-
1
-
-
84929761323
-
Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success - a personal perspective
-
E. Hastie, and R.J. Samulski Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success - a personal perspective Hum Gene Ther 26 2015 257 265
-
(2015)
Hum Gene Ther
, vol.26
, pp. 257-265
-
-
Hastie, E.1
Samulski, R.J.2
-
2
-
-
2642512201
-
Clades of Adeno-associated viruses are widely disseminated in human tissues
-
G. Gao, L.H. Vandenberghe, M.R. Alvira, Y. Lu, R. Calcedo, X. Zhou, and J.M. Wilson Clades of Adeno-associated viruses are widely disseminated in human tissues J Virol 78 2004 6381 6388
-
(2004)
J Virol
, vol.78
, pp. 6381-6388
-
-
Gao, G.1
Vandenberghe, L.H.2
Alvira, M.R.3
Lu, Y.4
Calcedo, R.5
Zhou, X.6
Wilson, J.M.7
-
3
-
-
79954622209
-
Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
-
F. Mingozzi, and K.A. High Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges Nat Rev Genet 12 2011 341 355
-
(2011)
Nat Rev Genet
, vol.12
, pp. 341-355
-
-
Mingozzi, F.1
High, K.A.2
-
4
-
-
84887030173
-
Gene therapy on the move
-
K.B. Kaufmann, H. Buning, A. Galy, A. Schambach, and M. Grez Gene therapy on the move EMBO Mol Med 5 2013 1642 1661
-
(2013)
EMBO Mol Med
, vol.5
, pp. 1642-1661
-
-
Kaufmann, K.B.1
Buning, H.2
Galy, A.3
Schambach, A.4
Grez, M.5
-
5
-
-
0036678455
-
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
-
Q. Xie, W. Bu, S. Bhatia, J. Hare, T. Somasundaram, A. Azzi, and M.S. Chapman The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy Proc Natl Acad Sci U S A 99 2002 10405 10410
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10405-10410
-
-
Xie, Q.1
Bu, W.2
Bhatia, S.3
Hare, J.4
Somasundaram, T.5
Azzi, A.6
Chapman, M.S.7
-
6
-
-
84903587200
-
Engineering adeno-associated viruses for clinical gene therapy
-
M.A. Kotterman, and D.V. Schaffer Engineering adeno-associated viruses for clinical gene therapy Nat Rev Genet 15 2014 445 451
-
(2014)
Nat Rev Genet
, vol.15
, pp. 445-451
-
-
Kotterman, M.A.1
Schaffer, D.V.2
-
7
-
-
59149090531
-
Heparin binding induces conformational changes in Adeno-associated virus serotype 2
-
H.C. Levy, V.D. Bowman, L. Govindasamy, R. McKenna, K. Nash, K. Warrington, W. Chen, N. Muzyczka, X. Yan, T.S. Baker, and et al. Heparin binding induces conformational changes in Adeno-associated virus serotype 2 J Struct Biol 165 2009 146 156
-
(2009)
J Struct Biol
, vol.165
, pp. 146-156
-
-
Levy, H.C.1
Bowman, V.D.2
Govindasamy, L.3
McKenna, R.4
Nash, K.5
Warrington, K.6
Chen, W.7
Muzyczka, N.8
Yan, X.9
Baker, T.S.10
-
8
-
-
79956061794
-
Conformational changes in adeno-associated virus type 1 induced by genome packaging
-
B. Gerlach, J.A. Kleinschmidt, and B. Bottcher Conformational changes in adeno-associated virus type 1 induced by genome packaging J Mol Biol 409 2011 427 438
-
(2011)
J Mol Biol
, vol.409
, pp. 427-438
-
-
Gerlach, B.1
Kleinschmidt, J.A.2
Bottcher, B.3
-
9
-
-
84889571789
-
Adeno-associated virus structural biology as a tool in vector development
-
L.M. Drouin, and M. Agbandje-McKenna Adeno-associated virus structural biology as a tool in vector development Future Virol 8 2013 1183 1199
-
(2013)
Future Virol
, vol.8
, pp. 1183-1199
-
-
Drouin, L.M.1
Agbandje-McKenna, M.2
-
10
-
-
33744900338
-
High-level transgene expression in nonhuman primate liver with novel adeno-associated virus serotypes containing self-complementary genomes
-
G.P. Gao, Y. Lu, X. Sun, J. Johnston, R. Calcedo, R. Grant, and J.M. Wilson High-level transgene expression in nonhuman primate liver with novel adeno-associated virus serotypes containing self-complementary genomes J Virol 80 2006 6192 6194
-
(2006)
J Virol
, vol.80
, pp. 6192-6194
-
-
Gao, G.P.1
Lu, Y.2
Sun, X.3
Johnston, J.4
Calcedo, R.5
Grant, R.6
Wilson, J.M.7
-
11
-
-
84896730363
-
Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans
-
M. Mietzsch, F. Broecker, A. Reinhardt, P.H. Seeberger, and R. Heilbronn Differential adeno-associated virus serotype-specific interaction patterns with synthetic heparins and other glycans J Virol 88 2014 2991 3003
