Common variants in serum/glucocorticoid regulated kinase 1 (SGK1) and blood pressure responses to dietary sodium or potassium interventions: A family-based association study

Kidney and Blood Pressure Research

Volumn 40, Issue 4, 2015, Pages 424-434

  Chu, Chao ^a,b   Wang, Yang ^a,b   Wang, Man ^a   Mu, Jian Jun ^a,b   Liu, Fu Qiang ^a,b   Wang, Lan ^a   Ren, Ke Yu ^a,b   Wang, Dan ^a,b   Yuan, Zu Yi ^a,b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Blood pressure; Potassium; Serum glucocorticoid regulated kinase 1; Singlenucleotide polymorphism; Sodium

Indexed keywords

POTASSIUM; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM; IMMEDIATE EARLY PROTEIN; POTASSIUM INTAKE; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; SODIUM INTAKE;

ADULT; ARTICLE; BLOOD PRESSURE RESPONSE; CARDIOVASCULAR PARAMETERS; CHINA; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; HIGH SODIUM INTAKE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; POTASSIUM EXCRETION; POTASSIUM INTAKE; POTASSIUM URINE LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RURAL AREA; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM EXCRETION; SODIUM INTAKE; SODIUM RESTRICTION; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE; ADOLESCENT; ARTERIAL PRESSURE; BLOOD PRESSURE; DIET; DRUG EFFECTS; EPIDEMIOLOGY; FAMILY; GENETICS; MIDDLE AGED; PHARMACOLOGY; PREHYPERTENSION; RURAL POPULATION; YOUNG ADULT;

ADOLESCENT; ADULT; ARTERIAL PRESSURE; BLOOD PRESSURE; CHINA; DIET; DIET, SODIUM-RESTRICTED; FAMILY; FEMALE; GENE FREQUENCY; HUMANS; IMMEDIATE-EARLY PROTEINS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM, DIETARY; PREHYPERTENSION; PROTEIN-SERINE-THREONINE KINASES; RURAL POPULATION; SODIUM, DIETARY; YOUNG ADULT;

EID: 84939622175     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000368518     Document Type: Article

References (34)

