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Volumn 25, Issue 1, 2013, Pages 40-48

Updates in the treatment of basal/triple-negative breast cancer

Author keywords

antiangiogenesis; basal like breast cancer; polyadenosine diphosphate ribose polymerase; targeted therapies; triple negative breast cancer

Indexed keywords

ANDROGEN RECEPTOR; ANTHRACYCLINE DERIVATIVE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BRCA1 PROTEIN; BUPARLISIB; CAPECITABINE; CARBOPLATIN; CEDIRANIB; CYCLOPHOSPHAMIDE; CYTOTOXIC AGENT; DNA; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ESTROGEN RECEPTOR; IXABEPILONE; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OLAPARIB; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PLATINUM DERIVATIVE; PROTEIN KINASE B; TAXANE DERIVATIVE; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR; VELIPARIB;

EID: 84873089796     PISSN: 1040872X     EISSN: 1473656X     Source Type: Journal    
DOI: 10.1097/GCO.0b013e32835c1633     Document Type: Review
Times cited : (42)

References (71)
  • 1
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 2
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    • Prat A, Parker JS, Karginova O, et al. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res 2010; 12:R68.
    • (2010) Breast Cancer Res , vol.12
    • Prat, A.1    Parker, J.S.2    Karginova, O.3
  • 3
    • 40949121882 scopus 로고    scopus 로고
    • Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
    • Cheang MC, Voduc D, Bajdik C, et al. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res 2008; 14:1368-1376.
    • (2008) Clin Cancer Res , vol.14 , pp. 1368-1376
    • Cheang, M.C.1    Voduc, D.2    Bajdik, C.3
  • 4
    • 67649211199 scopus 로고    scopus 로고
    • Invasive ductal carcinoma of the breast with the 'triple-negative' phenotype: Prognostic implications of EGFR immunoreactivity
    • Viale G, Rotmensz N, Maisonneuve P, et al. Invasive ductal carcinoma of the breast with the 'triple-negative' phenotype: prognostic implications of EGFR immunoreactivity. Breast Cancer Res Treat 2009; 116:317-328.
    • (2009) Breast Cancer Res Treat , vol.116 , pp. 317-328
    • Viale, G.1    Rotmensz, N.2    Maisonneuve, P.3
  • 5
    • 70849122251 scopus 로고    scopus 로고
    • Triple-negative breast cancer-current status and future directions
    • Gluz O, Liedtke C, Gottschalk N, et al. Triple-negative breast cancer-current status and future directions. Ann Oncol 2009; 20:1913-1927.
    • (2009) Ann Oncol , vol.20 , pp. 1913-1927
    • Gluz, O.1    Liedtke, C.2    Gottschalk, N.3
  • 6
    • 84865573852 scopus 로고    scopus 로고
    • Targeting triple-negative breast cancer: Optimising therapeutic outcomes
    • Gelmon K, Dent R, Mackey JR, et al. Targeting triple-negative breast cancer: optimising therapeutic outcomes. Ann Oncol 2012; 23:2223-2234.
    • (2012) Ann Oncol , vol.23 , pp. 2223-2234
    • Gelmon, K.1    Dent, R.2    MacKey, J.R.3
  • 7
    • 79952253747 scopus 로고    scopus 로고
    • Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer
    • Gonzalez-Angulo AM, Timms KM, Liu S, et al. Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer. Clin Cancer Res 2011; 17:1082-1089.
    • (2011) Clin Cancer Res , vol.17 , pp. 1082-1089
    • Gonzalez-Angulo, A.M.1    Timms, K.M.2    Liu, S.3
  • 8
    • 79959733228 scopus 로고    scopus 로고
    • An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients
    • Vollebergh MA, Lips EH, Nederlof PM, et al. An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients. Ann Oncol 2011; 22:1561-1570.
    • (2011) Ann Oncol , vol.22 , pp. 1561-1570
    • Vollebergh, M.A.1    Lips, E.H.2    Nederlof, P.M.3
  • 9
    • 84865552486 scopus 로고    scopus 로고
    • Clinical correlates of 'BRCAness' in triple-negative breast cancer of patients receiving adjuvant chemotherapy
    • Oonk AMM, van Rijn C, Smits MM, et al. Clinical correlates of 'BRCAness' in triple-negative breast cancer of patients receiving adjuvant chemotherapy. Ann Oncol 2012; 23:2301-2305.
