Assessment of ToxCast phase II for mitochondrial liabilities using a high-throughput respirometric assay

Toxicological Sciences

Volumn 146, Issue 2, 2015, Pages 226-234

  Wills, Lauren P ^a   Beeson, Gyda C ^a,b   Hoover, Douglas B ^b   Schnellmann, Rick G ^b,c   Beeson, Craig C ^a,b  

^a MitoHealth Inc   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Cell cultur; In vitro and alternatives; Kidney; Safety evaluation; Systems toxicology

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; DIDECYLDIMETHYLAMMONIUM CHLORIDE; DINITRO ORTHO CRESOL; OLIGOMYCIN; ORGANOFLUORINE DERIVATIVE; PENTACHLOROPHENOL; PERFLUOROOCTANESULFONAMIDE; TRIBUTYLTIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY ASSAY; ENZYME INHIBITION; FEMALE; HEPG2 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMORTALIZED CELL LINE; IN VITRO STUDY; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; LUNG MITOCHONDRION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; RESPIROMETRY; TOXICOLOGY; ANIMAL; CELL LINE; CELL RESPIRATION; DRUG EFFECTS; ELECTRON TRANSPORT; RABBIT; TOXICITY TESTING;

ANIMALS; CELL LINE; CELL RESPIRATION; ELECTRON TRANSPORT; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MITOCHONDRIA; RABBITS; TOXICITY TESTS;

EID: 84939611964     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv085     Document Type: Article

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