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Volumn 18, Issue 8, 2015, Pages 515-523

Polypill for prevention of cardiovascular disease in an Urban Iranian population with special focus on nonalcoholic steatohepatitis: A pragmatic randomized controlled trial within a cohort (PolyIran - Liver) – Study protocol

Author keywords

Atherosclerosis; Iran; Liver; Primary prevention; Secondary prevention

Indexed keywords

ACETYLSALICYLIC ACID; ALANINE AMINOTRANSFERASE; ATORVASTATIN; HYDROCHLOROTHIAZIDE; VALSARTAN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTITHROMBOCYTIC AGENT; DIURETIC AGENT; DRUG COMBINATION; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 84939526102     PISSN: 10292977     EISSN: 17353947     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (27)

References (34)
  • 1
    • 84874616900 scopus 로고    scopus 로고
    • Prevention of non-communicable diseases: What can be done?
    • Merat S, Malekzadeh R. Prevention of non-communicable diseases: what can be done? Arch Iran Med. 2013; 16(3): 136-7.
    • (2013) Arch Iran Med , vol.16 , Issue.3 , pp. 136-137
    • Merat, S.1    Malekzadeh, R.2
  • 2
    • 0038165393 scopus 로고    scopus 로고
    • A strategy to reduce cardiovascular disease by more than 80%
    • Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80%. BMJ. 2003; 326(7404): 1419.
    • (2003) BMJ , vol.326 , Issue.7404 , pp. 1419
    • Wald, N.J.1    Law, M.R.2
  • 4
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials
    • Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, Peto R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009; 373(9678): 1849-60.
    • (2009) Lancet , vol.373 , Issue.9678 , pp. 1849-1860
    • Baigent, C.1    Blackwell, L.2    Collins, R.3    Emberson, J.4    Godwin, J.5    Peto, R.6
  • 5
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet. 2005; 366(9493): 1267-78.
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3    Blackwell, L.4    Buck, G.5    Pollicino, C.6
  • 6
    • 83255193890 scopus 로고    scopus 로고
    • Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: A randomised controlled trial
    • ulbulia R, Bowman L, Wallendszus K, Parish S, Armitage J, Peto R, et al. Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20,536 high-risk individuals: a randomised controlled trial. Lancet 2011; 378(9808): 2013-20.
    • (2011) Lancet , vol.378 , Issue.9808 , pp. 2013-2020
    • Ulbulia, R.1    Bowman, L.2    Wallendszus, K.3    Parish, S.4    Armitage, J.5    Peto, R.6
  • 7
    • 67650082354 scopus 로고    scopus 로고
    • Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    • Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009; 338: b1665.
    • (2009) BMJ , vol.338
    • Law, M.R.1    Morris, J.K.2    Wald, N.J.3
  • 8
    • 84895857118 scopus 로고    scopus 로고
    • Cardiovascular disorders in the context of non-alcoholic Fatty liver disease: A literature review
    • Karbasi-Afshar R, Saburi A, Khedmat H. Cardiovascular disorders in the context of non-alcoholic Fatty liver disease: a literature review. J Tehran Heart Cent. 2014; 9(1): 1-8.
    • (2014) J Tehran Heart Cent , vol.9 , Issue.1 , pp. 1-8
    • Karbasi-Afshar, R.1    Saburi, A.2    Khedmat, H.3
  • 9
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • Soderberg C, Stal P, Askling J, Glaumann H, Lindberg G, Marmur J, et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hematology. 2010; 51(2): 595-602.
    • (2010) Hematology , vol.51 , Issue.2 , pp. 595-602
    • Soderberg, C.1    Stal, P.2    Askling, J.3    Glaumann, H.4    Lindberg, G.5    Marmur, J.6
  • 10
    • 84861329163 scopus 로고    scopus 로고
    • Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population
    • Stepanova M, Younossi ZM. Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population. Clin Gastroenterol Hepatol. 2012; 10(6): 646-50.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , Issue.6 , pp. 646-650
    • Stepanova, M.1    Younossi, Z.M.2
  • 11
    • 84860469242 scopus 로고    scopus 로고
    • Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