    • (2012) Ann Oncol , vol.23 , pp. 2301-2305
    • Oonk, A.M.M.1    Van Rijn, C.2    Smits, M.M.3
  • 10
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X, et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121:2750-2767.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 11
    • 78951482208 scopus 로고    scopus 로고
    • Deconstructing the molecular portraits of breast cancer
    • Prat A, Perou CM. Deconstructing the molecular portraits of breast cancer. Mol Oncol 2011; 5:5-23.
    • (2011) Mol Oncol , vol.5 , pp. 5-23
    • Prat, A.1    Perou, C.M.2
  • 12
    • 79959520764 scopus 로고    scopus 로고
    • Molecular stratification of triple-negative breast cancers
    • Perou CM. Molecular stratification of triple-negative breast cancers. Oncologist 2011; 16 (Suppl 1):61-70.
    • (2011) Oncologist , vol.16 , Issue.SUPPL. 1 , pp. 61-70
    • Perou, C.M.1
  • 13
    • 80051536989 scopus 로고    scopus 로고
    • Triple-negative and basal-like breast cancer: Implications for oncologists
    • Lachapelle J, Foulkes WD. Triple-negative and basal-like breast cancer: implications for oncologists. Curr Oncol 2011; 18:161-164.
    • (2011) Curr Oncol , vol.18 , pp. 161-164
    • Lachapelle, J.1    Foulkes, W.D.2
  • 15
    • 84866866082 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Are we making headway at least?
    • Arnedos M, Bihan C, Delaloge S, Andre F. Triple-negative breast cancer: are we making headway at least? Ther Adv Med Oncol 2012; 4:195-210.
    • (2012) Ther Adv Med Oncol , vol.4 , pp. 195-210
    • Arnedos, M.1    Bihan, C.2    Delaloge, S.3    Andre, F.4
  • 16
    • 62549091454 scopus 로고    scopus 로고
    • Breast cancer subtypes and response to docetaxel in node-positive breast cancer: Use of an immunohistochemical definition in the BCIRG 001 trial
    • Hugh J, Hanson J, Cheang MC, et al. Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J Clin Oncol 2009; 27:1168-1176.
    • (2009) J Clin Oncol , vol.27 , pp. 1168-1176
    • Hugh, J.1    Hanson, J.2    Cheang, M.C.3
  • 17
    • 77957710541 scopus 로고    scopus 로고
    • Effect of neoadjuvant anthracycline-taxane-based chemotherapy in different biological breast cancer phenotypes: Overall results from the GeparTrio study
    • Huober J, von Minckwitz G, Denkert C, et al. Effect of neoadjuvant anthracycline-taxane-based chemotherapy in different biological breast cancer phenotypes: overall results from the GeparTrio study. Breast Cancer Res Treat 2010; 124:133-140.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 133-140
    • Huober, J.1    Von Minckwitz, G.2    Denkert, C.3
  • 18
    • 78649732579 scopus 로고    scopus 로고
    • Adjuvant docetaxel for high-risk, nodenegative breast cancer
    • Martin M, Segui MA, Anton A, et al. Adjuvant docetaxel for high-risk, nodenegative breast cancer. N Engl J Med 2010; 363:2200-2210.
    • (2010) N Engl J Med , vol.363 , pp. 2200-2210
    • Martin, M.1    Segui, M.A.2    Anton, A.3
  • 19
    • 23844549918 scopus 로고    scopus 로고
    • Breast cancer molecular subtypes respond differently to preoperative chemotherapy
    • Rouzier R, Perou CM, Symmans WF, et al. Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Res 2005; 11:5678-5685.
    • (2005) Clin Cancer Res , vol.11 , pp. 5678-5685
    • Rouzier, R.1    Perou, C.M.2    Symmans, W.F.3
  • 20
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes
    • Carey LA, Dees EC, Sawyer L, et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 2007; 13:2329-2334.
    • (2007) Clin Cancer Res , vol.13 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 21
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    • Liedtke C, Mazouni C, Hess KR, et al. Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol 2008; 26:1275-1281.
    • (2008) J Clin Oncol , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3
  • 22
    • 84862893473 scopus 로고    scopus 로고
    • Pathological complete response and accelerated drug approval in early breast cancer
    • Prowell TM, Pazdur R. Pathological complete response and accelerated drug approval in early breast cancer. N Engl J Med 2012; 366:2438-2441.
