, Fukai Y, Masuda N, Miyazaki T, Nakajima M, et al. (2002) High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Res 62: 7162-7165.
17. Chen C, Matesic LE, (2007) The Nedd4-like family of E3 ubiquitin ligases and cancer. Cancer Metastasis Rev 26: 587-604.
18. Chen C, Sun X, Guo P, Dong XY, Sethi P, et al. (2007) Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Oncogene 26: 2386-2394.
19. Li Y, Zhou Z, Alimandi M, Chen C, (2009) WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. Oncogene 28: 2948-2958.
20. Chen C, Zhou Z, Liu R, Li Y, Azmi PB, et al. (2008) The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. Oncogene 27: 6845-6855.
21. Edwards TL, Clowes VE, Tsang HT, Connell JW, Sanderson CM, et al. (2009) Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. Biochem J 423: 31-39.
22. Zhang X, Srinivasan SV, Lingrel JB, (2004) WWP1-dependent ubiquitination and degradation of the lung Kruppel-like factor, KLF2. Biochem Biophys Res 316: 139-148.
23. Li Y, Zhou Z, Chen C, (2008) WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis. Cell Death Differ 15: 1941-1951.
24. Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, et al. (2006) Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 312: 1223-1227.
25. Zhi X, Chen C, (2012) WWP1: a versatile ubiquitin E3 ligase in signaling and diseases. Cell Mol Life Sci 69: 1425-1434.
26. Yang Y, Liao B, Wang S, Yan B, Jin Y, et al. (2013) E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation. Proc Natl Acad Sci U S A 110: 5115-5120.
27. McGettrick AF, O'Neill LA, (2010) Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol 22: 20-27.
28. Barton GM, Kagan JC, (2009) A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol 9: 535-542.
29. Kawai T, Akira S, (2011) Regulation of innate immune signaling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med 3: 513-527.
30. Shembade N, Harhaj NS, Liebl DJ, Harhaj EW, (2007) Essential role for TAX1BP1 in the termination of TNF-alpha, IL-1 and LPS-mediated NF-kappaB and JNK signaling. EMBO J 26: 3910-3922.
31. Shi M, Deng W, Bi E, Mao K, Ji Y, et al. (2008) TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat Immunol 9: 369-377.
32. Lee JO, Lee SK, Kim N, Kim JH, You GY, et al. (2013) E3 ubiquitin ligase, WWP1, interacts with AMPKalpha2 and downregulates its expression in skeletal muscle C2C12 cells. J Biol Chem 288: 4673-4680.
33. Subik K, Shu L, Wu C, Liang Q, Hicks D, et al. (2012) The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. Bone 50: 813-823.