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Volumn 24, Issue , 2015, Pages 94-104

Engineering the AAV capsid to optimize vector-host-interactions

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[No Author keywords available]

Indexed keywords

PARVOVIRUS VECTOR;

EID: 84939788603     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.08.002     Document Type: Article
Times cited : (84)

References (76)
  • 1
    • 84929761323 scopus 로고    scopus 로고
    • Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success - a personal perspective
    • E. Hastie, and R.J. Samulski Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success - a personal perspective Hum Gene Ther 26 2015 257 265
    • (2015) Hum Gene Ther , vol.26 , pp. 257-265
    • Hastie, E.1    Samulski, R.J.2
  • 3
    • 79954622209 scopus 로고    scopus 로고
    • Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
    • F. Mingozzi, and K.A. High Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges Nat Rev Genet 12 2011 341 355
    • (2011) Nat Rev Genet , vol.12 , pp. 341-355
    • Mingozzi, F.1    High, K.A.2
  • 6
    • 84903587200 scopus 로고    scopus 로고
    • Engineering adeno-associated viruses for clinical gene therapy
    • M.A. Kotterman, and D.V. Schaffer Engineering adeno-associated viruses for clinical gene therapy Nat Rev Genet 15 2014 445 451
    • (2014) Nat Rev Genet , vol.15 , pp. 445-451
    • Kotterman, M.A.1    Schaffer, D.V.2
  • 8
    • 79956061794 scopus 로고    scopus 로고
    • Conformational changes in adeno-associated virus type 1 induced by genome packaging
    • B. Gerlach, J.A. Kleinschmidt, and B. Bottcher Conformational changes in adeno-associated virus type 1 induced by genome packaging J Mol Biol 409 2011 427 438
    • (2011) J Mol Biol , vol.409 , pp. 427-438
    • Gerlach, B.1    Kleinschmidt, J.A.2    Bottcher, B.3
  • 9
    • 84889571789 scopus 로고    scopus 로고
    • Adeno-associated virus structural biology as a tool in vector development
    • L.M. Drouin, and M. Agbandje-McKenna Adeno-associated virus structural biology as a tool in vector development Future Virol 8 2013 1183 1199
    • (2013) Future Virol , vol.8 , pp. 1183-1199
    • Drouin, L.M.1    Agbandje-McKenna, M.2
  • 10
    • 33744900338 scopus 로고    scopus 로고
    • High-level transgene expression in nonhuman primate liver with novel adeno-associated virus serotypes containing self-complementary genomes
    • G.P. Gao, Y. Lu, X. Sun, J. Johnston, R. Calcedo, R. Grant, and J.M. Wilson High-level transgene expression in nonhuman primate liver with novel adeno-associated virus serotypes containing self-complementary genomes J Virol 80 2006 6192 6194
    • (2006) J Virol , vol.80 , pp. 6192-6194
    • Gao, G.P.1    Lu, Y.2    Sun, X.3    Johnston, J.4    Calcedo, R.5    Grant, R.6    Wilson, J.M.7
  • 11
    • 84896730363 scopus 로고    scopus 로고
    • Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans
    • M. Mietzsch, F. Broecker, A. Reinhardt, P.H. Seeberger, and R. Heilbronn Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans J Virol 88 2014 2991 3003
    • (2014) J Virol , vol.88 , pp. 2991-3003
    • Mietzsch, M.1    Broecker, F.2    Reinhardt, A.3    Seeberger, P.H.4    Heilbronn, R.5
  • 12
    • 83655164541 scopus 로고    scopus 로고
    • Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway
    • M. Nonnenmacher, and T. Weber Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway Cell Host Microbe 10 2011 563 576
    • (2011) Cell Host Microbe , vol.10 , pp. 563-576
    • Nonnenmacher, M.1    Weber, T.2
