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Volumn 7, Issue 6, 2015, Pages 1009-1020

Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers

Author keywords

CDK2; EZH2; Phosphorylation

Indexed keywords

ACTIN; CYCLIN DEPENDENT KINASE 2; CYCLIN E; METHIONINE; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL] ISONIPECOTAMIDE; NUCLEOPHOSMIN; PHOSPHO NUCLEOPHOSMIN; ROSCOVITINE; TRANSCRIPTION FACTOR EZH2; TUBULIN; UNCLASSIFIED DRUG;

EID: 84939503541     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (44)

References (31)
  • 4
    • 37248999372 scopus 로고    scopus 로고
    • Triple negative tumours: A critical review
    • Reis-Filho JS and Tutt AN. Triple negative tumours: a critical review. Histopathology 2008; 52: 108-118.
    • (2008) Histopathology , vol.52 , pp. 108-118
    • Reis-Filho, J.S.1    Tutt, A.N.2
  • 5
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y and Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121: 2750-2767.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3    Sanders, M.E.4    Chakravarthy, A.B.5    Shyr, Y.6    Pietenpol, J.A.7
  • 8
    • 57749092800 scopus 로고    scopus 로고
    • Triple-negative/basallike breast cancer: Review
    • Rakha EA and Ellis IO. Triple-negative/basallike breast cancer: review. Pathology 2009; 41: 40-47.
    • (2009) Pathology , vol.41 , pp. 40-47
    • Rakha, E.A.1    Ellis, I.O.2
  • 9
    • 45149094267 scopus 로고    scopus 로고
    • Basal-like breast cancer: A critical review
    • Rakha EA, Reis-Filho JS and Ellis IO. Basal-like breast cancer: a critical review. J Clin Oncol 2008; 26: 2568-2581.
    • (2008) J Clin Oncol , vol.26 , pp. 2568-2581
    • Rakha, E.A.1    Reis-Filho, J.S.2    Ellis, I.O.3
  • 10
    • 9644310201 scopus 로고    scopus 로고
    • Molecular portraits of breast cancer: Tumour subtypes as distinct disease entities
    • Sorlie T. Molecular portraits of breast cancer: tumour subtypes as distinct disease entities. Eur J Cancer 2004; 40: 2667-2675.
    • (2004) Eur J Cancer , vol.40 , pp. 2667-2675
    • Sorlie, T.1
  • 13
    • 84873089796 scopus 로고    scopus 로고
    • Updates in the treatment of basal/triple-negative breast cancer
    • Shastry M and Yardley DA. Updates in the treatment of basal/triple-negative breast cancer. Curr Opin Obstet Gynecol 2013; 25: 40-48.
    • (2013) Curr Opin Obstet Gynecol , vol.25 , pp. 40-48
    • Shastry, M.1    Yardley, D.A.2
  • 14
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing: Knowns and unknowns
    • Simon JA and Kingston RE. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 2009; 10: 697-708.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 15
    • 84885393469 scopus 로고    scopus 로고
    • Transcriptional regulation by Polycomb group proteins
    • Di Croce L and Helin K. Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol 2013; 20: 1147-1155.
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 1147-1155
    • Di Croce, L.1    Helin, K.2
  • 16
    • 84863690032 scopus 로고    scopus 로고
    • Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers
    • De Brot M, Rocha RM, Soares FA and Gobbi H. Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers. Pathology 2012; 44: 303-312.
    • (2012) Pathology , vol.44 , pp. 303-312
    • De Brot, M.1    Rocha, R.M.2    Soares, F.A.3    Gobbi, H.4
  • 20
    • 50649122298 scopus 로고    scopus 로고
    • The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype
    • Voduc D, Nielsen TO, Cheang MC and Foulkes WD. The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype. Hum Pathol 2008; 39: 1431-1437.
    • (2008) Hum Pathol , vol.39 , pp. 1431-1437
    • Voduc, D.1    Nielsen, T.O.2    Cheang, M.C.3    Foulkes, W.D.4
  • 21
    • 78649807567 scopus 로고    scopus 로고
    • Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
    • Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA and Reinberg D. Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev 2010; 24: 2615-2620.
    • (2010) Genes Dev , vol.24 , pp. 2615-2620
    • Kaneko, S.1    Li, G.2    Son, J.3    Xu, C.F.4    Margueron, R.5    Neubert, T.A.6    Reinberg, D.7
  • 23
    • 78650511231 scopus 로고    scopus 로고
    • CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells
    • Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC and Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol 2011; 13: 87-94.
    • (2011) Nat Cell Biol , vol.13 , pp. 87-94
    • Wei, Y.1    Chen, Y.H.2    Li, L.Y.3    Lang, J.4    Yeh, S.P.5    Shi, B.6    Yang, C.C.7    Yang, J.Y.8    Lin, C.Y.9    Lai, C.C.10    Hung, M.C.11
  • 24
    • 80051496158 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability
    • Wu SC and Zhang Y. Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of enhancer of zeste 2 (Ezh2) regulates its stability. J Biol Chem 2011; 286: 28511-28519.
    • (2011) J Biol Chem , vol.286 , pp. 28511-28519
    • Wu, S.C.1    Zhang, Y.2
  • 26
    • 37149040456 scopus 로고    scopus 로고
    • Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: Identification of genes potentially related to epithelial-mesenchymal transition
    • Lien HC, Hsiao YH, Lin YS, Yao YT, Juan HF, Kuo WH, Hung MC, Chang KJ and Hsieh FJ. Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene 2007; 26: 7859-7871.
    • (2007) Oncogene , vol.26 , pp. 7859-7871
    • Lien, H.C.1    Hsiao, Y.H.2    Lin, Y.S.3    Yao, Y.T.4    Juan, H.F.5    Kuo, W.H.6    Hung, M.C.7    Chang, K.J.8    Hsieh, F.J.9
  • 27
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • van den Heuvel S and Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993; 262: 2050-2054.
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 29
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E and Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003; 22: 5323-5335.
    • (2003) EMBO J , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 30
    • 55849145532 scopus 로고    scopus 로고
    • Mammary tumors initiated by constitutive Cdk2 activation contain an invasive basal-like component
    • Corsino PE, Davis BJ, Norgaard PH, Parker NN, Law M, Dunn W and Law BK. Mammary tumors initiated by constitutive Cdk2 activation contain an invasive basal-like component. Neoplasia 2008; 10: 1240-1252.
    • (2008) Neoplasia , vol.10 , pp. 1240-1252
    • Corsino, P.E.1    Davis, B.J.2    Norgaard, P.H.3    Parker, N.N.4    Law, M.5    Dunn, W.6    Law, B.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.