    • (2012) N Engl J Med , vol.366 , pp. 2438-2441
    • Prowell, T.M.1    Pazdur, R.2
  • 23
    • 59149087388 scopus 로고    scopus 로고
    • Phase II genomics study of ixabepilone as neoadjuvant treatment for breast cancer
    • Baselga J, Zambetti M, Llombart-Cussac A, et al. Phase II genomics study of ixabepilone as neoadjuvant treatment for breast cancer. J Clin Oncol 2009; 27:526-534.
    • (2009) J Clin Oncol , vol.27 , pp. 526-534
    • Baselga, J.1    Zambetti, M.2    Llombart-Cussac, A.3
  • 24
    • 77953025896 scopus 로고    scopus 로고
    • Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer
    • Perez EA, Patel T, Moreno-Aspitia A. Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer. Breast Cancer Res Treat 2010; 121:261-271.
    • (2010) Breast Cancer Res Treat , vol.121 , pp. 261-271
    • Perez, E.A.1    Patel, T.2    Moreno-Aspitia, A.3
  • 25
    • 58149503624 scopus 로고    scopus 로고
    • Ixabepilone: Targeting bIII-tubulin expression in taxane-resistant malignancies
    • Dumontet C, Jordan MA, Lee FFY. Ixabepilone: targeting bIII-tubulin expression in taxane-resistant malignancies. Mol Cancer Ther 2009; 8: 17-25.
    • (2009) Mol Cancer Ther , vol.8 , pp. 17-25
    • Dumontet, C.1    Jordan, M.A.2    Lee, F.F.Y.3
  • 26
    • 77953561265 scopus 로고    scopus 로고
    • High beta-III tubulin expression in triple-negative (TN) breast cancer (BC) subtype and correlation to ixabepilone response: A retrospective analysis
    • 8 June
    • Horak CE, Lee FY, Xu L, et al. High beta-III tubulin expression in triple-negative (TN) breast cancer (BC) subtype and correlation to ixabepilone response: a retrospective analysis. ASCO Meeting Abstracts; 8 June 2009; 27(15S): 3587.
    • (2009) ASCO Meeting Abstracts , vol.27 , Issue.15 , pp. 3587
    • Horak, C.E.1    Lee, F.Y.2    Xu, L.3
  • 27
    • 84855549777 scopus 로고    scopus 로고
    • Adjuvant capecitabine, docetaxel, cyclophosphamide, and epirubicin for early breast cancer: Final analysis of the randomized FinXX trial
    • Joensuu H, Kellokumpu-Lehtinen PL, Huovinen R, et al. Adjuvant capecitabine, docetaxel, cyclophosphamide, and epirubicin for early breast cancer: final analysis of the randomized FinXX trial. J Clin Oncol 2012; 30:11-18.
    • (2012) J Clin Oncol , vol.30 , pp. 11-18
    • Joensuu, H.1    Kellokumpu-Lehtinen, P.L.2    Huovinen, R.3
  • 28
    • 79953775871 scopus 로고    scopus 로고
    • First efficacy results of a randomized, open-label, phase III study of adjuvant doxorubicin plus cyclophosphamide followed by docetaxel with or without capecitabine in high-risk early breast cancer
    • Abstract
    • O'Shaughnessy J, Devchand P, Stokoe C. First efficacy results of a randomized, open-label, phase III study of adjuvant doxorubicin plus cyclophosphamide followed by docetaxel with or without capecitabine in high-risk early breast cancer. SABCS 2010; 2010:Abstract S4-S2.
    • (2010) SABCS 2010
    • O'Shaughnessy, J.1    Devchand, P.2    Stokoe, C.3
  • 29
    • 84873094077 scopus 로고    scopus 로고
    • Final results from randomized phase II trial of preoperative docetaxel (D) and capecitabine (C) given sequentially or concurrently for HER2-negative breast cancers
    • abstr 1118
    • Zelnak AB, Harichand-Herdt S, StybloTM, et al. Final results from randomized phase II trial of preoperative docetaxel (D) and capecitabine (C) given sequentially or concurrently for HER2-negative breast cancers. J Clin Oncol 2011; 29(Suppl):abstr 1118.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Zelnak, A.B.1    Styblotm, H.S.2
  • 30
    • 77949908546 scopus 로고    scopus 로고
    • Efficacy of neoadjuvant cisplatin in triple-negative breast cancer
    • Silver DP, Richardson AL, Eklund AC, et al. Efficacy of neoadjuvant cisplatin in triple-negative breast cancer. J Clin Oncol 2010; 28:1145-1153.