  • 13
    • 84856953535 scopus 로고    scopus 로고
    • Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis
    • S. Uhrig, O. Coutelle, T. Wiehe, L. Perabo, M. Hallek, and H. Buning Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis Gene Ther 19 2012 210 218
    • (2012) Gene Ther , vol.19 , pp. 210-218
    • Uhrig, S.1    Coutelle, O.2    Wiehe, T.3    Perabo, L.4    Hallek, M.5    Buning, H.6
  • 14
    • 84869015419 scopus 로고    scopus 로고
    • Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network
    • P.J. Xiao, and R.J. Samulski Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network J Virol 86 2012 10462 10473
    • (2012) J Virol , vol.86 , pp. 10462-10473
    • Xiao, P.J.1    Samulski, R.J.2
  • 15
    • 33750712806 scopus 로고    scopus 로고
    • Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus
    • F. Sonntag, S. Bleker, B. Leuchs, R. Fischer, and J.A. Kleinschmidt Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus J Virol 80 2006 11040 11054
    • (2006) J Virol , vol.80 , pp. 11040-11054
    • Sonntag, F.1    Bleker, S.2    Leuchs, B.3    Fischer, R.4    Kleinschmidt, J.A.5
  • 17
    • 0036246727 scopus 로고    scopus 로고
    • The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity
    • A. Girod, C.E. Wobus, Z. Zadori, M. Ried, K. Leike, P. Tijssen, J.A. Kleinschmidt, and M. Hallek The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity J Gen Virol 83 2002 973 978
    • (2002) J Gen Virol , vol.83 , pp. 973-978
    • Girod, A.1    Wobus, C.E.2    Zadori, Z.3    Ried, M.4    Leike, K.5    Tijssen, P.6    Kleinschmidt, J.A.7    Hallek, M.8
  • 18
    • 84866152302 scopus 로고    scopus 로고
    • Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry
    • R. Popa-Wagner, M. Porwal, M. Kann, M. Reuss, M. Weimer, L. Florin, and J.A. Kleinschmidt Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry J Virol 86 2012 9163 9174
    • (2012) J Virol , vol.86 , pp. 9163-9174
    • Popa-Wagner, R.1    Porwal, M.2    Kann, M.3    Reuss, M.4    Weimer, M.5    Florin, L.6    Kleinschmidt, J.A.7
  • 20
    • 33846324384 scopus 로고    scopus 로고
    • A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8
    • B. Akache, D. Grimm, X. Shen, S. Fuess, S.R. Yant, D.S. Glazer, J. Park, and M.A. Kay A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8 Mol Ther 15 2007 330 339
    • (2007) Mol Ther , vol.15 , pp. 330-339
    • Akache, B.1    Grimm, D.2    Shen, X.3    Fuess, S.4    Yant, S.R.5    Glazer, D.S.6    Park, J.7    Kay, M.A.8
  • 21
    • 34250727017 scopus 로고    scopus 로고
    • A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis
    • L. Zhong, W. Zhao, J. Wu, B. Li, S. Zolotukhin, L. Govindasamy, M. Agbandje-McKenna, and A. Srivastava A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis Mol Ther 15 2007 1323 1330
    • (2007) Mol Ther , vol.15 , pp. 1323-1330
    • Zhong, L.1    Zhao, W.2    Wu, J.3    Li, B.4    Zolotukhin, S.5    Govindasamy, L.6    Agbandje-McKenna, M.7    Srivastava, A.8
  • 22
    • 84892967754 scopus 로고    scopus 로고
    • Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo
    • L. Song, M.A. Kauss, E. Kopin, M. Chandra, T. Ul-Hasan, E. Miller, G.R. Jayandharan, A.E. Rivers, G.V. Aslanidi, C. Ling, and et al. Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo Cytotherapy 15 2013 986 998
    • (2013) Cytotherapy , vol.15 , pp. 986-998
    • Song, L.1    Kauss, M.A.2    Kopin, E.3    Chandra, M.4    Ul-Hasan, T.5    Miller, E.6    Jayandharan, G.R.7    Rivers, A.E.8    Aslanidi, G.V.9    Ling, C.10
  • 25
