Telmisartan mediates anti-inflammatory and not cognitive function through PPAR-γ agonism via SARM and MyD88 signaling

Pharmacology Biochemistry and Behavior

Volumn 137, Issue , 2015, Pages 60-68

  Prathab Balaji, S ^a   Vijay Chand, C ^a   Justin, A ^a   Ramanathan, M ^a  

^a PSG COLLEGE OF PHARMACY   (India)

Author keywords

Cytokines; LPS; Morris water maze; Neuroinflammation; NF ?B; TLR4

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TELMISARTAN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ARMADILLO DOMAIN PROTEIN; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; CYTOSKELETON PROTEIN; MYD88 PROTEIN, RAT; SARM1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOTTING; BODY TEMPERATURE; CELL REGENERATION; COGNITION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL BEHAVIORAL TEST; EXPERIMENTAL INFLAMMATION; HIPPOCAMPUS; LOCOMOTION; MALE; MOTOR COORDINATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; INFLAMMATION; MAZE TEST; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARMADILLO DOMAIN PROTEINS; BENZIMIDAZOLES; BENZOATES; COGNITION; CYTOSKELETAL PROTEINS; INFLAMMATION; MALE; MAZE LEARNING; MYELOID DIFFERENTIATION FACTOR 88; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84939798874     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.08.007     Document Type: Article

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