    • (2010) J Clin Oncol , vol.28 , pp. 1145-1153
    • Silver, D.P.1    Richardson, A.L.2    Eklund, A.C.3
  • 31
    • 54949097426 scopus 로고    scopus 로고
    • Platinum-based chemotherapy in triplenegative breast cancer
    • Sirohi B, Arnedos M, Popat S, et al. Platinum-based chemotherapy in triplenegative breast cancer. Ann Oncol 2008; 19:1847-1852.
    • (2008) Ann Oncol , vol.19 , pp. 1847-1852
    • Sirohi, B.1    Arnedos, M.2    Popat, S.3
  • 32
    • 82155199636 scopus 로고    scopus 로고
    • Chemotherapy (CT) with or without carboplatin as neoadjuvant treatment in patients with basal-like breast cancer: GEICAM 2006-03-A multicenter, randomized phase II study
    • abstr 1015
    • Alba E, Chacon JI, Lluch A, et al. Chemotherapy (CT) with or without carboplatin as neoadjuvant treatment in patients with basal-like breast cancer: GEICAM 2006-03-A multicenter, randomized phase II study. J Clin Oncol 2011; 29(Suppl):abstr 1015.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Alba, E.1    Chacon, J.I.2    Lluch, A.3
  • 33
    • 80054117561 scopus 로고    scopus 로고
    • TBCRC009: A multicenter phase II study of cisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response
    • abstr 1025
    • Isakoff SJ, Goss PE, Mayer EL, et al. TBCRC009: a multicenter phase II study of cisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response. J Clin Oncol 2011; 29(Suppl):abstr 1025.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Isakoff, S.J.1    Goss, P.E.2    Mayer, E.L.3
  • 34
    • 84866165483 scopus 로고    scopus 로고
    • Results of a phase II open-label, nonrandomized trial of cisplatin chemotherapy in patients with BRCA1-positive metastatic breast cancer
    • Byrski T, Dent R, Blecharz P, et al. Results of a phase II open-label, nonrandomized trial of cisplatin chemotherapy in patients with BRCA1-positive metastatic breast cancer. Breast Cancer Res 2012; 14:R110.
    • (2012) Breast Cancer Res , vol.14
    • Byrski, T.1    Dent, R.2    Blecharz, P.3
  • 35
    • 78751610848 scopus 로고    scopus 로고
    • Iniparib plus chemotherapy in metastatic triple-negative breast cancer
    • O'Shaughnessy J, Osborne C, Pippen JE, et al. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 2011; 364:205-214.
    • (2011) N Engl J Med , vol.364 , pp. 205-214
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.E.3
  • 36
    • 80052330662 scopus 로고    scopus 로고
    • A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC
    • abstr 1007
    • O'Shaughnessy J, Schwartzberg LS, Danso MA, et al. A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC). J Clin Oncol 2011; 29(Suppl):abstr 1007.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • O'Shaughnessy, J.1    Schwartzberg, L.S.2    Danso, M.A.3
  • 37
    • 84876310246 scopus 로고    scopus 로고
    • SOLTI NeoPARP: A phase II, randomized study of two schedules of iniparib plus paclitaxel and paclitaxel alone as neoadjuvant therapy in patients with triple-negative breast cancer (TNBC
    • abstr 1011
    • Llombart A, Lluch A, Villanueva C, et al. SOLTI NeoPARP: a phase II, randomized study of two schedules of iniparib plus paclitaxel and paclitaxel alone as neoadjuvant therapy in patients with triple-negative breast cancer (TNBC). J Clin Oncol 2012; 30(Suppl):abstr 1011.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Llombart, A.1    Lluch, A.2    Villanueva, C.3
  • 38
    • 84858198901 scopus 로고    scopus 로고
    • Failure of iniparib to inhibit poly(ADPRibose) polymerase in vitro
    • Patel AG,De Lorenzo SB, Flatten KS, et al. Failure of iniparib to inhibit poly(ADPRibose) polymerase in vitro. Clin Cancer Res 2012; 18:1655-1662.
    • (2012) Clin Cancer Res , vol.18 , pp. 1655-1662
    • Patel, A.G.1    De Lorenzo, S.B.2    Flatten, K.S.3
  • 39
    • 84862907868 scopus 로고    scopus 로고
    • Iniparib nonselectively modifies cysteinecontaining proteins in tumor cells and is not a bona fide PARP inhibitor
    • Liu X, Shi Y, Maag DX, et al. Iniparib nonselectively modifies cysteinecontaining proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res 2012; 18:510-523.