-
(2014)
J Virol
, vol.88
, pp. 2991-3003
-
-
Mietzsch, M.1
Broecker, F.2
Reinhardt, A.3
Seeberger, P.H.4
Heilbronn, R.5
-
12
-
-
83655164541
-
Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway
-
M. Nonnenmacher, and T. Weber Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway Cell Host Microbe 10 2011 563 576
-
(2011)
Cell Host Microbe
, vol.10
, pp. 563-576
-
-
Nonnenmacher, M.1
Weber, T.2
-
13
-
-
84856953535
-
Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis
-
S. Uhrig, O. Coutelle, T. Wiehe, L. Perabo, M. Hallek, and H. Buning Successful target cell transduction of capsid-engineered rAAV vectors requires clathrin-dependent endocytosis Gene Ther 19 2012 210 218
-
(2012)
Gene Ther
, vol.19
, pp. 210-218
-
-
Uhrig, S.1
Coutelle, O.2
Wiehe, T.3
Perabo, L.4
Hallek, M.5
Buning, H.6
-
14
-
-
84869015419
-
Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network
-
P.J. Xiao, and R.J. Samulski Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network J Virol 86 2012 10462 10473
-
(2012)
J Virol
, vol.86
, pp. 10462-10473
-
-
Xiao, P.J.1
Samulski, R.J.2
-
15
-
-
33750712806
-
Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus
-
F. Sonntag, S. Bleker, B. Leuchs, R. Fischer, and J.A. Kleinschmidt Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus J Virol 80 2006 11040 11054
-
(2006)
J Virol
, vol.80
, pp. 11040-11054
-
-
Sonntag, F.1
Bleker, S.2
Leuchs, B.3
Fischer, R.4
Kleinschmidt, J.A.5
-
16
-
-
24644509652
-
Green fluorescent protein-tagged adeno-associated virus particles allow the study of cytosolic and nuclear trafficking
-
K. Lux, N. Goerlitz, S. Schlemminger, L. Perabo, D. Goldnau, J. Endell, K. Leike, D.M. Kofler, S. Finke, M. Hallek, and et al. Green fluorescent protein-tagged adeno-associated virus particles allow the study of cytosolic and nuclear trafficking J Virol 79 2005 11776 11787
-
(2005)
J Virol
, vol.79
, pp. 11776-11787
-
-
Lux, K.1
Goerlitz, N.2
Schlemminger, S.3
Perabo, L.4
Goldnau, D.5
Endell, J.6
Leike, K.7
Kofler, D.M.8
Finke, S.9
Hallek, M.10
-
17
-
-
0036246727
-
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity
-
A. Girod, C.E. Wobus, Z. Zadori, M. Ried, K. Leike, P. Tijssen, J.A. Kleinschmidt, and M. Hallek The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity J Gen Virol 83 2002 973 978
-
(2002)
J Gen Virol
, vol.83
, pp. 973-978
-
-
Girod, A.1
Wobus, C.E.2
Zadori, Z.3
Ried, M.4
Leike, K.5
Tijssen, P.6
Kleinschmidt, J.A.7
Hallek, M.8
-
18
-
-
84866152302
-
Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry
-
R. Popa-Wagner, M. Porwal, M. Kann, M. Reuss, M. Weimer, L. Florin, and J.A. Kleinschmidt Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry J Virol 86 2012 9163 9174
-
(2012)
J Virol
, vol.86
, pp. 9163-9174
-
-
Popa-Wagner, R.1
Porwal, M.2
Kann, M.3
Reuss, M.4
Weimer, M.5
Florin, L.6
Kleinschmidt, J.A.7
-
19
-
-
45549090635
-
Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses
-
L. Zhong, B. Li, C.S. Mah, L. Govindasamy, M. Agbandje-McKenna, M. Cooper, R.W. Herzog, I. Zolotukhin, K.H. Warrington Jr., K.A. Weigel-Van Aken, and et al. Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses Proc Natl Acad Sci U S A 105 2008 7827 7832
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 7827-7832
-
-
Zhong, L.1
Li, B.2
Mah, C.S.3
Govindasamy, L.4
Agbandje-Mckenna, M.5
Cooper, M.6
Herzog, R.W.7
Zolotukhin, I.8
Warrington, K.H.9
Weigel-Van Aken, K.A.10
-
20
-
-
33846324384
-
A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8
-
B. Akache, D. Grimm, X. Shen, S. Fuess, S.R. Yant, D.S. Glazer, J. Park, and M.A. Kay A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8 Mol Ther 15 2007 330 339
-
(2007)
Mol Ther
, vol.15
, pp. 330-339
-
-
Akache, B.1
Grimm, D.2
Shen, X.3
Fuess, S.4
Yant, S.R.5
Glazer, D.S.6
Park, J.7
Kay, M.A.8
-
21
-
-
34250727017
-
A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis
-
L. Zhong, W. Zhao, J. Wu, B. Li, S. Zolotukhin, L. Govindasamy, M. Agbandje-McKenna, and A. Srivastava A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis Mol Ther 15 2007 1323 1330
