Carrier-Mediated Transport of Nicotine Across the Inner Blood-Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H+ Gradient

Journal of Pharmaceutical Sciences

Volumn 104, Issue 9, 2015, Pages 3069-3075

  Tega, Yuma ^a   Kubo, Yoshiyuki ^a   Yuzurihara, Chihiro ^a   Akanuma, Shin Ichi ^a   Hosoya, Ken Ichi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

blood retinal barrier; drug transport; in vitro models; membrane transport; membrane transporter; nicotine; organic cation transporter; TR iBRB2 cells; transporters

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 4 AMINOHIPPURIC ACID; CARNITINE; CHOLINE; CLONIDINE; DESIPRAMINE; MEPYRAMINE; NICOTINE; ORGANIC CATION TRANSPORTER; PROPIVERINE; PROPRANOLOL; SEROTONIN; TETRYLAMMONIUM; THIAMINE; TIMOLOL; TRITIUM; VERAPAMIL; CARRIER PROTEIN; CATION; HYDROGEN;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD RETINA BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; INNER BLOOD RETINAL BARRIER; LIPOPHILICITY; MALE; MEMBRANE TRANSPORT; NONHUMAN; RAT; TEMPERATURE; ANIMAL; CELL LINE; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; PHYSIOLOGY; RETINA; RETINA BLOOD VESSEL; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-RETINAL BARRIER; CARRIER PROTEINS; CATIONS; CELL LINE; ENDOTHELIAL CELLS; HYDROGEN; MALE; NICOTINE; ORGANIC CATION TRANSPORT PROTEINS; PYRILAMINE; RATS; RATS, WISTAR; RETINA; RETINAL VESSELS; VERAPAMIL;

EID: 84939254438     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24453     Document Type: Article

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