Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease

Medicine and Science in Sports and Exercise

Volumn 47, Issue 9, 2015, Pages 1814-1824

  Cho, Jinkyung ^a   Shin, Min Kyoo ^a   Kim, Donghyun ^a   Lee, Inhwan ^a   Kim, Shinuk ^b   Kang, Hyunsik ^a  

^a Sungkyunkwan University   (South Korea)

^b Sangmyung University   (South Korea)

Author keywords

ALZHEIMER DISEASE; COGNITIVE FUNCTION; NEUROPATHOLOGY; PHYSICAL EXERCISE

Indexed keywords

AMYLOID; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; NERVE PROTEIN;

ALZHEIMER DISEASE; ANIMAL; ANIMAL EXPERIMENT; BLOOD; COGNITION DISORDERS; DISEASE MODEL; METABOLISM; PATHOLOGY; PSYCHOLOGY; RUNNING; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION DISORDERS; CORTICOSTERONE; DISEASE MODELS, ANIMAL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; PHYSICAL CONDITIONING, ANIMAL; RUNNING;

EID: 84939572180     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000612     Document Type: Article

References (40)

1. Adlard PA, Perreau VM, Cotman CW,. The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol Aging. 2005; 26 (4): 511-20.
2. Adlard PA, Perreau VM, Pop V, Cotman CW,. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci. 2005; 25 (17): 4217-21.
3. Ando S, Kobayashi S, Waki H, Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine. J Neurosci Res. 2002; 70 (3): 519-27.
4. Barnard ND, Bush AI, Ceccarelli A, Dietary and lifestyle guidelines for the prevention of Alzheimer's disease. Neurobiol Aging. 2014; 35 (2 Suppl): S74-8.
5. Belarbi K, Burnouf S, Fernandez-Gomez FJ, Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology. Neurobiol Dis. 2011; 43 (2): 486-94.
6. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM,. Forecasting the global burden of Alzheimer's disease. Alzheimers Dement. 2007; 3 (3): 186-91.
7. Burns JM, Cronk BB, Anderson HS, Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology. 2008; 71 (3): 210-6.
8. Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR,. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. 2004; 124 (1): 71-9.
9. García-Mesa Y, Giménez-Llort L, López LC, Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse. Neurobiol Aging. 2012; 33 (6): 1124.e13-29.
10. García-Mesa Y, López-Ramos JC, Giménez-Llort L, Physical exercise protects against Alzheimer's disease in 3xTg-AD mice. J Alzheimers Dis. 2011; 24 (3): 421-54.
11. Geda YE, Roberts RO, Knopman DS, Physical exercise, aging, and mild cognitive impairment: a population-based study. Arch Neurol. 2010; 67 (1): 80-6.
12. Giménez-Llort L, García Y, Buccieri K, Gender-specific neuroimmunoendocrine response to treadmill exercise in 3xTg-AD mice. Int J Alzheimers Dis. 2010; 2010: 128354.
13. Griffin ÉW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly AM,. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav. 2011; 104 (5): 934-41.
14. Hardy J, Selkoe DJ,. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002; 297 (5580): 353-6.
15. Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J,. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013; 1 (1): 82.
16. Ingelsson M, Fukumoto H, Newell KL, Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology. 2004; 62 (6): 925-31.
17. Kazim SF, Blanchard J, Dai CL, Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2014; 71: 110-30.
18. Ke HC, Huang HJ, Liang KC, Hsieh-Li HM,. Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise. Brain Res. 2011; 1403: 1-11.
19. Leasure JL, Jones M,. Forced and voluntary exercise differentially affect brain and behavior. Neuroscience. 2008; 156 (3): 456-65.
20. Leem YH, Lim HJ, Shim SB, Cho JY, Kim BS, Han PL,. Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. J Neurosci Res. 2009; 87 (11): 2561-70.
21. Liu HL, Zhao G, Zhang H, Shi LD,. Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice. Behav Brain Res. 2013; 256: 261-72.
22. Mattson MP, Maudsley S, Martin B,. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004; 27 (10): 589-94.
23. Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW,. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation. 2008; 5: 13.
24. Oddo S, Caccamo A, Shepherd JD, Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003; 39 (3): 409-21.
25. Palop JJ, Mucke L,. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci. 2010; 13 (7): 812-8.
26. Peng SX, Garzon DJ, Marchese M, Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci. 2009; 29 (29): 9321-9.
27. Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW,. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. 1991; 7 (5): 695-702.
28. Ploughman M, Granter-Button S, Chernenko G, Exercise intensity influences the temporal profile of growth factors involved in neuronal plasticity following focal ischemia. Brain Res. 2007; 1150: 207-16.
29. Revilla S, Suñol C, García-Mesa Y, Giménez-Llort L, Sanfeliu C, Cristòfol R,. Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain. Neuropharmacology. 2014; 81: 55-63.
30. Scarmeas N, Luchsinger JA, Schupf N, Physical activity, diet, and risk of Alzheimer disease. JAMA. 2009; 302 (6): 627-37.
31. Shin MK, Kim HG, Baek SH, Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques. Neurobiol Aging. 2014; 35 (5): 990-1001.
32. Sofi F, Valecchi D, Bacci D, Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med. 2011; 269 (1): 107-17.
33. Sterniczuk R, Antle MC, Laferla FM, Dyck RH,. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes. Brain Res. 2010; 1348: 149-55.
34. Stranahan AM, Khalil D, Gould E,. Running induces widespread structural alterations in the hippocampus and entorhinal cortex. Hippocampus. 2007; 17 (11): 1017-22.
35. Terry RD, Masliah E, Salmon DP, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991; 30 (4): 572-80.
36. Trinh NH, Hoblyn J, Mohanty S, Yaffe K,. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003; 289 (2): 210-6.
37. Um HS, Kang EB, Goo JH, Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease. Neurosci Res. 2011; 69 (2): 161-73.
38. Yágüez L, Shaw KN, Morris R, Matthews D,. The effects on cognitive functions of a movement-based intervention in patients with Alzheimer's type dementia: a pilot study. Int J Geriatr Psychiatry. 2011; 26 (2): 173-81.
39. Yuede CM, Zimmerman SD, Dong H, Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Dis. 2009; 35 (3): 426-32.
40. Yoshiyama Y, Higuchi M, Zhang B, Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007; 53 (3): 337-51.