-
(2007)
Mol Ther
, vol.15
, pp. 1323-1330
-
-
Zhong, L.1
Zhao, W.2
Wu, J.3
Li, B.4
Zolotukhin, S.5
Govindasamy, L.6
Agbandje-McKenna, M.7
Srivastava, A.8
-
22
-
-
84892967754
-
Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo
-
L. Song, M.A. Kauss, E. Kopin, M. Chandra, T. Ul-Hasan, E. Miller, G.R. Jayandharan, A.E. Rivers, G.V. Aslanidi, C. Ling, and et al. Optimizing the transduction efficiency of capsid-modified AAV6 serotype vectors in primary human hematopoietic stem cells in vitro and in a xenograft mouse model in vivo Cytotherapy 15 2013 986 998
-
(2013)
Cytotherapy
, vol.15
, pp. 986-998
-
-
Song, L.1
Kauss, M.A.2
Kopin, E.3
Chandra, M.4
Ul-Hasan, T.5
Miller, E.6
Jayandharan, G.R.7
Rivers, A.E.8
Aslanidi, G.V.9
Ling, C.10
-
23
-
-
84878678218
-
Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo
-
N. Gabriel, S. Hareendran, D. Sen, R.A. Gadkari, G. Sudha, R. Selot, M. Hussain, R. Dhaksnamoorthy, R. Samuel, N. Srinivasan, and et al. Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo Hum Gene Ther Methods 24 2013 80 93
-
(2013)
Hum Gene Ther Methods
, vol.24
, pp. 80-93
-
-
Gabriel, N.1
Hareendran, S.2
Sen, D.3
Gadkari, R.A.4
Sudha, G.5
Selot, R.6
Hussain, M.7
Dhaksnamoorthy, R.8
Samuel, R.9
Srinivasan, N.10
-
24
-
-
0141454787
-
Identification of a heparin-binding motif on adeno-associated virus type 2 capsids
-
A. Kern, K. Schmidt, C. Leder, O.J. Muller, C.E. Wobus, K. Bettinger, C.W. Von der Lieth, J.A. King, and J.A. Kleinschmidt Identification of a heparin-binding motif on adeno-associated virus type 2 capsids J Virol 77 2003 11072 11081
-
(2003)
J Virol
, vol.77
, pp. 11072-11081
-
-
Kern, A.1
Schmidt, K.2
Leder, C.3
Muller, O.J.4
Wobus, C.E.5
Bettinger, K.6
Von Der Lieth, C.W.7
King, J.A.8
Kleinschmidt, J.A.9
-
25
-
-
0038618725
-
Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding
-
S.R. Opie, K.H. Warrington Jr., M. Agbandje-McKenna, S. Zolotukhin, and N. Muzyczka Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding J Virol 77 2003 6995 7006
-
(2003)
J Virol
, vol.77
, pp. 6995-7006
-
-
Opie, S.R.1
Warrington, K.H.2
Agbandje-McKenna, M.3
Zolotukhin, S.4
Muzyczka, N.5
-
26
-
-
84871928310
-
Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer
-
R.C. Munch, H. Janicki, I. Volker, A. Rasbach, M. Hallek, H. Buning, and C.J. Buchholz Displaying high-affinity ligands on adeno-associated viral vectors enables tumor cell-specific and safe gene transfer Mol Ther 21 2013 109 118
-
(2013)
Mol Ther
, vol.21
, pp. 109-118
-
-
Munch, R.C.1
Janicki, H.2
Volker, I.3
Rasbach, A.4
Hallek, M.5
Buning, H.6
Buchholz, C.J.7
-
27
-
-
33645064807
-
Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors
-
O.J. Muller, B. Leuchs, S.T. Pleger, D. Grimm, W.M. Franz, H.A. Katus, and J.A. Kleinschmidt Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors Cardiovasc Res 70 2006 70 78
-
(2006)
Cardiovasc Res
, vol.70
, pp. 70-78
-
-
Muller, O.J.1
Leuchs, B.2
Pleger, S.T.3
Grimm, D.4
Franz, W.M.5
Katus, H.A.6
Kleinschmidt, J.A.7
-
28
-
-
84939830659
-
Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors
-
R.C. Munch, A. Muth, A. Muik, T. Friedel, J. Schmatz, B. Dreier, A. Trkola, A. Pluckthun, H. Buning, and C.J. Buchholz Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors Nat Commun 6 2015 6246
-
(2015)
Nat Commun
, vol.6
, pp. 6246
-
-
Munch, R.C.1
Muth, A.2
Muik, A.3
Friedel, T.4
Schmatz, J.5
Dreier, B.6
Trkola, A.7
Pluckthun, A.8
Buning, H.9
Buchholz, C.J.10
-
29
-
-
48949120141
-
Recent developments in adeno-associated virus vector technology
-
H. Buning, L. Perabo, O. Coutelle, S. Quadt-Humme, and M. Hallek Recent developments in adeno-associated virus vector technology J Gene Med 10 2008 717 733
-
(2008)
J Gene Med
, vol.10
, pp. 717-733
-
-
Buning, H.1
Perabo, L.2
Coutelle, O.3
Quadt-Humme, S.4
Hallek, M.5
-
30
-
-
0033007934
-
Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab′gamma)2 antibody
-