    • (2012) Clin Cancer Res , vol.18 , pp. 510-523
    • Liu, X.1    Shi, Y.2    Maag, D.X.3
  • 40
    • 77955856734 scopus 로고    scopus 로고
    • Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first-or second-line treatment of patients with metastatic triple-negative breast cancer: Results from the safety cohort of a phase I/II multicenter trial
    • Dent RA, Lindeman GJ, Clemons M, et al. Safety and efficacy of the oral PARP inhibitor olaparib (AZD2281) in combination with paclitaxel for the first-or second-line treatment of patients with metastatic triple-negative breast cancer: Results from the safety cohort of a phase I/II multicenter trial. J Clin Oncol 2010; 28 (Suppl 15):1018.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15 , pp. 1018
    • Dent, R.A.1    Lindeman, G.J.2    Clemons, M.3
  • 41
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, nonrandomised study
    • Gelmon KA, Tischkowitz M, Mackay H, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, nonrandomised study. Lancet Oncol 2011; 12:852-861.
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    MacKay, H.3
  • 42
    • 4344695312 scopus 로고    scopus 로고
    • Randomized phase II study of two irinotecan schedules for patients with metastatic breast cancer refractory to an anthracycline, a taxane, or both
    • Perez EA, Hillman DW, Mailliard JA, et al. Randomized phase II study of two irinotecan schedules for patients with metastatic breast cancer refractory to an anthracycline, a taxane, or both. J Clin Oncol 2004; 22:2849-2855.
    • (2004) J Clin Oncol , vol.22 , pp. 2849-2855
    • Perez, E.A.1    Hillman, D.W.2    Mailliard, J.A.3
  • 43
    • 84859868092 scopus 로고    scopus 로고
    • First phase 1 trial of NKTR-102 (Peg-Irinotecan) reveals early evidence of broad antitumor activity in three different schedules
    • 21-24 October Geneva, Switzerland. Poster
    • von Hoff DD, Jameson GS, Borad MJ, et al. First phase 1 trial of NKTR-102 (Peg-Irinotecan) reveals early evidence of broad antitumor activity in three different schedules. EORTC-NCI-AACR Symposium on 'Molecular Targets and Cancer Therapeutics' Meeting; 21-24 October 2008; Geneva, Switzerland. Poster no. 595.
    • (2008) EORTC-NCI-AACR Symposium on 'Molecular Targets and Cancer Therapeutics' Meeting , pp. 595
    • Von Hoff, D.D.1    Jameson, G.S.2    Borad, M.J.3
  • 44
    • 84871789626 scopus 로고    scopus 로고
    • Significant antitumor activity in a randomized phase 2 study comparing 2 schedules of Nktr-102 in patients (Pts with metastatic breast cancer (MBC)
    • abstract 101P
    • Awada A, Chan S, Jerusalem GHM, et al. Significant antitumor activity in a randomized phase 2 study comparing 2 schedules of Nktr-102 in patients (Pts) with metastatic breast cancer (MBC). Ann Oncol 2012; 23(Suppl 2):abstract 101P.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 2
    • Awada, A.1    Chan, S.2    Jerusalem, G.H.M.3
  • 45
    • 84873090784 scopus 로고    scopus 로고
    • Final analysis of phase II study of EZN-2208 (PEG-SN38) in metastatic breast cancer (MBC
    • abstr 1017
    • Cynthia RC, Osborne JOS, Holmes FA, et al. Final analysis of phase II study of EZN-2208 (PEG-SN38) in metastatic breast cancer (MBC). J Clin Oncol 2012; 30(Suppl):abstr 1017.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Cynthia, R.C.1    Jos, O.2    Holmes, F.A.3
  • 46
    • 70349642532 scopus 로고    scopus 로고
    • Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer
    • Linderholm BK, Hellborg H, Johansson U, et al. Significantly higher levels of vascular endothelial growth factor (VEGF) and shorter survival times for patients with primary operable triple-negative breast cancer. Ann Oncol 2009; 20:1639-1646.
    • (2009) Ann Oncol , vol.20 , pp. 1639-1646
    • Linderholm, B.K.1    Hellborg, H.2    Johansson, U.3
  • 47
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357:2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 48
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles DW, Chan A, Dirix LY, et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010; 28:3239-3247.
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 49
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Dieras V, Glaspy J, et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 2011; 29:1252-1260.