    • 0038618725 scopus 로고    scopus 로고
    • Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding
    • S.R. Opie, K.H. Warrington Jr., M. Agbandje-McKenna, S. Zolotukhin, and N. Muzyczka Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding J Virol 77 2003 6995 7006
    • (2003) J Virol , vol.77 , pp. 6995-7006
    • Opie, S.R.1    Warrington, K.H.2    Agbandje-McKenna, M.3    Zolotukhin, S.4    Muzyczka, N.5
  • 26
    • 84871928310 scopus 로고    scopus 로고
    • Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer
    • R.C. Munch, H. Janicki, I. Volker, A. Rasbach, M. Hallek, H. Buning, and C.J. Buchholz Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer Mol Ther 21 2013 109 118
    • (2013) Mol Ther , vol.21 , pp. 109-118
    • Munch, R.C.1    Janicki, H.2    Volker, I.3    Rasbach, A.4    Hallek, M.5    Buning, H.6    Buchholz, C.J.7
  • 27
    • 33645064807 scopus 로고    scopus 로고
    • Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors
    • O.J. Muller, B. Leuchs, S.T. Pleger, D. Grimm, W.M. Franz, H.A. Katus, and J.A. Kleinschmidt Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors Cardiovasc Res 70 2006 70 78
    • (2006) Cardiovasc Res , vol.70 , pp. 70-78
    • Muller, O.J.1    Leuchs, B.2    Pleger, S.T.3    Grimm, D.4    Franz, W.M.5    Katus, H.A.6    Kleinschmidt, J.A.7
  • 29
  • 30
    • 0033007934 scopus 로고    scopus 로고
    • Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab′gamma)2 antibody
    • J.S. Bartlett, J. Kleinschmidt, R.C. Boucher, and R.J. Samulski Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab′gamma)2 antibody Nat Biotechnol 17 1999 181 186
    • (1999) Nat Biotechnol , vol.17 , pp. 181-186
    • Bartlett, J.S.1    Kleinschmidt, J.2    Boucher, R.C.3    Samulski, R.J.4
  • 31
    • 0036893196 scopus 로고    scopus 로고
    • Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands
    • S. Ponnazhagan, G. Mahendra, S. Kumar, J.A. Thompson, and M. Castillas Jr. Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands J Virol 76 2002 12900 12907
    • (2002) J Virol , vol.76 , pp. 12900-12907
    • Ponnazhagan, S.1    Mahendra, G.2    Kumar, S.3    Thompson, J.A.4    Castillas, M.5
  • 32
    • 48349091919 scopus 로고    scopus 로고
    • Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase
    • M.D. Stachler, I. Chen, A.Y. Ting, and J.S. Bartlett Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase Mol Ther 16 2008 1467 1473
    • (2008) Mol Ther , vol.16 , pp. 1467-1473
    • Stachler, M.D.1    Chen, I.2    Ting, A.Y.3    Bartlett, J.S.4
  • 33
    • 0036229828 scopus 로고    scopus 로고
    • Adeno-associated virus capsids displaying immunoglobulin-binding domains permit antibody-mediated vector retargeting to specific cell surface receptors
    • M.U. Ried, A. Girod, K. Leike, H. Buning, and M. Hallek Adeno-associated virus capsids displaying immunoglobulin-binding domains permit antibody-mediated vector retargeting to specific cell surface receptors J Virol 76 2002 4559 4566
    • (2002) J Virol , vol.76 , pp. 4559-4566
    • Ried, M.U.1    Girod, A.2    Leike, K.3    Buning, H.4    Hallek, M.5
  • 34
    • 84873366065 scopus 로고    scopus 로고
    • Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag
    • Y. Liu, Y. Fang, Y. Zhou, E. Zandi, C.L. Lee, K.I. Joo, and P. Wang Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag Small 9 2013 421 429
    • (2013) Small , vol.9 , pp. 421-429
    • Liu, Y.1    Fang, Y.2    Zhou, Y.3    Zandi, E.4    Lee, C.L.5    Joo, K.I.6    Wang, P.7
  • 37
    • 84864868331 scopus 로고    scopus 로고
    • Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors
    • K. Varadi, S. Michelfelder, T. Korff, M. Hecker, M. Trepel, H.A. Katus, J.A. Kleinschmidt, and O.J. Muller Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors Gene Ther 19 2012 800 809
    • (2012) Gene Ther , vol.19 , pp. 800-809
    • Varadi, K.1    Michelfelder, S.2    Korff, T.3    Hecker, M.4    Trepel, M.5    Katus, H.A.6    Kleinschmidt, J.A.7    Muller, O.J.8
  • 40
    • 84866313008 scopus 로고    scopus 로고
    • Impact of capsid modifications by selected peptide ligands on recombinant adeno-associated virus serotype 2-mediated gene transduction
    • M. Naumer, R. Popa-Wagner, and J.A. Kleinschmidt Impact of capsid modifications by selected peptide ligands on recombinant adeno-associated virus serotype 2-mediated gene transduction J Gen Virol 93 2012 2131 2141
    • (2012) J Gen Virol , vol.93 , pp. 2131-2141
    • Naumer, M.1    Popa-Wagner, R.2    Kleinschmidt, J.A.3
  • 41
    • 33745776920 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism
    • L. Perabo, D. Goldnau, K. White, J. Endell, J. Boucas, S. Humme, L.M. Work, H. Janicki, M. Hallek, A.H. Baker, and et al. Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism J Virol 80 2006 7265 7269
    • (2006) J Virol , vol.80 , pp. 7265-7269
    • Perabo, L.1    Goldnau, D.2    White, K.3    Endell, J.4    Boucas, J.5    Humme, S.6    Work, L.M.7    Janicki, H.8    Hallek, M.9    Baker, A.H.10
  • 45
    • 32844470411 scopus 로고    scopus 로고
    • Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus
    • L. Perabo, J. Endell, S. King, K. Lux, D. Goldnau, M. Hallek, and H. Buning Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus J Gene Med 8 2006 155 162
    • (2006) J Gene Med , vol.8 , pp. 155-162
    • Perabo, L.1    Endell, J.2    King, S.3    Lux, K.4    Goldnau, D.5    Hallek, M.6    Buning, H.7
  • 46
    • 32344438754 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
    • N. Maheshri, J.T. Koerber, B.K. Kaspar, and D.V. Schaffer Directed evolution of adeno-associated virus yields enhanced gene delivery vectors Nat Biotechnol 24 2006 198 204
    • (2006) Nat Biotechnol , vol.24 , pp. 198-204
    • Maheshri, N.1    Koerber, J.T.2    Kaspar, B.K.3    Schaffer, D.V.4
  • 47
    • 73949097812 scopus 로고    scopus 로고
    • Optimization of stealth adeno-associated virus vectors by randomization of immunogenic epitopes
    • S. Maersch, A. Huber, H. Buning, M. Hallek, and L. Perabo Optimization of stealth adeno-associated virus vectors by randomization of immunogenic epitopes Virology 397 2010 167 175
    • (2010) Virology , vol.397 , pp. 167-175
    • Maersch, S.1    Huber, A.2    Buning, H.3    Hallek, M.4    Perabo, L.5
  • 48
    • 84856546741 scopus 로고    scopus 로고
    • Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells
    • P. Asuri, M.A. Bartel, T. Vazin, J.H. Jang, T.B. Wong, and D.V. Schaffer Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells Mol Ther 20 2012 329 338
    • (2012) Mol Ther , vol.20 , pp. 329-338
    • Asuri, P.1    Bartel, M.A.2    Vazin, T.3    Jang, J.H.4    Wong, T.B.5    Schaffer, D.V.6
  • 49
    • 44949131860 scopus 로고    scopus 로고
    • In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses
    • D. Grimm, J.S. Lee, L. Wang, T. Desai, B. Akache, T.A. Storm, and M.A. Kay In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses J Virol 82 2008 5887 5911
    • (2008) J Virol , vol.82 , pp. 5887-5911
    • Grimm, D.1    Lee, J.S.2    Wang, L.3    Desai, T.4    Akache, B.5    Storm, T.A.6    Kay, M.A.7
