Maternal nicotine exposure induces epithelial-mesenchymal transition in rat offspring lungs

Neonatology

Volumn 108, Issue 3, 2015, Pages 179-187

  Chen, Chung Ming ^a,c   Chou, Hsiu Chu ^a   Huang, Liang Ti ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

E cadherin; Fibroblast specific protein 1; N cadherin; Nicotine; Smooth muscle actin

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CALVASCULIN; COLLAGEN; NERVE CELL ADHESION MOLECULE; NICOTINE TARTRATE; SMOOTH MUSCLE ACTIN; SODIUM CHLORIDE; UVOMORULIN; VIMENTIN; 8-OXO-7-HYDRODEOXYGUANOSINE; ACTIN; CADHERIN; CALCIUM BINDING PROTEIN; DEOXYGUANOSINE; FSP1 PROTEIN, RAT; NICOTINE; SMOOTH MUSCLE ACTIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHIOLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; IMMUNOREACTIVITY; LUNG; LUNG PARENCHYMA; MATERNAL SMOKING; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RAT; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; IMMUNOLOGY; LACTATION; LUNG FIBROSIS; MATERNAL EXPOSURE; METABOLISM; PATHOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; ANIMALS, NEWBORN; CADHERINS; CALCIUM-BINDING PROTEINS; COLLAGEN; DEOXYGUANOSINE; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; LACTATION; LUNG; MATERNAL EXPOSURE; NICOTINE; PREGNANCY; PULMONARY FIBROSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84939486799     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000437012     Document Type: Article

References (25)

1. Abbott LC, Winzer-Serhan UH: Smoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models. Crit Rev Toxicol 2012; 42: 279-303
2. Engelstad HJ, Roghair RD, Calarge CA, Colaizy TT, Stuart S, Haskell SE: Perinatal outcomes of pregnancies complicated by maternal depression with or without selective serotonin reuptake inhibitor therapy. Neonatology 2014; 105: 149-154
3. Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Vora H, Rappaport EB, Avol E, Peters JM: Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax 2000; 55: 271-276
4. Wongtrakool C, Wang N, Hyde DM, Roman J, Spindel ER: Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors. Am J Respir Cell Mol Biol 2012; 46: 695-702
5. Maritz GS, Harding R: Life-long programming implications of exposure to tobacco smoking and nicotine before and soon after birth: evidence for altered lung development. Int J Environ Res Public Health 2011; 8: 875-898
6. Lavezzi AM, Corna MF, Alfonsi G, Matturri L: Possible role of the alpha7 nicotinic receptors in mediating nicotine's effect on developing lung-implications in unexplained human perinatal death. BMC Pulm Med 2014; 14: 11
7. Luck W, Nau H, Hansen R, Steldinger R: Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers. Dev Pharmacol Ther 1985; 8: 384-395
8. Zanetti F, Giacomello M, Donati Y, Carnesecchi S, Frieden M, Barazzone-Argiroffo C: Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells. Free Radic Biol Med 2014; 76: 173-184
9. Nemmar A, Raza H, Subramaniyan D, John A, Elwasila M, Ali BH, Adeghate E: Evaluation of the pulmonary effects of short-term nose-only cigarette smoke exposure in mice. Exp Biol Med (Maywood) 2012; 237: 1449-1456
10. Jensen K, Nizamutdinov D, Guerrier M, Afroze S, Dostal D, Glaser S: General mechanisms of nicotine-induced fibrogenesis. FASEB J 2012; 26: 4778-4787
11. Morse D, Rosas IO: Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev Physiol 2014; 76: 493-513
12. Huang LT, Chou HC, Lin CM, Yeh TF, Chen CM: Maternal nicotine exposure exacerbates neonatal hyperoxia-induced lung fibrosis in rats. Neonatology 2014; 106: 94-101
13. Kalluri R, Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-1428
14. Li G, Satyamoorthy K, Herlyn M: N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res 2001; 61: 3819-3825
15. Zou W, Zou Y, Zhao Z, Li B, Ran P: Nicotineinduced epithelial-mesenchymal transition via Wnt/β-catenin signaling in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2013; 304:L199-L209
16. Chou HC, Chen CM: Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring. Reprod Toxicol 2014; 50: 4-10
17. Murrin LC, Ferrer JR, Wanyun Z, Haley NJ: Nicotine administration to rats: methodological considerations. Life Sci 1987; 40: 1699-1708
18. Ma N, Nicholson CJ, Wong M, Holloway AC, Hardy DB: Fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase. Toxicol Appl Pharmacol 2014; 275: 1-11
19. Luck W, Nau H: Nicotine and cotinine concentrations in serum and urine of infants exposed via passive smoking or milk from smoking mothers. J Pediatr 1985; 107: 816-820
20. Marnett LJ: Oxy-radicals and DNA damage. Carcinogenesis 2000; 21: 361-370
21. Yamagami K, Yamamoto Y, Kume M, Ishikawa Y, Yamaoka Y, Hiai H, Toyokuni S: Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in rat liver after ischemia-reperfusion: distinct localization of the two oxidatively modified products. Antioxid Redox Signal 2000; 2: 127-136
22. Vijayaraghavan M, Wanibuchi H, Karim R, Yamamoto S, Masuda C, Nakae D, Konishi Y, Fukushima S: Dimethylarsinic acid induces 8-hydroxy-2'-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats. Cancer Lett 2001; 165: 11-17
23. Hinz B: Mechanical aspects of lung fibrosis: a spotlight on the myofibroblast. Proc Am Thorac Soc 2012; 9: 137-147
24. Zeisberg M, Neilson EG: Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119: 1429-1437
25. Zapletal A, Houstěk J, Samanek M, Copova M, Paul T: Lung function in children and adolescents with idiopathic interstitial pulmonary fibrosis. Pediatr Pulmonol 1985; 1: 154-166