Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

Clinical Epigenetics

Volumn 7, Issue 1, 2015, Pages

  Curry, Edward ^a   Green, Ian ^a   Chapman Rothe, Nadine ^a   Shamsaei, Elham ^a   Kandil, Sarah ^a   Cherblanc, Fanny L ^a   Payne, Luke ^a   Bell, Emma ^a   Ganesh, Thota ^b   Srimongkolpithak, Nitipol ^a   Caron, Joachim ^a   Li, Fengling ^c   Uren, Anthony G ^d   Snyder, James P ^e   Vedadi, Masoud ^c   Fuchter, Matthew J ^a   Brown, Robert ^a,f  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

^e EMORY UNIVERSITY   (United States)

^f INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE METHYLTRANSFERASE; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; PROTEIN EHMT2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER CELL LINE; CANCER GROWTH; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION; GENE IDENTIFICATION; GENE SILENCING; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MDA MB 231 CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION;

EID: 84939526901     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-015-0118-9     Document Type: Article

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