  • 50
    • 54849391500 scopus 로고    scopus 로고
    • DNA shuffling of adeno-associated virus yields functionally diverse viral progeny
    • J.T. Koerber, J.H. Jang, and D.V. Schaffer DNA shuffling of adeno-associated virus yields functionally diverse viral progeny Mol Ther 16 2008 1703 1709
    • (2008) Mol Ther , vol.16 , pp. 1703-1709
    • Koerber, J.T.1    Jang, J.H.2    Schaffer, D.V.3
  • 56
    • 77953439661 scopus 로고    scopus 로고
    • A viral assembly factor promotes AAV2 capsid formation in the nucleolus
    • F. Sonntag, K. Schmidt, and J.A. Kleinschmidt A viral assembly factor promotes AAV2 capsid formation in the nucleolus Proc Natl Acad Sci U S A 107 2010 10220 10225
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10220-10225
    • Sonntag, F.1    Schmidt, K.2    Kleinschmidt, J.A.3
  • 57
    • 0031906147 scopus 로고    scopus 로고
    • Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions
    • C. Summerford, and R.J. Samulski Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions J Virol 72 1998 1438 1445
    • (1998) J Virol , vol.72 , pp. 1438-1445
    • Summerford, C.1    Samulski, R.J.2
  • 58
    • 0035976603 scopus 로고    scopus 로고
    • Real-time single-molecule imaging of the infection pathway of an adeno-associated virus
    • G. Seisenberger, M.U. Ried, T. Endress, H. Buning, M. Hallek, and C. Brauchle Real-time single-molecule imaging of the infection pathway of an adeno-associated virus Science 294 2001 1929 1932
    • (2001) Science , vol.294 , pp. 1929-1932
    • Seisenberger, G.1    Ried, M.U.2    Endress, T.3    Buning, H.4    Hallek, M.5    Brauchle, C.6
  • 59
    • 0032589751 scopus 로고    scopus 로고
    • AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection
    • C. Summerford, J.S. Bartlett, and R.J. Samulski AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection Nat Med 5 1999 78 82
    • (1999) Nat Med , vol.5 , pp. 78-82
    • Summerford, C.1    Bartlett, J.S.2    Samulski, R.J.3
  • 60
    • 33748494015 scopus 로고    scopus 로고
    • Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry
    • A. Asokan, J.B. Hamra, L. Govindasamy, M. Agbandje-McKenna, and R.J. Samulski Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry J Virol 80 2006 8961 8969
    • (2006) J Virol , vol.80 , pp. 8961-8969
    • Asokan, A.1    Hamra, J.B.2    Govindasamy, L.3    Agbandje-McKenna, M.4    Samulski, R.J.5
  • 61
    • 53149152604 scopus 로고    scopus 로고
    • Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line
    • M. Stiefelhagen, L. Sellner, J.A. Kleinschmidt, A. Jauch, S. Laufs, F. Wenz, W.J. Zeller, S. Fruehauf, and M.R. Veldwijk Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line Genet Vaccines Ther 6 2008 12
    • (2008) Genet Vaccines Ther , vol.6 , pp. 12
    • Stiefelhagen, M.1    Sellner, L.2    Kleinschmidt, J.A.3    Jauch, A.4    Laufs, S.5    Wenz, F.6    Zeller, W.J.7    Fruehauf, S.8    Veldwijk, M.R.9
  • 62
    • 47349124310 scopus 로고    scopus 로고
    • Generation of efficient human blood progenitor-targeted recombinant adeno-associated viral vectors (AAV) by applying an AAV random peptide library on primary human hematopoietic progenitor cells
    • L. Sellner, M. Stiefelhagen, J.A. Kleinschmidt, S. Laufs, F. Wenz, S. Fruehauf, W.J. Zeller, and M.R. Veldwijk Generation of efficient human blood progenitor-targeted recombinant adeno-associated viral vectors (AAV) by applying an AAV random peptide library on primary human hematopoietic progenitor cells Exp Hematol 36 2008 957 964
    • (2008) Exp Hematol , vol.36 , pp. 957-964
