Memory programming in CD8+T-cell differentiation is intrinsic and is not determined by CD4 help

Nature Communications

Volumn 6, Issue , 2015, Pages

  Kim, Juhyun ^a   Ryu, Su Jeong ^a   Oh, Keunhee ^a   Ju, Ji Min ^a   Jeon, Ji Yeong ^a   Nam, Giri ^a   Lee, Dong Sup ^a   Kim, Hang Rae ^a   Kim, Joo Young ^b   Chang, Jun ^b   Sproule, Thomas ^c   Choi, Kyungho ^a   Roopenian, Derry ^c   Choi, Eun Young ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

^c JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; H60 ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN; UNCLASSIFIED DRUG; ANTIBODY; GAMMA INTERFERON; MICROSPHERE; MINOR H ANTIGEN H60; RNA;

ANTIGEN; CELLS AND CELL COMPONENTS; IMAGE ANALYSIS; MEMORY; PHENOTYPIC PLASTICITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; FUNCTIONAL DISEASE; HELPER CELL; MALE; MEMORY CELL; MEMORY PROGRAMMING; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; ADOPTIVE TRANSFER; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INBRED MOUSE STRAIN; METABOLISM; PHYSIOLOGY;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; MICE; MICE, INBRED STRAINS; MICROSPHERES; MINOR HISTOCOMPATIBILITY ANTIGENS; RNA;

EID: 84939446003     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8994     Document Type: Article

References (48)

1. + T-cell response. Nat. Rev. Immunol. 4, 595-602 (2004).
2. + T lymphocytes. Nature 421, 852-856 (2003).
3. Shedlock, D. J. & Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300, 337-339 (2003).
4. Sun, J. C. & Bevan, M. J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300, 339-342 (2003).
5. Schoenberger, S. P., Toes, R. E., van der Voort, E. I., Offringa, R. & Melief, C. J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393, 480-483 (1998).
6. + memory T cell subsets. Proc. Natl Acad. Sci. USA 101, 5610-5615 (2004).
7. + T cells: when, where, and how. Ann. Rev. Immunol 24, 519-540 (2006).
8. Schluns, K. S. & Lefrancois, L. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3, 269-279 (2003).
9. + T cell without effector differentiation. Proc. Natl Acad. Sci. USA 103, 19454-19459 (2006).
10. Peperzak, V., Xiao, Y., Veraar, E. A. & Borst, J. CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production. J. Clin. Invest. 120, 168-178 (2010).
11. + effector T cell pool. J. Immunol. 191, 3025-3036 (2013).
12. Antoniou, A. et al. T cell tolerance and activation to a transgene-encoded tumor antigen. Eur. J. Immunol. 26, 1094-1102 (1996).
13. + T cells. J. Exp. Med. 177, 1587-1592 (1993).
14. Filatenkov, A. A. et al. CD4 T cell-dependent conditioning of dendritic cells to produce IL-12 results in CD8-mediated graft rejection and avoidance of tolerance. J. Immunol. 174, 6909-6917 (2005).
15. Zhai, Y., Wang, Y., Wu, Z. & Kupiec-Weglinski, J. W. Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help. J. Immunol. 179, 4529-4534 (2007).
16. Roopenian, D., Choi, E. Y. & Brown, A. The immunogenomics of minor histocompatibility antigens. Immunol. Rev. 190, 86-94 (2002).
17. Choi, E. Y. et al. Quantitative analysis of the immune response to mouse non- MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others. J. Immunol. 166, 4370-4379 (2001).
18. Choi, E. Y. et al. Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide. Immunity 17, 593-603 (2002).
19. Malarkannan, S. et al. The molecular and functional characterization of a dominant minor H antigen, H60. J. Immunol. 161, 3501-3509 (1998).
20. Scott, D. et al. Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens. Immunity 12, 711-720 (2000).
21. Jung, K. M. & Choi, E. Y. Role for CD40 and CD40L expression in generating CD8 T cell response to minor histocompatibility antigen, H60. Immune Netw. 7, 6 (2007).
22. Ryu, S. J. et al. Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60. Blood 113, 4273-4280 (2009).
23. Choi, J. H. et al. TCR diversity of H60-specific CD8 T cells during the response evolution and influence of CD4 help. Transplantation 87, 1609-1616 (2009).
24. Alexander, M. A., Damico, C. A., Wieties, K. M., Hansen, T. H. & Connolly, J. M. Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes. J. Exp. Med. 173, 849-858 (1991).
25. Wherry, E. J., Puorro, K. A., Porgador, A. & Eisenlohr, L. C. The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained. J. Immunol. 163, 3735-3745 (1999).
26. Song, M. G. et al. In vivo imaging of differences in early donor cell proliferation in graft-versus-host disease hosts with different pre-conditioning doses. Mol. Cells 33, 79-86 (2012).
27. Jeon, J. Y., Jung, K. M., Chang, J. & Choi, E. Y. Characterization of CTL clones specific for single antigen, H60 minor histocompatibility antigen. Immune Netw. 11, 100-106 (2011).
28. + T cells. J. Exp. Med. 204, 2015-2021 (2007).
29. Moon, J. J. et al. Tracking epitope-specific T cells. Nat. Protoc. 4, 565-581 (2009).
30. Wherry, E. J. T cell exhaustion. Nat. Immunol. 12, 492-499 (2011).
31. + T cell exhaustion during chronic viral infection. Immunity 31, 309-320 (2009).
32. + T cell exhaustion during chronic viral infection. Immunity 27, 670-684 (2007).
33. Blackburn, S. D., Shin, H., Freeman, G. J. & Wherry, E. J. Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade. Proc. Natl Acad. Sci. USA 105, 15016-15021 (2008).
34. Ha, S. J. et al. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J. Exp. Med. 205, 543-555 (2008).
35. + T cell differentiation into short-lived effector cells leading to memory degeneration. J. Exp. Med. 208, 1605-1620 (2011).
36. Ehst, B. D., Ingulli, E. & Jenkins, M. K. Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection. Am. J. Transplant. 3, 1355-1362 (2003).
37. + T cell fates via the graded expression of T-bet transcription factor. Immunity 27, 281-295 (2007).
38. D'Souza, W. N. & Hedrick, S. M. Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J. Immunol. 177, 777-781 (2006).
39. + T cell lineage commitment. Nat. Immunol. 6, 793-799 (2005).
40. Zehn, D., Lee, S. Y. & Bevan, M. J. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458, 211-214 (2009).
41. Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R. & Ahmed, R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77, 4911-4927 (2003).
42. + T cell generation after acute infection. J. Immunol. 179, 53-63 (2007).
43. + T cells during infection with intracellular bacteria promotes differentiation primarily into a central (CD62LhighCD44high) subset. J. Immunol. 174, 5341-5350 (2005).
44. Vezys, V. et al. Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J. Exp. Med. 203, 2263-2269 (2006).
45. + T cells in primary and secondary responses. Proc. Natl Acad. Sci. USA 107, 193-198 (2010).
46. Khanolkar, A., Fuller, M. J. & Zajac, A. J. CD4 T cell-dependent CD8 T cell maturation. J. Immunol. 172, 2834-2844 (2004).
47. + T-cell help. Nature 462, 510-513 (2009).
48. Kouskoff, V., Signorelli, K., Benoist, C. & Mathis, D. Cassette vectors directing expression of T cell receptor genes in transgenic mice. J. Immunol. Methods 180, 273-280 (1995).