Epithelial to mesenchymal transition is associated with rapamycin resistance

Oncotarget

Volumn 6, Issue 23, 2015, Pages 19500-19513

  Holder, Ashley M ^a,b   Akcakanat, Argun ^a   Adkins, Farrell ^c   Evans, Kurt ^a   Chen, Huiqin ^a   Wei, Caimiao ^a   Milton, Denai R ^a   Li, Yisheng ^a   Do, Kim Anh ^a   Janku, Filip ^a   Meric Bernstam, Funda ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c DEPARTMENT OF COLORECTAL SURGERY   (United States)

Author keywords

Biomarker; E cadherin; Epithelial to mesenchymal transition (EMT); Rapamycin; Trametinib

Indexed keywords

HISTONE DEACETYLASE; MITOGEN ACTIVATED PROTEIN KINASE; RAPAMYCIN; SMAD3 PROTEIN; TRAMETINIB; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; ANTINEOPLASTIC AGENT; CADHERIN; CDH1 PROTEIN, HUMAN; HISTONE DEACETYLASE INHIBITOR; HOMEODOMAIN PROTEIN; MICRORNA; MIRN200 MICRORNA, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MTOR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PYRIDONE DERIVATIVE; PYRIMIDINONE DERIVATIVE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZEB1; ZEB1 PROTEIN, HUMAN;

ACHN CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CANCER RESISTANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SENSITIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; IN VITRO STUDY; MCF 7 CELL LINE; MDA MB 231 CELL LINE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; MCF-7 CELL LINE; METABOLISM; MUTATION; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; TIME FACTOR; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CADHERINS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASE INHIBITORS; HOMEODOMAIN PROTEINS; HUMANS; MCF-7 CELLS; MICE, NUDE; MICRORNAS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDONES; PYRIMIDINONES; RNA INTERFERENCE; SIROLIMUS; SNAIL FAMILY TRANSCRIPTION FACTORS; TIME FACTORS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS; ZINC FINGER E-BOX-BINDING HOMEOBOX 1;

EID: 84939248365     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3669     Document Type: Article

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