    • Min HK, Kapoor A, Fuchs M, Mirshahi F, Zhou H, Maher J, et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012; 15(5): 665-74.
    • (2012) Cell Metab , vol.15 , Issue.5 , pp. 665-674
    • Min, H.K.1    Kapoor, A.2    Fuchs, M.3    Mirshahi, F.4    Zhou, H.5    Maher, J.6
  • 14
    • 84886906559 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and the re- nin-angiotensin system: Implications for treatment
    • Paschos P, Tziomalos K. Nonalcoholic fatty liver disease and the re- nin-angiotensin system: Implications for treatment. World J Hepatol. 2012; 4(12): 327-31.
    • (2012) World J Hepatol , vol.4 , Issue.12 , pp. 327-331
    • Paschos, P.1    Tziomalos, K.2
  • 16
    • 77954643491 scopus 로고    scopus 로고
    • A pilot double-blind randomised placebo-controlled trial of the effects of fìxed-dose combination therapy ('polypill') on cardiovascular risk factors
    • Malekzadeh F, Marshall T, Pourshams A, Gharravi M, Aslani A, Nat- eghi A, et al. A pilot double-blind randomised placebo-controlled trial of the effects of fìxed-dose combination therapy ('polypill') on cardiovascular risk factors. Int J Clin Pract. 2010; 64(9): 1220-7.
    • (2010) Int J Clin Pract , vol.64 , Issue.9 , pp. 1220-1227
    • Malekzadeh, F.1    Marshall, T.2    Pourshams, A.3    Gharravi, M.4    Aslani, A.5    Nateghi, A.6
  • 17
    • 84940757679 scopus 로고    scopus 로고
    • Polypill for the prevention of cardiovascular disease (PolyIran): Study design and rationale for a pragmatic cluster randomized controlled trial
    • Ostovaneh MR, Poustchi H, Hemming K, Marjani H, Pourshams A, Nateghi A, et al. Polypill for the prevention of cardiovascular disease (PolyIran): study design and rationale for a pragmatic cluster randomized controlled trial. Eur J Prev Cardiol. 2014.
    • (2014) Eur J Prev Cardiol
    • Ostovaneh, M.R.1    Poustchi, H.2    Hemming, K.3    Marjani, H.4    Pourshams, A.5    Nateghi, A.6
  • 18
    • 77952241649 scopus 로고    scopus 로고
    • Cohort Profile: The Golestan Cohort Study--a prospective study of oesophageal cancer in northern Iran
    • Pourshams A, Khademi H, Malekshah AF, Islami F, Nouraei M, Sad- jadi AR, et al. Cohort Profile: The Golestan Cohort Study--a prospective study of oesophageal cancer in northern Iran. Int J Epidemiol. 2010; 39(1): 52-9.
    • (2010) Int J Epidemiol , vol.39 , Issue.1 , pp. 52-59
    • Pourshams, A.1    Khademi, H.2    Malekshah, A.F.3    Islami, F.4    Nouraei, M.5    Sadjadi, A.R.6
  • 19
    • 0018750520 scopus 로고
    • A new design for randomized clinical trials
    • Zelen M. A new design for randomized clinical trials. N Engl J Med. 1979; 300(22): 1242-5.
    • (1979) N Engl J Med , vol.300 , Issue.22 , pp. 1242-1245
    • Zelen, M.1
  • 20
    • 36549056996 scopus 로고    scopus 로고
    • The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation
    • Hamaguchi M, Kojima T, Itoh Y, Harano Y, Fujii K, Nakajima T, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol. 2007; 102(12): 2708-15.
    • (2007) Am J Gastroenterol , vol.102 , Issue.12 , pp. 2708-2715
    • Hamaguchi, M.1    Kojima, T.2    Itoh, Y.3    Harano, Y.4    Fujii, K.5    Nakajima, T.6
  • 21
    • 79952207246 scopus 로고    scopus 로고
    • Gender-specific differences in adipose distribution and adipo- cytokines influence adolescent nonalcoholic fatty liver disease
    • Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Pennell CE, de Klerk N, et al. Gender-specific differences in adipose distribution and adipo- cytokines influence adolescent nonalcoholic fatty liver disease. Hepatology. 2011; 53(3): 800-9.
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 800-809
    • Ayonrinde, O.T.1    Olynyk, J.K.2    Beilin, L.J.3    Mori, T.A.4    Pennell, C.E.5    de Klerk, N.6
  • 22
    • 2142655782 scopus 로고    scopus 로고
    • Visceral fat thickness measured by ultrasonography can estimate not only visceral obesity but also risks of cardiovascular and metabolic diseases
    • Kim SK, Kim HJ, Hur KY, Choi SH, Ahn CW, Lim SK, et al. Visceral fat thickness measured by ultrasonography can estimate not only visceral obesity but also risks of cardiovascular and metabolic diseases. Am J Clin Nutr. 2004; 79(4): 593-9.
