-
2
-
-
84922480032
-
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
-
Buitrago Santanilla, A. et al. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules. Science 347, 49-53 (2015).
-
(2015)
Science
, vol.347
, pp. 49-53
-
-
Buitrago Santanilla, A.1
-
3
-
-
84925610421
-
Multi-kilo delivery of AMG 925 featuring a Buchwald-Hartwig amination and processing with insoluble synthetic intermediates
-
Affouard, C. et al. Multi-kilo delivery of AMG 925 featuring a Buchwald-Hartwig amination and processing with insoluble synthetic intermediates. Org. Process Res. Dev. 19, 476-485 (2015).
-
(2015)
Org. Process Res. Dev.
, vol.19
, pp. 476-485
-
-
Affouard, C.1
-
4
-
-
79952637489
-
Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals
-
Magano, J. and Dunetz, J. R. Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals. Chem. Rev. 111, 2177-2250 (2011).
-
(2011)
Chem. Rev.
, vol.111
, pp. 2177-2250
-
-
Magano, J.1
Dunetz, J.R.2
-
7
-
-
70349527578
-
Formation of ArF from LPdAr(F): Catalytic conversion of aryl triflates to aryl fluorides
-
Watson, D. A. et al. Formation of ArF from LPdAr(F): catalytic conversion of aryl triflates to aryl fluorides. Science 325, 1661-1664 (2009).
-
(2009)
Science
, vol.325
, pp. 1661-1664
-
-
Watson, D.A.1
-
8
-
-
84887074433
-
An improved catalyst system for the Pd-catalyzed fluorination of (hetero)aryl triflates
-
Lee, H. G., Milner, P. J. and Buchwald, S. L. An improved catalyst system for the Pd-catalyzed fluorination of (hetero)aryl triflates. Org. Lett. 15, 5602-5605 (2013).
-
(2013)
Org. Lett.
, vol.15
, pp. 5602-5605
-
-
Lee, H.G.1
Milner, P.J.2
Buchwald, S.L.3
-
9
-
-
84896312828
-
Pd-catalyzed nucleophilic fluorination of aryl bromides
-
Lee, H. G., Milner, P. J. and Buchwald, S. L. Pd-catalyzed nucleophilic fluorination of aryl bromides. J. Am. Chem. Soc. 136, 3792-3795 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 3792-3795
-
-
Lee, H.G.1
Milner, P.J.2
Buchwald, S.L.3
-
10
-
-
84874971232
-
Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions
-
Bruno, N. C., Tudge, M. T. and Buchwald, S. L. Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions. Chem. Sci. 4, 916-920 (2013).
-
(2013)
Chem. Sci.
, vol.4
, pp. 916-920
-
-
Bruno, N.C.1
Tudge, M.T.2
Buchwald, S.L.3
-
11
-
-
78449260529
-
A multiligand based Pd catalyst for C-N crosscoupling reactions
-
Fors, B. P. and Buchwald, S. L. A multiligand based Pd catalyst for C-N crosscoupling reactions. J. Am. Chem. Soc. 132, 15914-15917 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 15914-15917
-
-
Fors, B.P.1
Buchwald, S.L.2
-
12
-
-
84887966036
-
Synthesis of solid 2-pyridylzinc reagents and their application inNegishi reactions
-
Colombe, J. R., Bernhardt, S., Stathakis, C., Buchwald, S. L. and Knochel, P. Synthesis of solid 2-pyridylzinc reagents and their application inNegishi reactions. Org. Lett. 15, 5754-5757 (2013).
-
(2013)
Org. Lett.
, vol.15
, pp. 5754-5757
-
-
Colombe, J.R.1
Bernhardt, S.2
Stathakis, C.3
Buchwald, S.L.4
Knochel, P.5
-
15
-
-
0037200180
-
A new chromium-based catalyst coated with paraffin for ethylene oligomerization and the effect of chromium state on oligomerization selectivity
-
Fang, Y. et al. A new chromium-based catalyst coated with paraffin for ethylene oligomerization and the effect of chromium state on oligomerization selectivity. Appl. Catal. A 235, 33-38 (2002).
-
(2002)
Appl. Catal. A
, vol.235
, pp. 33-38
-
-
Fang, Y.1
-
16
-
-
0037696802
-
Grubbs catalyst in paraffin: An air-stable preparation for alkene metathesis
-
Taber, D. F. and Frankowski, K. J. Grubbs catalyst in paraffin: an air-stable preparation for alkene metathesis. J. Org. Chem. 68, 6047-6048 (2003).
-
(2003)
J. Org. Chem.
, vol.68
, pp. 6047-6048
-
-
Taber, D.F.1
Frankowski, K.J.2
-
17
-
-
33750874090
-
Potassiumhydride in paraffin: A useful base for organic synthesis
-
Taber, D. F. and Nelson, C.G. Potassiumhydride in paraffin: a useful base for organic synthesis. J. Org. Chem. 71, 8973-8974 (2006).
