RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

Nucleic Acids Research

Volumn 43, Issue 13, 2015, Pages 6439-6449

  Hase, Katsunori ^a,b   Fujiwara, Yuuki ^a,c   Kikuchi, Hisae ^a   Aizawa, Shu ^a   Hakuno, Fumihiko ^b   Takahashi, Shin Ichiro ^b   Wada, Keiji ^a   Kabuta, Tomohiro ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c WASEDA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; LAMP2C PROTEIN; MEMBRANE PROTEIN; POLYADENYLIC ACID; POLYCYTIDYLIC ACID; POLYGUANYLIC ACID; POLYTHYMIDYLIC ACID; POLYURIDYLIC ACID; RNA; SINGLE STRANDED DNA; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; POLY(DG);

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL ISOLATION; CELL TRANSPORT; CONTROLLED STUDY; CYTOSOL; DNA METHYLATION; DNA SEQUENCE; DNA TRANSFER; DNAUTOPHAGY; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; RNA SEQUENCE; RNA TRANSPORT; RNAUTOPHAGY; ANIMAL; CHEMISTRY; METABOLISM;

ANIMALS; AUTOPHAGY; DNA; DNA METHYLATION; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOMES; MICE; POLY G; RNA;

EID: 84939639310     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv579     Document Type: Article

References (35)