    • Sellner, L.1    Stiefelhagen, M.2    Kleinschmidt, J.A.3    Laufs, S.4    Wenz, F.5    Fruehauf, S.6    Zeller, W.J.7    Veldwijk, M.R.8
  • 63
    • 65249116937 scopus 로고    scopus 로고
    • Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries
    • S. Michelfelder, J. Kohlschutter, A. Skorupa, S. Pfennings, O. Muller, J.A. Kleinschmidt, and M. Trepel Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries PLoS ONE 4 2009 e5122
    • (2009) PLoS ONE , vol.4
    • Michelfelder, S.1    Kohlschutter, J.2    Skorupa, A.3    Pfennings, S.4    Muller, O.5    Kleinschmidt, J.A.6    Trepel, M.7
  • 64
    • 77955654722 scopus 로고    scopus 로고
    • Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library
    • Y. Ying, O.J. Muller, C. Goehringer, B. Leuchs, M. Trepel, H.A. Katus, and J.A. Kleinschmidt Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library Gene Ther 17 2010 980 990
    • (2010) Gene Ther , vol.17 , pp. 980-990
    • Ying, Y.1    Muller, O.J.2    Goehringer, C.3    Leuchs, B.4    Trepel, M.5    Katus, H.A.6    Kleinschmidt, J.A.7
  • 65
    • 78149421208 scopus 로고    scopus 로고
    • A new recombinant adeno-associated virus (AAV)-based random peptide display library system: infection-defective Aav1.9-3 as a novel detargeted platform for vector evolution
    • K. Adachi, and H. Nakai A new recombinant adeno-associated virus (AAV)-based random peptide display library system: infection-defective Aav1.9-3 as a novel detargeted platform for vector evolution Gene Ther Regul 5 2010 31 55
    • (2010) Gene Ther Regul , vol.5 , pp. 31-55
    • Adachi, K.1    Nakai, H.2
  • 66
    • 78349236992 scopus 로고    scopus 로고
    • A novel directed evolution method to enhance cell-type specificity of adeno-associated virus vectors
    • S. Marsch, A. Huber, M. Hallek, H. Buning, and L. Perabo A novel directed evolution method to enhance cell-type specificity of adeno-associated virus vectors Comb Chem High Throughput Screen 13 2010 807 812
    • (2010) Comb Chem High Throughput Screen , vol.13 , pp. 807-812
    • Marsch, S.1    Huber, A.2    Hallek, M.3    Buning, H.4    Perabo, L.5
  • 68
    • 84880540708 scopus 로고    scopus 로고
    • In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous
    • D. Dalkara, L.C. Byrne, R.R. Klimczak, M. Visel, L. Yin, W.H. Merigan, J.G. Flannery, and D.V. Schaffer In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous Sci Transl Med 5 2013 189ra176
    • (2013) Sci Transl Med , vol.5 , pp. 189ra176
    • Dalkara, D.1    Byrne, L.C.2    Klimczak, R.R.3    Visel, M.4    Yin, L.5    Merigan, W.H.6    Flannery, J.G.7    Schaffer, D.V.8
  • 73
    • 70449338146 scopus 로고    scopus 로고
    • A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Muller cells
    • R.R. Klimczak, J.T. Koerber, D. Dalkara, J.G. Flannery, and D.V. Schaffer A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Muller cells PLoS ONE 4 2009 e7467
    • (2009) PLoS ONE , vol.4
    • Klimczak, R.R.1    Koerber, J.T.2    Dalkara, D.3    Flannery, J.G.4    Schaffer, D.V.5
  • 76
    • 77649273563 scopus 로고    scopus 로고
    • Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    • S.J. Gray, B.L. Blake, H.E. Criswell, S.C. Nicolson, R.J. Samulski, T.J. McCown, and W. Li Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB) Mol Ther 18 2010 570 578
    • (2010) Mol Ther , vol.18 , pp. 570-578
    • Gray, S.J.1    Blake, B.L.2    Criswell, H.E.3    Nicolson, S.C.4    Samulski, R.J.5    McCown, T.J.6    Li, W.7


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