J.S. Bartlett, J. Kleinschmidt, R.C. Boucher, and R.J. Samulski Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab′gamma)2 antibody Nat Biotechnol 17 1999 181 186
-
(1999)
Nat Biotechnol
, vol.17
, pp. 181-186
-
-
Bartlett, J.S.1
Kleinschmidt, J.2
Boucher, R.C.3
Samulski, R.J.4
-
31
-
-
0036893196
-
Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands
-
S. Ponnazhagan, G. Mahendra, S. Kumar, J.A. Thompson, and M. Castillas Jr. Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligands J Virol 76 2002 12900 12907
-
(2002)
J Virol
, vol.76
, pp. 12900-12907
-
-
Ponnazhagan, S.1
Mahendra, G.2
Kumar, S.3
Thompson, J.A.4
Castillas, M.5
-
32
-
-
48349091919
-
Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase
-
M.D. Stachler, I. Chen, A.Y. Ting, and J.S. Bartlett Site-specific modification of AAV vector particles with biophysical probes and targeting ligands using biotin ligase Mol Ther 16 2008 1467 1473
-
(2008)
Mol Ther
, vol.16
, pp. 1467-1473
-
-
Stachler, M.D.1
Chen, I.2
Ting, A.Y.3
Bartlett, J.S.4
-
33
-
-
0036229828
-
Adeno-associated virus capsids displaying immunoglobulin-binding domains permit antibody-mediated vector retargeting to specific cell surface receptors
-
M.U. Ried, A. Girod, K. Leike, H. Buning, and M. Hallek Adeno-associated virus capsids displaying immunoglobulin-binding domains permit antibody-mediated vector retargeting to specific cell surface receptors J Virol 76 2002 4559 4566
-
(2002)
J Virol
, vol.76
, pp. 4559-4566
-
-
Ried, M.U.1
Girod, A.2
Leike, K.3
Buning, H.4
Hallek, M.5
-
34
-
-
84873366065
-
Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag
-
Y. Liu, Y. Fang, Y. Zhou, E. Zandi, C.L. Lee, K.I. Joo, and P. Wang Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag Small 9 2013 421 429
-
(2013)
Small
, vol.9
, pp. 421-429
-
-
Liu, Y.1
Fang, Y.2
Zhou, Y.3
Zandi, E.4
Lee, C.L.5
Joo, K.I.6
Wang, P.7
-
35
-
-
84905728122
-
A chemical switch for controlling viral infectivity
-
M. Horner, B. Kaufmann, G. Cotugno, E. Wiedtke, H. Buning, D. Grimm, and W. Weber A chemical switch for controlling viral infectivity Chem Commun 50 2014 10319 10322
-
(2014)
Chem Commun
, vol.50
, pp. 10319-10322
-
-
Horner, M.1
Kaufmann, B.2
Cotugno, G.3
Wiedtke, E.4
Buning, H.5
Grimm, D.6
Weber, W.7
-
36
-
-
73249123039
-
Engineering adeno-associated virus serotype 2-based targeting vectors using a new insertion site-position 453-and single point mutations
-
J. Boucas, K. Lux, A. Huber, S. Schievenbusch, M.J. von Freyend, L. Perabo, S. Quadt-Humme, M. Odenthal, M. Hallek, and H. Buning Engineering adeno-associated virus serotype 2-based targeting vectors using a new insertion site-position 453-and single point mutations J Gene Med 11 2009 1103 1113
-
(2009)
J Gene Med
, vol.11
, pp. 1103-1113
-
-
Boucas, J.1
Lux, K.2
Huber, A.3
Schievenbusch, S.4
Von Freyend, M.J.5
Perabo, L.6
Quadt-Humme, S.7
Odenthal, M.8
Hallek, M.9
Buning, H.10
-
37
-
-
84864868331
-
Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors
-
K. Varadi, S. Michelfelder, T. Korff, M. Hecker, M. Trepel, H.A. Katus, J.A. Kleinschmidt, and O.J. Muller Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors Gene Ther 19 2012 800 809
-
(2012)
Gene Ther
, vol.19
, pp. 800-809
-
-
Varadi, K.1
Michelfelder, S.2
Korff, T.3
Hecker, M.4
Trepel, M.5
Katus, H.A.6
Kleinschmidt, J.A.7
Muller, O.J.8
-
38
-
-
79961162172
-
Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo
-
S. Michelfelder, K. Varadi, C. Raupp, A. Hunger, J. Korbelin, C. Pahrmann, S. Schrepfer, O.J. Muller, J.A. Kleinschmidt, and M. Trepel Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo PLoS ONE 6 2011 e23101
-
(2011)
PLoS ONE
, vol.6
-
-
Michelfelder, S.1
Varadi, K.2
Raupp, C.3
Hunger, A.4
Korbelin, J.5
Pahrmann, C.6
Schrepfer, S.7
Muller, O.J.8
Kleinschmidt, J.A.9
Trepel, M.10
-
39
-
-
0041808929
-
Receptor targeting of adeno-associated virus vectors
-
H. Buning, M.U. Ried, L. Perabo, F.M. Gerner, N.A. Huttner, J. Enssle, and M. Hallek Receptor targeting of adeno-associated virus vectors Gene Ther 10 2003 1142 1151
-
(2003)
Gene Ther
, vol.10
, pp. 1142-1151
-
-
Buning, H.1
