Englerin a agonizes the TRPC4/C5 cation channels to inhibit tumor cell line proliferation

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Carson, Cheryl ^a   Raman, Pichai ^a   Tullai, Jennifer ^a   Xu, Lei ^a   Henault, Martin ^a   Thomas, Emily ^a   Yeola, Sarita ^a   Lao, Jianmin ^c   McPate, Mark ^a   Martin Verkuyl, J ^a   Marsh, George ^a   Sarber, Jason ^a   Amaral, Adam ^a   Bailey, Scott ^a   Lubicka, Danuta ^a   Pham, Helen ^a   Miranda, Nicolette ^a   Ding, Jian ^a   Tang, Hai Ming ^a   Ju, Haisong ^a   Tranter, Pamela ^a   Ji, Nan ^a   Krastel, Philipp ^b   Jain, Rishi K ^a   Schumacher, Andrew M ^c   Loureiro, Joseph J ^a   George, Elizabeth ^a   Berellini, Giuliano ^a   Ross, Nathan T ^a   Bushell, Simon M ^a   Erdemli, Gül ^a   Solomon, Jonathan M ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ENGLERIN A; ENGLERIN B; ML 204; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4 AGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5 AGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1 AGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1 ANTAGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6 ANTAGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8 AGONIST; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8 ANTAGONIST; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 3 AGONIST; VANILLOID RECEPTOR 3 ANTAGONIST; VANILLOID RECEPTOR 4 AGONIST; VANILLOID RECEPTOR 4 ANTAGONIST; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; SESQUITERPENE; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC4 ION CHANNEL; TRPC5 PROTEIN, HUMAN;

A 498 CELL LINE; A 673 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CANCER INHIBITION; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG EFFICACY; DRUG FORMULATION; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SENSITIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; ELECTROPHYSIOLOGY; FEMALE; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; HG U133 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; LETHAL DOSE; MALE; MEAN ARTERIAL PRESSURE; MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; RODENT; SINGLE DRUG DOSE; TRPC4 GENE; TUMOR CELL LINE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, RENAL CELL; DRUG EFFECTS; GENETIC TRANSFECTION; KIDNEY NEOPLASMS; NUDE MOUSE; RNA INTERFERENCE;

RODENTIA;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL PROLIFERATION; HEK293 CELLS; HUMANS; INDOLES; KIDNEY NEOPLASMS; MICE; MICE, NUDE; PIPERIDINES; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SESQUITERPENES, GUAIANE; TRANSFECTION; TRPC CATION CHANNELS;

EID: 84939251128     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127498     Document Type: Article

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