1. Lawes CM, Vander HS, Rodgers A: Global burden of blood-pressure-related disease, 2001. Lancet 2008;371:1513-1518.
2. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP: Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ 2013;346:f1378.
3. Aburto NJ, Ziolkovska A, Hooper L, Elliott P, Cappuccio FP, Meerpohl JJ: Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ 2013;346:f1326.
4. Mente A, O'Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, Morrison H, Li W, Wang X, Di C, Mony P, Devanath A, Rosengren A, Oguz A, Zatonska K, Yusufali AH, Lopez-Jaramillo P, Avezum A, Ismail N, Lanas F, Puoane T, Diaz R, Kelishadi R, Iqbal R, Yusuf R, Chifamba J, Khatib R, Teo K, Yusuf S: Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med 2014;371:601-611.
5. Geleijnse JM, Kok FJ, Grobbee DE: Blood pressure response to changes in sodium and potassium intake: a metaregression analysis of randomised trials. J Hum Hypertens 2003;17:471-480.
6. Chen J: Sodium sensitivity of blood pressure in Chinese populations. Curr Hypertens Rep 2010;12:127-134.
7. Zhao Q, Gu D, Kelly TN, Hixson JE, Rao DC, Jaquish CE, Chen J, Huang J, Chen CS, Gu CC, Whelton PK, He J: Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study. Am J Hypertens 2010;23:606-613.
8. Firestone GL, Giampaolo JR, O'Keeffe BA: Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 2003;13:1-12.
9. Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL: Characterization of sgk, a novel member of the serine/ threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 1993;13:2031-2040.
10. Waldegger S, Barth P, Raber G, Lang F: Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci USA 1997;94:4440-4445.
11. Voelkl J, Mia S, Meissner A, Ahmed MS, Feger M, Elvira B, Walker B, Alessi DR, Alesutan I, Lang F: PKB/SGKresistant GSK-3 signaling following unilateral ureteral obstruction. Kidney Blood Press Res 2013;38:156-164.
12. Towhid ST, Liu GL, Ackermann TF, Beier N, Scholz W, Fuchss T, Toulany M, Rodemann HP, Lang F: Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem 2013;32:838-848.
13. Borst O, Schaub M, Walker B, Schmid E, Munzer P, Voelkl J, Alesutan I, Rodriguez JM, Vogel S, Schoenberger T, Metzger K, Rath D, Umbach A, Kuhl D, Muller II, Seizer P, Geisler T, Gawaz M, Lang F: Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis. Arterioscler Thromb Vasc Biol 2015;35:547-557.
14. Zecevic M, Heitzmann D, Camargo SM, Verrey F: SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytes. Pflugers Arch 2004;448:29-35.
15. Wang D, Sun H, Lang F, Yun CC: Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1. Am J Physiol Cell Physiol 2005;289:C802-810.
16. Arroyo JP, Lagnaz D, Ronzaud C, Vazquez N, Ko BS, Moddes L, Ruffieux-Daidie D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O: Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol 2011;22:1707-1719.
17. Soundararajan R, Pearce D, Ziera T: The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol 2012;350:242-247.
18. Zhou X, Zhang Z, Shin MK, Horwitz SB, Levorse JM, Zhu L, Sharif-Rodriguez W, Streltsov DY, Dajee M, Hernandez M, Pan Y, Urosevic-Price O, Wang L, Forrest G, Szeto D, Zhu Y, Cui Y, Michael B, Balogh LA, Welling PA, Wade JB, Roy S, Sullivan KA: Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure. Hypertension 2013;62:288-294.
19. Faresse N, Lagnaz D, Debonneville A, Ismailji A, Maillard M, Fejes-Toth G, Naray-Fejes-Toth A, Staub O: Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype. Am J Physiol Renal Physiol 2012;302:F977-985.
20. Busjahn A, Luft FC: Twin studies in the analysis of minor physiological differences between individuals: Cell Physiol Biochem 2003;13:51-58.
21. Gu D, Rice T, Wang S, Yang W, Gu C, Chen CS, Hixson JE, Jaquish CE, Yao ZJ, Liu DP, Rao DC, He J: Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population. Hypertension 2007;50:116-122.
22. Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M, Morgenstern BZ: Human blood pressure determination by sphygmomanometry. Circulation 1993;88:2460-2470.
23. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575.
24. Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265.
25. Horvath S, Xu X, Laird NM: The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001;9:301-306.
26. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995;57:298-300.
27. Wulff P, Vallon V, Huang DY, Volkl H, Yu F, Richter K, Jansen M, Schlunz M, Klingel K, Loffing J, Kauselmann G, Bosl MR, Lang F, Kuhl D: Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest 2002;110:1263-1268.
28. Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F: SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am J Physiol Regul Integr Comp Physiol 2005;289:R395-395R401.
29. Ackermann TF, Boini KM, Beier N, Scholz W, Fuchss T, Lang F: EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem 2011;28:137-146.
30. Busjahn A, Aydin A, Uhlmann R, Krasko C, Bahring S, Szelestei T, Feng Y, Dahm S, Sharma AM, Luft FC, Lang F: Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Hypertension 2002;40:256-260.
31. von WF, Berglund G, Carlson J, Mansson H, Hedblad B, Melander O: Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. Kidney Int 2005;68:2164-2172.
32. Rao AD, Sun B, Saxena A, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams JS: Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake. J Hum Hypertens 2013;27:176-180.
33. Li C, Yang X, He J, Hixson JE, Gu D, Rao DC, Shimmin LC, Huang J, Gu CC, Chen J, Li J, Kelly TN: A genebased analysis of variants in the serum/glucocorticoid regulated kinase (SGK) genes with blood pressure responses to sodium intake: the GenSalt Study. PLoS One 2014;9:e98432.
34. Huang DY, Wulff P, Volkl H, Loffing J, Richter K, Kuhl D, Lang F, Vallon V: Impaired regulation of renal K+ elimination in the sgk1-knockout mouse. J Am Soc Nephrol 2004;15:885-891.