Ried, M.U.2
Perabo, L.3
Gerner, F.M.4
Huttner, N.A.5
Enssle, J.6
Hallek, M.7
-
40
-
-
84866313008
-
Impact of capsid modifications by selected peptide ligands on recombinant adeno-associated virus serotype 2-mediated gene transduction
-
M. Naumer, R. Popa-Wagner, and J.A. Kleinschmidt Impact of capsid modifications by selected peptide ligands on recombinant adeno-associated virus serotype 2-mediated gene transduction J Gen Virol 93 2012 2131 2141
-
(2012)
J Gen Virol
, vol.93
, pp. 2131-2141
-
-
Naumer, M.1
Popa-Wagner, R.2
Kleinschmidt, J.A.3
-
41
-
-
33745776920
-
Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism
-
L. Perabo, D. Goldnau, K. White, J. Endell, J. Boucas, S. Humme, L.M. Work, H. Janicki, M. Hallek, A.H. Baker, and et al. Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism J Virol 80 2006 7265 7269
-
(2006)
J Virol
, vol.80
, pp. 7265-7269
-
-
Perabo, L.1
Goldnau, D.2
White, K.3
Endell, J.4
Boucas, J.5
Humme, S.6
Work, L.M.7
Janicki, H.8
Hallek, M.9
Baker, A.H.10
-
42
-
-
1342268978
-
Development of efficient viral vectors selective for vascular smooth muscle cells
-
L.M. Work, S.A. Nicklin, N.J. Brain, K.L. Dishart, D.J. Von Seggern, M. Hallek, H. Buning, and A.H. Baker Development of efficient viral vectors selective for vascular smooth muscle cells Mol Ther 9 2004 198 208
-
(2004)
Mol Ther
, vol.9
, pp. 198-208
-
-
Work, L.M.1
Nicklin, S.A.2
Brain, N.J.3
Dishart, K.L.4
Von Seggern, D.J.5
Hallek, M.6
Buning, H.7
Baker, A.H.8
-
43
-
-
0034843445
-
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells
-
S.A. Nicklin, H. Buening, K.L. Dishart, M. de Alwis, A. Girod, U. Hacker, A.J. Thrasher, R.R. Ali, M. Hallek, and A.H. Baker Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells Mol Ther 4 2001 174 181
-
(2001)
Mol Ther
, vol.4
, pp. 174-181
-
-
Nicklin, S.A.1
Buening, H.2
Dishart, K.L.3
De Alwis, M.4
Girod, A.5
Hacker, U.6
Thrasher, A.J.7
Ali, R.R.8
Hallek, M.9
Baker, A.H.10
-
44
-
-
0032728739
-
Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2
-
A. Girod, M. Ried, C. Wobus, H. Lahm, K. Leike, J. Kleinschmidt, G. Deleage, and M. Hallek Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2 Nat Med 5 1999 1438
-
(1999)
Nat Med
, vol.5
, pp. 1438
-
-
Girod, A.1
Ried, M.2
Wobus, C.3
Lahm, H.4
Leike, K.5
Kleinschmidt, J.6
Deleage, G.7
Hallek, M.8
-
45
-
-
32844470411
-
Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus
-
L. Perabo, J. Endell, S. King, K. Lux, D. Goldnau, M. Hallek, and H. Buning Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus J Gene Med 8 2006 155 162
-
(2006)
J Gene Med
, vol.8
, pp. 155-162
-
-
Perabo, L.1
Endell, J.2
King, S.3
Lux, K.4
Goldnau, D.5
Hallek, M.6
Buning, H.7
-
46
-
-
32344438754
-
Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
-
N. Maheshri, J.T. Koerber, B.K. Kaspar, and D.V. Schaffer Directed evolution of adeno-associated virus yields enhanced gene delivery vectors Nat Biotechnol 24 2006 198 204
-
(2006)
Nat Biotechnol
, vol.24
, pp. 198-204
-
-
Maheshri, N.1
Koerber, J.T.2
Kaspar, B.K.3
Schaffer, D.V.4
-
47
-
-
73949097812
-
Optimization of stealth adeno-associated virus vectors by randomization of immunogenic epitopes
-
S. Maersch, A. Huber, H. Buning, M. Hallek, and L. Perabo Optimization of stealth adeno-associated virus vectors by randomization of immunogenic epitopes Virology 397 2010 167 175
-
(2010)
Virology
, vol.397
, pp. 167-175
-
-
Maersch, S.1
Huber, A.2
Buning, H.3
Hallek, M.4
Perabo, L.5
-
48
-
-
84856546741
-
Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells
-
P. Asuri, M.A. Bartel, T. Vazin, J.H. Jang, T.B. Wong, and D.V. Schaffer Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells Mol Ther 20 2012 329 338
-
(2012)
Mol Ther
, vol.20
, pp. 329-338
-
-
Asuri, P.1
Bartel, M.A.2
Vazin, T.3
Jang, J.H.4
Wong, T.B.5
Schaffer, D.V.6
-
49
-
-
44949131860
-
In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses
-
D. Grimm, J.S. Lee, L. Wang, T. Desai, B. Akache, T.A. Storm, and M.A. Kay In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses J Virol 82 2008 5887 5911
