PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction

Kidney and Blood Pressure Research

Volumn 38, Issue 1, 2014, Pages 156-164

  Voelkl, Jakob ^a   Mia, Sobuj ^a   Meissner, Adrian ^a   Ahmed, Mohamed S ^a   Feger, Martina ^a   Elvira, Bernat ^a   Walker, Britta ^a   Alessi, Dario R ^b   Alesutan, Ioana ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Glycogen synthase kinase 3; Protein kinase B; Renal fibrosis; Serum and glucocorticoid inducible kinase; Unilateral ureteral obstruction; Wnt; catenin

Indexed keywords

BETA CATENIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; LYMPHOID ENHANCER FACTOR 1; PROTEIN KINASE B; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMOOTH MUSCLE ACTIN; TRANSCRIPTION FACTOR TWIST; COLLAGEN; GLYCOGEN SYNTHASE KINASE 3 ALPHA; GLYCOGEN SYNTHASE KINASE 3 BETA; IMMEDIATE EARLY PROTEIN; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; ALPHA SMOOTH MUSCLE ACTIN; PROTEIN; PROTEIN SGK; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DICKKOPF 1 GENE; ENZYME PHOSPHORYLATION; GENE; KIDNEY FIBROSIS; KIDNEY PARENCHYMA; LYMPHOID ENHANCER FACTOR 1 GENE; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR TWIST GENE; UNILATERAL URETER OBSTRUCTION; URETER OBSTRUCTION; WILD TYPE; ANIMAL; BIOSYNTHESIS; GENETICS; MUTATION; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC ANIMAL; WNT SIGNALING PATHWAY; DKK1 GENE; LEF1 GENE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TWIST GENE; UNILATERAL URETERAL OBSTRUCTION; WESTERN BLOTTING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BETA CATENIN; COLLAGEN; GLYCOGEN SYNTHASE KINASE 3; IMMEDIATE-EARLY PROTEINS; MICE; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; URETERAL OBSTRUCTION; WNT SIGNALING PATHWAY;

EID: 84897464225     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000355763     Document Type: Article

References (40)

