Downregulation of BDNF expression by PKC and by TNF-in human endothelial cells

Pharmacology

Volumn 96, Issue 1-2, 2015, Pages 1-10

  Xu, Hui ^a,b   Czerwinski, Petra ^b   Xia, Ning ^b   Förstermann, Ulrich ^b   Li, Huige ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Angiogenesis; BDNF; Endothelial cells; Neurotrophin; TNF PKC

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 4ALPHA PHORBOL DIDECANOATE; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MATRIGEL; MESSENGER RNA; NEUROTROPHIN RECEPTOR P75; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; ROTTLERIN; TUMOR NECROSIS FACTOR ALPHA; 2-(1-(3-DIMETHYLAMINOPROPYL)-5-METHOXYINDOL-3-YL)-3-(1H-INDOL-3-YL)MALEIMIDE; ACETOPHENONE DERIVATIVE; BENZOPYRAN DERIVATIVE; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; CARBAZOLE DERIVATIVE; CYCLOPEPTIDE; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; NERVE GROWTH FACTOR RECEPTOR; NERVE PROTEIN; NGFR PROTEIN, HUMAN; PHORBOL ESTER; WP9QY PEPTIDE;

ANGIOGENESIS; ANGIOGENESIS ASSAY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA STABILITY; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ACETOPHENONES; BENZOPYRANS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDOLES; MALEIMIDES; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; PEPTIDES, CYCLIC; PHORBOL ESTERS; PROTEIN KINASE C; RECEPTOR, TRKB; RECEPTORS, NERVE GROWTH FACTOR; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84939570751     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000430823     Document Type: Article

References (40)

1. Barde YA, Edgar D, Thoenen H: Purification of a new neurotrophic factor from mammalian brain. EMBO J 1982; 1: 549-553.
2. Lewin GR, Barde YA: Physiology of the neurotrophins. Annu Rev Neurosci 1996; 19: 289-317.
3. Benraiss A, et al: Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J Neurosci 2001; 21: 6718-6731.
4. Shirakura M, et al: Postischemic administration of Sendai virus vector carrying neurotrophic factor genes prevents delayed neuronal death in gerbils. Gene Ther 2004; 11: 784-790.
5. Schäbitz WR, et al: Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1997; 17: 500-506.
6. Chen J, et al: Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice. J Cereb Blood Flow Metab 2005; 25: 281-290.
7. Duda DG, Jain RK: Pleiotropy of tissue-specific growth factors: from neurons to vessels via the bone marrow. J Clin Invest 2005; 115: 596-598.
8. Donovan MJ, et al: Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development 2000; 127: 4531-4540.
9. Kermani P, et al: Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest 2005; 115: 653-663.
10. Fujimura H, et al: Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 2002; 87: 728-734.
11. Lommatzsch M, et al: The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 2005; 26: 115-123.
12. Kerschensteiner M, et al: Activated human T cells, B cells, and monocytes produce brainderived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 1999; 189: 865-870.
13. Donovan MJ, et al: Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol 1995; 147: 309-324.
14. Nakahashi T, et al: Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 2000; 470: 113-117.
15. Ejiri J, et al: Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease. Circulation 2005; 112: 2114-2120.
16. Li H, et al: Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene. Mol Pharmacol 1998; 53: 630-637.
17. Li H, et al: Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase. Circulation 2002; 106: 2250-2256.
18. Xu H, et al: Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc Res 2008; 78: 349-355.
19. Tapley P, Lamballe F, Barbacid M: K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene 1992; 7: 371-381.
20. Yamashita T, Tohyama M: The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 2003; 6: 461-467.
21. Chen G, Goeddel DV: TNF-R1 signaling: a beautiful pathway. Science 2002; 296: 1634-1635.
22. Takasaki W, et al: Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNF alpha binding to its receptor. Nat Biotechnol 1997; 15: 1266-1270.
23. Gschwendt M, et al: Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett 1996; 392: 77-80.
24. Gschwendt M, et al: Rottlerin, a novel protein kinase inhibitor. Biochem Biophys Res Commun 1994; 199: 93-98.
25. Martiny-Baron G, et al: Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem 1993; 268: 9194-9197.
26. Sun CY, et al: Brain-derived neurotrophic factor inducing angiogenesis through modulation of matrix-degrading proteases. Chin Med J (Engl) 2006; 119: 589-595.
27. Wang YD, et al: Brain derived neurotrophic factor induces endothelial cells angiogenesis through AKT and ERK1/2 signal pathway. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008; 16: 175-180.
28. Kermani P, Hempstead B: Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. Trends Cardiovasc Med 2007; 17: 140-143.
29. Wagner N, et al: Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev 2005; 19: 2631-2642.
30. Goukassian DA, et al: Tumor necrosis factoralpha receptor p75 is required in ischemia-induced neovascularization. Circulation 2007; 115: 752-762.
31. Hempstead BL: The many faces of p75NTR. Curr Opin Neurobiol 2002; 12: 260-267.
32. Rickhag M, Teilum M, Wieloch T: Rapid and long-term induction of effector immediate early genes (BDNF, Neuritin and Arc) in periinfarct cortex and dentate gyrus after ischemic injury in rat brain. Brain Res 2007; 1151: 203-210.
33. Parain K, et al: Reduced expression of brainderived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport 1999; 10: 557-561.
34. Bright R, Mochly-Rosen D: The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke 2005; 36: 2781-2790.
35. Nagatsu T, et al: Changes in cytokines and neurotrophins in Parkinson's disease. J Neural Transm Suppl 2000; 60: 277-290.
36. Bayas A, et al: Human cerebral endothelial cells are a potential source for bioactive BDNF. Cytokine 2002; 19: 55-58.
37. Sainson RC, et al: TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood 2008; 111: 4997-5007.
38. Terry CM, et al: TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells. Am J Physiol 1999; 276:H1493-H1501.
39. Ferro TJ, et al: Tumor necrosis factor-alpha activates pulmonary artery endothelial protein kinase C. Am J Physiol 1993; 264:L7-L14.
40. Newton AC: Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev 2001; 101: 2353-2364.