    • (2004) Am J Clin Nutr , vol.79 , Issue.4 , pp. 593-599
    • Kim, S.K.1    Kim, H.J.2    Hur, K.Y.3    Choi, S.H.4    Ahn, C.W.5    Lim, S.K.6
  • 24
    • 0017161239 scopus 로고
    • Validity of the ultrasonic technique as a method of measuring subcutaneous adipose tissue
    • Haymes EM, Lundegren HM, Loomis JL, Buskirk ER. Validity of the ultrasonic technique as a method of measuring subcutaneous adipose tissue. Ann Hum Biol. 1976; 3(3): 245-51.
    • (1976) Ann Hum Biol , vol.3 , Issue.3 , pp. 245-251
    • Haymes, E.M.1    Lundegren, H.M.2    Loomis, J.L.3    Buskirk, E.R.4
  • 25
    • 0032892245 scopus 로고    scopus 로고
    • Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: The British Regional Heart Study
    • Ebrahim S, Papacosta O, Whincup P, Wannamethee G, Walker M, Nicolaides AN, et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. Stroke. 1999; 30(4): 841-50.
    • (1999) Stroke , vol.30 , Issue.4 , pp. 841-850
    • Ebrahim, S.1    Papacosta, O.2    Whincup, P.3    Wannamethee, G.4    Walker, M.5    Nicolaides, A.N.6
  • 26
    • 0037012410 scopus 로고    scopus 로고
    • Evaluation of carotid artery and aortic intima-media thickness measurements for exclusion of significant coronary atheroscle rosis in patients scheduled for heart valve surgery
    • Belhassen L, Carville C, Pelle G, Monin JL, Teiger E, Duval-Moulin AM, et al. Evaluation of carotid artery and aortic intima-media thickness measurements for exclusion of significant coronary atheroscle rosis in patients scheduled for heart valve surgery. J Am Coll Cardiol. 2002; 39(7): 1139-44.
    • (2002) J Am Coll Cardiol , vol.39 , Issue.7 , pp. 1139-1144
    • Belhassen, L.1    Carville, C.2    Pelle, G.3    Monin, J.L.4    Teiger, E.5    Duval-Moulin, A.M.6
  • 28
    • 48049092244 scopus 로고    scopus 로고
    • Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes
    • Jamali R, Khonsari M, Merat S, Khoshnia M, Jafari E, Bahram Kal- hori A, et al. Persistent alanine aminotransferase elevation among the general Iranian population: prevalence and causes. World J Gastroenterol. 2008; 14(18): 2867-71.
    • (2008) World J Gastroenterol , vol.14 , Issue.18 , pp. 2867-2871
    • Jamali, R.1    Khonsari, M.2    Merat, S.3    Khoshnia, M.4    Jafari, E.5    Bahram Kal- hori, A.6
  • 29
    • 77954416860 scopus 로고    scopus 로고
    • Mediation and moderation of treatment effects in randomised controlled trials of complex interventions
    • Emsley R, Dunn G, White IR. Mediation and moderation of treatment effects in randomised controlled trials of complex interventions. Stat Methods Med Res. 2010; 19(3): 237-70.
    • (2010) Stat Methods Med Res , vol.19 , Issue.3 , pp. 237-270
    • Emsley, R.1    Dunn, G.2    White, I.R.3
  • 30
    • 18744406319 scopus 로고    scopus 로고
    • Multiplicity in randomised trials II: Subgroup and interim analyses
    • Schulz KF, Grimes DA. Multiplicity in randomised trials II: subgroup and interim analyses. Lancet. 2005; 365(9471): 1657-61.
    • (2005) Lancet , vol.365 , Issue.9471 , pp. 1657-1661
    • Schulz, K.F.1    Grimes, D.A.2
  • 32
    • 84883759656 scopus 로고    scopus 로고
    • Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD)
    • Verma S, Jensen D, Hart J, Mohanty SR. Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD). Liver Int. 2013; 33(9): 1398-405.
    • (2013) Liver Int , vol.33 , Issue.9 , pp. 1398-1405
    • Verma, S.1    Jensen, D.2    Hart, J.3    Mohanty, S.R.4
  • 34
    • 84938375234 scopus 로고    scopus 로고
    • Gallstone disease and obesity: A population-based study on abdominal fat distribution and gender differences
    • Radmard AR, Merat S, Kooraki S, Ashrafi M, Keshtkar A, Sharafkhah M, et al. Gallstone disease and obesity: A population-based study on abdominal fat distribution and gender differences. Ann Hepatol. 2015. [In press]
    • (2015) Ann Hepatol
    • Radmard, A.R.1    Merat, S.2    Kooraki, S.3    Ashrafi, M.4    Keshtkar, A.5    Sharafkhah, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.