1. Liu,F., Lee,J.Y., Wei,H., Tanabe,O., Engel,J.D., Morrison,S.J. and Guan,J.L. (2010) FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood, 116, 4806-4814.
2. Pua,H.H., Guo,J., Komatsu,M. and He,Y.W. (2009) Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J. Immunol., 182, 4046-4055.
3. Futerman,A.H. and van Meer,G. (2004) The cell biology of lysosomal storage disorders. Nat. Rev. Mol. Cell Biol., 5, 554-565.
4. Kawane,K., Fukuyama,H., Kondoh,G., Takeda,J., Ohsawa,Y., Uchiyama,Y. and Nagata,S. (2001) Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science, 292, 1546-1549.
5. Haud,N., Kara,F., Diekmann,S., Henneke,M., Willer,J.R., Hillwig,M.S., Gregg,R.G., Macintosh,G.C., Gartner,J., Alia,A. et al. (2011) rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proc. Natl. Acad. Sci. U.S.A., 108, 1099-1103.
6. Henneke,M., Diekmann,S., Ohlenbusch,A., Kaiser,J., Engelbrecht,V., Kohlschutter,A., Kratzner,R., Madruga-Garrido,M., Mayer,M., Opitz,L. et al. (2009) RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection. Nat. Genet., 41, 773-775.
7. Mizushima,N., Levine,B., Cuervo,A.M. and Klionsky,D.J. (2008) Autophagy fights disease through cellular self-digestion. Nature, 451, 1069-1075.
8. Mizushima,N. and Klionsky,D.J. (2007) Protein turnover via autophagy: implications for metabolism. Annu. Rev. Nutr., 27, 19-40.
9. Sahu,R., Kaushik,S., Clement,C.C., Cannizzo,E.S., Scharf,B., Follenzi,A., Potolicchio,I., Nieves,E., Cuervo,A.M. and Santambrogio,L. (2011) Microautophagy of cytosolic proteins by late endosomes. Dev. Cell, 20, 131-139.
10. Chiang,H.L., Terlecky,S.R., Plant,C.P. and Dice,J.F. (1989) A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science, 246, 382-385.
11. Cuervo,A.M. and Dice,J.F. (1996) A receptor for the selective uptake and degradation of proteins by lysosomes. Science, 273, 501-503.
12. Klionsky,D.J., Cuervo,A.M., Dunn,W.A. Jr, Levine,B., van der Klei,I. and Seglen,P.O. (2007) How shall I eat thee? Autophagy, 3, 413-416.
13. Fujiwara,Y., Kikuchi,H., Aizawa,S., Furuta,A., Hatanaka,Y., Konya,C., Uchida,K., Wada,K. and Kabuta,T. (2013) Direct uptake and degradation of DNA by lysosomes. Autophagy, 9, 1167-1171.
14. Fujiwara,Y., Furuta,A., Kikuchi,H., Aizawa,S., Hatanaka,Y., Konya,C., Uchida,K., Yoshimura,A., Tamai,Y., Wada,K. et al. (2013) Discovery of a novel type of autophagy targeting RNA. Autophagy, 9, 403-409.
15. Kabuta,T., Furuta,A., Aoki,S., Furuta,K. and Wada,K. (2008) Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J. Biol. Chem., 283, 23731-23738.
16. Houseley,J. and Tollervey,D. (2009) The many pathways of RNA degradation. Cell, 136, 763-776.
17. Fujiwara,Y., Hase,K., Wada,K. and Kabuta,T. (2015) An RNautophagy/DNautophagy receptor, LAMP2C, possesses an arginine-rich motif that mediates RNA/DNA-binding. Biochem. Biophys. Res. Commun., 460, 281-286.
18. Haider,S.M., Parkinson,G.N. and Neidle,S. (2003) Structure of a G-quadruplex-ligand complex. J. Mol. Biol., 326, 117-125.
19. Siddiqui-Jain,A., Grand,C.L., Bearss,D.J. and Hurley,L.H. (2002) Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl. Acad. Sci. U.S.A., 99, 11593-11598.
20. Subramanian,M., Rage,F., Tabet,R., Flatter,E., Mandel,J.L. and Moine,H. (2011) G-quadruplex RNA structure as a signal for neurite mRNA targeting. EMBO Rep., 12, 697-704.
21. Haeusler,A.R., Donnelly,C.J., Periz,G., Simko,E.A., Shaw,P.G., Kim,M.S., Maragakis,N.J., Troncoso,J.C., Pandey,A., Sattler,R. et al. (2014) C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature, 507, 195-200.
22. Weiss,M.A. and Narayana,N. (1998) RNA recognition by arginine-rich peptide motifs. Biopolymers, 48, 167-180.
23. Patel,D.J. (1999) Adaptive recognition in RNA complexes with peptides and protein modules. Curr. Opin. Struct. Biol., 9, 74-87.
24. Ye,X., Gorin,A., Frederick,R., Hu,W., Majumdar,A., Xu,W., McLendon,G., Ellington,A. and Patel,D.J. (1999) RNA architecture dictates the conformations of a bound peptide. Chem. Biol., 6, 657-669.
25. Wolberger,C., Vershon,A.K., Liu,B., Johnson,A.D. and Pabo,C.O. (1991) Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell, 67, 517-528.
26. Ellenberger,T.E., Brandl,C.J., Struhl,K. and Harrison,S.C. (1992) The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell, 71, 1223-1237.
27. Tucker,K.L. (2001) Methylated cytosine and the brain: a new base for neuroscience. Neuron, 30, 649-652.
28. den Boon,J.A., Diaz,A. and Ahlquist,P. (2010) Cytoplasmic viral replication complexes. Cell Host Microbe, 8, 77-85.
29. Nakahira,K., Haspel,J.A., Rathinam,V.A., Lee,S.J., Dolinay,T., Lam,H.C., Englert,J.A., Rabinovitch,M., Cernadas,M., Kim,H.P. et al. (2011) Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol., 12, 222-230.
30. DeJesus-Hernandez,M., Mackenzie,I.R., Boeve,B.F., Boxer,A.L., Baker,M., Rutherford,N.J., Nicholson,A.M., Finch,N.A., Flynn,H., Adamson,J. et al. (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron, 72, 245-256.
31. Renton,A.E., Majounie,E., Waite,A., Simon-Sanchez,J., Rollinson,S., Gibbs,J.R., Schymick,J.C., Laaksovirta,H., van Swieten,J.C., Myllykangas,L. et al. (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron, 72, 257-268.
32. Li,Y.R., King,O.D., Shorter,J. and Gitler,A.D. (2013) Stress granules as crucibles of ALS pathogenesis. J. Cell Biol., 201, 361-372.
33. Fecto,F. and Siddique,T. (2011) Making connections: pathology and genetics link amyotrophic lateral sclerosis with frontotemporal lobe dementia. J. Mol. Neurosci., 45, 663-675.
34. Xu,Z., Poidevin,M., Li,X., Li,Y., Shu,L., Nelson,D.L., Li,H., Hales,C.M., Gearing,M., Wingo,T.S. et al. (2013) Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration. Proc. Natl. Acad. Sci. U.S.A., 110, 7778-7783.
35. Donnelly,C.J., Zhang,P.W., Pham,J.T., Haeusler,A.R., Mistry,N.A., Vidensky,S., Daley,E.L., Poth,E.M., Hoover,B., Fines,D.M. et al. (2013) RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron, 80, 415-428.