-
(2008)
J Virol
, vol.82
, pp. 5887-5911
-
-
Grimm, D.1
Lee, J.S.2
Wang, L.3
Desai, T.4
Akache, B.5
Storm, T.A.6
Kay, M.A.7
-
50
-
-
54849391500
-
DNA shuffling of adeno-associated virus yields functionally diverse viral progeny
-
J.T. Koerber, J.H. Jang, and D.V. Schaffer DNA shuffling of adeno-associated virus yields functionally diverse viral progeny Mol Ther 16 2008 1703 1709
-
(2008)
Mol Ther
, vol.16
, pp. 1703-1709
-
-
Koerber, J.T.1
Jang, J.H.2
Schaffer, D.V.3
-
51
-
-
84894242894
-
Selection and evaluation of clinically relevant AAV variants in a xenograft liver model
-
L. Lisowski, A.P. Dane, K. Chu, Y. Zhang, S.C. Cunningham, E.M. Wilson, S. Nygaard, M. Grompe, I.E. Alexander, and M.A. Kay Selection and evaluation of clinically relevant AAV variants in a xenograft liver model Nature 506 2014 382 386
-
(2014)
Nature
, vol.506
, pp. 382-386
-
-
Lisowski, L.1
Dane, A.P.2
Chu, K.3
Zhang, Y.4
Cunningham, S.C.5
Wilson, E.M.6
Nygaard, S.7
Grompe, M.8
Alexander, I.E.9
Kay, M.A.10
-
52
-
-
0042031468
-
In vitro selection of viral vectors with modified tropism: the adeno-associated virus display
-
L. Perabo, H. Buning, D.M. Kofler, M.U. Ried, A. Girod, C.M. Wendtner, J. Enssle, and M. Hallek In vitro selection of viral vectors with modified tropism: the adeno-associated virus display Mol Ther 8 2003 151 157
-
(2003)
Mol Ther
, vol.8
, pp. 151-157
-
-
Perabo, L.1
Buning, H.2
Kofler, D.M.3
Ried, M.U.4
Girod, A.5
Wendtner, C.M.6
Enssle, J.7
Hallek, M.8
-
53
-
-
0042360384
-
Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors
-
O.J. Muller, F. Kaul, M.D. Weitzman, R. Pasqualini, W. Arap, J.A. Kleinschmidt, and M. Trepel Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors Nat Biotechnol 21 2003 1040 1046
-
(2003)
Nat Biotechnol
, vol.21
, pp. 1040-1046
-
-
Muller, O.J.1
Kaul, F.2
Weitzman, M.D.3
Pasqualini, R.4
Arap, W.5
Kleinschmidt, J.A.6
Trepel, M.7
-
54
-
-
84899970187
-
Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy
-
J. Sallach, G. Di Pasquale, F. Larcher, N. Niehoff, M. Rubsam, A. Huber, J. Chiorini, D. Almarza, S.A. Eming, H. Ulus, and et al. Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy Mol Ther 22 2014 929 939
-
(2014)
Mol Ther
, vol.22
, pp. 929-939
-
-
Sallach, J.1
Di Pasquale, G.2
Larcher, F.3
Niehoff, N.4
Rubsam, M.5
Huber, A.6
Chiorini, J.7
Almarza, D.8
Eming, S.A.9
Ulus, H.10
-
55
-
-
84916891798
-
Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter
-
T. Cronin, L.H. Vandenberghe, P. Hantz, J. Juttner, A. Reimann, A.E. Kacso, R.M. Huckfeldt, V. Busskamp, H. Kohler, P.S. Lagali, and et al. Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter EMBO Mol Med 6 2014 1175 1190
-
(2014)
EMBO Mol Med
, vol.6
, pp. 1175-1190
-
-
Cronin, T.1
Vandenberghe, L.H.2
Hantz, P.3
Juttner, J.4
Reimann, A.5
Kacso, A.E.6
Huckfeldt, R.M.7
Busskamp, V.8
Kohler, H.9
Lagali, P.S.10
-
56
-
-
77953439661
-
A viral assembly factor promotes AAV2 capsid formation in the nucleolus
-
F. Sonntag, K. Schmidt, and J.A. Kleinschmidt A viral assembly factor promotes AAV2 capsid formation in the nucleolus Proc Natl Acad Sci U S A 107 2010 10220 10225
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 10220-10225
-
-
Sonntag, F.1
Schmidt, K.2
Kleinschmidt, J.A.3
-
57
-
-
0031906147
-
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions
-
C. Summerford, and R.J. Samulski Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions J Virol 72 1998 1438 1445
-
(1998)
J Virol
, vol.72
, pp. 1438-1445
-
-
Summerford, C.1
Samulski, R.J.2
-
58
-
-
0035976603
-
Real-time single-molecule imaging of the infection pathway of an adeno-associated virus
-
G. Seisenberger, M.U. Ried, T. Endress, H. Buning, M. Hallek, and C. Brauchle Real-time single-molecule imaging of the infection pathway of an adeno-associated virus Science 294 2001 1929 1932
-
(2001)
Science
, vol.294
, pp. 1929-1932
-
-
Seisenberger, G.1
Ried, M.U.2
Endress, T.3
Buning, H.4
Hallek, M.5
Brauchle, C.6
-
59
-
-
0032589751
-
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection
-
C. Summerford, J.S. Bartlett, and R.J. Samulski AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection Nat Med 5 1999 78 82
-
(1999)
Nat Med
, vol.5
, pp. 78-82
-
-
Summerford, C.1
Bartlett, J.S.2
Samulski, R.J.3
-
60
-
-
33748494015
-
Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry
-
A. Asokan, J.B. Hamra, L. Govindasamy, M. Agbandje-McKenna, and R.J. Samulski Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry J Virol 80 2006 8961 8969
-
(2006)
J Virol
, vol.80
, pp. 8961-8969
-
-
Asokan, A.1
Hamra, J.B.2
Govindasamy, L.3
Agbandje-McKenna, M.4
Samulski, R.J.5
-
61
-
-
53149152604
-
Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line
-
M. Stiefelhagen, L. Sellner, J.A. Kleinschmidt, A. Jauch, S. Laufs, F. Wenz, W.J. Zeller, S. Fruehauf, and M.R. Veldwijk Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line Genet Vaccines Ther 6 2008 12
-
(2008)
Genet Vaccines Ther
, vol.6
, pp. 12
-
-
Stiefelhagen, M.1
Sellner, L.2
Kleinschmidt, J.A.3
Jauch, A.4
Laufs, S.5
Wenz, F.6
Zeller, W.J.7
Fruehauf, S.8
Veldwijk, M.R.9
-
62
-
-
47349124310
-
Generation of efficient human blood progenitor-targeted recombinant adeno-associated viral vectors (AAV) by applying an AAV random peptide library on primary human hematopoietic progenitor cells
-
L. Sellner, M. Stiefelhagen, J.A. Kleinschmidt, S. Laufs, F. Wenz, S. Fruehauf, W.J. Zeller, and M.R. Veldwijk Generation of efficient human blood progenitor-targeted recombinant adeno-associated viral vectors (AAV) by applying an AAV random peptide library on primary human hematopoietic progenitor cells Exp Hematol 36 2008 957 964
-
(2008)
Exp Hematol
, vol.36
, pp. 957-964
-
-
Sellner, L.1
Stiefelhagen, M.2
Kleinschmidt, J.A.3
Laufs, S.4
Wenz, F.5
Fruehauf, S.6
Zeller, W.J.7
Veldwijk, M.R.8
-
63
-
-
65249116937
-
Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries
-
S. Michelfelder, J. Kohlschutter, A. Skorupa, S. Pfennings, O. Muller, J.A. Kleinschmidt, and M. Trepel Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries PLoS ONE 4 2009 e5122
-
(2009)
PLoS ONE
, vol.4
-
-
Michelfelder, S.1
Kohlschutter, J.2
Skorupa, A.3
Pfennings, S.4
Muller, O.5
Kleinschmidt, J.A.6
Trepel, M.7
-
64
-
-
77955654722
-
Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library
-
Y. Ying, O.J. Muller, C. Goehringer, B. Leuchs, M. Trepel, H.A. Katus, and J.A. Kleinschmidt Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library Gene Ther 17 2010 980 990
-
(2010)
Gene Ther
, vol.17
, pp. 980-990
-
-
Ying, Y.1
Muller, O.J.2
Goehringer, C.3
Leuchs, B.4
Trepel, M.5
Katus, H.A.6
Kleinschmidt, J.A.7
-
65
-
-
78149421208
-
A new recombinant adeno-associated virus (AAV)-based random peptide display library system: infection-defective Aav1.9-3 as a novel detargeted platform for vector evolution
-
K. Adachi, and H. Nakai A new recombinant adeno-associated virus (AAV)-based random peptide display library system: infection-defective Aav1.9-3 as a novel detargeted platform for vector evolution Gene Ther Regul 5 2010 31 55
-
(2010)
Gene Ther Regul
, vol.5
, pp. 31-55
-
-
Adachi, K.1
Nakai, H.2
-
66
-
-
78349236992
-
A novel directed evolution method to enhance cell-type specificity of adeno-associated virus vectors
-
S. Marsch, A. Huber, M. Hallek, H. Buning, and L. Perabo A novel directed evolution method to enhance cell-type specificity of adeno-associated virus vectors Comb Chem High Throughput Screen 13 2010 807 812
-
(2010)
Comb Chem High Throughput Screen
, vol.13
, pp. 807-812
-
-
Marsch, S.1
Huber, A.2
Hallek, M.3
Buning, H.4
Perabo, L.5
-
67
-
-
79953325690
-
An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells
-
J.H. Jang, J.T. Koerber, J.S. Kim, P. Asuri, T. Vazin, M. Bartel, A. Keung, I. Kwon, K.I. Park, and D.V. Schaffer An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells Mol Ther 19 2011 667 675
-
(2011)
Mol Ther
, vol.19
, pp. 667-675
-
-
Jang, J.H.1
Koerber, J.T.2
Kim, J.S.3
Asuri, P.4
Vazin, T.5
Bartel, M.6
Keung, A.7
Kwon, I.8
Park, K.I.9
Schaffer, D.V.10
-
68
-
-