    • (2011) J Clin Oncol , vol.29 , pp. 1252-1260
    • Robert, N.J.1    Dieras, V.2    Glaspy, J.3
  • 50
    • 79959876844 scopus 로고    scopus 로고
    • Meta-analysis of patients with triple-negative breast cancer (TNBC from three randomized trials of first-line bevacizumab (BV) and chemotherapy treatment for metastatic breast cancer (MBC)
    • P6-12-03
    • O'Shaughnessy J, Romieu G, Dieras V, et al. Meta-analysis of patients with triple-negative breast cancer (TNBC) from three randomized trials of first-line bevacizumab (BV) and chemotherapy treatment for metastatic breast cancer (MBC). Cancer Res 2011; 70(Suppl 24):P6-12-03.
    • (2011) Cancer Res , vol.70 , Issue.SUPPL. 24
    • O'Shaughnessy, J.1    Romieu, G.2    Dieras, V.3
  • 51
    • 84863719309 scopus 로고    scopus 로고
    • Second-line bevacizumab-containing therapy in patients with triple-negative breast cancer: Subgroup analysis of the RIBBON-2 trial
    • Brufsky A, Valero V, Tiangco B, et al. Second-line bevacizumab-containing therapy in patients with triple-negative breast cancer: subgroup analysis of the RIBBON-2 trial. Breast Cancer Res Treat 2012; 133:1067-1075.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 1067-1075
    • Brufsky, A.1    Valero, V.2    Tiangco, B.3
  • 52
    • 84870622658 scopus 로고    scopus 로고
    • Final overall survival (OS) and safety analyses of RIBBON-2 a randomized phase III trial of bevacizumab (BEV) versus placebo (PL) combined with second-line chemotherapy (CT) for HER2-negative BEV-naive metastatic breast cancer (MBC)
    • 18 September
    • Brufsky AM, Hurvitz SA, Perez EA, et al. Final overall survival (OS) and safety analyses of RIBBON-2, a randomized phase III trial of bevacizumab (BEV) versus placebo (PL) combined with second-line chemotherapy (CT) for HER2-negative BEV-naive metastatic breast cancer (MBC). ASCO Meeting Abstracts; 18 September 2012; 30(Suppl 27):100.
    • (2012) ASCO Meeting Abstracts , vol.30 , Issue.SUPPL. 27 , pp. 100
    • Brufsky, A.M.1    Hurvitz, S.A.2    Perez, E.A.3
  • 53
    • 84859728286 scopus 로고    scopus 로고
    • First-line bevacizumab-containing therapy for triple-negative breast cancer: Analysis of 585 patients treated in the ATHENA study
    • Thomssen C, Pierga JY, Pritchard KI, et al. First-line bevacizumab-containing therapy for triple-negative breast cancer: analysis of 585 patients treated in the ATHENA study. Oncology 2012; 82:218-227.
    • (2012) Oncology , vol.82 , pp. 218-227
    • Thomssen, C.1    Pierga, J.Y.2    Pritchard, K.I.3
  • 54
    • 84873089903 scopus 로고    scopus 로고
    • Bevacizumab (Bev) combined with paclitaxel (Pac) as first-line therapy for metastatic triple-negative breast cancer (TNBC): Analysis of 147 patients (pts) treated in routine oncology practice in Germany
    • Schneeweiss A, Foerster F, Hollburg W, et al. Bevacizumab (Bev) combined with paclitaxel (Pac) as first-line therapy for metastatic triple-negative breast cancer (TNBC): analysis of 147 patients (pts) treated in routine oncology practice in Germany. Eur J Cancer 2011; 47 (Suppl 1):S352.
