Glutaredoxin 1 (Grx1) protects human retinal pigment epithelial cells from oxidative damage by preventing AKT glutathionylation

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 5, 2015, Pages 2821-2832

  Liu, Xiaobin ^a   Jann, Jamieson ^a   Xavier, Christy ^a   Wu, Hongli ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

AKT; Apoptosis; Glutaredoxin 1; Glutathionylation; Oxidative stress

Indexed keywords

GLUTAREDOXIN 1; HOE 33342; HYDROGEN PEROXIDE; OXIDOREDUCTASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; BAX PROTEIN, HUMAN; CARRIER PROTEIN; GLRX PROTEIN, HUMAN; GLUTAREDOXIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSPORTER; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CELL DAMAGE; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CELL VIABILITY ASSAY; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE SILENCING; GLUTATHIONYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; CELL PROTECTION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; GENE KNOCKDOWN TECHNIQUES; GLUTAREDOXINS; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; HYDROGEN PEROXIDE; MEMBRANE TRANSPORT PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINAL PIGMENT EPITHELIUM;

EID: 84939803090     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-15876     Document Type: Article

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