Dimethylarsinic acid induces 8-hydroxy-2′-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats

Cancer Letters

Volumn 165, Issue 1, 2001, Pages 11-17

  Vijayaraghavan, Meenakshi ^a   Wanibuchi, Hideki ^a   Karim, Rezaul ^a   Yamamoto, Shinji ^a   Masuda, Chikayoshi ^a   Nakae, Dai ^b   Konishi, Yoichi ^b   Fukushima, Shoji ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

2u globulin; 8 OHdG; Dimethylarsinic acid; Oxidative damage; Renal cell proliferation

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALPHA 2U GLOBULIN; CACODYLIC ACID; CYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARSENIC POISONING; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; HISTOPATHOLOGY; KIDNEY CELL; KIDNEY INJURY; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; CACODYLIC ACID; DEOXYGUANOSINE; DNA; HERBICIDES; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; RATS;

ANIMALIA;

EID: 0035836780     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00711-4     Document Type: Article

References (31)

1. Arsenic ingestion and internal cancers: A review
2. Cancer among workers exposed to arsenic and other substances in a copper smelter
3. Is the genotoxic effect of arsenic mediated by oxygen free radicals?
4. Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species
5. Species differences in the metabolism of arsine compounds
6. Induction of DNA damage by dirnethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical
7. DNA-strand breaks induced by dimethylarsinic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals
8. Renal lesions induced in F344/DuCrj rats by 4-weeks administration of dimethylarsinic acid
9. Possible carcinogenic potential of dimethyl arsenic acid as assessed in rat in vivo models: A review
10. Formation of 8-hydroxydeoxyguanosine, hydroxyl free radical adduct of DNA in granulocytes exposed to the tumor promoter, tetradecanoylphorbolacetate
11. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
12. Prooxidant states and tumor promotion
13. Inhibition of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland
14. 2u-globulin nephropathy
15. 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors
16. Lack of induction of epithelial cell proliferation by sodium saccharin and sodium L-ascorbate in the urinary bladder of NCI-Black-Reiter (NBR) male rats
17. Lack of promotion effects of sodium L-ascorbate on urinary bladder carcinogenesis in NCI-Black-Reiter (NBR) male rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine
18. Lack of promoting potential of dimethylarsinic acid in the kidney of male NCI-Black Reiter rats
19. Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)-phthalate and di(2-ethylhexyl)adipate
20. Hydroxy free radical adduct of deoxyguanosine; sensitive detection and mechanisms of formation
21. Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA
22. Detection of apoptotic cells in human colorectal cancer by two different in situ methods: Antibody against single-stranded DNA and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) methods
23. The early stage of absorption of injected horseradish peroxidase in the proximal convoluted tubules of the mouse kidney: Ultrastructural cytochemistry by a new technique
24. Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics
25. Tissue distribution and retention of 74As-dimethylarsinic acid in mice and rats
26. Tumorigenic effect of dimethylarsinic acid in the rat
27. Formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma
28. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions
29. Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: Association with elevated ornithine decarboxylase activity and formation of 8-hydroxyguanosine in the liver
30. Enhancement of the stress response by low concentrations of arsenite in arsenitepretreated Reuber H35 hepatoma cells
31. Metals and disorders of cell accumulation: Modulation of apoptosis and cell proliferation