    • (2011) Eur J Cancer , vol.47 , Issue.SUPPL. 1
    • Schneeweiss, A.1    Foerster, F.2    Hollburg, W.3
  • 55
    • 80052882569 scopus 로고    scopus 로고
    • The effect on pCR of bevacizumab and/or antimetabolites added to standard neoadjuvant chemotherapy: NSABP protocol B-40
    • Bear HD, Tang G, Rastogi P, et al. The effect on pCR of bevacizumab and/or antimetabolites added to standard neoadjuvant chemotherapy: NSABP protocol B-40. J Clin Oncol 2011; 29(Suppl 18):LBA1005.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 18
    • Bear, H.D.1    Tang, G.2    Rastogi, P.3
  • 56
    • 80052870827 scopus 로고    scopus 로고
    • Neoadjuvant bevacizumab and anthracycline-taxane-based chemotherapry in 686 triple-negative primary breast cancers: Secondary endpoint analysis of the GeparQuinto study (GBG 44
    • Gerber B, Eidtmann H, Rezai M, et al. Neoadjuvant bevacizumab and anthracycline-taxane-based chemotherapry in 686 triple-negative primary breast cancers: secondary endpoint analysis of the GeparQuinto study (GBG 44). J Clin Oncol 2011; 29 (Suppl 15):1006.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 15 , pp. 1006
    • Gerber, B.1    Eidtmann, H.2    Rezai, M.3
  • 57
    • 84873077360 scopus 로고    scopus 로고
    • ARTemis: Randomized trial with neoadjuvant chemotherapy for patients with early breast cancer
    • Earl HM, Blenkinsop C, Grybowicz L, et al. ARTemis: randomized trial with neoadjuvant chemotherapy for patients with early breast cancer. J Clin Oncol 2012; 30 (Suppl 15):TS1144.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 15
    • Earl, H.M.1    Blenkinsop, C.2    Grybowicz, L.3
  • 58
    • 84873080150 scopus 로고    scopus 로고
    • NSAB FB-6: Phase II trial of weekly paclitaxel (WP) and pazopanib following doxorubicin and cyclophosphamide (AC) as neoadjuvant therapy for HER2-negative locally advanced breast cancer (LABC
    • Tan AR, Buyse ME, Rastogi P, et al. NSAB FB-6: phase II trial of weekly paclitaxel (WP) and pazopanib following doxorubicin and cyclophosphamide (AC) as neoadjuvant therapy for HER2-negative locally advanced breast cancer (LABC). J Clin Oncol 2012; 30 (Suppl 15):1025.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 15 , pp. 1025
    • Tan, A.R.1    Buyse, M.E.2    Rastogi, P.3
  • 59
    • 4143150688 scopus 로고    scopus 로고
    • Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    • Nielsen TO, Hsu FD, Jensen K, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004; 10:5367-5374.
    • (2004) Clin Cancer Res , vol.10 , pp. 5367-5374
    • Nielsen, T.O.1    Hsu, F.D.2    Jensen, K.3
  • 60
    • 43549106185 scopus 로고    scopus 로고
    • Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer
    • Abstract 308
    • O'Shaughnessy J, Weckstein D, Vukelja SJ, et al. Preliminary results of a randomized phase II study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer. Breast Cancer Res Treat 2007; 106 (Suppl 1):S32; Abstract 308.
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. 1
    • O'Shaughnessy, J.1    Weckstein, D.2    Vukelja, S.J.3
  • 61
    • 84860697370 scopus 로고    scopus 로고
    • Cetuximab \+ cisplatin in estrogen receptor-negative, progesterone receptor-negative, HER2-negative (triplenegative) metastatic breast cancer: Results of the randomized phase II BALI-1 trial
    • Baselga J, Stemmer S, Pego A, et al. Cetuximab \+ cisplatin in estrogen receptor-negative, progesterone receptor-negative, HER2-negative (triplenegative) metastatic breast cancer: results of the randomized phase II BALI-1 trial. Cancer Res 2011; 70(Suppl 24):PD01-01.
    • (2011) Cancer Res , vol.70 , Issue.SUPPL. 24
    • Baselga, J.1    Stemmer, S.2    Pego, A.3
  • 62
    • 84864101306 scopus 로고    scopus 로고
    • TBCRC 001: Randomized phase ii study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
    • Carey LA, Rugo HS, Marcom PK, et al. TBCRC 001: randomized phase ii study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer. J Clin Oncol 2012; 30:2615-2623.
    • (2012) J Clin Oncol , vol.30 , pp. 2615-2623
    • Carey, L.A.1    Rugo, H.S.2    Marcom, P.K.3
  • 63
    • 84873084721 scopus 로고    scopus 로고
    • Panitumumab in combination with FEC 100 (5-fluorouracile, epirubicin, cyclophosphamide) followed by docetaxel (T) in patients with operable, triple negative breast cancer (TNBC): Final results of a multicentre neoadjuvant pilot phase II study
    • P3-14-01
    • Nabholtz J-M, Weber B, Gligorov J, et al. Panitumumab in combination with FEC 100 (5-fluorouracile, epirubicin, cyclophosphamide) followed by docetaxel (T) in patients with operable, triple negative breast cancer (TNBC): final results of a multicentre neoadjuvant pilot phase II study. Cancer Res 2012; 71(Suppl 24):P3-14-01.