1. Bascands JL, Schanstra JP: Obstructive nephropathy: insights from genetically engineered animals. Kidney Int 2005;68:925-937.
2. Samarakoon R, Overstreet JM, Higgins SP, Higgins PJ: TGF-beta1 -SMAD/p53/USF2 -PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis. Cell Tissue Res 2012;347:117-128.
3. Grgic I, Duffield JS, Humphreys BD: The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol 2012;27:183-193.
4. Kriz W, Kaissling B, Le Hir M: Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest 2011;121:468-474.
5. Liu Y: New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 2010;21:212-222.
6. Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J: Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int 2010;78:668-678.
7. Yanagita M: Inhibitors/antagonists of TGF-beta system in kidney fibrosis. Nephrol Dial Transplant 2012;27:3686-3691.
8. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V: (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006;86:1151-1178.
9. Sakoda H, Gotoh Y, Katagiri H, Kurokawa M, Ono H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Fukushima Y, Abe M, Shojima N, Kikuchi M, Oka Y, Hirai H, Asano T: Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 2003;278:25802-25807.
10. Shaw M, Cohen P, Alessi DR: Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF- 1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett 1997;416:307-311.
11. Wyatt AW, Hussain A, Amann K, Klingel K, Kandolf R, Artunc F, Grahammer F, Huang DY, Vallon V, Kuhl D, Lang F: DOCA-induced phosphorylation of glycogen synthase kinase 3beta. Cell Physiol Biochem 2006;17:137-144.
12. Aoyama T, Matsui T, Novikov M, Park J, Hemmings B, Rosenzweig A: Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Circulation 2005;111:1652-1659.
13. Hardt SE, Sadoshima J: Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ Res 2002;90:1055-1063.
14. He W, Dai C, Li Y, Zeng G, Monga SP, Liu Y: Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol 2009;20:765-776.
15. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F, Belaiba RS, Gorlach A, Wulff P, Daut J, Dalton ND, Ross J, Jr. , Flogel U, Schrader J, Osswald H, Kandolf R, Kuhl D, Lang F: SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. J Mol Med (Berl) 2006;84:396-404.
16. Zheng H, Li W, Wang Y, Liu Z, Cai Y, Xie T, Shi M, Wang Z, Jiang B: Glycogen synthase kinase-3 beta regulates Snail and beta-catenin expression during Fas-induced epithelial-mesenchymal transition in gastrointestinal cancer. Eur J Cancer 2013;49:2734-2746.
17. Doble BW, Woodgett JR: Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007;185:73-84.
18. McManus EJ, Sakamoto K, Armit LJ, Ronaldson L, Shpiro N, Marquez R, Alessi DR: Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J 2005;24:1571-1583.
19. Rodriguez-Pena AB, Grande MT, Eleno N, Arevalo M, Guerrero C, Santos E, Lopez-Novoa JM: Activation of Erk1/2 and Akt following unilateral ureteral obstruction. Kidney Int 2008;74:196-209.
20. Ivanova L, Butt MJ, Matsell DG: Mesenchymal transition in kidney collecting duct epithelial cells. Am J Physiol Renal Physiol 2008;294:F1238-1248.
21. Zhou L, Li Y, Zhou D, Tan RJ, Liu Y: Loss of Klotho contributes to kidney injury by derepression of Wnt/betacatenin signaling. J Am Soc Nephrol 2013;24:771-785.
22. Wu D, Pan W: GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci 2010;35:161-168.
23. Xu C, Kim NG, Gumbiner BM: Regulation of protein stability by GSK3 mediated phosphorylation. Cell Cycle 2009;8:4032-4039.
24. Ding VW, Chen RH, McCormick F: Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. J Biol Chem 2000;275:32475-32481.
25. Metcalfe C, Bienz M: Inhibition of GSK3 by Wnt signalling-two contrasting models. J Cell Sci 2011;124:3537-3544.
26. Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, Korswagen HC, Schutte M, Clevers H: Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. J Biol Chem 2009;284:35308-35313.
27. Bouskila M, Hunter RW, Ibrahim AF, Delattre L, Peggie M, van Diepen JA, Voshol PJ, Jensen J, Sakamoto K: Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. Cell Metab 2010;12:456-466.
28. Chevalier RL, Forbes MS, Thornhill BA: Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 2009;75:1145-1152.
29. Xiong M, Gong J, Liu Y, Xiang R, Tan X: Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition. Am J Physiol Renal Physiol 2012;303:F1107-F1115.
30. Byun HO, Jung HJ, Seo YH, Lee YK, Hwang SC, Hwang ES, Yoon G: GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) beta1-induced senescence. Exp Cell Res 2012;318:1808-1819.
31. Webb IG, Nishino Y, Clark JE, Murdoch C, Walker SJ, Makowski MR, Botnar RM, Redwood SR, Shah AM, Marber MS: Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic betaadrenergic remodelling of the heart. Cardiovasc Res 2010;87:494-503.
32. Voskas D, Ling LS, Woodgett JR: Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling? F1000 Biol Rep 2010;2:82.
33. Monick MM, Carter AB, Robeff PK, Flaherty DM, Peterson MW, Hunninghake GW: Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin. J Immunol 2001;166:4713-4720.
34. Lee YJ, Han HJ: Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3beta, Snail1, and beta-catenin in renal proximal tubule cells. Am J Physiol Renal Physiol 2010;298:F1263-1275.
35. Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R: TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nat Cell Biol 2009;11:881-889.
36. Lang F, Klingel K, Wagner CA, Stegen C, Warntges S, Friedrich B, Lanzendorfer M, Melzig J, Moschen I, Steuer S, Waldegger S, Sauter M, Paulmichl M, Gerke V, Risler T, Gamba G, Capasso G, Kandolf R, Hebert SC, Massry SG, Broer S: Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. Proc Natl Acad Sci USA 2000;97:8157-8162.
37. Quinkler M, Zehnder D, Eardley KS, Lepenies J, Howie AJ, Hughes SV, Cockwell P, Hewison M, Stewart PM: Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria. Circulation 2005;112:1435-1443.
38. Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P, Kuhl D, Lang F: Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1. J Mol Med (Berl) 2006;84:737-746.
39. Voelkl J, Lin Y, Alesutan I, Ahmed MS, Pasham V, Mia S, Gu S, Feger M, Saxena A, Metzler B, Kuhl D, Pichler BJ, Lang F: Sgk1 sensitivity of Na(+)/H(+) exchanger activity and cardiac remodeling following pressure overload. Basic Res Cardiol 2012;107:236.
40. Voelkl J, Pasham V, Ahmed MS, Walker B, Szteyn K, Kuhl D, Metzler B, Alesutan I, Lang F: Sgk1-dependent stimulation of cardiac na/h(+) exchanger nhe1 by dexamethasone. Cell Physiol Biochem 2013;32:25-38.