84880540708
-
In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous
-
D. Dalkara, L.C. Byrne, R.R. Klimczak, M. Visel, L. Yin, W.H. Merigan, J.G. Flannery, and D.V. Schaffer In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous Sci Transl Med 5 2013 189ra176
-
(2013)
Sci Transl Med
, vol.5
, pp. 189ra176
-
-
Dalkara, D.1
Byrne, L.C.2
Klimczak, R.R.3
Visel, M.4
Yin, L.5
Merigan, W.H.6
Flannery, J.G.7
Schaffer, D.V.8
-
69
-
-
84943455137
-
Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors
-
M. Trepel, J. Korbelin, E. Spies, M.B. Heckmann, A. Hunger, B. Fehse, H.A. Katus, J.A. Kleinschmidt, O.J. Muller, and S. Michelfelder Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors Gene Ther 2015
-
(2015)
Gene Ther
-
-
Trepel, M.1
Korbelin, J.2
Spies, E.3
Heckmann, M.B.4
Hunger, A.5
Fehse, B.6
Katus, H.A.7
Kleinschmidt, J.A.8
Muller, O.J.9
Michelfelder, S.10
-
70
-
-
45749099260
-
Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles
-
W. Li, A. Asokan, Z. Wu, T. Van Dyke, N. DiPrimio, J.S. Johnson, L. Govindaswamy, M. Agbandje-McKenna, S. Leichtle, D.E. Redmond Jr., and et al. Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles Mol Ther 16 2008 1252 1260
-
(2008)
Mol Ther
, vol.16
, pp. 1252-1260
-
-
Li, W.1
Asokan, A.2
Wu, Z.3
Van Dyke, T.4
Diprimio, N.5
Johnson, J.S.6
Govindaswamy, L.7
Agbandje-McKenna, M.8
Leichtle, S.9
Redmond, D.E.10
-
71
-
-
62649151797
-
A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection
-
L. Yang, J. Jiang, L.M. Drouin, M. Agbandje-McKenna, C. Chen, C. Qiao, D. Pu, X. Hu, D.Z. Wang, J. Li, and et al. A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection Proc Natl Acad Sci U S A 106 2009 3946 3951
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3946-3951
-
-
Yang, L.1
Jiang, J.2
Drouin, L.M.3
Agbandje-Mckenna, M.4
Chen, C.5
Qiao, C.6
Pu, D.7
Hu, X.8
Wang, D.Z.9
Li, J.10
-
72
-
-
62649174755
-
Directed evolution of adeno-associated virus to an infectious respiratory virus
-
K.J. Excoffon, J.T. Koerber, D.D. Dickey, M. Murtha, S. Keshavjee, B.K. Kaspar, J. Zabner, and D.V. Schaffer Directed evolution of adeno-associated virus to an infectious respiratory virus Proc Natl Acad Sci U S A 106 2009 3865 3870
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3865-3870
-
-
Excoffon, K.J.1
Koerber, J.T.2
Dickey, D.D.3
Murtha, M.4
Keshavjee, S.5
Kaspar, B.K.6
Zabner, J.7
Schaffer, D.V.8
-
73
-
-
70449338146
-
A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Muller cells
-
R.R. Klimczak, J.T. Koerber, D. Dalkara, J.G. Flannery, and D.V. Schaffer A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Muller cells PLoS ONE 4 2009 e7467
-
(2009)
PLoS ONE
, vol.4
-
-
Klimczak, R.R.1
Koerber, J.T.2
Dalkara, D.3
Flannery, J.G.4
Schaffer, D.V.5
-
74
-
-
73849091644
-
Molecular evolution of adeno-associated virus for enhanced glial gene delivery
-
J.T. Koerber, R. Klimczak, J.H. Jang, D. Dalkara, J.G. Flannery, and D.V. Schaffer Molecular evolution of adeno-associated virus for enhanced glial gene delivery Mol Ther 17 2009 2088 2095
-
(2009)
Mol Ther
, vol.17
, pp. 2088-2095
-
-
Koerber, J.T.1
Klimczak, R.2
Jang, J.H.3
Dalkara, D.4
Flannery, J.G.5
Schaffer, D.V.6
-
75
-
-
75049084578
-
Directed evolution of adeno-associated virus for glioma cell transduction
-
C.A. Maguire, D. Gianni, D.H. Meijer, L.A. Shaket, H. Wakimoto, S.D. Rabkin, G. Gao, and M. Sena-Esteves Directed evolution of adeno-associated virus for glioma cell transduction J Neurooncol 96 2010 337 347
-
(2010)
J Neurooncol
, vol.96
, pp. 337-347
-
-
Maguire, C.A.1
Gianni, D.2
Meijer, D.H.3
Shaket, L.A.4
Wakimoto, H.5
Rabkin, S.D.6
Gao, G.7
Sena-Esteves, M.8
-
76
-
-
77649273563
-
Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
-
S.J. Gray, B.L. Blake, H.E. Criswell, S.C. Nicolson, R.J. Samulski, T.J. McCown, and W. Li Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB) Mol Ther 18 2010 570 578
-
(2010)
Mol Ther
, vol.18
, pp. 570-578
-
-
Gray, S.J.1
Blake, B.L.2
Criswell, H.E.3
Nicolson, S.C.4
Samulski, R.J.5
McCown, T.J.6
Li, W.7
|