    • (2012) Cancer Res , vol.71 , Issue.SUPPL. 24
    • Nabholtz, J.-M.1    Weber, B.2    Gligorov, J.3
  • 64
    • 34548701082 scopus 로고    scopus 로고
    • Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basaltype/' triple-negative' breast cancer cell lines growing in vitro
    • Finn RS, Dering J, Ginther C, et al. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basaltype/' triple-negative' breast cancer cell lines growing in vitro. Breast Cancer Res Treat 2007; 105:319-326.
    • (2007) Breast Cancer Res Treat , vol.105 , pp. 319-326
    • Finn, R.S.1    Dering, J.2    Ginther, C.3
  • 65
    • 84873084968 scopus 로고    scopus 로고
    • A phase II preoperative study of dasatinib a multi-targeted tyrosine kinase inhibitor in locally advanced 'triple-negative' breast cancer patients
    • P3-14-09
    • Rimawi M, Rodriguez A, Yang W, et al. A phase II preoperative study of dasatinib, a multi-targeted tyrosine kinase inhibitor, in locally advanced 'triple-negative' breast cancer patients. Cancer Res 2012; 71(Suppl 24): P3-14-09.
    • (2012) Cancer Res , vol.71 , Issue.SUPPL. 24
    • Rimawi, M.1    Rodriguez, A.2    Yang, W.3
  • 66
    • 80455173400 scopus 로고    scopus 로고
    • Dasatinib as a single agent in triplenegative breast cancer: Results of an open-label phase 2 study
    • Finn RS, Bengala C, Ibrahim N, et al. Dasatinib as a single agent in triplenegative breast cancer: results of an open-label phase 2 study. Clin Cancer Res 2011; 17:6905-6913.
    • (2011) Clin Cancer Res , vol.17 , pp. 6905-6913
    • Finn, R.S.1    Bengala, C.2    Ibrahim, N.3
  • 67
    • 84873092076 scopus 로고    scopus 로고
    • Targeting the androgen receptor (AR) in women with AR\+ ER-/PR-metastatic breast cancer (MBC)
    • 30 May
    • Gucalp A, Tolaney SM, Isakoff SJ, et al. Targeting the androgen receptor (AR) in women with AR\+ ER-/PR-metastatic breast cancer (MBC). ASCO Meeting Abstracts; 30 May 2012; 30(Suppl 15):1006.
    • (2012) ASCO Meeting Abstracts , vol.30 , Issue.SUPPL. 15 , pp. 1006
    • Gucalp, A.1    Tolaney, S.M.2    Isakoff, S.J.3
  • 68
    • 80054113710 scopus 로고    scopus 로고
    • Unravelling the epigenomic dimension of breast cancers
    • Dedeurwaerder S, Fumagalli D, Fuks F. Unravelling the epigenomic dimension of breast cancers. Curr Opin Oncol 2011; 23:559-565.
    • (2011) Curr Opin Oncol , vol.23 , pp. 559-565
    • Dedeurwaerder, S.1    Fumagalli, D.2    Fuks, F.3
  • 69
    • 77957583101 scopus 로고    scopus 로고
    • Evaluation of BRCA1 inactivation by promoter methylation as a marker of triple-negative and basal-like breast cancers
    • Grushko TA, Nwachukwu C, Charoenthammaraksa S, et al. Evaluation of BRCA1 inactivation by promoter methylation as a marker of triple-negative and basal-like breast cancers. ASCO Meeting Abstracts; 14 June 2010; 28(Suppl 15):10510.
    • (2010) ASCO Meeting Abstracts; 14 June , vol.28 , Issue.SUPPL. 15 , pp. 10510
    • Grushko, T.A.1    Nwachukwu, C.2    Charoenthammaraksa, S.3
  • 70
    • 84861968080 scopus 로고    scopus 로고
    • Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat
    • Tate CR, Rhodes LV, Segar HC, et al. Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostat. Breast Cancer Res 2012; 14:R79.
    • (2012) Breast Cancer Res , vol.14
    • Tate, C.R.1    Rhodes, L.V.2    Segar, H.C.3
  • 71
    • 84873085766 scopus 로고    scopus 로고
    • Using epigenetic reprogramming to target triple-negative breast cancer
    • 8 June
    • Sharma D, Knight BB, Yacoub R, et al. Using epigenetic reprogramming to target triple-negative breast cancer. ASCO Meeting Abstracts; 8 June 2009; 27(15S):e14565.
    • (2009) ASCO Meeting Abstracts , vol.27 , Issue.15
    • Sharma, D.1    Knight, B.B.2    Yacoub, R.3


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