-
(2006)
J. Org. Chem.
, vol.71
, pp. 8973-8974
-
-
Taber, D.F.1
Nelson, C.G.2
-
18
-
-
0034926661
-
Fluorine substituent effects (on bioactivity)
-
Smart, B. E. Fluorine substituent effects (on bioactivity). J. Fluor. Chem. 109, 3-11 (2001).
-
(2001)
J. Fluor. Chem.
, vol.109
, pp. 3-11
-
-
Smart, B.E.1
-
19
-
-
17044421336
-
Orthogonal multipolar interactions in structural chemistry and biology
-
Paulini, R., Muller, K. and Diederich, F. Orthogonal multipolar interactions in structural chemistry and biology. Angew. Chem. Int. Ed. 44, 1788-1805 (2005).
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 1788-1805
-
-
Paulini, R.1
Muller, K.2
Diederich, F.3
-
20
-
-
34848848499
-
Fluorine in pharmaceuticals: Looking beyond intuition
-
Muller, K., Faeh, C. and Diederich, F. Fluorine in pharmaceuticals: looking beyond intuition. Science 317, 1881-1886 (2007).
-
(2007)
Science
, vol.317
, pp. 1881-1886
-
-
Muller, K.1
Faeh, C.2
Diederich, F.3
-
21
-
-
84921732682
-
Modern carbon-fluorine bond forming reactions for aryl fluoride synthesis
-
Campbell, M. G. and Ritter, T. Modern carbon-fluorine bond forming reactions for aryl fluoride synthesis. Chem. Rev. 115, 612-633 (2015).
-
(2015)
Chem. Rev.
, vol.115
, pp. 612-633
-
-
Campbell, M.G.1
Ritter, T.2
-
22
-
-
85178394634
-
Aromatic fluorine compounds. I. A new method for their preparation
-
Balz, G. and Schiemann, G. Aromatic fluorine compounds. I. A new method for their preparation. Ber. Dtsch. Chem. Gesell. 60, 1186-1190 (1927).
-
(1927)
Ber. Dtsch. Chem. Gesell.
, vol.60
, pp. 1186-1190
-
-
Balz, G.1
Schiemann, G.2
-
23
-
-
0001046519
-
Aromatic fluorine compounds. VII. Replacement of aromatic -Cl and -NO2 groups by F
-
Finger, G. C. and Kruse, C. W. Aromatic fluorine compounds. VII. Replacement of aromatic -Cl and -NO2 groups by -F. J. Am. Chem. Soc. 78, 6034-6037 (1956).
-
(1956)
J. Am. Chem. Soc.
, vol.78
, pp. 6034-6037
-
-
Finger, G.C.1
Kruse, C.W.2
-
24
-
-
75449093256
-
The organometallic fluorine chemistry of palladium and rhodium: Studies toward aromatic fluorination
-
Grushin, V. V. The organometallic fluorine chemistry of palladium and rhodium: studies toward aromatic fluorination. Acc. Chem. Res. 43, 160-171 (2010).
-
(2010)
Acc. Chem. Res.
, vol.43
, pp. 160-171
-
-
Grushin, V.V.1
-
25
-
-
33846796141
-
Aryl-fluoride reductive elimination from Pd(II): Feasibility assessment from theory and experiment
-
Yandulov, D. V. and Tran, N. T. Aryl-fluoride reductive elimination from Pd(II): feasibility assessment from theory and experiment. J. Am. Chem. Soc. 129, 1342-1358 (2007).
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 1342-1358
-
-
Yandulov, D.V.1
Tran, N.T.2
-
27
-
-
79951876322
-
U. S. Advances in the field of p-conjugated 2, 29:69,20-terpyridines
-
Wild, A., Winter, A., Schlutter, F. and Schubert, U. S. Advances in the field of p-conjugated 2,29:69,20-terpyridines. Chem. Soc. Rev. 40, 1459-1511 (2011).
-
(2011)
Chem. Soc. Rev.
, vol.40
, pp. 1459-1511
-
-
Wild, A.1
Winter, A.2
Schlutter, F.3
Schubert4
-
28
-
-
65249123657
-
2-Pyridyl P19-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects
-
DeGoey, D. A. et al. 2-Pyridyl P19-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects. J. Med. Chem. 52, 2571-2586 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2571-2586
-
-
DeGoey, D.A.1
-
29
-
-
78650664109
-
The slow-release strategy in Suzuki-Miyaura coupling
-
Lennox, A. J. J. and Lloyd-Jones, G. C. The slow-release strategy in Suzuki-Miyaura coupling. Isr. J. Chem. 50, 664-674 (2010).
-
(2010)
Isr. J. Chem.
, vol.50
, pp. 664-674
-
-
Lennox, A.J.J.1
Lloyd-Jones, G.C.2
-
30
-
-
84925459184
-
Academia-industry symbiosis in organic chemistry
-
Michaudel, Q., Ishihara, Y. and Baran, P. S. Academia-industry symbiosis in organic chemistry. Acc. Chem. Res. 48, 712-721 (2015).
-
(2015)
Acc. Chem. Res.
, vol.48
, pp. 712-721
-
-
Michaudel, Q.1
Ishihara, Y.2
Baran, P.S.3
|